Clinical trials: Gastro-Intestinal Disorders
Non Small Cell Lung Cancer, Colorectal Cancer
FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors
This is a Phase 1 dose-finding study of FT536 given in combination with a monoclonal antibody following lymphodepletion in participants with advanced solid tumors.
- Conditions
- Non Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT05395052
- Testing
- FT536, Cyclophosphamide, Fludarabine
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Fate Therapeutics
Gastroesophageal Reflux Disease
Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease
BACKGROUND: Gastroesophageal reflux disease is a very frequent clinical condition and nocturnal symptoms are a cause of quality of life impairment, poor sleep quality and absenteeism.
- Trial name
- IBELGA (NCT02706938)
- Testing
- Head of bed elevation, Standard treatment
- Where
- Colombia
- Volunteers
- 65 people
- Sponsor
- Universidad Nacional de Colombia
Ischemic Stroke, Dysphagia
Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial
Ischemic stroke is a common clinical disease, often accompanied by dysphagia. At present, clinical treatment for patients with dysphagia after ischemic stroke is limited.
- Trial name
- NCT06737549
- Testing
- Nerver growth factor (NGF) injection, EA intervention, Acupuncture intervention
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Dysphagia
Validation of the Gugging Swallowing Screen for the Intensive Care Unit
Aetiology of dysphagia after extubation is unknown and considered to be multifactorial. Use of a standardized dysphagia- screening permits an early diagnosis.
- Trial name
- GUSS-ICU (NCT04532398)
- Testing
- Gugging swallowing screen - ICU (GUSS-ICU) index test, Flexible Endoscopic Evaluation of Swallowing (FEES) reference test
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, GERD
One Anastomosis Gastric Bypass With Excluded Stomach Fundoplication: FundoRing vs Nissen vs OAGB Without Fundoplication
Background and study aims: Currently, one anastomosis Gastric Bypass (OAGB) is a common bariatric procedure. Obesity and gastroesophageal reflux disease (GERD) are steadily increasing world weight and antireflux surgery must be…
- Trial name
- FundoRing (NCT04828733)
- Testing
- laparoscopic one anastomosis gastric bypass with excluded stomach fundoplication: FundoRingOAGB and suture cruroplasty, laparoscopic one anastomosis gastric bypass with excluded stomach Nissen fundoplication and suture cruroplasty, Standard laparoscopic one anastomosis gastric bypass with cruroplasty. Not used fundoplication.
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Dysphagia
Neuromuscular Electrical Stimulation (NMES) Treatment Technique Therapy in the Management of Young Infants With Severe Dysphagia
The goal of this study is to obtain data that well help inform the feasibility and design of a randomized control trial of the therapeutic Neuromuscular Electrical Stimulation (NMES) technique in improving the swallowing function…
- Trial name
- NCT01723358
- Testing
- Neuromuscular electrical stimulation (NMES)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Erosive Reflux Disease, Heartburn
Observationa Study is a Prospective and Multi-institutional Observational Study.
This observational study is a prospective, multi-institutional non intervention study to examine the prescription patterns, corresponding treatment effects and safety in routine clinical practice for patients prescribed for the…
- Conditions
- Erosive Reflux Disease, Heartburn, Acid Regurgitation
- Trial name
- NCT06952855
- Where
- South Korea
- Volunteers
- 5,536 people
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Bariatric Surgery (Gastric Bypass), Overweight
The Effect of Different Macronutrients on Gastrointestinal Hormone Secretion After Gastric Bypass Operation
The purpose of this study is to determine the type of macronutrient (carbohydrate, lipid or protein) that most potently stimulates the endogen secretion of different gut hormones (primary outcome = Glucagon-Like peptide-1) in…
- Trial name
- NCT02372526
- Testing
- Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kirstine Nyvold Bojsen-Moeller
Lynch Syndrome
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer
The purpose of this study is to determine the proportion of patients diagnosed with Lynch syndrome in colorectal cancer patients with the loss of staining by immunohistochemistry (IHC) of any of the mismatch repair (MMR)…
- Trial name
- NCT03047226
- Testing
- next-generation sequencing
- Where
- 7 sites in China
- Volunteers
- 311 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Eosinophilic Esophagitis
Eosinophilic Esophagitis Clinical Therapy Comparison Trial
Eosinophilic Esophagitis (EoE) is a disorder in which a type of white blood cell (eosinophil) involved in allergic reactions, enter and cover the walls of the esophagus (food pipe).
- Trial name
- NCT01821898
- Testing
- Oral Budesonide, Elimination diet
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Baylor College of Medicine
Gastroesophageal Reflux Disease (GERD)
Retrospective TIF Study for Treatment of Gastroesophageal Reflux Disease (GERD). The RetroTIF Study
The purpose of this retrospective, open-label, post-market study is to evaluate the safety and efficacy of Transoral Incisionless Fundoplication (TIF) performed with EsophyX (brand name) in a broad range of GastroEsophageal…
- Trial name
- RetroTIF (NCT01327963)
- Testing
- Transoral Incisionless Fundoplication
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- EndoGastric Solutions
Solid Tumors, Colorectal Cancer
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
The main purpose of this 3-part study is to evaluate the safety and efficacy of the study drug known as LY2880070 in participants with advanced or metastatic solid tumors.
- Conditions
- Solid Tumors, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT02632448
- Testing
- LY2880070, Gemcitabine
- Where
- 16 sites in United States, Canada and 2 more
- Volunteers
- 229 people
- Sponsor
- Esperas Pharma Inc.
Refractory Aggressive B-cell Lymphomas, Refractory B-Cell Non-Hodgkin Lymphoma
Acalabrutinib + Liso-Cel In R/R Aggressive B-Cell Lymphomas
This research is being done to assess the effectiveness and safety of acalabrutinib combined with lisocabtagene maraleucel (liso-cel) for people with relapsed/refractory aggressive B-cell lymphoma.
- Conditions
- Refractory Aggressive B-cell Lymphomas, Refractory B-Cell Non-Hodgkin Lymphoma, Aggressive B-cell NHL, Diffuse Large B-cell Lymphoma (DLBCL)
- Trial name
- NCT05583149
- Testing
- ACALABRUTINIB, LISOCABTAGENE MARALEUCEL, Lymphodepleting chemotherapy
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Patrick C. Johnson, MD
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Hypnotherapy Through Self-exercises in Children With Functional Abdominal Pain in Primary Care
The goal of this randomised controlled trial is to study the (cost-)effectiveness of home-based hypnotherapy by self-exercises in children with functional abdominal pain (FAP) or irritable bowel syndrome (IBS) in primary care.
- Conditions
- Functional Gastrointestinal Disorders, Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome
- Trial name
- ZelfHy (NCT05636358)
- Testing
- Home-based hypnotherapy
- Where
- Netherlands
- Volunteers
- 152 people
- Sponsor
- University Medical Center Groningen
Obesity
A Study Of Gastrointestinal Tolerability Of PF05212389 In Obese Subjects
This study examines whether a gradual increase of dose improves the gastrointestinal tolerability (nausea and vomiting) of PF05212389
- Trial name
- NCT01472848
- Sponsor
- Pfizer
Achalasia Cardia
Comparison of Balloon Dilatation and Per Oral Endoscopic Myotomy in Children With Achalasia Cardia
To compare the efficacy of balloon dilatation (BD) and per oral endoscopic myotomy (POEM) in improving the symptoms of children with achalasia in short and long term Presently most guidelines such as American Society for…
- Trial name
- NCT07167355
- Testing
- POEM, BALLOON DILATATION
- Volunteers
- 70 people
- Sponsor
- Asian Institute of Gastroenterology, India
Gastro-esophageal Reflux Disease With Ulceration.
Relationship of Obesity With GERD Among Nigerians
Obesity is a strong risk factor for GERD. This study assessed the role of obesity among patients having erosive GERD and controls.
- Trial name
- NCT02888808
- Testing
- Gastroscopy
- Volunteers
- 160 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Deglutition Disorder, Dysphagia
The Turkish Feeding/Swallowing Impact Survey
The purpose of this study is to test the reliability and validity of the Turkish Feeding/Swallowing Impact Survey among caregivers of pediatric patients with swallowing disorders.
- Conditions
- Deglutition Disorder, Dysphagia, Outcome Assessment, Quality of Life
- Trial name
- NCT03005093
- Testing
- CAREGIVERS, CHILDREN OF CAREGIVERS
- Where
- Turkey (Türkiye)
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Microstomia, Scleroderma
Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease
The principal objective is to measure the degree to which oral microstomia caused by sclerosing skin disease improves after treating patients with local hyaluronidase injections.
- Conditions
- Microstomia, Scleroderma, CREST Syndrome, Scleromyxedema
- Trial name
- NCT04656704
- Testing
- hyaluronidase injected intradermally
- Sponsor
- Brigham and Women's Hospital
Achalasia, Gastric Fistula
Outcome Analysis of POEM and Endoluminal Therapies
Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.
- Conditions
- Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer
- Trial name
- NCT03123835
- Testing
- Endoscopic Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
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