Clinical trials: Gastrointestinal Microbiota
Hiv, Atherosclerosis
Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in…
- Conditions
- Hiv, Atherosclerosis, Diet, Healthy
- Trial name
- NCT06560840
- Testing
- dietary intervention
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Fudan University
Type 2 Diabetes
The Interaction Between Protein Intake, Gut Microbiota and Type 2 Diabetes in Subjects With Different Ethnic Backgrounds
Context and justification: There is growing evidence that the gut microbiota is a key element in the pathophysiology of cardio-metabolic diseases (CMD) such as Type 2 Diabetes (T2D).
- Trial name
- MICRODIET (NCT03732690)
- Testing
- Diet HP, Diet LP
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Photoaging
Effects of Dietary Soy Protein on Facial Wrinkles in Postmenopausal Women
Soy and soy-derived products are the primary dietary sources of isoflavones, particularly daidzein and genistein, for humans. Isoflavones are noted to have several effects on the skin including proliferation of keratinocytes…
- Trial name
- NCT04871750
- Testing
- Soy protein, Casein protein
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Gestational Diabetes Mellitus in Childbirth, Neurodevelopmental Disorders
Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers
The prospective multicenter study GD-Brain provides a better knowledge on the basis of neurological impairment in children born to mothers with gestational diabetes (GDM).
- Trial name
- GD-BRAIN (NCT03032991)
- Where
- Spain
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Ulcerative Colitis
Fecal Microbiota Transplantation and Newly Diagnosed Ulcerative Colitis (UC)
In this FinUC study we are trying to find out the efficacy and safety of the Fecal microbiota transplantation (FMT) in newly diagnosed active ulcerative colitis patients.
- Trial name
- FinUC (NCT04687150)
- Testing
- Fecal microbiota transplantation, Colored water
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Turku University Hospital
Excessive Intestinal Gas Production
Evaluation of a 28-day Fermented Milk Product Consumption Twice Daily as Compared to a Non-fermented Milk Product on Intestinal Gas Production in Healthy Subjects High Dihydrogen Producers
The purpose of this study is to assess the effect of a 28-day fermented milk product consumption twice daily on intestinal gas production of dihydrogen (H2) and methane (CH4) in healthy subjects high H2 producers.
- Trial name
- BREEZE (NCT03015441)
- Testing
- Milk product fermented by lactic bacteria or not fermented
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Colorectal Cancer, Inflammatory Bowel Diseases
Microbiota-anastomotic Leak Among Colorectal Surgery Patients : Pilot Study
The study is based on the hypothesis that patients with postoperative anastomotic leakage have a different bacterial profile contributing to poor tissue healing, and that patients operated for colon cancer presumably have a…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Microbiota, Anastomotic Leak
- Trial name
- NCT03496441
- Testing
- Fecal sample collection for analysis
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Acute Pancreatitis, Microbial Colonization
Microbiota in Acute Pancreatitis: Prospective Multicenter Study
The objective of the study is to classify and carry out a quantitative analysis of the different bacterial species present in the intestinal microbiota of patients with acute pancreatitis and determine if there are significant…
- Trial name
- NCT04038554
- Testing
- Feces and saliva analysis
- Where
- 2 sites in Spain
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Renal Insufficiency, Chronic, Inflammation
Effects of Cranberry Supplementation on Chronic Kidney Disease Patients.
Patients with chronic kidney disease (CKD) have several complications that are linked to oxidative stress and inflammation, and among the most recently studied is the alteration of the intestinal microbiota.
- Conditions
- Renal Insufficiency, Chronic, Inflammation, Oxidative Stress, Gastrointestinal Microbiome
- Trial name
- NCT04377919
- Testing
- Cranberry
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Aged, Healthy
Low Grade Inflammation, Gut Microbiota and Barrier Function in Elderly Humans
Cardiovascular diseases (CVD) are the main cause of death in the European Union. A large part of the aging process, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks…
- Trial name
- NCT01218165
- Testing
- Probiotic drink, Control Group
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Bladder and Bowel Dysfunction
Bladder and Bowel Dysfunction in Children
Background: Bladder and bowel dysfunction (BBD) is characterized by lower urinary tract symptoms accompanied by bowel complaints. BBD is a common condition in childhood.
- Trial name
- NCT05318365
- Testing
- Polyethylene Glycol 3350, Urotherapy
- Where
- 3 sites in Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gastro-Intestinal Disorder
Fructose Effect on Neuroinflammation and Feelings
Fructose is increasingly present in our food. The increase in its consumption is associated with the increase in the prevalence of several pathologies such as metabolic syndrome or hepatic steatosis.
- Trial name
- MOODYFRUCTOSE (NCT05371067)
- Testing
- Fructose respiratory test
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Laparoscopic Cholecystectomy
Analysis of the Impact of Cholecystectomy on Gut Microbiome in Adults
Laparoscopic cholecystectomy (LC) is widely used in the gallbladder stone, gallbladder polyp, gallbladder cancer and other diseases.
- Trial name
- NCT03836170
- Testing
- Laparoscopic cholecystectomy
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Colorectal Cancer
Microbiome-based Diagnostic Tool for the Screening of Colorectal Cancer (GUILTI)
Colorectal cancer (CRC) is one of the most common cancer and cause of cancer death worldwide. Population-based screening programs for average risk populations have proven effective in reducing both incidence and mortality of CRC…
- Trial name
- GUILTI (NCT06738173)
- Testing
- Gut microbiome testing
- Where
- Italy
- Volunteers
- 1,202 people
- Sponsor
- Catholic University of the Sacred Heart
Spondyloarthritis, Crohn Disease
Characterization of the Intestinal Microbiota in Patients With Inflammatory Bowel Disease and/or Spondyloarthritis and Study of the Impact of an Anti-TNF Alpha Therapy
Spondyloarthritis and inflammatory bowel diseases are common diseases, frequently met together in overlap syndromes. Their physiopathology remains puzzling.
- Conditions
- Spondyloarthritis, Crohn Disease, Ulcerative Colitis
- Trial name
- MIST (NCT03359642)
- Testing
- blood sample, stool samples, food questionnaire
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Bordeaux
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Healthy Subjects
Identification of Physiological Biomarkers of Gastro-intestinal Discomforts Induced by Milk Consumption
This study aims to explore digestibility of lactose and milk proteins, gut permeability, microbiota composition and psychological wellbeing status in healthy subjects who are non-habitual milk consumers due to milk-related…
- Trial name
- MIDI (NCT04205045)
- Testing
- Lactose Breath Test, Gut permeability test, Milk Test
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paola Vitaglione
Depression During Pregnancy
The Association Between Gut Microbiota Diversity and Postpartum Depression
This study aims to examine whether naturally occurring bacteria in the gastrointestinal tract are associated with mood changes following childbirth, including postpartum depression.
- Trial name
- NCT07227753
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
REM Sleep Behavior Disorder
Gut Microbiota in the Progression of Alpha-synucleinopathies
The aim of this study is to correlate baseline gut microbiota features and the progression of neurodegeneration in the established cohort of patients with early Parkinson's disease.
- Trial name
- NCT05353868
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 490 people
- Sponsor
- Chinese University of Hong Kong
Sarcopenia
The Characteristics of Gut Microbiota in Patients With Sarcopenia and the Development of Probiotics
The primary aim of this study is to identify the composition and characteristics of the gut microbiota in patients with sarcopenia in older adults, and compare these with the gut microbiota characteristics of older adults and…
- Trial name
- NCT07334210
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
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