Clinical trials: Gastric Bypass
Obesity, Morbid, Diabetes Mellitus, Type 2
Impact of an Increased Restrictive Factor of One Anastomosis Gastric Bypass on Metabolic Outcomes Type 2 Diabetes.
The purpose of the study is to evaluate the effect of an increased restrictive factor of one gastric anastomosis (OAGB) using a "FundoRing" fundoplication on metabolic outcomes in type 2 diabetes mellitus.
- Trial name
- NCT06176443
- Testing
- One anastomosis gastric bypass with combined fundoplication, One anastomosis gastric bypass without combined fundoplication
- Where
- Kazakhstan
- Volunteers
- 300 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Obesity, Type 2 Diabetes Mellitus
A Study to Examine Changes in GIP Plasma Levels Following Gastric Bypass Surgery in Obese Patients
Obesity is a multinational epidemic. There is evidence that despite educational measures and increased public awareness, the number of obese individuals continues to increase.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Insulin Resistance
- Trial name
- NCT00207389
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Boston Medical Center
Branched-chain Amino Acid Metabolism, Insulin Sensitivity
Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes
Elevated circulating levels of certain amino acids (the building blocks of protein) are strongly associated with insulin resistance.
- Trial name
- BCAAM-PD (NCT01786941)
- Testing
- Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training, GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Duke University
Gastric Procedures, Lung Resection Procedures
Study of ECHELON ENDOPATH(TM) Staple Line Reinforcement
This prospective, single-arm, multi-center evaluation will collect clinical data in a post-market setting. The two types of procedures studied will be gastric and thoracic.
- Trial name
- NCT04544865
- Testing
- Staple Line Reinforcement
- Where
- 8 sites in United States
- Volunteers
- 240 people
- Sponsor
- Ethicon Endo-Surgery
Obesity
A Prospective Study Evaluating The Utility of Transnasal Endoscopy With Roux en Y Gastric Bypass
Improvements in imaging technology have allowed for the development of small endoscopes ("slim scopes") half the size of a typical endoscope.
- Trial name
- NCT01526772
- Testing
- Endoscopy
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Roux en Y Gastric Bypass
A Comparison of Sustained and Extended Release Bupropion Following Bariatric Surgery
This study is being conducted to evaluate how the body absorbs and processes the sustained release (SR) and extended release (XL) medication bupropion (Wellbutrin®).
- Trial name
- NCT02173886
- Testing
- Bupropion SR and XL
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Weight Loss
Study of Effects From Gastric Bypass Weight Loss on Brain Tissue
This study will evaluate how large, intentional weight reduction affects the human brain and possible ways to reverse the changes associated with excess body weight.
- Trial name
- NCT00357344
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Morbid Obesity
Morbid Obesity: Effects of Conservative Treatments and Gastric Bypass Surgery
The purpose of this study is to evaluate the effects of conservative treatments of obesity with surgery (gastric bypass).
- Trial name
- NCT00239850
- Testing
- lifestyle changes
- Where
- Norway
- Volunteers
- 209 people
- Sponsor
- Norwegian University of Science and Technology
Morbid Obesity
Effect of Bariatric Surgery on Bile Acid Homeostasis
The purpose of this study is to evaluate the effect of bariatric surgery in bile acid homeostasis and its interrelationship with the metabolic changes induced by the surgery.
- Trial name
- NCT02366624
- Where
- Chile
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Severe Obesity, Type 2 Diabetes Mellitus in Obese
L-Cell Activity in Small Intestine as Biliopancreatic Loop in Obese Patients With DM2 Submitted to RYGBP
Prevalence of Obesity and its association with Diabetes Mellitus 2 (DM2) affect a significant percentage of the world's population with great socioeconomic impact, especially for developing countries.
- Trial name
- NCT05446415
- Testing
- Analyze basal expression incretin for immunolabeling and mRNA expression glucagon-like secretion peptide-1 (GLP-1) and peptide YY (PYY 3-36) incretins by L cells.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obesity, Weight Gain
Endoscopic Argon Plasma Coagulation Vs. Control For Weight Regain After Gastric Surgery
Bariatric surgery procedures have consistently been demonstrated to reduce long-term co-morbidities and mortality. Despite its benefits, weight regain is common, usually initiating around two years after the initial procedure…
- Trial name
- NCT03055754
- Testing
- Argon randomized arm, Control arm
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Kaiser Clinic and Hospital
Hyperinsulinemic Hypoglycemia, Postprandial Hypoglycemia
Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass
The aim of this study is investigating the effect of a novel glucagon analogue administration in gastric bypass operated individuals, who are reactive hypoglycemic.
- Trial name
- NCT03984370
- Testing
- ZP4207
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Bariatric Surgery, Weight Loss
The Banded Mini Gastric Bypass Trial: A Prospective Randomized Controlled Trial
Rationale: Investigate if there is a significant weight reduction expressed in total body weight loss percentage (%TBWL) in patients 5 years after surgery, whom underwent a mini gastric bypass (MGB-OAGB) with addition of the…
- Conditions
- Bariatric Surgery, Weight Loss, Comorbidities and Coexisting Conditions
- Trial name
- RiMini (NCT05472922)
- Testing
- Placement of MiniMizer Gastric Ring, Normal MGB-OAGB
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Marc van Det
Morbid Obesity
Comparison of Gastric Bypass and Sleeve Gastrectomy in Metabolic and Cardiovascular Indices
Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery.
- Trial name
- NCT03851874
- Testing
- Bariatric surgery
- Volunteers
- 28 people
- Sponsor
- National and Kapodistrian University of Athens
Obesity
Endostapler Gastric Bypass Study
The goal of this prospective, post-market study is to evaluate safety and efficacy of the AEON™ Endostapler when used in laparoscopic Roux-en-Y gastric bypass surgery.
- Trial name
- NCT04712526
- Testing
- AEON Endostapler
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lexington Medical Inc.
Obesity, Gallstones
Obeticholic Acid in Bariatric and Gallstone Disease
By binding to the nuclear receptor FXR, bile acids not only regulate their own turn-over but presumably also pivotal steps in cholesterol, triglyceride and glucose metabolism as shown in laboratory animals.
- Trial name
- OCABSGS (NCT01625026)
- Testing
- Obeticholic acid
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Obesity, Severe Obesity
Prospective Study of an Explainable AI Tool to Support Biliopancreatic Limb Selection in One-Anastomosis Gastric Bypass
This prospective observational cohort study will develop and externally validate a human-supervised, explainable artificial-intelligence decision-support model for analysing factors associated with biliopancreatic limb length…
- Conditions
- Obesity, Severe Obesity, Metabolic Disease
- Trial name
- JI-AI-OAGB (NCT07818317)
- Testing
- One-anastomosis gastric bypass with observed biliopancreatic limb length
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Obesity
Gastric Banding After Failed Gastric Bypass
The safety and efficacy of the Adhesix Bioring adjustable gastric band will be assessed in patients after failed RYGB.
- Trial name
- NCT02528565
- Testing
- Adhesix Bioring
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Duomed
Morbid Obesity
Stapled vs Hand Sewn Anastomosis in Roux en Y Gastric Bypass for Morbid Obesity: Randomized Clinical Trial
The purpose of this study is to compare postoperative complications between hand sewn and stapled anastomosis after performing Roux en Y-Gastric Bypass as a treatment for morbid obesity.
- Trial name
- STAVHAS (NCT02077517)
- Testing
- Roux en Y Gastric Bypass
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh