Clinical trials: Gastro-Intestinal Disorders
GERD
ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA)
OBJECTIVES To study the safety and efficacy of Endoscopic Anti Reflux Mucosal Ablation (ARMA) procedure for the treatment of proton pump inhibitor (PPI) dependent gastro-esophageal reflux disease (GERD) DESIGN OF THE Prospective…
- Trial name
- ARMA (NCT04243668)
- Testing
- ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA)
- Where
- India
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists
Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying
This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients.
- Conditions
- Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists, Intermittent Fasting, Intraoperative Complication Due to Anesthesia
- Trial name
- NCT07140289
- Testing
- Ultrasound of gastric contents
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wael Saasouh, MD
Lynch Syndrome, Polyposis Syndrome, Hereditary Mixed, 1
PSYLIVED: the Psychological Impacts of Living With an Inherited Colorectal Cancer Predisposition Syndrome
Why? PSYLIVED is a qualitative study that aims to understand the psychological experience of individuals living with inherited colorectal cancer.
- Conditions
- Lynch Syndrome, Polyposis Syndrome, Hereditary Mixed, 1, Polyposis Syndrome, Hereditary Mixed, 2
- Trial name
- PSYLIVED (NCT06447961)
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
Iron Deficiency Anemia Treatment, Microbial Colonization
GI Effects of Iron in Healthy Volunteers
Over recent years there has been a lot of research looking at how the bacteria in our gut affects our health. Some medications are known to cause changes in gut bacteria.
- Conditions
- Iron Deficiency Anemia Treatment, Microbial Colonization, Iron-deficiency, Iron Deficiency Anemia
- Trial name
- NCT04705662
- Testing
- Lactulose breath test, Stool sample, Daily Diary
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr Anthony Hobson
Constipation, Fecal Incontinence
Diagnosis of Functional Defecation Disorders in Childhood
Purpose To compare different kinds of diagnostic investigations in order to identify the most sensitive and least invasive when diagnosing constipation.
- Trial name
- NCT00230360
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Stress, Psychological, Stress, Physiological
Effects of Relaxing Breathing With Biofeedback or Meditative Stimulation on Performances During OSCE of Medical Students
Objective Structured Clinical Examination (OSCE) is a newly implemented evaluation standard for medical student and is a determinant part of the national competition they have to undergo.
- Conditions
- Stress, Psychological, Stress, Physiological, Exam Stress, Performance Anxiety
- Trial name
- ECOSTRESS (NCT05136586)
- Testing
- Biofeedback, Meditation, Control and biofeedback post OSCE
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
IBS - Irritable Bowel Syndrome, Anxiety
Study to Evaluate the Efficacy of Arrae's Bloat & Calm Alchemy Capsules to Reduce Bloating, Heartburn and Gas, and Alleviate the Intensity of IBS Symptoms
This is an open-label observational crossover trial to study the efficacy of a commercial dietary supplement and its effect on common symptoms of IBS (such as bloating, gas, heartburn, and other symptoms).
- Trial name
- NCT05197413
- Testing
- Arrae bloat supplement
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Arrae
Eosinophilic Esophagitis
Esophageal String Test in Eosinophilic Esophagitis
The overall goal of this study is to develop a novel minimally invasive device, the Esophageal String Test (EST) to monitor esophageal inflammation during treatment of the rare disease Eosinophilic Esophagitis (EoE) in a safe and…
- Trial name
- NCT02008903
- Where
- 6 sites in United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gastroesophageal Reflux Disease, Barrett's Esophagus
Survey Study on Barrett's Esophagus Screening
The goal of this study is to optimize Barrett's Esophagus (BE) screening to reduce the incidence, morbidity, and mortality of Esophageal Adenocarcinoma (EAC).
- Conditions
- Gastroesophageal Reflux Disease, Barrett's Esophagus, Esophagus Adenocarcinoma
- Trial name
- SCREEN-BE (NCT04408105)
- Testing
- Primary Care Provider Survey, Gastroenterologist Survey, Patient Survey
- Where
- 7 sites in United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Presbyphagia, Abnormal Tongue Pressure
Effect of Biofeedback Tongue Strengthening Program on Tongue Pressure and Swallowing Performance
Aging is often accompanied by a decline in bodily functions, including the swallowing process. Tongue-strengthening exercises have been shown to improve tongue strength and thickness in healthy adults and the elderly, thereby…
- Trial name
- NCT07080996
- Testing
- Strengthening training with biofeedback, Endurance training with biofeedback
- Where
- Thailand
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dysphagia
Comparison of Traditional Dysphagia Therapy and Developed Protocol for Dysphagia Patients in Intensive Care Unit
Dysphagia (swallowing disorders) in intensive care unit (ICU) patients is associated with poor outcomes, including aspiration pneumonia, prolonged hospitalization, and increased mortality.
- Trial name
- NCT07005427
- Testing
- dysphagia therapy, Designed protocol for dysphagia
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Gastroesophageal Reflux, Dyspepsia
Effects of Diet on Reflux and Dyspepsia
Reflux and dyspeptic symptoms are common affecting 10-20% of the population on a regular basis. Reflux symptoms such as heartburn and regurgitation are caused by the return of acid or non-acid gastric contents into the esophagus.
- Trial name
- NCT02425553
- Testing
- Diet
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Swallowing Disorders
Modelling of Pharyngeal Laryngeal Effectiveness
The purpose of this study is to collect the signals of pharyngeal laryngeal activity through five non-invasive sensors (microphone, accelerometer, surface electromyography (EMG), nasal cannula and oximeter) in order to identify…
- Trial name
- Eph-L (NCT06014710)
- Testing
- Swallowing evaluation
- Where
- 4 sites in France
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Irritable Bowel Syndrome, Quality of Life
Effect of Stress Ball on Irritable Bowel Syndrome
Objective: This study will be conducted to evaluate the effect of stress ball on symptom severity, quality of life, depression, anxiety and stress in patients with irritable bowel syndrome (IBS).
- Conditions
- Irritable Bowel Syndrome, Quality of Life, Depression, Anxiety
- Trial name
- NCT05931107
- Testing
- Stress ball practice group (Stress ball squeezing)
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Bedriye Cansu DEMİRKIRAN
Pulmonary Aspiration of Gastric Contents
Body Position and Ultrasound Examination of the Gastric Antrum
Pulmonary aspiration of gastric contents is a complication causing significant morbidity and mortality related to anesthesia. Ultrasound examination of the gastric antrum allows the detection of preoperative gastric contents…
- Trial name
- POSIGAST (NCT04097236)
- Testing
- Qualitative and quantitative assessment of gastric content volume with bed elevation, Qualitative and quantitative assessment of gastric content volume without bed elevation
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Autism Spectrum Disorder
Eating Behaviours, Diet and Gastrointestinal Symptoms in Children With Autism Spectrum Disorders
This case-control study aims to compare the differences in eating behaviours, nutritional status, diet quality and gastrointestinal (GI) health between Chinese children aged 3-6 years with autism spectrum disorders (ASD) (n=65)…
- Trial name
- NCT03270306
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
GERD
Clinical Trial to Assess the PK/PD of YYD601 20mg After Oral Administration if Healthy Adult Subjects (Phase1)
Clinical Trial to Assess the PK/PD of YYD601 20mg After Oral Administration if Healthy Adult Subjects (Phase1)
- Trial name
- NCT03985319
- Testing
- YYD601 20mg, Nexium tab 20mg
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Stomach Ulcer, Gastroesophageal Reflux
Pharmacodynamics and Safety of CDFR0209
This is a randomized, open-label, two-way crossover study to investigate the pharmacodynamics(24 hour gastric pH) and the safety between repeated doses of CDFR0209 and Losec in Healthy Male Volunteers
- Trial name
- NCT02710994
- Testing
- CDFR0209, Losec
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Pregnancy, Respiratory Aspiration of Gastric Contents
Gastric Emptying Following an Oral Carbohydrate Load in Women Admitted for Elective Cesarean Delivery
Because of the risk of pulmonary aspiration, patients are asked to comply with the fasting guidelines when they are scheduled for an elective cesarean section.
- Trial name
- NCT03593980
- Testing
- Cranberry juice
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Eosinophilic Esophagitis, Celiac Disease
Dose Escalation Study to Evaluate an Experimental New Treatment (CALY-002) in Healthy Subjects and Subjects With Celiac Disease and Eosinophilic Esophagitis
This is a single and multiple ascending study to characterize the safety, PK, PD and clinical effect in healthy volunteers and participants with Celiac Disease and Eosinophilic Esophagitis.
- Trial name
- NCT04593251
- Testing
- CALY-002
- Where
- 13 sites in Belgium, Finland and 3 more
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Calypso Biotech BV
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