Clinical trials: Gastrointestinal Disorders, Functional
Irritable Bowel Syndrome
Effect of Modified Cellulose on Colonic Fermentation of Inulin
A 3-way randomised cross-over study to test the hypothesis that combining either psyllium or methylcellulose to form a gel incorporating inulin will reduce gas production as compared to inulin given with a placebo, maltodextrin.
- Trial name
- COCOA2 (NCT05911347)
- Testing
- Psyllium, Methylcellulose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Advanced Pancreatic Adenocarcinoma, Pancreatic Adenocarcinoma
Resistance Training Intervention to Improve Physical Function in Patients With Pancreatic Cancer Receiving Combination Chemotherapy or Have Undergone Surgery, PancStrength Study
This clinical trial studies the safety of a real-time tele-exercise resistance training (training done using a tablet) in maintaining skeletal muscle, strength, physical function, and health-related quality of life in patients…
- Conditions
- Advanced Pancreatic Adenocarcinoma, Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8
- Trial name
- NCT04837118
- Testing
- Educational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Intestinal Diseases, Irritable Bowel Syndrome
Biomarkers for Intestinal Permeability in Patients With Constipation
Our overall objective with this study is firstly to provide a comprehensive assessment of intestinal permeability, mucosal barrier function using existing biomarkers and secondly to explore novel biomarkers for measuring…
- Conditions
- Intestinal Diseases, Irritable Bowel Syndrome, Constipation
- Trial name
- NCT02246647
- Testing
- Permeability measurement, Esophagogastroduodenoscopy, Flexible sigmoidoscopy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome, Gallstone Disease
Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.
This study aims to evaluate pharmacokinetic profile, safety and establish bioequivalence of the investigational drug Trimedat® 76,95 mg orally disintegrating tablets compared to the reference drug Trimedat® 100 mg tablets in…
- Conditions
- Irritable Bowel Syndrome, Gallstone Disease, GERD, Biliary Dyskinesia
- Trial name
- NCT07421011
- Testing
- Trimedat®
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Gastrointestinal Cancer, Head and Neck Cancer
Microvascular Function in Patients Undergoing 5-Fluorouracil Chemotherapy
The primary aim of this study is to investigate potential differences in vascular function between patients receiving 5-Fluorouracil (5-FU) chemotherapy, patients receiving chemotherapies other than 5-FU, cancer survivors who…
- Conditions
- Gastrointestinal Cancer, Head and Neck Cancer, Breast Cancer, Chemotherapy Effect
- Trial name
- NCT04042298
- Testing
- Arterial blood pressure, Skin microcirculatory blood flow, Brachial artery blood flow
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Colorectal Cancer (CRC) Screening
A Novel Multi-functional Artificial Intelligence System on Treatment Efficacy and Implementation in Colonoscopy
To overcome non-neoplastic polyp (NNP) resections, computer-aided diagnosis (CADx) systems have been developed. In a meta-analysis, the performance of CADx systems was superior to endoscopists.
- Trial name
- mAInstream (NCT07844252)
- Testing
- CADe/CADx
- Volunteers
- 2,818 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Irritable Bowel Syndrome, Microbial Colonization
Microbiota Profiling in IBS
This study investigates differences in microbiota profiles and metabolite levels between mild and severe IBS patients, compared to matched healthy controls. Two fecal samples, with one month in between, will be analyzed.
- Conditions
- Irritable Bowel Syndrome, Microbial Colonization, Dietary Habits
- Trial name
- IBSQUtrition (NCT03720314)
- Testing
- NA observational study
- Where
- Netherlands
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Functional Gastrointestinal Disorders, Infant Conditions
Prevalence of FGIDs and Probiotics Study
This is a study to evaluate the prevalence of FGIDs in infants using the Thai version of Rome IV diagnostic questionnaire for functional gastrointestinal disorders in infants and evaluate the efficacy of Limosilactobacillus…
- Trial name
- PROOF (NCT06309199)
- Testing
- Biogaia
- Where
- Thailand
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Fibromyalgia, Irritable Bowel Syndrome
Patient-reported Outcome Measures (PROMs) in Patients With Bodily Stress Syndrome: Protocol for a Prospective Cohort Study
This cohort study implements patient reported outcome measures (PROMs) for patients with bodily stress syndrome in a clinic for functional disorders.
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Somatic Symptom, Chronic Fatigue Syndrome
- Trial name
- SYMPA (NCT04667611)
- Testing
- Psychosocial interventions
- Where
- Finland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Cystic Fibrosis, Lung Disease
Magnetic Resonance Imaging (MRI) for Early Diagnosis of Cystic Fibrosis (CF)
In patients with Cystic Fibrosis (CF) the clinical course of lung disease is crucial for individual prognosis and life expectancy.
- Trial name
- NCT00760071
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Exocrine Pancreatic Insufficiency, Chronic Pancreatitis
A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects
The purpose of this study is to collect pancreas fluid from the duodenum using the endoscopic pancreas function collection method in healthy participants after pancreatic stimulation with human secretin.
- Trial name
- NCT07285863
- Testing
- Secretin (human synthetic) - ChiRhoClin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Constipation, Children
Comparison of Anorectal Manometry and 3D Manometry in Diagnosis of Functional Disorders in Children
Pressures measured by manometric solid-state catheters may differ according to the type of the catheter and specific anatomy and physiology of anorectum.
- Conditions
- Constipation, Children, Fecal Incontinence
- Trial name
- NCT02812823
- Testing
- High-resolution anorectal manometry
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Acute Pancreatitis
The Evaluation of Pro/Antioxidative Profile and Diagnostic Parameters in the Patients With Pancreatic Disease
The study aims to assess and analyze some selected antioxidants and laboratory parameters during hospitalization of the patients with acute pancreatitis.
- Trial name
- NCT03028181
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Cystic Fibrosis
Effect of the CFTR-modulating Triple Therapy Elexacaftor - Tezacaftor - Ivacaftor
The aim of this study is to investigate the frequency distribution, cytokine profile and function of peripheral, mononuclear leukocyte populations (monocytes, NK cells, T/B lymphocytes) and their correlation to clinical and…
- Trial name
- NCT05576324
- Testing
- Elexacaftor / Ivacaftor / Tezacaftor
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Crohn's Disease, Short Bowel Syndrome
Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn's Disease Patients
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations.
- Conditions
- Crohn's Disease, Short Bowel Syndrome, Malabsorption Syndromes, Celiac Disease
- Trial name
- NCT00138879
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- St Mark's Hospital Foundation
Inflammation, Colon, Irritable
The Role of Intestinal Inflammation in Irritable Bowel Syndrome (IBS)
The research project addresses the following hypotheses (A) the normal balance of beneficial and detrimental commensal intestinal bacteria is deranged in IBS, with selective alterations in clinically defined patient subsets i.e.…
- Conditions
- Inflammation, Colon, Irritable, Colonic Diseases, Functional, Irritable Bowel Syndrome
- Trial name
- K23 (NCT01072903)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Gum Chewing, Preoperative
Preoperative Chewing Gum on Anxiety and Postoperative Nausea and Vomiting, Gastrointestinal Function
The aim of this study was to investigate the effects of chewing gum before surgery on preoperative anxiety, postoperative gastrointestinal functions (time to first gas, time to first defecation, bowel sounds, abdominal…
- Conditions
- Gum Chewing, Preoperative, Anxiety, Postoperative Nausea and Vomiting
- Trial name
- NCT06603025
- Testing
- chewing gum
- Where
- Cyprus
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Irritable Bowel Syndrome
Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial
Evidence exists to support low-grade inflammation as the inciting factor leading to visceral hypersensitivity and alteration in motility in irritable bowel syndrome.In the medical literature,there is ample in vitro and in vivo…
- Trial name
- CuTIBS (NCT00779493)
- Testing
- curcumin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Hepatitis C, Hepatitis B
Neurocognitive Functioning in Patients With Hepatitis C Pre- and Post-Treatment With Antiviral Medication
The estimated global prevalence of hepatitis C (HCV) infection is approximately 3% (170 million individuals). In Canada there are an estimated 240,000 people infected with HCV.
- Trial name
- NCT00188201
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Oral Hypofunction
Program of Community Oral Function Enhancement
The purpose of this study examined the effects of oral exercise on oral function among older adults in Taiwan, focusing on gender-related outcome differences.
- Trial name
- NCT06794814
- Testing
- oral exercise
- Where
- Taiwan
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University