Clinical trials: Gastrointestinal Disorders, Functional
Cancer Esophagus, Pancreatic Cancer
Effect of Chewing Gum on Postoperative Bowel Function Following Upper GI Tract Cancer Surgery
Every patient undergoing surgery in the abdomen will experience temporary paralysis of bowel function. This study evaluates whether chewing gum can reduce the bowel paralysis after surgery in patients undergoing either esophageal…
- Trial name
- NCT02260128
- Testing
- Chewing gum
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Michael Bau Mortensen
Ulcerative Colitis, Irritable Bowel Syndrome
Fecal Microbiota Transplantation for Health Improvement (TFM3)
Search for mechanisms of the effect of fecal transplantation on a healthy organism and various nosological forms.
- Conditions
- Ulcerative Colitis, Irritable Bowel Syndrome, Crohn Disease, Irritable Bowel
- Trial name
- TFM3 (NCT04011943)
- Testing
- Fecal Microbiota Transplantation
- Where
- Russia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal Research and Clinical Center of Physical-Chemical Medicine
Cystic Fibrosis, Healthy
Real-Time Assessment of Lung Structure and Function in Children and Young Adults With CF Using Electrical Impedance Tomography
The purpose of this study is to determine the ability of electrical impedance tomography (EIT) to identify structural and functional physiological changes that occur with disease progression in cystic fibrosis patients.
- Trial name
- NCT05455671
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Intestinal Failure, Short Bowel Syndrome
Resting Energy Expenditure by Gastrointestinal Functional Status
This prospective, comparative interventional study will evaluate resting energy expenditure in adults with different gastrointestinal functional status.
- Trial name
- NCT07714499
- Testing
- Protocol-Defined Metabolic and Body Composition Assessment
- Where
- Slovenia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
HIV Infections, Hiv
Acceptability, Feasibility, and Preliminary Impact of a Web-based, HIV Prevention Toolkit With Cisgender Male Couples in Lima, Peru
This digital couples-based HIV/STI prevention intervention project will determine preliminary efficacy to improve uptake of evidence-based strategies and a tailored prevention plan among cisgender male couples who are in a…
- Conditions
- HIV Infections, Hiv, Sexually Transmitted Infections (Not HIV or Hepatitis), Sexually Transmitted Diseases
- Trial name
- NCT05873855
- Testing
- Para ti, para mi, para nosotros (P3), Waitlist Control Para ti, para mi, para nosotros (P3)
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Florida International University
Liver Dysfunction
Pharmacokinetics Study of Nemonoxacin Malate Capsules in Subjects With Moderate Impaired Hepatic Function
This is a single center, open-label, non-randomized, 1:1 parallel control and single dose administration study design. Healthy subjects will be matched to moderate hepatic function impaired (Child-Pugh B，7-9) subjects in age…
- Trial name
- NCT02604498
- Testing
- Nemonoxacin
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhejiang Medicine Co., Ltd.
Irritable Bowel Syndrome
Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome
This study aimed to evaluate the effects of a Low-FODMAP diet on intestinal permeability, symptom severity, and quality of life in patients with Irritable Bowel Syndrome (IBS).
- Trial name
- NCT07467278
- Testing
- low fodmap diet, dietary intervention
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Stress Urinary Incontinence, Fecal Incontinence
Effects of Single Dose Citalopram and Reboxetine on Urethral and Anal Closure Function on Healthy Female Subjects
This study will investigate if citalopram, a selective serotonin reuptake inhibitor, is reducing the opening pressure of the urethra and possibly causing or worsening stress urinary incontinence.
- Trial name
- NCT04097288
- Testing
- Citalopram 40mg, Reboxetine 8 mg
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Lupus Erythematosus, Systemic, Gastrointestinal Microbiome
Assessment of Cognitive Function and Gut Microbiota Analysis in Real World Patients With Lupus Cerebrovascular Disease
Based on clinical manifestations, laboratory data and intestinal microflora detection, the cognitive function characteristics of patients with systemic lupus erythematosus and cerebrovascular disease and its relationship with…
- Trial name
- NCT05636670
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Crohn's Disease
Acupuncture Treatment for Active Crohn's Disease
The purpose of this study is to observe the efficacy and safety of acupuncture and moxibustion for Crohn's disease and the regulation mechanism of intestinal microbiota and peripheral immunity.
- Trial name
- NCT02559037
- Testing
- Acupuncture and moxibustion
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Stroke
Changes of Swallowing Function and Oropharyngeal Muscle Mass on Sonography After Comprehensive Swallowing Therapy and Neuromuscular Electrical Stimulation in Stroke Patients With Dysphagia
1. The inter-rater and intra-rater reliability of sonography. 2. To explore that sonography is a clinically practical tool for assessing the changes of oropharyngeal muscles mass. 3.
- Trial name
- NCT04728737
- Testing
- swallowing therapy, IOPI therapy, neuromuscular electrical stimulation (NMES) therapy
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Gastrointestinal Motility Disorder
Intestinal Dysmotility in Patients With Functional Digestive Symptoms
Automatic and non-invasive diagnostic methods based on the analysis of internal (intraluminal) and external (abdominal) images have been recently developed to measure intestinal motility.
- Trial name
- NCT04764019
- Testing
- High resolution intestinal manometry
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Irritable Bowel Syndrome
The Effect of the Low FODMAP Diet and Dietary Oligofructose on Gastrointestinal Form, Function and Microbiota
Some carbohydrates, complex sugars, which are found in grains, fruit and vegetables, cannot be digested by humans. When eaten they pass through the small bowel to the large bowel, or colon.
- Trial name
- FOG (NCT02259465)
- Testing
- low FODMAP diet, Oligofructose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Neurogenic Bladder, Neurogenic Bowel
The Role of Active Administration of Peristeen Bowel Evacuation for the Management of Urinary Tract Infection
This study investigates whether active use of transanal irrigation (Peristeen®) effectively manages urinary tract infection among patients with the diagnosis of neurogenic bladder.
- Conditions
- Neurogenic Bladder, Neurogenic Bowel, Spina Bifida, Fecal Incontinence
- Trial name
- NCT04815226
- Testing
- Peristeen Transanal Irrigation
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Parkinson's Disease (PD)
Untreated Parkinson's Disease Work-up Assessing Resident Microbiota and Duodenal Barrier Function
The UPWARD study is a prospective hypothesis-generating study in individuals with untreated Parkinson's disease (PD) and age-matched healthy controls (HCs).
- Trial name
- UPWARD (NCT07418658)
- Testing
- Invasive sampling procedures, Non-invasive sampling procedures
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis
Study of Ibuprofen to Preserve Lung Function in Patients With Cystic Fibrosis
OBJECTIVES: I. Determine the effect of different doses of ibuprofen on neutrophil (polymorphonuclear leukocyte; PMN) delivery to a mucosal surface (the oral mucosa) in patients with cystic fibrosis and healthy controls. II.
- Trial name
- NCT00004440
- Testing
- ibuprofen
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- FDA Office of Orphan Products Development
Liver Cirrhosis
Renal Function Determination in Patients With Liver Cirrhosis
We have several ways to appropriately determine renal function in healthy patients and in several diseases, in cirrhotic population we dont have a precise tool that has sufficient precision that reflects glomerular function…
- Trial name
- NCT02047240
- Where
- Mexico
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Cystic Fibrosis
Gut Imaging for Function and Transit in Cystic Fibrosis 3 Junior
Recently trial data has shown that the medicine KaftrioTM (Elexacaftor/ Tezacaftor/ Ivacaftor) improves lung function in children aged 6 to 11 years who have cystic fibrosis (CF).
- Trial name
- GIFT-CFJunior (NCT05699148)
- Testing
- Elexacaftor / Ivacaftor / Tezacaftor
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Functional Dyspepsia, Gastritis
The Prevalence and the Pathophysiological Role of Non-Helicobacter Pylori Helicobacter Spp. in Well-defined Gastric Diseases and (Pre-) Malignancies
The goal of this clinical trial is to discover the prevalence of NHPH bacteria (Non-Helicobacter pylori Helicobacter species) in patients with one of the following conditions: 1.
- Conditions
- Functional Dyspepsia, Gastritis, Gastritis Chronic, Gastric Cancer (GC)
- Trial name
- HELIS (NCT07770126)
- Where
- 3 sites in Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Spinal Cord Injuries, Constipation
Transdermal Administration by a Novel Wireless Iontophoresis Device
Persons with spinal cord injury (SCI) have neurogenic bowel disorders which is associated with significant morbidity. The negative impact of bowel complications is often at the top of the list of problems reported by persons with…
- Conditions
- Spinal Cord Injuries, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT06351852
- Testing
- Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center