Clinical trials: Gastric Bypass
Post-operative Pain Management
Efficacy of Exparel (TM) on Post-operative Pain After Laparoscopic Gastric Bypass Using Circular EEA Stapler
This will be a comparative study between two cohorts of patients undergoing Roux-en-Y Gastric bypass. One cohort (75 patients) will receive FDA approved Exparel® (liposome bupivacaine injection solution) injections…
- Trial name
- NCT03187379
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Matthew Kroh
Obesity, Morbid, Gastroesophageal Reflux (GERD)
AJYR+GV vs RYGB for GERD
This study focuses on gastroesophageal reflux disease (GERD), a condition in which stomach acid flows back into the esophagus (the tube that carries food from the mouth to the stomach), causing heartburn and other symptoms.
- Trial name
- NCT07768202
- Testing
- sleeve gastrectomy with Roux-en-Y antrojejunal anastomosis, AJYR+SG, Roux-en-Y gastric bypass, RYGB
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Victor Dib Institute
Obesity, Bone Loss
The Effect of Gastric Bypass Surgery on Gut Hormones Related to Bone Remodeling and Intestinal Growth.
The overall purpose is to explore the link between the gut and the bones by investigating meal stimulated changes in the blood level of a number of hormones and markers related to intestinal growth and bone turnover in patients…
- Trial name
- NCT01700686
- Testing
- Meal test and dexa scan
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Copenhagen
Inadequate Initial Weight Loss, Persistent Clinically Severe Obesity
Laparoscopic Revision Gastric Bypass for Inadequate Initial Weight Loss
The main aim of this study is to analyze and report traditional, patient-centered, and composite intermediate-term outcomes after laparoscopic revision Roux-en-Y gastric bypass surgery for inadequate initial weight loss.
- Trial name
- IIWL (NCT01040377)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Francisco
Obesity
Effect of Gastric Bypass Surgery on Pancreatic Islet and Incretin Function - Follow-up Study
To examine pancreatic islet function and incretin function during intravenous and oral stimulation >2 years after gastric bypass surgery in patients with normal glucose tolerance.
- Trial name
- NCT02161666
- Where
- Denmark
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Morbid Obesity, Bariatric Surgery
Randomized Trial of Preoperative Diets Before Bariatric Surgery
Randomized clinical trial of two preoperative diets before bariatric surgery (gastric bypass)comparing standard diet and Prodimed (VLCD) in 100 morbidly obese patients selected for a gastric bypass procedure
- Conditions
- Morbid Obesity, Bariatric Surgery, Gastric Bypass
- Trial name
- NCT01652105
- Testing
- Standard diet versus standard VLCD (Prodimed)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Lievensberg Ziekenhuis
Hypoglycemia, Obesity, Morbid
The Effect of 'Medical Nutrition Therapy' on Post-bariatric Hypoglycemia 2-4 Years After Gastric Bypass Surgery
This is a pilot study to explore the effect of 'medical nutritional therapy' in patients diagnosed with post-bariatric hypoglycemia (PBH), 2-4 years after gastric bypass surgery.
- Trial name
- NCT05011682
- Testing
- Regular diet, 10-point nutrition plan
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- Helse Nord-Trøndelag HF
Pancreatic Cancer, Periampullary Tumor
Double Bypass Versus Stent-treatment in Irresectable Pancreatic Cancer
Double bypass (hepaticojejunostomy + gastrojejunostomy) is compared to stent strategy in patients planned for curative pancreatic resection in whom peroperative findings makes resection impossible.
- Trial name
- NCT01569282
- Testing
- Hepaticojejunostomy and gastroenterostomy, Stent strategy
- Where
- 6 sites in Sweden
- Sponsor
- Göteborg University
Laparoscopic Sleeve Gastrectomy, Sleeve Gastrectomy
A Retrospective Multicenter Comparison of Laparoscopic and Robotic-Assisted Roux-en-Y Gastrectomy
The prevalence of obesity has tripled in the last 50 years with presently about 1.7 billion of the world population aged 18 years and over either overweight or obese.1 In the US alone, 35% of the population is obese.2 Although…
- Trial name
- NCT05224791
- Testing
- Roux-en-Y Gastric Bypass, Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Obesity, Morbid, Type2 Diabetes
The Endocrine Secretome After Gastric Bypass Surgery
Examination of the molecular phenotype and composition of endocrine cells in the gastrointestinal tract correlated to analyses of blood for hormones/analytes before and after Roux-en-Y gastric bypass surgery in morbidly obese…
- Trial name
- NCT03093298
- Testing
- Enteroscopy with biopsy sampling and mixed meal test
- Volunteers
- 28 people
- Sponsor
- Filip Krag Knop
Roux-en-Y Gastric Bypass, Obesity
Meal Glycaemic Index and Exercise After Gastric Bypass
The study will evaluate postprandial glucose excursions and gut hormone secretion after ingestion of meals with different glycaemic index (GI) values (high vs low) followed by an acute bout of exercise or rest in gastric bypass…
- Trial name
- NCT03478098
- Testing
- Low GI mealtest, Low GI mealtest and subsequent exercise, High GI mealtest
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kirstine Nyvold Bojsen-Moeller
Obesity, Morbid, Diabetes Mellitus, Type 2
Different Limb Lengths in Gastric Bypass Surgery
Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of…
- Conditions
- Obesity, Morbid, Diabetes Mellitus, Type 2, Hypertension, Dyslipidemias
- Trial name
- SLIM (NCT04219787)
- Testing
- Long BPL LRYGB, Short BPL LRYGB
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- Clarunis - Universitäres Bauchzentrum Basel
Diabetes, Surgery
Tailored Bilio-Pancreatic Limb and HbA1c 10 Years Post Mini-Gastric Bypass
Diabetes is now or soon will be a worldwide epidemic. Diabetes has impact on both healthcare costs in addition to the costs in human lives, suffering and disability. Treatment that lowers Hemoglobin A1c (HbA1c) improved outcomes.
- Trial name
- BPLLvHbA1c (NCT04442698)
- Testing
- Mini-Gastric Bypass Original Technique
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kular Hospital
Obesity, Fatty Liver
Impact of Bariatric Surgery on the Evolution of Nonalcoholic Fatty Liver Disease: a Comparative Clinical Trial Between Sleeve Gastrectomy and Gastric Bypass
Aim: To compare prospectively two bariatric surgery techniques: sleeve gastrectomy (SG) vs gastric bypass (GB) in the evolution of nonalcoholic fatty liver disease (NAFLD) measured by the transient elastography in the first year.
- Trial name
- NCT02394353
- Testing
- Transient hepatic elastography
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Brazil
Overweight
Trial of Leptin Administration After Roux-en-Y Gastric Bypass
This is a pilot and feasibility study to examine a novel intervention using leptin in weight-reduced individuals who have undergone bariatric surgery but still remain obese.
- Trial name
- NCT00710814
- Testing
- Leptin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Columbia University
Obesity
Effect of Acute Exercise on Food Intake and Energy Expenditure Following a Gastric Bypass
This pilot study will use a crossover design to explore the effects of acute exercise following bariatric surgery on food intake, energy expenditure, appetite, food reward, appetite hormones, and inflammatory response.
- Trial name
- ExoABari (NCT04348617)
- Testing
- Moderate exercise, Rest
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
Obesity
Fructose-induced Intestinal de Novo Lipogenesis
8 healthy volunteers, 8 pre-bypass obese subjects, 8 subjects between 12-18 months post-bypass, and 8 subjects matched to the post-bypass patients will be studied in two sub-studies Sub-study 1) after ingestion of two or three…
- Trial name
- FIDNL (NCT01792089)
- Testing
- fat+protein meal, Fat + protein + 13C fructose meal, Fat+protein+13C fructose+glucose meal
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Gastric Procedures, Lung Resection Procedures
Study of ECHELON ENDOPATH(TM) Staple Line Reinforcement
This prospective, single-arm, multi-center evaluation will collect clinical data in a post-market setting. The two types of procedures studied will be gastric and thoracic.
- Trial name
- NCT04544865
- Testing
- Staple Line Reinforcement
- Where
- 8 sites in United States
- Volunteers
- 240 people
- Sponsor
- Ethicon Endo-Surgery
Obesity
Cerebrospinal Fluid Biomarkers in Bariatric Surgery
The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms.
- Trial name
- NCT04350892
- Testing
- Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Very Low Calorie Diet (VLCD)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obesity, Morbid, Postoperative Pain
Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting
The purpose of this research study is to evaluate the drug gabapentin (Neurontin®) for its ability to reduce postoperative pain, the need for morphine-like pain medication, and the severity and frequency of postoperative nausea…
- Conditions
- Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
- Trial name
- NCT00886236
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina