Clinical trials: Gastro-Intestinal Disorder
Gastro-esophageal Reflux
Evaluation of Esomeprazole in Treating Gastro-esophageal Reflux Disease (GERD) in Head and Neck Cancer Patients Exposed to Radiation Therapy
The purpose of this research study is to measure acid reflux into the throat both before and after medical treatment in people who have had radiation therapy to their head and neck for the treatment of cancer.
- Trial name
- NCT00222079
- Testing
- Esomeprazole (Nexium)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Douglas Trask
Infections, Rotavirus, Rotavirus Vaccines
A Study to Evaluate Immune Response and Safety of Two Doses of GSK Biologicals' HRV Liquid Vaccine in Healthy Infants.
This study will provide data on the immune response and safety of GSK Biologicals' HRV liquid vaccine when given along with the routine infant immunizations in Philippines.
- Trial name
- NCT00432380
- Testing
- Rotarix™
- Where
- Philippines
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bacterial Infection, Diarrhea
Milk Ingredients and Resistance Against E-coli-induced GastroEnteritis (MIRAGE)
Background: The incidence of gastrointestinal infections is very high. In Western countries at least 30% of the population suffers from at least one food-borne infection per year.
- Conditions
- Bacterial Infection, Diarrhea, Gastroenteritis
- Trial name
- MIRAGE (NCT01800396)
- Testing
- Milk protein, Milk protein rich in phospholipids
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Cold Argon Plasma
Cold Argon Plasma (CAP) Application in the Wound Treatment After Open Hemorrhoidectomy
This is single-center, prospective, randomized study
- Trial name
- NCT03907306
- Testing
- Wound healing
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Inflammatory Bowel Disease
Cytokine Production of Colonic Tissue From IBD Patients
Chronic intestinal inflammation characterizes inflammatory bowel diseases (IBD), which consist mainly of Crohn's disease and ulcerative colitis.
- Trial name
- NCT02828748
- Testing
- no intervention in patients treatment, only biopsy taken
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Inflammatory Bowel Diseases, Crohns Disease
Autoimmune Paradoxical Reactions in IBD Longitudinal Cohort
Purpose: Inflammatory bowel disease patients undergoing treatment with varying biologic agents will be evaluated for incidences of paradoxical immune reactions, the risk factors associated with those paradoxical immune reactions…
- Conditions
- Inflammatory Bowel Diseases, Crohns Disease, Ulcerative Colitis, Colitis
- Trial name
- APRIL (NCT02503514)
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Ulcerative Colitis
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects and Subjects With Mild to Moderate Ulcerative Colitis
To assess the safety and tolerability of single subcutaneous (SC) and intravenous (IV) doses of AMG 181 in healthy subjects and of a single SC dose in subjects with mild to moderate ulcerative colitis (UC)
- Trial name
- NCT01164904
- Testing
- Amg 181
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Amgen
IBD, Crohns Disease
IBDSL Biobank Project. Molecular Markers for Diagnosis and Therapy Response in IBD.
The IBD South Limburg (IBDSL) project was initially designed as a prospective population based cohort study. Since 1991, all new IBD cases have been enrolled in the cohort and prospectively followed.
- Conditions
- IBD, Crohns Disease, Ulcerative Colitis
- Trial name
- IBDSL (NCT02130349)
- Where
- 3 sites in Netherlands
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Crohn's Disease, CAM
Efficacy of Acupuncture and Moxibustion Treatment in Patients With Quiescent Crohn's Disease:Evaluation With fMRI
The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease.
- Trial name
- NCT01696838
- Testing
- electroacupuncture, moxibustion
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Colorectal Cancer
Polyp Measurement Device
Colorectal cancer is the second-leading cause of cancer death in the United States. Colorectal cancer screening is recommended to begin at age 50 years for most men and women at average risk for this disease.
- Trial name
- NCT03856255
- Testing
- Micro-Tech Endoscopic Gauge
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Irritable Bowel Syndrome
Pilot Study of the Physiological Effects of an Integrative Medicine Approach in Irritable Bowel Syndrome
Although underutilized, what is emerging as one of the best ways of evaluating inflammation in the body, particularly in difficult to observe regions, is through the use of Fluorodeoxyglucose (FDG) positron emission tomography…
- Trial name
- IBS (NCT03370614)
- Testing
- IBS Group, Healthy Control Group
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Dysphagia, Respiratory Complications
Trial- Dysphagia From ETT or GI Endoscopy
The purpose of this study is to conduct a randomized clinical trial to compare the incidence of dysphagia in patients receiving general anesthesia with and without an endotracheal tube for Upper gastrointestinal endoscopy.
- Trial name
- NCT02460055
- Testing
- endotracheal tube, propofol, Fentanyl
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Gastric Cancer
Study of Convernsion Therapy Using S1/Paclitaxel Chemotherapy Plus Apatinib in Unresectable Gastric Cancer
The prognosis of metastatic gastric cancer is poor. Chemotherapy occasionally converts an initially unresectable gastric cancer to a resectable cancer.
- Trial name
- NCT02529878
- Testing
- S1/Paclitaxel chemotherapy plus Apatinib
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Stomach Neoplasms
The Effect of Preoperative Hemotologic Markers on Postoperative Long-term and Short-term Outcomes for Laparoscopic Gastrectomy
The purpose of this study is to explore the effect of preoperative hemotologic markers on postoperative long-term and short-term outcomes for laparoscopic gastrectomy.
- Trial name
- NCT02930278
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Shigellosis
A Study to Determine If a New Shigella Vaccine is Safe, Induces Immunity and The Best Dose Among Kenyan Infants
In this study, the tetravalent bioconjugate candidate vaccine Shigella4V will be tested to obtain first-in-human data on its safety and immunogenicity in infants and to identify the preferred dose of Shigella4V in 9 month old…
- Trial name
- NCT04056117
- Testing
- Shigella 4V, MenACWY, Rabies
- Where
- 2 sites in Kenya
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
Adenocarcinoma Esophagus, Adenocarcinoma of the Stomach
Molecular Analysis of Gastric and OEsophageal Cancers STudy
A prospective translational tissue collection study to identify biomarkers predictive of treatment response/resistance and biomarkers of prognostic value from a series of patients who are investigated for and diagnosed with early…
- Conditions
- Adenocarcinoma Esophagus, Adenocarcinoma of the Stomach, Adenocarcinoma - GEJ, Squamous Cell Car. - Esophagus
- Trial name
- MAGnET (NCT06702384)
- Testing
- biopsy
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Gastric Cancer
Validating the Safety and Effectiveness of ENDOANGEL Upper Gastrointestinal Endoscope Image Auxiliary Diagnostic Software
The upper Gastrointestinal Endoscope Image Auxiliary Diagnostic Software developed by Wuhan ENDOANGEL Medical Technology Co., Ltd.
- Trial name
- NCT05470452
- Testing
- The reading process is assisted by ENDOANGEL, No ENDOANGEL assistance during the reading process
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Inflammatory Bowel Diseases, Pregnancy Related
Pregnancy in Greek Female Patients With Inflammatory Bowel Disease - Panhellenic Recording
The aim of the present study is to retrospectively record all the successful pregnancies in Greek IBD patients within the last 10 years and prospectively record all the future pregnancies for the next 4 years.
- Trial name
- NCT05562726
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandra Hospital, Athens, Greece
Ulcerative Colitis, Colon Cancer
Study of Effects of L-Arginine in Colitis and Colon Cancer
The purpose of this study is to look at the importance of L-Arginine in the digestive tract. L-Arginine is an amino acid and is important in making proteins within the cell.
- Trial name
- NCT01091558
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Periodontitis, Inflammatory Bowel Diseases
The Effect of Non-Surgical Periodontal Therapy on Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disease of the gastrointestinal tract characterised by complex interactions between genetic susceptibility, environmental factors, microbiota and host…
- Trial name
- NCT06245278
- Testing
- ELISA (Enzyme-Linked ImmunoSorbent Assay)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
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