Clinical trials: Gastrointestinal Tumor Surgery
Adrenocortical Carcinoma, Peritoneal Carcinomatosis
Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma
Adrenocortical carcinoma (ACC) is a rare tumor with an overall 5-year mortality rate of 75 - 90% and an average survival from the time of diagnosis of 14.5 months.
- Trial name
- NCT03127774
- Testing
- Cisplatin, Sodium thiosulfate, Cytoreductive surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Columbia University
Colorectal Cancer
Dietary Fiber Before Colorectal Cancer Surgery
The aim of this randomized controlled trial is to investigate the feasibility of increasing preoperative dietary fiber intake in individuals with colorectal cancer who will undergo surgery.
- Trial name
- NCT06212817
- Testing
- Dietary intervention
- Where
- 3 sites in Netherlands
- Volunteers
- 54 people
- Sponsor
- Wageningen University
Oesophageal Cancer
Post Oesophagectomy Outcomes in a Single Regional Centre in Australia
Literature review/rationale for project Oesophageal cancer is associated with a grim prognosis despite many advances in treatment.
- Trial name
- NCT06662513
- Testing
- No Intervention: Observational Cohort
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Launceston General Hospital
Rectal Cancer
Robotic Versus Laparoscopic Approach for Rectal Cancer Surgery
Colorectal cancer is a common malignancy in Viet Nam. Laparoscopic surgery becomes a standard treatment in many centers. Today, robotic surgery is a new option for treating colorectal cancer with some advantages such as magnified…
- Trial name
- NCT03931980
- Testing
- Robotic-assisted rectal cancer resection and Laparoscopic rectal cancer resection
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Binh Dan Hospital
Pancreatic Cancer, Liver Metastases
Simultaneous Resection of Pancreatic Cancer and Liver Oligometastasis After Induction Chemotherapy
This study is a multi-center phase 3 trial to evaluate a treatment strategy for selecting patients who can benefit from the synchronous resection of primary pancreatic cancer and liver oligometastasis after induction…
- Conditions
- Pancreatic Cancer, Liver Metastases, Surgery
- Trial name
- NCT03398291
- Testing
- Synchronous resection of primary pancreatic cancer and liver oligometastasis, Standard chemotherapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Localized Colon Carcinoma, Stage IIB Colon Cancer AJCC v8
Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer
This phase II trial tests how well immunotherapy (toripalimab) works for reducing the risk of cancer recurrence after surgery in patients with mismatch repair deficient stage IIB, IIC, or III colon cancer.
- Conditions
- Localized Colon Carcinoma, Stage IIB Colon Cancer AJCC v8, Stage IIC Colon Cancer AJCC v8, Stage III Colon Cancer AJCC v8
- Trial name
- NCT07140679
- Testing
- Biopsy Procedure, Biospecimen Collection, Colonoscopy
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Gastric Cancer
da Vinci SP Robotic Gastrectomy
Laparoscopic surgery revolutionized the surgical treatment of gastric cancer saving large incsion and associated pain. Robotic surgical system was introduced to enhance the minimally invasive surgery using articulating robotic…
- Trial name
- NCT05051670
- Testing
- da vinc SP gastrectomy
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Yonsei University
Bladder Carcinoma, Prostate Tumor
Validation Study on the Removal of EpCAM-positive Tumour Cells From Blood Collected During Tumour Surgery Using Catumaxomab/Catuvab Device
The REMOVE study was an open-label, multicenter validation study on the removal of EpCAM-positive tumor cells from blood collected during tumor surgery using the CATUVAB Kit.
- Conditions
- Bladder Carcinoma, Prostate Tumor, Gallbladder Carcinoma, Endometrial Carcinoma
- Trial name
- REMOVE (NCT06789224)
- Testing
- CATUVAB
- Where
- 6 sites in Germany
- Volunteers
- 136 people
- Sponsor
- Lindis Bloodcare GmbH
Gastric Cancer, Peritoneal Carcinomatosis
Intraperitoneal Chemotherapy in Gastric Cancer With Peritoneal Carcinomatosis
Peritoneal carcinomatosis (PC) in gastric cancer (GC) is considered a fatal disease, without expectation of definitive cure. Since conventional surgery is not indicated in the palliative setting, and systemic chemotherapy…
- Trial name
- NCT05541146
- Testing
- Intraperitoneal chemotherapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Rectal Cancer Stage I
Endoscopic (EID) Versus Surgical (TAMIS) Local Excision for Early Stage Rectal Cancer
In this clinical trial, we compare the endoscopic technique, endoscopic intermuscular dissection (EID), with the surgical technique, transanal minimally invasive surgery (TAMIS) for the treatment of early stage rectal cancer.
- Trial name
- ENSURE (NCT07846046)
- Testing
- Endoscopic Intermuscular Dissection (EID), Transanal Minimally Invasive Surgery (TAMIS)
- Where
- 19 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Amsterdam UMC, location VUmc
Colorectal Neoplasms, Urologic Neoplasms
A Novel Robotic System for Single Port and Natural Orifice Transluminal Endoscopic Surgery
This is a prospective, single center, multispecialty study that aimed to evaluate the clinical feasibility and safety of single port surgery and NOTES (mainly transanal and transoral surgery) using a novel single port robotic…
- Conditions
- Colorectal Neoplasms, Urologic Neoplasms, Urologic Diseases, Nasopharyngeal Neoplasms
- Trial name
- NCT03010813
- Testing
- Robotic single port surgery and NOTES
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Chinese University of Hong Kong
Pancreatic Fistula, Whipple Operation
Identifing Risk Factors for Pancreaticojejunostomy Leakage Following Pancreaticoduodenectomy
Pancreatic cancer is an aggresive type of cancer with poor mean survival rates despite improvements in chemotherapy regimens and advances in surgical techniques. Surgery is the only therapeutic option with an intend to treat.
- Conditions
- Pancreatic Fistula, Whipple Operation, Pancreaticoduodenectomy, POPF
- Trial name
- NCT04798560
- Testing
- Pancreaticoduodenectomy
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Dimitrios Vouros
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Colorectal Cancer
Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- OMEGA (NCT00467142)
- Testing
- bevacizumab, fluorouracil, irinotecan hydrochloride
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Institut Bergonié
Colon Carcinoma, Rectum Carcinoma
Trial for Retractor Sponge Evaluation in Laparoscopic Colorectal Surgery
Laparoscopic surgery of the distal colon and rectum requires surgery with an appropriate field of view. A commonly used technique to create a clear exposure is the steep Trendelenburg position in which the patient is positioned…
- Trial name
- SPONGE (NCT03334383)
- Testing
- Sponge
- Where
- Netherlands
- Volunteers
- 188 people
- Sponsor
- St. Antonius Hospital
Surgical Site Infections, Colorectal Cancer
Risk Factor Assessment for the Development of Surgical Site Infection in Patients Undergoing Colorectal Cancer Surgery
Surgical site infection (SSI) is a common complication following colorectal cancer (CRC) surgery and represents a significant cause of slower postoperative recovery and prolonged hospital stay.
- Trial name
- NCT07104903
- Testing
- Data collection from medical records
- Where
- Serbia
- Volunteers
- 62 people
- Sponsor
- Oncology Institute of Vojvodina
Colorectal Cancer, Liver Metastases
Impact of Surgical Management for Relapse After Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis
For patients with initially unresectable colorectal liver metastasis (IU-CRLM) receiving effective conversion therapy, disease relapse after conversion hepatectomy is common due to the extensive tumor load.
- Trial name
- NCT05462470
- Testing
- Repeat Liver Surgery, Non-Repeat Liver Surgery
- Volunteers
- 255 people
- Sponsor
- Fudan University
Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer
The Use of Contrast Enhanced Ultrasound (CEUS) In Post-Surgical Pancreatic Cancer Patients to Evaluate Local Disease Recurrence
This pilot study is testing whether a special type of ultrasound called contrast-enhanced ultrasound (CEUS) can help detect if pancreatic cancer has come back after surgery.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer, Local Disease
- Trial name
- NCT07910383
- Testing
- Lumason, Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Esophageal Cancer
Combination Chemotherapy Plus Radiation Therapy Followed By Surgery in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00006472
- Testing
- carboplatin, fluorouracil, paclitaxel
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- Medstar Health Research Institute
TME, Rectal Cancer Surgery
REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department
The purpose of this multicenter randomized non-inferiority trial is to evaluate the safety of low anterior resection for rectal cancer performed with versus without a diverting stoma in patients with a low predicted risk of…
- Conditions
- TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer
- Trial name
- RELOAD (NCT07463261)
- Testing
- Without a preventive stoma, With a preventive stoma
- Where
- 7 sites in Russia
- Volunteers
- 442 people
- Sponsor
- ANO Scientific and Practical Club for the Development of Modern Medical Technologies
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