Clinical trials: Gastrointestinal Disorder, Functional
IBS - Irritable Bowel Syndrome
Pre-analytical Influences on a Blood Test Study
Chronic diarrhoea is common and often believed to result from irritable bowel syndrome (IBS). However, up to 50% of patients with an IBS diagnosis may have something called Bile Acid Diarrhoea (BAD) instead.
- Trial name
- NCT05434949
- Testing
- Blood test, Analyses of samples
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
GVHD, Bone Marrow Transplant Failure
α1-antitrypsin (AAT) Levels and Functions in Allogeneic Bone Marrow Transplantation and Throughout Progression Into GVHD
Create a personalized time and context curve of patient circulating α1-antitrypsin (AAT) levels and functions before hematopoietic stem cell transplantation and throughout progression into GVHD. PRIMARY ENDPOINT 1.
- Conditions
- GVHD, Bone Marrow Transplant Failure, Alpha 1-Antitrypsin
- Trial name
- AATGVHD-MARK (NCT03188601)
- Where
- 4 sites in Israel
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Colorectal Cancer
Anthocyanin-Rich Berry Supplementation in Patients With Colorectal Cancer
This prospective, open-label interventional study evaluated the effects of short-term supplementation with an anthocyanin-rich freeze-dried black raspberry and strawberry preparation in patients undergoing treatment for…
- Trial name
- NCT07819539
- Testing
- Anthocyanin-Rich Freeze-Dried Berry Supplement
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Healthy Subjects, Functional Dyspepsia
Cerebral Cortical Influences on Autonomic Function
This is an exploratory neurophysiological study that will determine the impact of non-invasive brain stimulation on autonomic regulation, with a focus on gastrointestinal function.
- Conditions
- Healthy Subjects, Functional Dyspepsia, Irritable Bowel Syndrome
- Trial name
- NCT03869372
- Testing
- rTMS
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- David Levinthal
Hepatic Impairment, NASH - Nonalcoholic Steatohepatitis
Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses of MGL-3196 in Subjects With Varying Degrees of Hepatic Impairment and Healthy Matched Control Subjects
The purpose of this study is to directly characterize the pharmacokinetic (PK) profiles of MGL-3196 and its major metabolite (MGL-3623) following administration of multiple oral doses (QD x 6 days) in subjects with varying…
- Conditions
- Hepatic Impairment, NASH - Nonalcoholic Steatohepatitis, Cirrhosis, Liver
- Trial name
- NCT04643795
- Testing
- MGL-3196
- Where
- 3 sites in United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Cystic Fibrosis, Biomarkers
New Markers of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function in Sweat
The aim of the study is to identify new biomarkers of CFTR function in sweat and in sweat gland.
- Trial name
- NCT03993600
- Testing
- Sweat test (Macroduct Sweat Collection System) and skin biopsy (Punch Biopsy)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Liver Dysfunction
A Pharmacokinetic Study of CKD-501 in Patients With Impaired Hepatic Function
The purpose of this study is to evaluate pharmacokinetics of CKD-501 in patients with impaired hepatic function compared with normal hepatic function.
- Trial name
- NCT02005744
- Testing
- CKD-501
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Blastocystis Infections
Molecular Characterization of Blastocystis Isolates From Human by Restriction Fragment Length Polymorphism (RFLP) Analysis
Blastocystis is an anaerobic unicellular protozoal parasite infecting the gastrointestinal tract of humans and a wide range of animals.
- Trial name
- NCT05580393
- Testing
- RFLP analysis of SSU rRNA
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Crohn Disease, Functional Gastrointestinal Disorders
Gastro-intestinal Biopotential Recorder by Means of Surface ELEctrodes
The goal of this clinical trial is to compare the gastro-intestinal biopotentials recorded with a homemade device using surface electrodes placed on the abdomen in healthy volunteers, Crohn's disease patients without fibrosis…
- Conditions
- Crohn Disease, Functional Gastrointestinal Disorders, Healthy
- Trial name
- GRELE (NCT06197334)
- Testing
- Gastro-intestinal biopotentials recording
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Functional Dyspepsia, Chronic Atrophic Gastritis (CAG)
Correlation Study of Atrophic Gastritis and Dyspepsia Symptoms
Background: Dyspepsia is a common gastrointestinal complaint globally, affecting approximately 21.8% of the population. Among patients presenting with dyspeptic symptoms, over 80% are diagnosed with functional dyspepsia (FD)…
- Trial name
- NCT07250308
- Where
- China
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Hepatic Impairment
A Study to Evaluate AMG 133 in Participants With Varying Degrees of Hepatic Impairment or Normal Hepatic Function
The primary objective of the trial is to evaluate the pharmacokinetics (PK) of AMG 133 after a single subcutaneous (SC) dose in participants with mild, moderate, or severe hepatic impairment compared to participants with normal…
- Trial name
- NCT07428525
- Testing
- AMG 133
- Where
- 5 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Amgen
Hepatic Insufficiency
Clinical Trial of FCN-437c Capsule in Patients With Hepatic Insufficiency
To evaluate and compare the safety and efficacy of FCN-437c in subjects with mild and moderate liver impairment and healthy subjects, and to provide a basis for clinical medication in patients with liver impairment.
- Trial name
- NCT06620731
- Testing
- FCN-437c capsule
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Non-Alcoholic Fatty Liver Disease
Liver Health and Metabolic Function in People With Obesity
This project aims to determine the effect of significant weight loss on rates on hepatic fibrogenesis in people with obesity.
- Trial name
- NCT03701828
- Testing
- Weight loss surgery
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Allergy, Gastrointestinal Function
Can Supplementation With Lactobacillus Reuteri and Omega-3 Fatty Acids During Pregnancy and Lactation Reduce the Risk of Allergic Disease in Infancy?
The incidence of allergic disease has increased worldwide during the last decades. Initially, a lot of effort has been put in elucidating which of the known risk factors commonly associated to the development of allergic disease…
- Trial name
- PROOM-3 (NCT01542970)
- Testing
- Omega-3 fatty acids, Refined coconut and peanut oil without L. reuteri, L. reuteri
- Where
- Sweden
- Volunteers
- 496 people, healthy volunteers welcome
- Sponsor
- Ostergotland County Council, Sweden
Liver Cirrhosis, Liver Failure
Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"
The purpose of this study is to evaluate the effects on plasma exchange with 5% albumin on albumin functional capacity, cardiocirculatory, renal and cerebral function in cirrhotic patients with "acute-on-chronic liver failure".
- Trial name
- NCT01201720
- Testing
- Plasma exchange with albumin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Instituto Grifols, S.A.
Hepatic Insufficiency
A Pharmacokinetic Study of Simufilam in Subjects With Impaired Hepatic Function
Evaluate simufilam levels in the blood of hepatically impaired individuals compared to Healthy individuals of similar demographics
- Trial name
- NCT06390410
- Testing
- Simufilam
- Where
- 3 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Cassava Sciences, Inc.
Cystic Fibrosis
Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF
Cystic fibrosis has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-AOX (NCT02690064)
- Testing
- Acute Antioxidant, Chronic Antioxidant
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Augusta University
Inflammatory Bowel Disease, Irritable Bowel Syndrome
BÜHLMANN fCAL™ ELISA - Aid in Differentiation of IBD From IBS
The purpose of this study is to confirm the sensitivity and specificity of the BÜHLMANN fCAL™ ELISA as an aid in diagnosis to differentiate between Inflammatory Bowel Disease (IBD; Crohn's Disease (CD), Ulcerative Colitis (UC)…
- Trial name
- NCT02351635
- Testing
- fecal calprotectin level
- Where
- 7 sites in United States
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- Bühlmann Laboratories AG
Change of Transit or Circulation, Obesity
The Effect of Prebiotics on Gastrointestinal Functioning and Metabolism
The study will investigate the effect of cereal based prebiotic fibres on intestinal health and functioning and host metabolism.
- Trial name
- NCT02491125
- Testing
- soluble wheat bran fibre
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Irritable Bowel Syndrome (IBS), Anxiety
Anxiety and Depression in IBS: A Brain-Gut Axis Study
This study aims to understand how the gut and the brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety and depression.
- Conditions
- Irritable Bowel Syndrome (IBS), Anxiety, Depression
- Trial name
- NCT07646834
- Testing
- Observational Study (No Intervention)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital