Clinical trials: Gastrointestinal Hormones
Obesity
The Effect of Liraglutide on the GIT
Liraglutide is a glucose-like peptide 1 agonist, currently used as an effective weight-loss treatment. Its mechanism of action has not yet been elucidated.
- Trial name
- LIRHV (NCT04008290)
- Testing
- 0.6 mg Liraglutide
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Metabolic Syndrome, Obesity
Potential Beneficial Effects of Resveratrol
We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.
- Trial name
- NCT01150955
- Testing
- Resveratrol
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Eating Behavior, Overweight
Snacks and Satiety
This study is designed to compare two types of snacks (almonds or a cereal-based snack), eaten between meals, on measures of appetite, including appetitive hormones, self-reported feelings of hunger and fullness, and food intake…
- Conditions
- Eating Behavior, Overweight, Obesity
- Trial name
- NCT03947281
- Testing
- Almond snack, Cereal-based snack
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Colonic Neoplasms, Colonic Polyps
Strigolactones and Dysplastic Colonic Lesions or Cancer
The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.
- Trial name
- NCT02824835
- Testing
- biopsy during colonoscopy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Energy Intake, Gastrointestinal Hormones
Effects of Oral Pre-loads on Subsequent Energy Intake
The aim of this project is to investigate the effect of erythritol (given as pre-load), compared to sucrose, sucralose, and water on energy intake during a subsequent ad libitum test meal in healthy participants.
- Conditions
- Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT04713137
- Testing
- Erythritol, Sucrose, Sucralose
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
The Impact of Sleep Restriction on Gastric Emptying, Appetite and Energy Intake
This study aims to examine if partial sleep deprivation results in alterations blood markers and subjective markers of homeostatic, and hedonic appetite, as well as provide initial data as to the impact of sleep restriction on…
- Trial name
- NCT05953285
- Testing
- Sleep restriction
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Growth Hormone Deficiency
Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency
The purpose of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic-intramyocellular lipids in patients with growth hormone deficiency (GHD).
- Trial name
- NCT00646815
- Testing
- growth hormone (genotropin)
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
Effect of POCO on Gastric Function in HV
This study aims to investigate changes in gastric motility (including gastric accommodation), nutrient volume tolerance, gastric emptying and gastrointestinal hormones in healthy volunteers after an acute intake of a combination…
- Trial name
- POCO (NCT03682835)
- Testing
- FDGard
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastrointestinal Motility Disorder, Disturbance of Salivary Secretion
Nitric Oxide Control of Migrating Motor Complex: L-NMMA Effects in Relation to Receptor Blockades
The aim is to elucidate how NO works in conjunction with other neurotransmitters to regulate the migrating motility complex (MMC).
- Trial name
- LNMMA (NCT02245165)
- Testing
- L-Nitro-Monomethyl-Arginine (LNMMA) 10 mg/kg IV, saline
- Where
- Sweden
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Uppsala University
The Focus of the Study is Healthy Volunteers
Appetite Regulation by a Breakfast Soft Bread
The aim of this study is to evaluate the appetite rating of a soft bread with a high content of fibre and protein (Puravita Breakfast®) as well as its capacity to modulate postprandial levels of glucose, insulin and…
- Trial name
- NCT02090049
- Testing
- Puravita Breakfast, Control
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Puratos
Digestive Physiology, Gastrointestinal Motility
Effects of Exendin(9-39) on Gastroduodenal Motility
The purpose of this study in humans is to define the effects of the endogenous hormone GLP-1 on gastroduodenal motility and on endocrine pancreatic secretion by using the specific GLP-1 receptor antagonist exendin(9-39).
- Conditions
- Digestive Physiology, Gastrointestinal Motility, Gastrointestinal Hormones, Glucagon-like Peptide 1
- Trial name
- NCT00468091
- Testing
- exendin(9-39)amide, atropine
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Obesity
Protein Dose-repsonse Effect on GLP-1, PYY and Appetite in Male Subjects
Dietary protein appears to be the most satiating and thermogenic macronutrient. However, how protein exerts its effect on appetite is not fully known.
- Trial name
- Protein (NCT01561235)
- Testing
- Dose-reponse effect of protein on appetite and appetite-regulating hormones
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
Studies of the Early Meal Phase in Healthy Individuals - Nutrient Absorption and Gastrointestinal Hormone Secretion
To investigate gastrointestinal hormone secretions and nutrient absorption during the early meal phase we will recruit 12 healthy young men. They will be equipped with peripheral intravenous catheters for frequent blood sampling.
- Trial name
- NCT03543423
- Testing
- Oral glucose tolerance test, Liquid mixed meal test
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Non Alcoholic Fatty Liver Disease, Type 2 Diabetes
Pathophysiological Implications of the Incretin Hormones in Patients With Liver Disease With and Without Diabetes
The main objective of this study is to analyze the pathophysiological implications of glucagon and the incretin hormones in patients with liver disease (Non alcoholic fatty liver disease (NAFLD) or cirrhosis) with and without…
- Conditions
- Non Alcoholic Fatty Liver Disease, Type 2 Diabetes, Liver Cirrhosis
- Trial name
- NCT01492283
- Testing
- OGTT, IIGI
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Physiological Satiation Mechanisms
Acute Effects of the Two Alternative Sweeteners D-allulose and Erythritol on Metabolism
The aim of this project is to investigate the effect of intragastric (ig) D-allulose on metabolic parameters in general and to investigate the effect of sweet taste receptor blockade on GI hormone responses, glycemic control…
- Trial name
- NCT04027283
- Testing
- Erythritol, Erythritol + lactisole, D-allulose
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Gastrointestinal Hormones, Glycemic Control
Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose
This project aims to compare the acute metabolic effects of the three sweeteners sucrose, glucose, and fructose on GI hormones (GLP-1, PYY, CCK, GIP, and ghrelin).
- Conditions
- Gastrointestinal Hormones, Glycemic Control, Blood Coagulation Function, Gastric Emptying
- Trial name
- NCT06799715
- Testing
- Sucrose, Glucose, Fructose
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Childhood
GI Tract Biomarkers in Infants With Different Diets
Childhood obesity is increasing with more than one-third of adolescents currently overweight and one in five with obesity. The lifelong incidence of obesity-related morbidities is also increasing with childhood obesity.
- Trial name
- NCT03751137
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Cystic Fibrosis
Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis Airways
The general objective is to elucidate the mechanisms whereby sex hormones may modulate the severity of respiratory disease. An important component of this proposal is a systematic and intensive approach to characterize how the…
- Trial name
- NCT00700050
- Testing
- Hypertonic saline
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy
Blocking of the Gut Hormone Receptor for Glucagon-like Peptide 2 (GLP-2) by the GLP-2 Receptor Antagonist GLP-2(3-33)
This project will describe the role of physiological levels of GLP-2 in regulating the blood flow to the intestines and the effect of the antagonist GLP-2(3-33) in blocking these effects of GLP-2.
- Trial name
- GLP-2ant (NCT06774807)
- Testing
- Saline infusion, Saline injection, 1nmol antagonist infusion
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen