Clinical trials: Gastro Esophageal Reflux
Gastroesophageal Reflux
A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD
LNF is an effective intervention in the management of patients with chronic GERD requiring maintenance therapy. LNF is cost-effective compared with long-term medical therapy.
- Trial name
- NCT00182260
- Testing
- Proton Pump Inhibitors, Laparoscopic Nissen Fundoplication
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- McMaster University
Gastro-esophageal Reflux Disease
Diagnostic Yield of Post PRandial Esophageal High Resolution Impedance Manometry in Patients With Gastro-Esophageal Reflux Disease Symptoms Resistant to Proton Pump Inhibitor Therapy
Gastro-esophageal reflux disease (GERD) is defined as the reflux of gastric content into the esophagus that causes troublesome symptoms or complications.
- Trial name
- PRIMER (NCT03596476)
- Testing
- Upper gastrointestinal (GI) endoscopy, Wireless pH monitoring, Post prandial esophageal High Resolution Impedance Manometry
- Where
- 7 sites in France
- Volunteers
- 330 people
- Sponsor
- Hospices Civils de Lyon
Anesthesia
Electrical Acupoint Stimulation on Gastric Reflux During I-gel Ventilation
This study will compare the effects of transcutaneous acupoint electrical stimulation versus no stimulation on intraoperative gastric reflux in patients undergoing general anesthesia with i-gel airway device ventilation.
- Trial name
- ASGARD-igel (NCT07338448)
- Testing
- transcutaneous electrical acupoint stimulation, electrodes attachment
- Volunteers
- 116 people
- Sponsor
- Air Force Military Medical University, China
Non-erosive Reflux Disease, Reflux Disease, Gastro-Esophageal
Evaluation of the Efficacy and Safety of Eolo in Patients With NERD
Background: Non-erosive reflux disease (NERD) is a prevalent subtype of gastroesophageal reflux disease (GERD), often inadequately managed with proton pump inhibitors (PPIs) alone.
- Conditions
- Non-erosive Reflux Disease, Reflux Disease, Gastro-Esophageal, Nutraceutical
- Trial name
- NCT07041060
- Testing
- EOLO, PPI (proton pump inhibitor), Group C: Eolo
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bologna
Gastroesophageal Reflux
A Study of Cisapride in Patients With Symptomatic Gastro-Oesophageal Reflux Disease
The purpose of this study is to compare the efficacy and tolerability of cisapride with placebo in infants and children with gastro-oesophageal reflux disease (GORD).
- Trial name
- NCT01281553
- Testing
- Cisapride
- Volunteers
- 6 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Reflux Oesophagitis
Effect of 5, 10 or 25 mg of YF476 Daily for 14 Days on Stomach Acidity in Healthy Volunteers
The objective of the study was to assess whether the tolerance to the effect of YF476 on gastric pH observed with repeated doses in a previous study in healthy volunteers can be avoided by using smaller doses of YF476.
- Trial name
- NCT01597674
- Testing
- YF476
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Trio Medicines Ltd.
Reflux Esophagitis (RE), Non-erosive Reflux Disease (NERD)
Analysis of GERD Symptoms Using Gastroesophageal Reflux Impact Score Questionnaire for Quality of Life
Even the patients complain GERD symptoms such as heartburn and acid regurgitation the final diagnosis could be reflux esophagitis (RE), non-erosive reflux disease (NERD) and even functional heartburn (FH).
- Conditions
- Reflux Esophagitis (RE), Non-erosive Reflux Disease (NERD), Functional Heartburn (FH)
- Trial name
- NCT01536080
- Where
- South Korea
- Volunteers
- 207 people
- Sponsor
- Seoul National University Bundang Hospital
Obesity, Weight Loss
Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry
The purpose of this registry study is to collect data through medical chart review and in patient visits on the efficacy and safety of various Endoscopic Bariatric therapies (EBTs).
- Conditions
- Obesity, Weight Loss, Gastro Esophageal Reflux, Bariatric Surgery Candidate
- Trial name
- EBT (NCT04494048)
- Testing
- Endoscopic Bariatric Therapies
- Where
- United States
- Volunteers
- 9,999 people
- Sponsor
- Weill Medical College of Cornell University
Gastro-esophageal Reflux
Post Prandial High Resolution Impedance- Manometry
Nine to 30% of the population suffers from gastro-esophageal reflux disease (GERD) - suggestive symptoms (heartburn, regurgitation, chest pain, chronic couch, sore throat).
- Trial name
- NCT03306485
- Testing
- Correlating the number of reflux episodes detected on 1-h post prandial esophageal high resolution manometry combined and those detected on ambulatory 24-h pH-impedance monitoring performed on PPI
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Hospices Civils de Lyon
Gastroesophageal Reflux Disease With Ulceration
Anti-Reflux Mucosectomy in the Treatment of Refractory Gastro-esophageal Reflux
Gastroesophageal reflux disease (GERD) is one of the most common digestive diseases in Western countries, affecting 8% of the population in its typical and frequent form.
- Trial name
- MARRGO (NCT05745012)
- Testing
- endoscopic mucosal resection
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Microaspiration, Gastro Esophageal Reflux
Transpyloric Feeding for Prevention of Micro-aspiration
To determine the effect of transpyloric (TP) feeding on microaspiration and lung inflammation in ventilated preterm infants.
- Trial name
- NCT03646045
- Testing
- Transpyloric feeding
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Nemours Children's Clinic
Gastro Esophageal Reflux
A Placebo Controlled Trial With Baclofen for the Treatment of GERD Patients With Incomplete PPI Response
Reflux (acid and non-acid) mainly occurs during transient LES relaxations (TLESRs). The gamma-aminobutyric acid (GABA) receptor type B agonist baclofen was shown to inhibit TLESRs, thereby significantly decreasing acid reflux…
- Trial name
- NCT03835442
- Testing
- Baclofen
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Voice Disorders, Gastroesophageal Reflux
Quantifying Effects of Treatment of Pediatric Dysphonia
The diagnosis and management of childhood dysphonia is a significant clinical problem; however, there have been few studies aimed at defining standard assessment methods for pediatric dysphonia.
- Trial name
- NCT00237679
- Testing
- Neuromuscular Electrical Stimulation, Unstimulated
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Reflux Disease, Gastro-Esophageal
POLAR-STUDY: Polish AntiReflux Study
The goal of this observational study is to evaluate the current practice and outcomes of surgical treatment for gastroesophageal reflux disease (GERD) in adults undergoing antireflux surgery in Poland.
- Trial name
- POLAR (NCT07711912)
- Testing
- Prospective Clinical Observation and Follow-up
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- University of Warmia and Mazury in Olsztyn
Ulcerative Colitis, Crohn Disease
Systems Biology of Gastrointestinal and Related Diseases
This is a longitudinal observational study on patients with gastrointestinal and related disease. The study will be conducted for at least 10 years, following each participant over time, as they either go through relapses and…
- Conditions
- Ulcerative Colitis, Crohn Disease, Obesity, Colon Polyp
- Trial name
- NCT05579444
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Viome
Colon Polyp, Colon Disease
Endoscopy-related Phone Consultation During the COVID-19 Outbreak
The aim of this study is to evaluate patient and consultant experiences with phone consultations for endoscopy-related outpatient appointments during the COVID-19 outbreak.
- Conditions
- Colon Polyp, Colon Disease, Reflux, Gastroesophageal, Varices, Esophageal
- Trial name
- NCT04344964
- Testing
- None - NA
- Where
- Australia
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Austin Health
Gastroesophageal Reflux Disease, GERD
What is the Predictive Value of the Reflux Impact Scale
Gastric distress is a common phenomenon in our society. Heartburn and regurgitation occur daily in about 7% of the adult population,weekly 14-20% pf the adults and monthly in 34-44% of adults.
- Conditions
- Gastroesophageal Reflux Disease, GERD, Heartburn, Acid Regurgitation
- Trial name
- PREDICT (NCT00536328)
- Volunteers
- 938 people
- Sponsor
- AstraZeneca
Esophageal Cancer, Reflux, Gastroesophageal
Evaluating Acid Reflux After Oesophageal Stenting Using Anti-reflux Stents
Incurable oesophageal cancer remains a global problem and in South Africa the vast majority of patients with oesophageal cancer have advanced disease at first presentation and are not curable.
- Trial name
- NCT05303298
- Testing
- Anti-reflux oesophageal stent, Conventional oesophageal stent
- Where
- South Africa
- Volunteers
- 72 people
- Sponsor
- University of Cape Town
Gastro Esophageal Reflux Disease, Barrett Esophagus
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer.
- Trial name
- NCT06693622
- Testing
- Patient survey
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
GERD
Truncal Vagotomy in Patients Undergoing Revisional Sleeve Gastrectomy to Gastric Bypass
The purpose of this study is to investigate the efficacy of performing a truncal vagotomy along with a sleeve to bypass revision surgery in reducing the severity and/or incidence of gastroesophageal reflux disease (GERD)…
- Trial name
- NCT04901429
- Testing
- Truncal vagotomy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor Research Institute