Clinical trials: Gastroparesis
Gastroparesis
Safety, PK and Efficacy of PCS12852 on Gastric Emptying Rate in Patients With Moderate to Severe Gastroparesis
This is a randomized, double-blind, placebo-controlled study that will compare the effect of 2 different dosage regimens of PCS12852 on gastric emptying time to placebo in both idiopathic gastroparesis (IG) and diabetic…
- Trial name
- MOMENTUM (NCT05270460)
- Testing
- PCS12852
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- Processa Pharmaceuticals
Idiopathic Gastroparesis, Diabetic Gastroparesis
Open Label Safety Study of Tradipitant in Idiopathic and Diabetic Gastroparesis
This is a multicenter, open label, 3-month safety study with tradipitant in patients with idiopathic and diabetic gastroparesis.
- Conditions
- Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis
- Trial name
- NCT06836557
- Testing
- Tradipitant
- Where
- 3 sites in Belgium, Germany
- Volunteers
- 17 people
- Sponsor
- Vanda Pharmaceuticals
Gastroparesis
ABVN Phase 2 - Vagal Maneuvers
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators want to evaluate the effects of noninvasive stimulation of the auricular branch of the vagal nerve (ABVN) on vagal nerve…
- Trial name
- ABVN2 (NCT07881289)
- Testing
- Vagal Maneuvers
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Indiana University
Gastroparesis, Healthy Subjects
ABVN Phase 2 - Ear Stimulation
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN2 (NCT06491758)
- Testing
- ML1101 Stimulus Isolator
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Indiana University
Motility Disorder, Gastroparesis
Body Surface Gastric Mapping to Evaluate Patients With Upper Gastrointestinal Symptoms and Controls
This is an analytical validation observational cohort study is designed to provide evidence of: safety and reliability of Body Surface Gastric Mapping using the Gastric Alimetry System (GAS), normal reference values, and…
- Conditions
- Motility Disorder, Gastroparesis, Functional Dyspepsia, Cyclical Vomiting
- Trial name
- NCT05812339
- Testing
- Gastric Alimetry System
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Gastric Cancer, Gastric Outlet Obstruction
Stomach-Partitioning Versus Conventional Gastrojejunostomy for Malignant Gastric Outlet Obstruction: A Multicenter Randomized Controlled Trial
Gastric outlet obstruction (GOO) complicates locally advanced or metastatic gastric cancer and severely impairs oral intake, nutritional status, and quality of life.
- Trial name
- NCT07561073
- Testing
- stomach-partitioning gastrojejunostomy, conventional gastrojejunostomy
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- Guangxi Medical University
Gastroparesis
Different Doses of Naronapride vs. Placebo in Gastroparesis
This is a double-blind, randomized, multicenter, placebo-controlled, comparative phase II dose-finding trial. The trial will be conducted with four treatment groups in the form of a parallel group comparison and will serve to…
- Trial name
- MOVE-IT (NCT05621811)
- Testing
- Naronapride
- Where
- 24 sites in United States, Belgium
- Volunteers
- 328 people
- Sponsor
- Dr. Falk Pharma GmbH
Type 1 Diabetes, Gastroparesis Due to Diabetes Mellitus Type I
To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.
The goal of this clinical trial is to evaluate the efficacy and safety of Medtronic 780G automated insulin delivery system in adult persons with type 1 diabetes and gastroparesis.
- Trial name
- NCT07287943
- Testing
- Medtronic 780G AID
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Viral N. Shah
Gastroparesis
Cardiac Vagal Effects of GES in Patients With Gastroparesis and Vagal Nerve Action Potentials in Vagus Nerve
The objective of this study is to determine if Gastric Electrical Stimulation may influence vagal outflow via vagal afferent fibers that terminate in the Central Nervous System.
- Trial name
- GES (NCT02159586)
- Testing
- gastric electrical stimulator
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Indiana University
Achalasia, Gastroparesis
Disposable Endoscope Platform in Third Space Endoscopic Procedures
This is a prospective, single-arm unblinded study performed at a single tertiary center in the United States. All subjects will receive standard medical care and no experimental interventions are going to be performed.
- Trial name
- NCT06738628
- Testing
- (Esophageal or Gastric) Per-Oral Endoscopic Myotomy
- Where
- United States
- Sponsor
- Baylor College of Medicine
Diabetes, Gastroparesis
Effect Of Percutaneous Electrical Nerve Field Stimulation on Symptom Control/Nervous System Activity in Patients w/Diabetes Types 1/2
The purpose of this study is to evaluate whether stimulation of the vagus nerve can improve nausea and vomiting in diabetic gastroparetic patients.
- Trial name
- PENFS (NCT06783504)
- Testing
- PERCUTANEOUS ELECTRICAL FIELD NERVE STIMULATION
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Gastroparesis Nondiabetic
Effect of Gastric Electrical Stimulation on Serum Insulin Levels
The goal of this study is to determine how much effect turning off an individual's Gastric Electrical Stimulator (GES) for up to four hours will have on levels of insulin, C-peptide, GLP-1 and glucose levels.
- Trial name
- NCT07635576
- Testing
- Gastric Electrical Stimulator
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Indiana University
Gastroparesis, Delayed Gastric Emptying
Gastric Focused Ultrasound Stimulation
This randomized, sham-controlled crossover pilot study will evaluate whether noninvasive gastric focused ultrasound stimulation is associated with changes in postprandial gastric electrical activity and gastrointestinal symptoms…
- Trial name
- NCT07851727
- Testing
- Gastric Focused Ultrasound Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Evan (Huiliang) Wang
Irritable Bowel Syndrome (IBS), Functional Dyspepsia
Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms
The goal of this observational case-control study is to learn how stressful experiences, dietary habits, and blood nutrient levels are associated with gastrointestinal symptoms and symptoms of depression and anxiety in adults…
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Inflammatory Bowel Disease (IBD), Gastroparesis
- Trial name
- NCT07852819
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Gastroparesis
Vagus Nerve Response in Gastroparesis Patients
This study aims to characterize how vagus nerve compound action potentials (CNAPs) conduct along the vagus nerve in gastroparetic patients receiving GES therapy using a flexible, non-invasive multielectrode array (MEA).
- Trial name
- NCT04207996
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Indiana University
Digestive System Disorder, Dyspepsia
Domperidone in Treating Patients With Gastrointestinal Disorders
This phase III trial studies how well domperidone works in treating patients with gastrointestinal disorders. Domperidone may help control chronic gastrointestinal disorders and their symptoms, such as pain, bloating, and nausea…
- Conditions
- Digestive System Disorder, Dyspepsia, Esophagitis, Gastroesophageal Reflux Disease
- Trial name
- NCT01696734
- Testing
- Domperidone, Questionnaire Administration
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- M.D. Anderson Cancer Center
Idiopathic Gastroparesis, Diabetic Gastroparesis
Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
To investigate the safety and efficacy of tradipitant versus placebo in relieving nausea and other symptoms of gastroparesis.
- Conditions
- Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis
- Trial name
- NCT04028492
- Testing
- Tradipitant, Open Label Tradipitant
- Where
- 36 sites in United States
- Volunteers
- 979 people
- Sponsor
- Vanda Pharmaceuticals
Respiratory Aspiration of Gastric Contents
Gastric Ultrasound for Estimation of the Aspiration Risk Study
The purpose of this research study is to look at the effectiveness of current anesthesia guidelines regarding food and drink prior to surgery in patients who are likely to have food and drink remain in their stomach longer than…
- Trial name
- NCT03310528
- Testing
- Interview questionnaire, Gastric ultrasound exam
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Diabetic Gastroparesis
Thoracic Neuromodulation for Diabetic Gastroparesis
The global incidence of diabetes is rising. Gastroparesis is a significant complication of diabetes that results in debilitating symptoms and affects quality of life.
- Trial name
- TNM-DGp (NCT05273788)
- Testing
- 2400 ThorS-MagNT Stimulations at 1Hz, 2400 ThorS-MagNT Stimulations at 10Hz
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Medical University of South Carolina
Hemorrhagic Shock, Pediatric Trauma
Effect of Resuscitation on Gastric Emptying Using POCUS in Pediatric Trauma Patients
Pediatric trauma often leads to hemorrhagic shock, which reduces blood flow to the digestive tract and delays gastric emptying. This delay can cause fluid and food to remain in the stomach, increasing the risk of pulmonary…
- Conditions
- Hemorrhagic Shock, Pediatric Trauma, Delayed Gastric Emptying, Gastric Dysmotility
- Trial name
- NCT07810907
- Volunteers
- 50 people
- Sponsor
- Assiut University