Clinical trials: Gastro Esophageal Reflux Disorder
Esophageal Motility Disorders, Gastric Motor Dysfunction
Gastrointestinal Dysmotility on Aspiration Risk
The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment.
- Conditions
- Esophageal Motility Disorders, Gastric Motor Dysfunction, Aspiration Pneumonia, Gastro Esophageal Reflux
- Trial name
- NCT05455359
- Testing
- Prucalopride, Famotidine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
Gastro Esophageal Reflux Disorder
Safety, PK, and PD Comparison of UI059 and UIC202201 in Healthy Volunteers
A randomized, open-label, multiple-dose, crossover phase 1 clinical trial to compare and evaluate the safety, pharmacokinetics and pharmacodynamics characteristics after oral administration of UI059 and UIC202201 in healthy adult…
- Trial name
- NCT07727629
- Testing
- UI059, UIC202201
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Nocturnal Symptoms of GERD, Sleep Disorders in GERD
QUality of Sleep Improvement With Evening Topical Therapy for Non-Erosive Gastroesophageal Reflux Disease (The QUIET Trial)
The goal of this randomized, double-blind, single-center clinical trial is to learn if medical devices work to decrease nocturnal symptoms of GERD gastroesophageal reflux disease in adults' patients and improve sleeping time…
- Conditions
- Nocturnal Symptoms of GERD, Sleep Disorders in GERD, GERD (Gastroesophageal Reflux Disease), Non-Erosive Gastro-Esophageal Reflux Disease
- Trial name
- QUIET (NCT07700342)
- Where
- 2 sites in Poland
- Volunteers
- 50 people
- Sponsor
- Cellmedis
Gastro Esophageal Reflux, Obesity (Disorder)
Association Between Obesity and Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a chronic disorder marked by heartburn and regurgitation, resulting from the reflux of gastric acid or bile into the esophagus.
- Trial name
- NCT07199582
- Volunteers
- 200 people
- Sponsor
- Assiut University
Reflux Disease, Gastro-Esophageal
Breathing Exercises in Patients With Gastroesophageal Reflux
The aim of this study was to examine the effects of diaphragmatic breathing exercises combined with relaxation exercises on patient-reported reflux symptoms, quality of life, anxiety, and depression levels in patients diagnosed…
- Trial name
- NCT06812650
- Testing
- Medical treatment, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Karabuk University
Laryngomalacia, Gastro Esophageal Reflux
Initiation of Acid Suppression Therapy Prospective Outcomes for Laryngomalacia
Laryngomalacia (LM) is the most common cause of stridor in infants. Symptoms of gastroesophageal reflux (GER) are often seen in the setting of LM; therefore, acid suppression therapy (AST) has been empirically used in the…
- Trial name
- NCT04614974
- Testing
- Famotidine, Speech Language Therapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Reema Padia
Gastroesophageal Reflux Disease (GERD), Laryngopharyngeal Reflux (LPR)
Transoral Incisionless Fundoplication (TIF) for Laryngopharyngeal Reflux (LPR) Patients
In this research study the investigators want to learn more about the effectiveness of an endoscopic procedure (an endoscope is a lighted tube that is placed down the participants esophagus, through the participants mouth) which…
- Conditions
- Gastroesophageal Reflux Disease (GERD), Laryngopharyngeal Reflux (LPR), Reflux Disease, Gastro-Esophageal, Motility Disorder
- Trial name
- TIF-LPR (NCT05579587)
- Testing
- Transoral Incisionless Fundoplication
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
GERD - Gastro-Esophageal Reflux Disease, Anxiety Disorders
Important Correlation Between Anxiety and Reflux Symptoms in Patients With Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is one of the most common gastroenterological disorders with a reported prevalence of 10% to 20% percent in Europe and the USA and less than 5% in Asia.
- Trial name
- NCT06151067
- Testing
- High-Resolution Manometry, Upper-GI endoscopy, pH-Impedance testing
- Where
- Germany
- Volunteers
- 458 people
- Sponsor
- Evangelic Hospital Kalk Cologne
Sequelae of; Infection, Post Infection Glomerulonephritis
Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period.
- Conditions
- Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder)
- Trial name
- sequelae (NCT04846010)
- Testing
- PurWet, FurFat, PurApo
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- All Natural Medicine Clinic, LLC
Functional Dyspepsia, Gastro Esophageal Reflux
Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting
The purpose of this prospective cohort study is to compare upper GI symptoms and endoscopy findings in Canada with Japan and Iran, and correlate this with the upper GI microbiome.
- Conditions
- Functional Dyspepsia, Gastro Esophageal Reflux, Peptic Ulcer, Normal Control
- Trial name
- NCT03868267
- Where
- 3 sites in Canada, Iran and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Hamilton Health Sciences Corporation
Scleroderma, Dysphagia
Functional Luminal Imaging Probe (FLIP) Topography Use in Patients With Scleroderma and Trouble Swallowing
FLIP topography has been FDA cleared to evaluate a variety of esophageal conditions, but has never been evaluated in patients with scleroderma.
- Conditions
- Scleroderma, Dysphagia, GERD - Gastro-Esophageal Reflux Disease
- Trial name
- NCT03270722
- Testing
- FLIP topography, Upper Endoscopy
- Where
- United States
- Sponsor
- Stanford University
Gastro-Intestinal Disorder, Inflammatory Bowel Diseases
Image-Enhanced Endoscopy in the Gastrointestinal Tract
This study evaluates a range of endoscopic image enhancement techniques for assessing conditions involving the gastrointestinal tract.
- Conditions
- Gastro-Intestinal Disorder, Inflammatory Bowel Diseases, Gastro Esophageal Reflux, Atrophic Gastritis
- Trial name
- NCT04085211
- Where
- United Kingdom
- Volunteers
- 260 people
- Sponsor
- King's College Hospital NHS Trust
Quality of Life, Dysphagia
Lower Esophageal Sphincter (LES) Stimulation in Patients With Ineffective Esophageal Motility
The aim of this study is to evaluate gastroesophageal reflux disease - health related quality of life (GERD-HRQL) after electrical stimulation of the lower esophageal sphincter (LES) in patients with gastroesophageal reflux…
- Conditions
- Quality of Life, Dysphagia, Electrical Stimulation of the Lower Esophageal Sphincter, Gastro Esophageal Reflux
- Trial name
- DYSMOSTIM (NCT03476265)
- Testing
- Electrical Stimulation of the Lower Esophageal Sphincter
- Where
- Austria
- Volunteers
- 17 people
- Sponsor
- Austrian Society Of Surgical Oncology
Esophageal Motility Disorders, Gastro-esophageal Reflux
Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study
Pressure and flow (PF) analysis allow a detailed report on the bolus passing for each segment of the esophagus. This approach has evidence in oropharyngeal dysphagia, post reflux surgery dysphagia, gastroesophageal reflux in…
- Trial name
- pFlow (NCT03904004)
- Testing
- Peroral endoscopic myotomy, Neumatic dilatation, Botulinum toxin injection
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion Miguel Servet
Gastro Esophageal Reflux Disorder
GERD and Anti-Reflux Therapy Between Able-bodied and SCI Individuals
Respiratory dysfunction, esophageal dysmotility, and a gastroesophageal reflux disease (GERD) have been demonstrated to be highly prevalent in persons with SCI.
- Trial name
- NCT02584751
- Testing
- Omeprazole, 24 Hour pH Monitor, Pulmonary Function Examination
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center