Clinical trials: Gastrointestinal Tolerance
Energy Intake, Gastrointestinal Hormones
Effects of Oral Xylitol on Subsequent Energy Intake
The aim of this project is to investigate the effect of xylitol (given as pre-load), compared to sucrose, Ace-K, and water on energy intake during a subsequent ad libitum test meal in healthy participants.
- Conditions
- Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT05671965
- Testing
- Xylitol, Sucrose, Acesulfame Potassium
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy, Full-term Infants Who Are Formula-fed
Gastrointestinal Tolerance Evaluation of an Infant Formula
Prospective, double-blind, randomized study of 2 infant formulas.
- Trial name
- NCT03307122
- Testing
- Routine Infant Formula 1, Routine Infant Formula 2
- Where
- 8 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Chronic Hepatitis B
Targeting ANKRD11 Reverses HBV-Specific CD8+ T Cell Dysfunction and Tolerance
Achieving a functional cure for chronic hepatitis B (CHB) is largely hindered by the irreversible functional exhaustion and immune tolerance of hepatitis B virus (HBV)-specific CD8 positive T (CD8+ T) cells.
- Trial name
- NCT07777250
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing Municipal Administration of Hospitals
Bacterium; Agent
Colonization and Persistence of Bifidobacterium Longum
Healthy adults referred to as the absence of intestinal disorders, liver and kidney problems, lactose intolerance, and no use of ongoing medication for chronic diseases will be recruited.
- Trial name
- NCT01650753
- Testing
- Probiotic Powder
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Gastrointestinal Tolerance
Behavior of Infants Fed Formula Supplemented With Prebiotics
To observe the effects of partially hydrolyzed formula supplemented with oligosaccharides on symptoms of formula intolerance in healthy term infants.
- Trial name
- NCT02757924
- Testing
- Infant formula supplemented with prebiotics
- Where
- 11 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Chronic Hepatitis B
Clinical Study to Evaluate the Safety, Tolerance and Pharmacokinetic Characteristics of Single Administration of HRS-5635 Injection in Chinese Healthy Subjects and the Safety, Tolerance, Pharmacokinetics and Antiviral Effect of Multiple Administration in Patients With Chronic Hepatitis B
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-5635 in healthy adults and chronic hepatitis B. To explore the reasonable dosage of HRS-5635.
- Trial name
- NCT05808374
- Testing
- HRS-5635
- Where
- China
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Healthy Adult Subjects
Gastrointestinal Tolerance Assessment of T2309
Gastrointestinal Tolerance assessment of T2309 compared to a food supplement in 50 subjects.
- Trial name
- GATA (NCT04596605)
- Testing
- T2309, Nutrof Total
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Laboratoires Thea
Gastrointestinal Tolerance
Evaluation of an Oral Nutrition Supplement
The objective of this study is to capture gastrointestinal tolerance (GI) information on a nutrient dense oral nutritional supplement (ONS) in healthy elderly subjects.
- Trial name
- NCT01902212
- Testing
- Oral Nutritional Supplement
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Gastro-Intestinal Tolerance
Tolerance of an Oral Nutritional Supplement(ONS)
The objective of this study is to capture information on gastrointestinal tolerance (GI) of an oral nutritional supplement containing a new protein blend in healthy children aged ≥ 3 to ≤ 10 years.
- Trial name
- NCT01782456
- Testing
- Study Oral Nutritional Supplement
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Liver Fat, Type 2 Diabetes
EXIT: Prospective Study of the Response to Exercise
Background : Regular exercise is a cornerstone in the prevention and the management of comorbidities. Unfortunately, the metabolic benefit of exercise training is not universal and varies among individuals.
- Trial name
- EXIT (NCT02204670)
- Testing
- Acute release of irisin after a single exercise session.
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Gastrointestinal Tolerance
A Study Assessing the Tolerable Upper Intake Level and Safety of Sugars From Fiber
The purpose of this study is to determine the upper tolerable limit of Sugars from Fiber
- Trial name
- NCT05051202
- Testing
- Sugars from Fiber, Resistant Maltodextrin
- Where
- Ireland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cambridge Glycoscience
Regurgitation, Gastric, Diarrhea
To Assess the Safety and Tolerance of Infant Formula With Locust Bean Gum in Infants With Regurgitation
A randomized, controlled study to evaluate the safety and tolerance of an infant formula with locust bean gum in infants with regurgitation. (Solar)
- Trial name
- Solar (NCT04042454)
- Testing
- milk based anti-regurgitation infant formula, Milk based infant formula
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Energy Intake, Gastrointestinal Hormones
Effects of Oral Pre-loads on Subsequent Energy Intake
The aim of this project is to investigate the effect of erythritol (given as pre-load), compared to sucrose, sucralose, and water on energy intake during a subsequent ad libitum test meal in healthy participants.
- Conditions
- Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT04713137
- Testing
- Erythritol, Sucrose, Sucralose
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
Tolerance and Prebiotic Activity of Arabinoxylan-Oligosaccharides in Healthy Subjects
The purpose of the study is to evaluate the tolerance of a higher dose of arabinoxylan-oligosaccharides (AXOS) and their prebiotic activity in healthy subjects.
- Trial name
- NCT00852813
- Testing
- arabinoxylan-oligosaccharides (AXOS)
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Gastroesophageal Reflux, Esophageal Varices
A Study of Disposable Transnasal Esophagoscope
This is a pilot study of a novel disposable transnasal esophagoscope for feasibility, safety and tolerance.
- Conditions
- Gastroesophageal Reflux, Esophageal Varices, Esophageal Disease
- Trial name
- NCT01360515
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Conditions Influencing Health Status
Effects of Probiotics in Immune System of Healthy Adults
The present report describes the design of a clinical trial performed on healthy adult individuals to check whether the daily intake of the new Hero strains contribute to intestinal colonization, under safe and tolerable…
- Trial name
- SETOPROB (NCT01479543)
- Testing
- Probiotic CNCM I-4034, Probiotic CNCM I-4035, Probiotic CNCM I-4036
- Where
- 4 sites in Spain
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Hero Institute for Infant Nutrition
Steatorrhea, Growth
Tolerance and Digestibility of a New Formula in Healthy Infants
The great majority of infants formula contain fats exclusively from vegetable oil. Nevertheless, the use of both vegetable and dairy lipids is on a real interest to obtain an infant formula closer to the nutritional composition…
- Trial name
- NCT01184378
- Testing
- dairy lipids and soluble milk proteins
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lactalis
Healthy
Effect of POCO on Gastric Function in HV
This study aims to investigate changes in gastric motility (including gastric accommodation), nutrient volume tolerance, gastric emptying and gastrointestinal hormones in healthy volunteers after an acute intake of a combination…
- Trial name
- POCO (NCT03682835)
- Testing
- FDGard
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastrointestinal Motility Disorder, Dyspepsia
The Effect of Prucalopride (Resolor®) on Gastric Motor Function and Gastric Sensitivity
Functional Dyspepsia-Postprandial Distress Syndrome (FD-PDS), is characterized by meal-related symptoms such as early satiation and postprandial fullness.
- Trial name
- NCT04429802
- Testing
- Prucalopride
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastrointestinal Tolerance
A Double Blind Study on the Gastrointestinal Effects of Arabinoxylan (Leaf Fiber Extract).
The objective of this study is to investigate the effect on Arabinoxylan on gastrointestinal (GI) tolerance, bowel habits, and microbiota in adults.
- Trial name
- NCT04100460
- Testing
- 7.25 grams of Arabinoxylan leaf fiber extract, 14.5 grams of Arabinoxylan leaf fiber extract, Control - No Arabinoxylan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Comet Bio Inc.