Clinical trials: Gastric Precancerous Condition
Colorectal Cancer, Colorectal Adenoma
Volatile Markers in Digestive Cancer
The study is aimed to determine the potential of volatile marker testing for identification of gastrointestinal cancers (in particular - colorectal and gastric cancers), the related precancerous lesions in the stomach and colon.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Gastric Cancer, Peptic Ulcer Disease
- Trial name
- VOLGACORE (NCT02332213)
- Testing
- Breath sampling for volatile marker detection, Upper endoscopy with biopsies, Colonoscopy with biopsies or lesion removal when required
- Where
- 2 sites in Latvia, Lithuania
- Volunteers
- 2,022 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Gastric Cancer, Gastric Intestinal Metaplasia
Surveillance of Patients With Precancerous Lesions of the Stomach
The project will aim to identify and determine subgroups of patients with different risks of progression to gastric cancer and to assess appropriate follow-up intervals.
- Conditions
- Gastric Cancer, Gastric Intestinal Metaplasia, Gastric Atrophy, Gastric Dysplasia
- Trial name
- NCT03250091
- Testing
- Upper endoscopy with biopsies, Plasma/serum sampling, Biopsies for gastric microbiota
- Where
- Latvia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Chronic Atrophic Gastritis With Hyperplasia (Diagnosis)
Clinical Study of Weifuchun Treatment on Precancerous Lesions of Gastric Cancer
Research purpose To elucidate the effect mechanism and clinical effective of weifuchun in the prevention and treatment of chronic atrophic gastritis and precancerous lesions of gastric cancer.
- Trial name
- NCT03814629
- Testing
- Weifuchun
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- ShuGuang Hospital
Premalignant Conditions, Malignant Lesions
To Evaluate the Best Metric for Inspection Time During a Diagnostic and/or Surveillance Upper Gastrointestinal Endoscopy (Age ≥ 18 Years, Informed Consent), Between Total Inspection Time Versus Withdrawal Time, for the Identification of Malignant Lesions
Gastric cancer is the fifth cause of cancer-related mortality worldwide. Gastric carcinogenesis involves the progression from premalignant conditions such as atrophic gastritis and intestinal metaplasia to premalignant lesions…
- Conditions
- Premalignant Conditions, Malignant Lesions, Gastric, Esophageal
- Trial name
- NCT06696209
- Testing
- Analysis of the withdrawal time of the Upper Gastrointestinal Endoscopy, Analysis of the total time of the Upper Gastrointestinal Endoscopy, Upper gastrointestinal endoscopy: Common Practices
- Where
- Portugal
- Volunteers
- 1,290 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Gastric Cancer (GC), Premalignant Lesion
AI-Based Risk Prediction Model for Upper Digestive Tract Cancer
Upper digestive tract cancers are often preceded by pre-malignant lesions, but there is limited evidence regarding optimal risk prediction models and screening strategies for disease progression and cancer development.
- Conditions
- Gastric Cancer (GC), Premalignant Lesion, Gastric Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- NCT07605312
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Gastric Cancer, Preneoplastic Condition
BLI for the Diagnosis of Precancerous Conditions
Introduction: Traditionally, White Light Endoscopy (WLE), enhanced by biopsies following the updated Sydney system guidelines, has been the benchmark for diagnosing and classifying gastric preneoplastic conditions.
- Conditions
- Gastric Cancer, Preneoplastic Condition, Early Gastric Cancer
- Trial name
- NCT04768218
- Where
- Portugal
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Instituto Portugues de Oncologia, Francisco Gentil, Porto
Gastric Cancer, Precancerous Lesion of Digestive Tract
The Role of Extracellular DNA (ecDNA) in the Occurrence and Development of Gastric
ECDNA is almost non-existent in normal cells, but exists in nearly half of human cancer cells, indicating that studying such abnormal DNA is of great significance for our understanding of tumor formation and evolution.
- Conditions
- Gastric Cancer, Precancerous Lesion of Digestive Tract, Extrachromosomal DNA
- Trial name
- NCT05956847
- Testing
- gastroscopy
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Gastric Xanthoma, Helicobacter Pylori Infection
A Study on the Relationship Between Gastric Xanthoma and Gastric Cancer and Precancerous Lesions
To explore the effects of gastric xanthoma on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
- Conditions
- Gastric Xanthoma, Helicobacter Pylori Infection, Gastric Cancer, Intestinal Metaplasia
- Trial name
- NCT06282484
- Where
- China
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Esophageal Adenocarcinoma, Barrett's Esophagus
Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome
This is a randomized, open-label pilot study to assess whether treatment with chlorhexidine mouthwash can alter the esophageal and gastric cardia microbiome
- Conditions
- Esophageal Adenocarcinoma, Barrett's Esophagus, Reflux Esophagitis
- Trial name
- Mouthwash (NCT02513784)
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Gastric Lesion, Gastric Precancerous Condition
Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer
The goal of this study is to characterize and validate a signature of circulating biomarkers in plasma, associated with the presence of gastric preneoplasia in patients with preexisting gastric lesion compared with a control…
- Conditions
- Gastric Lesion, Gastric Precancerous Condition, Gastric Cancer
- Trial name
- PREGASIGN#1 (NCT05854368)
- Testing
- Additional blood collection as part of a blood sampling performed during routine care or specific for the research if not part of routine care., Blood collection
- Where
- 8 sites in France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Gastric Adenocarcinoma, Early Gastric Cancer
A Multicentre Observational Cross-Sectional Study of The Gastric Precancerous Epithelial Pathway Using High-Definition Endoscopy And Histopathology In India
To estimate the prevalence of histologically confirmed early gastric cancer (EGC) in an Indian multicentre cohort undergoing standardised high-quality upper gastrointestinal endoscopy.
- Trial name
- IND-PREP (NCT07486518)
- Where
- India
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Gastro Esophageal Reflux, Barrett Esophagus
PPI Therapy Impact on GERD After Sleeve Gastrectomy
The trial would to try to establish: The best post-operative PPI prescription protocol after Sleeve Gastrectomy The impact of PPI therapy on postoperative peptic diseases (erosive gastropathies, ulcers, duodenitis, esophagitis…
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Bariatric Surgery Candidate
- Trial name
- NCT04400136
- Testing
- Lansoprazole oral tablets 30 mg
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Helicobacter Infections, Stomach Neoplasms
Helicobacter Pylori Eradication to Prevent Gastric Cancer
Gastric cancer is the fourth most common type of cancer and the second leading cause of cancer-related death in the world. In China, more than 390,000 new patients are diagnosed with gastric cancer and more than 300,000 patients…
- Trial name
- NCT01133951
- Testing
- OAC triple therapy
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Jie-Jun Wang
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
Healthy, Barrett's Esophagus
Pilot Study to Image the Esophagus Using a SECM Tethered Endoscopic Capsule
The goal of this research is to test the imaging quality of the modified, larger diameter, tethered Spectrally Encoded Confocal Microscopy (SECM) capsule in healthy subjects, subjects with Barrett's Esophagus (BE), and subjects…
- Conditions
- Healthy, Barrett's Esophagus, Gastric Acid Reflux
- Trial name
- SECM (NCT02445014)
- Testing
- MGH SECM Imaging Capsule
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Barrett Esophagus, Esophageal Cancer
EsophaCap for the Detection of Early Esophageal Carcinoma
This study is to identify potential biomarkers for the early detection of Barrett's Esophagus, esophageal carcinoma (both adenocarcinoma and squamous cell carcinoma), and gastric cancer via sponge cytology.
- Conditions
- Barrett Esophagus, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT04214119
- Where
- 2 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Gastro Esophageal Reflux Disease, Barrett Esophagus
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer.
- Trial name
- NCT06693622
- Testing
- Patient survey
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy
Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy
The goal of this observational study is to learn whether bile acids and pepsin in saliva can help identify adults at higher risk of developing reflux-related esophageal disease after sleeve gastrectomy, including Los Angeles…
- Conditions
- Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy, Saliva Collection, Reflux Esophagitis (RE)
- Trial name
- ABSORB (NCT07607067)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Esophageal Cancer, Gastric Cancer
Molecular Assessment for Gastro-Esophageal Cancer
The goal of this minimally invasive interventional study is to learn if oncometabolic biomarkers, detected in the exhaled breath and blood can identify early-stage gastro-oesophageal cancer in patient at risk for…
- Conditions
- Esophageal Cancer, Gastric Cancer, Barrett Esophagus
- Trial name
- MAGEC (NCT06346054)
- Testing
- Breath analysis, Blood analysis
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Adenoma Colon, Gastric Precancerous Condition
Endoscopic Quality Improvement System Study
We intend to develop intelligent quality control and management software based on the work of digestive endoscopic artificial intelligence in the Department of Gastroenterology, Wuhan University Renmin Hospital, to accurately and…
- Trial name
- NCT04654247
- Testing
- Quality audit and feedback, Control
- Where
- China
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University