Clinical trials: Gastrointestinal Tumor Surgery
Esophageal Neoplasm
Volume Restriction in Esophageal Carcinoma Surgery: Randomized Clinical Trial
An exploratory single-centre randomized clinical trial was performed in order to investigate whether the fluid volume administered during esophageal carcinoma surgery affects pulmonary gas exchange and tissue perfusion.
- Trial name
- NCT02033213
- Testing
- Restrictive group, Liberal group
- Where
- Croatia
- Volunteers
- 16 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Liver Cancer
Intensive Neoadjuvant Chemotherapy in Treating Young Patients Undergoing Surgical Resection for High-Risk Hepatoblastoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed.
- Trial name
- NCT00077389
- Testing
- carboplatin, cisplatin, doxorubicin hydrochloride
- Where
- 24 sites in France, Ireland and 2 more
- Volunteers
- 57 people
- Sponsor
- University of Leicester
Colorectal Cancer
Radiation Therapy and Either Capecitabine or Fluorouracil With or Without Oxaliplatin Before Surgery in Treating Patients With Resectable Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, fluorouracil, and oxaliplatin work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00058474
- Testing
- capecitabine, fluorouracil, oxaliplatin
- Volunteers
- 1,608 people
- Sponsor
- NSABP Foundation Inc
Pancreatic Cancer, Malnutrition
Whipple Protein Study
Study investigators aim to assess the effect of providing high-protein nutritional supplementation before and after surgery
- Trial name
- WPS (NCT04306874)
- Testing
- Ensure Max Protein
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Thomas Jefferson University
Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum
CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery
This pilot phase I trial studies the side effects and best dose of CPI-613 when given together with fluorouracil in treating patients with colorectal cancer that has spread to other parts of the body and cannot be removed by…
- Conditions
- Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT02232152
- Testing
- 6,8-bis(benzylthio)octanoic acid, fluorouracil, pharmacological study
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Wake Forest University Health Sciences
Rectal Cancer
The Efficacy of Primary Total Mesorectal Excision (TME) Surgery Versus Neoadjuvant Chemotherapy Combined With TME Surgery in Low-risk Locally Advanced Rectal Cancer
Comparative analysis of the clinical efficacy between primary Total Mesorectal Excision (TME) surgery and neoadjuvant chemotherapy combined with TME surgery for low-risk locally advanced rectal cancer.
- Trial name
- TaLaR-02 (NCT05984485)
- Testing
- neoadjuvant chemotherapy plus total mesorectal excision, total mesorectal excision
- Where
- 6 sites in China
- Volunteers
- 766 people
- Sponsor
- Sun Yat-sen University
Gastric Cancer, Diabetes Mellitus, Type 2
Surgical TreAtment for Obesity Related Disease and Onco-Metabolic Surgery
This is a prospective, multi-center, randomized controlled trial to compare Billroth II reconstruction versus conventional Roux-en-Y reconstruction versus long limb Roux-en-Y reconstruction for glycemic control in patients with…
- Trial name
- STARDOM (NCT04284943)
- Testing
- Long limb Roux-en-Y reconstruction after subtotal gastrectomy, Conventional Roux-en-Y reconstruction after subtotal gastrectomy, Billroth II reconstruction after subtotal gastrectomy
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Korea University Anam Hospital
Colorectal Cancer
Fast Track Laparoscopic Surgery: A Better Option for Treating Colorectal Cancer Than Conventional Laparoscopic Surgery
To compare the outcomes of fast track laparoscopic surgery and conventional laparoscopic surgery.
- Trial name
- FTS (NCT01969591)
- Testing
- fast-track surgery, conventional postoperative surgery
- Volunteers
- 70 people
- Sponsor
- Quan Wang
Early Gastric Cancer
Fluorescence Guided Laparoscopic-Endoscopic Cooperative Sentinel Lymph Node Navigation Surgery Strategy for Early Gastric Cancer（IDEAL Stage 2b）
The main treatment for early gastric cancer (EGC) include endoscopic submucosal dissection (ESD) and radical gastrectomy. However, appropriate treatment for patients who exceed the absolute indications and noncurative resection…
- Trial name
- FLECSS (NCT06788548)
- Testing
- Fluorescence Guided Laparoscopic-Endoscopic Cooperative Sentinel Lymph Node Navigation Surgery, Laparoscopic D2 radical gastrectomy
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Beijing Friendship Hospital
Rectal Neoplasms
Robotic Assisted Transanal Total Mesorectal Excision Surgery for Rectal Cancer in Low Site
To investigates the feasibility, practicability, safety and subjective as well as functional outcome of Robotic transanal total mesentery excision for rectal cancer in low site.
- Trial name
- NCT03422835
- Testing
- R-TME, R-TaTME
- Volunteers
- 50 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Acute Kidney Injury, Pneumoperitoneum
The Effect of Pneumoperitoneum (Raised Pressure in the Peritoneal Cavity) During Robotic Kidney/Prostate Cancer Surgery.
Within all the surgical specialties, major surgeries are performed whenever possible, as minimally invasive procedures to reduce blood loss, reduce pain and discomfort after surgery, avoid major scars, provide a faster recovery…
- Conditions
- Acute Kidney Injury, Pneumoperitoneum, Kidney
- Trial name
- NCT04755452
- Testing
- Low intra-abdominal pressure, High (standard) intra-abdominal pressure
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aalborg University Hospital
Upper Gastrointestinal Disorders
CPET and Outcome After Oesophagogastric Cancer Surgery
Primary Aim: The present study is a retrospective analysis of prospectively collected clinical data. Anonymized data from patients collected during routine clinical care from 9 units in the United Kingdom who undertake upper…
- Trial name
- NCT03637647
- Testing
- Cardiopulmonary exercise testing
- Where
- United Kingdom
- Volunteers
- 611 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Gastric Cancer
Chemotherapy Alone vs. Chemotherapy + Surgical Resection in Patients With Limited-metastatic Adenocarcinoma of the Stomach or Esophagogastric Junction
Previously untreated patients with limited metastatic stage (see protocol for details on criteria) will receive 4 cycles of FLOT (5-Fluorouracil, Leucovorin, Oxaliplatin and Docetaxel).
- Trial name
- FLOT5 (NCT02578368)
- Testing
- 5-Fluorouracil, Leucovorin, Oxaliplatin
- Where
- Germany
- Volunteers
- 183 people
- Sponsor
- Krankenhaus Nordwest
Colon Cancer, Inflammatory Bowel Diseases
Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine
Patients receiving perioperative intravenous lidocaine, post operative restoration of bowel movement will be faster and decrease pain intensity, opioid consumption and side effects, length of hospital stay; probably as a result…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01155440
- Testing
- Lidocaine, Thoracic epidural block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Colorectal Cancer, Colorectal Neoplasms
Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery
The goal of this clinical trial is to learn which type of exercise before surgery best reduces complications after colorectal surgery in adults with colorectal cancer or precancerous lesions.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Postoperative Complications
- Trial name
- NCT07896174
- Testing
- Resistance Training Prehabilitation, Aerobic Training Prehabilitation, Standard Trimodal Care
- Where
- Hungary
- Volunteers
- 480 people
- Sponsor
- Semmelweis University
Colonic Neoplasms
Laparoscopic Versus Open Surgery for Colon Cancer With Visceral Obesity
This study aims to elucidate whether there is a difference in long-term prognosis between laparoscopic surgery and open surgery in colon cancer patients with visceral obesity.
- Trial name
- LOVO (NCT07314996)
- Testing
- Laparoscopic surgery, Open surgery
- Where
- China
- Volunteers
- 664 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Esophageal Cancer, Metastatic Cancer
European iNvestigation of SUrveillance After Resection for Esophageal Cancer
The ENSURE study will comprise two phases. Phase 1: European multicenter survey of surveillance protocols after esophageal cancer surgery ENSURE questionnaire will be circulated to representatives from participating European…
- Conditions
- Esophageal Cancer, Metastatic Cancer, Recurrent Esophageal Cancer, Chemoradiation
- Trial name
- ENSURE (NCT03461341)
- Testing
- High intensity postoperative oncologic surveillance
- Where
- 3 sites in Ireland, Sweden and 1 more
- Volunteers
- 3,000 people
- Sponsor
- St. James's Hospital, Ireland
Gastro Intestinal Cancer, Scoring Systems
Comparison of Scoring Systems in Gastrointestinal Cancer Surgery
Accurate prediction of postoperative morbidity and mortality is essential for optimizing perioperative management in patients undergoing gastrointestinal cancer surgery.
- Trial name
- NCT07325656
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Lütfi Kırdar City Hospital
Overall Survival, Postoperative Complications
Clinical Value of Left Colic Artery in Laparoscopic Radical Rectectomy
Colorectal cancer is one of the most common tumors in Asia. According to the recent research, surgical procedure could provide more treatment benefit in rectal cancer.
- Trial name
- NCT03349788
- Testing
- LCA-nP, LCA-P
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Esophageal Cancer, Surgery-Complications
Comparison of Endoscopy and Esophagram for the Routine Evaluation of Anastomosis After McKeown Esophagectomy
This retrospective cohort study reviewed patients who underwent McKeown esophagectomy. All patients routinely underwent either endoscopy or esophagram for the evaluation of anastomosis on postoperative day 7.
- Trial name
- NCT07043491
- Testing
- Endoscopy
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Sun Yat-sen University
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