Clinical trials: Gastrointestinal Motility
Minor Digestive Disorders
Prevention of the Minor Digestive Disorders by Lactobacillus Reuteri Supplementation
Aim of the study. To evaluate if L. reuteri DSM 17938 supplementation since the first days of life can reduce the onset of gaseous colic in neonates and the onset of minor digestive disorders such as regurgitation and…
- Trial name
- NCT01235884
- Testing
- Lactobacillus reuteri
- Where
- 8 sites in Italy
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- University of Bari
Functional Gastrointestinal Disorders
GLP-1 Inhibits Prandial Antro-duodeno-jejunal Motility in Humans
The inhibitory effect of low dose GLP-1 is investigated on prandial motility of the stomach, duodenum and jejunum in vivo in humans.
- Trial name
- GLPMOT (NCT02731664)
- Testing
- GLP-1, Intravenous saline
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Venous Insufficiency of Leg, Venous Leg Ulcer
Non Contrast MRI in Lower Extremity
We collected retrospectively the non contrast MRI in chia yi memorial hospital for different venous disease of lower extremity morphology and flow ananlysis were done.
- Conditions
- Venous Insufficiency of Leg, Venous Leg Ulcer, Venous Occlusion, Contrast Media Reaction
- Trial name
- NCT04995432
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Gastroesophageal Reflux
Oesophageal Acid Exposure in Healthy Subjects Over 96 Hours
First introduced over 40 years ago, the 24-hour catheter-based pH studies have previously been found to be the gold standard in the diagnosis of gastro-oesophageal reflux disease (GORD).
- Trial name
- NCT03417817
- Testing
- Bravo
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Gastroesophageal Reflux Disease With Esophagitis
Evaluate the Intestinal Microbiome in Patients With Erosive Gastroesophageal Reflux Disease and in Asymptomatic Healthy Controls
. In this study, we investigated intestinal microbiomes, in individuals with Gastroesophageal Reflux Disease and healthy individuals, using metagenomic techniques.
- Trial name
- NCT04248296
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Achalasia Cardia, Esophageal Cancer (EsC)
INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE
Esophageal Achalasia has been investigated as a potential risk factor for esophageal cancer (EC). Longstanding disease, repeated treatment, age and male sex seem the most relevant risk factors, but no clear effect size estimation…
- Trial name
- RECAP (NCT07022886)
- Testing
- achalasia treatments
- Where
- Italy
- Volunteers
- 47,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
GERD (Gastroesophageal Reflux Disease)
Study to Evaluate the Effect of Food on the Pharmacokinetics and Pharmacodynamics Characteristics in Healthy Adult Volunteers
A Randomized, Open-label, Oral in healthy volunteers
- Trial name
- NCT07364838
- Testing
- DW4421
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
GERD
Investigate Linaprazan Glurate/Linaprazan in Healthy Subjects
This is a Phase I, single-center, open label parallel-group, randomized study designed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD, by continuous intragastric pH measurment), safety and tolerability of single and…
- Trial name
- NCT05742984
- Testing
- linaprazan glurate 25 mg QD, linaprazan glurate 50 mg QD, linaprazan glurate 75 mg QD
- Where
- Slovenia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
Sedative During Endoscopy
Implementing Virtual Reality (VR) to Reduce Sedation
The study is a prospective pilot patients aged 21 to 65 undergoing screening colonoscopy or diagnostic upper endoscopy. Patients are administered minimal sedation (2 mg of Versed and 25 mg of Fentanyl) and are given Virtual…
- Trial name
- NCT06349564
- Testing
- Pico 4 Enterprise headset with noise cancelling headphones
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Gastroesophageal Reflux Disease
A Study to Compare PK, PD and Safety of the AD-214-02 and Rabeprazole
A study to compare safety, pharmacokinetics and pharmacodynamics of AD-214-02 to Rabeprazole in healthy volunteers.
- Trial name
- NCT04622358
- Testing
- AD-214-02, Rabeprazole
- Where
- South Korea
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Achalasia
Evaluation of a Novel Endoscopic Treatment for Achalasia
This study is to evaluate outcomes of a less invasive surgical procedure for the treatment of achalasia.
- Trial name
- POEM (NCT01770249)
- Testing
- Per-oral Endoscopic Esophagomyotomy (POEM)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Esophageal Achalasia
Laparoscopic Dor Versus Toupet Fundoplication for the Treatment of Idiopathic Esophageal Achalasia
The primary aim of this study is to test the hypothesis that Heller myotomy and Toupet fundoplication result in a lower rate of reflux symptoms and positive 24-hour pH testing when compared to Heller myotomy and Dor…
- Trial name
- NCT00490750
- Testing
- Dor fundoplication, Toupet fundoplication
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- L. Michael Brunt
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Gastroesophageal Reflux Disease
A Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of YPI 011 to Rabeprazole in Healthy Adult Subjects
A study to compare the safety, pharmacokinetics and pharmacodynamics of YPI 011 to Rabeprazole in healthy adult subjects
- Trial name
- NCT04703868
- Testing
- Rabeprazole Sodium 10mg, Rabeprazole Sodium 20mg
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Obesity, Gastro Esophageal Reflux Disease
Effect of Routine Anterior Crural Repair in De-Novo Gastroesophageal Reflux After Laparoscopic Sleeve Gastrectomy
The purpose of the study is to evaluate the superiority of anterior crural repair during sleeve gastrectomy over no repair in decreasing the incidence of gastroesophageal reflux disease.
- Trial name
- NCT04884074
- Testing
- Standard Sleeve Gastrectomy plus Anterior Crural Repair, Standard sleeve gastrectomy (SSG, the control group)
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Achalasia
Sensorimotor Dysfunction in Achalasia
This study is being done to assess the esophageal muscle (swallowing tube) in patients with and without achalasia to further understand and help direct the treatment for patients with achalasia.
- Trial name
- NCT02434991
- Testing
- Barostat
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Rumination Disorders
Treatment of Rumination by Biofeedback - a Randomized Controlled Trial
Rumination syndrome is characterized by effortless recurrent regurgitation of recently ingested food into the mouth, with consequent expulsion or re-chewing and swallowing.
- Trial name
- NCT02214472
- Testing
- Biofeedback
- Where
- 2 sites in Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Infant Nutrition Disorders, Gastrointestinal Dysfunction
Management of Infant Digestive Disorders and Quality of Life
The objective of the study is to measure the evolution of the quality of life in infants between 0 and 5 months old, not breastfed and suffering from regurgitation or colic.
- Trial name
- NCT04462640
- Testing
- Management of Infant Digestive Disorders and Quality of Life
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
GERD in Children, GERD
The Study of Nutrition of Children and Adolescents With GERD
This trial is to study the aspects of nutrition in children and adolescents with GERD compared to the sex and age-matched control group
- Trial name
- NCT04202276
- Testing
- diet assessment
- Where
- Russia
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Gastro Esophageal Reflux
Effect of Magnesium Alginate in Infants With Gastroesophageal Reflux.
Recurrent regurgitation stress the infants and their parents and often results in an inappropirate use of PPI prescription in infancy.
- Trial name
- NCT03881722
- Testing
- Mg alginate
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital