Clinical trials: Gastric Bypass
Roux-en-Y Gastric Bypass, Cholecystitis; Gallstone
Randomized Trial Comparing Gastric Bypass With and Without Cholecystectomy
The main objective of this pilot study is to show feasibility to collect peri-operative and postoperative clinical data of the study group of gastric bypass without cholecystectomy compared with the control group of gastric…
- Conditions
- Roux-en-Y Gastric Bypass, Cholecystitis; Gallstone, Gallbladder Diseases
- Trial name
- NCT04324515
- Testing
- Robotic gastric bypass with or without cholecystectomy
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Cholelithiasis, Ultrasonography
Laparoscopic Versus Transabdominal Ultrasound in Morbidly Obese Patients
The objective of this study is to prospectively compare laparoscopic ultrasound to transabdominal ultrasound for the detection of gallbladder pathology in obese patients presenting for laparoscopic gastric bypass.
- Conditions
- Cholelithiasis, Ultrasonography, Laparoscopic Gastric Bypass
- Trial name
- NCT00971750
- Where
- United States
- Volunteers
- 253 people
- Sponsor
- Gundersen Lutheran Medical Foundation
Clinically Severe Obesity, Inadequate Weight Loss
Laparoscopic Revision of Vertical Banded Gastroplasty to Gastric Bypass
The main aim of this study is to analyze and report the intermediate term outcomes after laparoscopic revision Roux-en-Y gastric bypass (RYGB) surgery for failed and/or complicated Vertical Banded Gastroplasty (VBG).
- Conditions
- Clinically Severe Obesity, Inadequate Weight Loss, Obesity Recidivism
- Trial name
- VBG (NCT01041131)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Roux en Y Gastric Bypass, Sleeve Gastrectomy
Venlafaxine PK Following Bariatric Surgery
This study is being conducted to evaluate how the body absorbs and processes the immediate release (IR) and sustained release (XR) medication venlafaxine (Effexor®).
- Trial name
- VLX (NCT02005107)
- Testing
- Venlafaxine IR and Venlafaxine XR
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Steatohepatitis, Morbid Obesity
Transoral Endoscopic Liver Biopsy During Laparoscopic Gastric Bypass
This research is being done to evaluate the ability to obtain a liver sample using upper endoscopy rather than through a laparoscopic procedure.
- Trial name
- NCT00512512
- Testing
- Transoral Endoscopic Liver Biopsy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Gastric Bypass, Depression
The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors
The morbidly obese frequently present with mood and anxiety disorders, which are often treated with serotonin reuptake inhibitors (SRI) antidepressant drugs.
- Conditions
- Gastric Bypass, Depression, Anxiety Disorder
- Trial name
- NCT01317147
- Testing
- Roux-en-Y gastric bypass (RYGBP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pittsburgh
Morbid Obesity
Long-term Adverse Effects After Bariatric Surgery on Oesophagus Epithelium
The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on oesophageal symptoms and disease, including the presence of Barrett oesophagus ≥ 5 years post-surgery.
- Trial name
- FUB-B (NCT03410849)
- Testing
- Gastroscopy
- Where
- Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Basel, Switzerland
Morbid Obesity, Insulin Resistance
Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery
The purpose of this research is to further study the effect weight loss after gastric bypass surgery has on the heart and blood pressure and on how the body uses or metabolizes the sugars, fats and proteins we eat.
- Conditions
- Morbid Obesity, Insulin Resistance, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT01007955
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Massachusetts, Worcester
Obesity and Obesity-related Medical Conditions
Bariatric Surgery vs. Semaglutide vs. Tirzepatide
The recent introduction of the new generation of anti-obesity medications (AOMs) will change the future of obesity treatment. These highly effective medications, such as high-dose semaglutide and tirzepatide, are hormone…
- Trial name
- NCT06803888
- Testing
- Bariatric Surgery, Semaglutide, Tirzepatide
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Ali Aminian
Bariatric Surgery Candidate, Pain, Postoperative
The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
This study is prospective, randomized trial in which the efficacy of liposomal bupivacaine (Exparel®) is compared to standard bupivacaine local surgical site injection in reducing total IV and oral morphine equivalents required…
- Trial name
- Exparel (NCT03196505)
- Testing
- Exparel 266 MG Per 20 ML Injection, Bupivacaine
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bariatric Surgery Candidate, Protein Deficiency
Effect of Protein Supplementation on Fat Free Mass Preservation After Bariatric Surgery
This double blind randomized placebo controlled trial investigates the effect of protein supplementation on fat free mass loss in patients who underwent a Roux-en-Y gastric bypass.
- Conditions
- Bariatric Surgery Candidate, Protein Deficiency, Muscle Loss
- Trial name
- PROMISE (NCT05570474)
- Testing
- Protein drink supplementation
- Where
- Netherlands
- Volunteers
- 266 people
- Sponsor
- Maasstad Hospital
Type2 Diabetes, Bariatric Surgery Candidate
Laparoscopic Gastric Bypass as Metabolic Surgery in Obesity Class 1
Prospective study including Mexican patients diagnosed with type 2 diabetes and class 1 obesity, undergoing laparoscopic gastric bypass.
- Conditions
- Type2 Diabetes, Bariatric Surgery Candidate, Laparoscopic Gastric Bypass, Obesity
- Trial name
- NCT04595396
- Testing
- Laparoscopic Gastric Bypass
- Where
- Mexico
- Volunteers
- 51 people
- Sponsor
- CARLOS ZERRWECK LOPEZ
Diabetes Mellitus Type 2
Effects on Remission of Type 2 Diabetes Mellitus Following Gastric Bypass Alone vs Gastric Bypass Combined With Truncal Vagotomy
This randomized, triple-blind clinical trial investigates whether adding truncal vagotomy to Roux-en-Y gastric bypass (RYGB) enhances remission of type 2 diabetes mellitus (T2DM) in patients with obesity.
- Trial name
- VagusSx (NCT07278115)
- Testing
- Roux-en-Y Gastric Bypass plus Truncal Vagotomy, Roux-en-Y Gastric Bypass
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- University Research Institute for the Study of Genetic & Malignant Disorders in Childhood
Liver Diseases
Hepatic Effects of Gastric Bypass Surgery
Liver disease in the morbidly obese is thought to occur due to the long-term presence of fat deposits in the liver, resulting in inflammation and scarring of the liver over time, which reduces liver function.
- Trial name
- NCT00701376
- Testing
- liver biopsy
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- The Cleveland Clinic
Obesity, Obesity, Morbid
Biological Sample Repository for Gastrointestinal Disorders
The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients…
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Gastro-Intestinal Disorder
- Trial name
- NCT05874726
- Testing
- Blood Collection, Urine Collection, Tissue Sample Collection
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Morbid Obesity
Morbid Obesity: Effects of Conservative Treatments and Gastric Bypass Surgery
The purpose of this study is to evaluate the effects of conservative treatments of obesity with surgery (gastric bypass).
- Trial name
- NCT00239850
- Testing
- lifestyle changes
- Where
- Norway
- Volunteers
- 209 people
- Sponsor
- Norwegian University of Science and Technology
Diabetes Mellitus, Prediabetes
Long Term Diabetes Improvement After Cancer Gastrectomy and Colectomy
There is evidence that gastrointestinal operations for non weight-losing purposes are beneficial for diabetes mellitus. Aiming to analyze such hypothesis, patients submitted to gastric bypass for morbid obesity, gastrectomy for…
- Conditions
- Diabetes Mellitus, Prediabetes, Morbid Obesity, Gastric Cancer
- Trial name
- NCT01518023
- Testing
- Interview, questionnaire, updated biochemical tests
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- University of Sao Paulo
Gastric Cancer
Study of Gastroduodenal Metallic Stent vs Gastrojejunostomy
Selection of the optimal treatment for gastric outlet obstruction in patients with radically unresectable gastric cancer remains controversial because previous studies comparing the two procedures had a small sample size as well…
- Trial name
- NCT02784470
- Testing
- gastroduodenal stent placement, gastrojejunostomy
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Asan Medical Center
Adherence, Medication
Intervention for Multivitamin Adherence on Bariatric Patients
This project has a parallel randomized controlled experimental design since within the methodology there will be a control of the conditions under study, that is, the selection of subjects, the way the treatment will be…
- Trial name
- CDIPMABP (NCT04612088)
- Testing
- Cognitive Dissonance
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Universidad Autonoma de Baja California
Type 2 Diabetes Mellitus, Obesity
Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes
There is substantial clinical evidence regarding the safety and efficacy of currently practiced bariatric surgical techniques to improve metabolic control and/or resolve type 2 diabetes (T2DM) in clinically severe obese patients…
- Trial name
- SLIMM-T2D (NCT01073020)
- Testing
- Allergan Adjustable Gastric Band Surgery, Intensive Medical Diabetes & Weight Management (Why WAIT) - Band Group, Roux-en-Y Gastric Bypass (RYGB) Surgery
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Joslin Diabetes Center