Clinical trials: Gender Differences
Obesity, Diabetes
"ISIS" Study of Sex Differences in Characteristics of Adiposity and Metabolism
The purpose of this study is to characterize differences in the structure and function of the body fat from two different parts of the body in young, healthy men and women.
- Trial name
- ISIS (NCT00704197)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Vascular Reactivity at High Altitude
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05525416
- Testing
- Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine
- Where
- 2 sites in Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Muscle Recovery, Oxidative Stress
Development of a Coffee Pulp Infusion as a Strategy for Recovery After Moderate Physical Exercise in a Healthy Population.
The goal of this clinical trial is to learn if a coffee pulp infusion works to improve muscle recovery after moderate physical exercise in a healthy adult population.
- Conditions
- Muscle Recovery, Oxidative Stress, Inflamation, Muscle Damage
- Trial name
- COPULP-REC (NCT07875699)
- Testing
- Two 250 mL infusions per day (one in the morning and one at night) for 45 consecutive days.
- Where
- Spain
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- David Ramiro Cortijo
Healthy Nutrition
Sex Differences in Metabolism Following a High-fat Meal
Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2…
- Trial name
- HFM (NCT05332301)
- Testing
- High-fat test meal
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kirsten Bell
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05001048
- Testing
- Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Congenital Heart Disease, Heart Failure
Gender Difference in NET Activation in Patients With Congenital Heart Disease and Heart Failure
Neutrophil hyperactivation has detrimental effects on cardiac tissue after injuries, leading to fibrosis lesions and cardiac dysfunction.
- Conditions
- Congenital Heart Disease, Heart Failure, Gender
- Trial name
- FIBRONETx (NCT05263843)
- Testing
- Biological markers of myocardial fibrosis
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autonomic Function
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
- Trial name
- CPB_Atropine (NCT06912048)
- Testing
- Oral glucose tolerance test with double-tracer dilution and atropine infusion
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Isokinetic Test, Force-velocity Profile
Sex Differences in Knee Strength and Speed in Male and Female Football Players
Force-velocity (F-V) profiling is increasingly used to describe the mechanical capacities of the knee extensors and knee flexors in football, but almost all available reference data come from male players.
- Conditions
- Isokinetic Test, Force-velocity Profile, Soccer Performance, Female Athletes
- Trial name
- NCT07810387
- Testing
- Isokinetic test
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Haute Ecole ARC Sante
Aging
Sex Differences in Vascular Responses to Exercise
A key early event in cardiovascular disease development is endothelial dysfunction, characterized by impaired flow-mediated dilation.
- Trial name
- NCT04128215
- Testing
- Control Period, Exercise Period
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Heat Intolerance, Heat Stress
Acquiring and Targeting Heat Exposures Necessary for Action
The purpose of this research study is to better understand ways that women and men differ physiologically, cognitively, physically, and cellularly to better prescribe helpful interventions that will prevent injury and risk of…
- Conditions
- Heat Intolerance, Heat Stress, Fatigue; Heat
- Trial name
- ATHENA (NCT05678738)
- Testing
- Antioxidant Berry Supplementation, Acute and Chronic Exercise-Heat Stress
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Male, Female
Sex-difference in Response to Resistance Exercise and Training
Sex-Difference in Response to Resistance Exercise and Training Given the importance of muscular strength for athletic performance as well as for daily activities in the general population-including clinical populations-and the…
- Conditions
- Male, Female, Healthy Adult
- Trial name
- WOMENRESIST S1 (NCT07692815)
- Testing
- Resistance exercise on a leg extension machine, Resistance training on a leg extension machine, Blood samples
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Alcoholism, Stress
Alcohol and Gender Effects on Stress Circuit Function
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo (an inactive compound) in non-drinking, recovering male and female alcoholics, with a specific emphasis on the…
- Conditions
- Alcoholism, Stress, Alcohol Dependence
- Trial name
- NCT00226694
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Stress
Differences by Sex and Genotype in the Effects of Stress on Executive Functions
The aim of this project is to test the effects of an environmental factor (mild stress) on prefrontal cortex (PFC) and the cognitive functions that depend on PFC (collectively called executive functions [EFs]), and to test our…
- Trial name
- NCT04273880
- Testing
- Methylphenidate, Vitamin C
- Where
- Canada
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dental Erosion
Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study
Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion.
- Trial name
- NCT02780973
- Testing
- Wearing of an intraoral device with bovine tooth samples
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Göttingen
Muscle Damage
Sex Differences in Muscle Damage Following Resistance Exercise at Low or High Intensity
Purpose: To investigate the impact of exercise load on resistance exercise-induced muscle damage in untrained males and females.
- Trial name
- EIMD-LOAD (NCT05111054)
- Testing
- Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Durham University
Physical Performance, Pain
Effect of Ski Sport on Physical Performance
The aim of the study is to investigate the effect of ski sport on physical performance, pain, and quality of life compared to sedentary individuals of similar age groups and to examine the existence of gender-specific differences.
- Conditions
- Physical Performance, Pain, Quality of Life
- Trial name
- NCT04913844
- Testing
- Physical performance tests and observational assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Alzheimer Disease, Dementia
Plasma Hydrogen Sulfide as a Biomarker for Alzheimer's Disease and Related Dementias
Hydrogen sulfide is a signaling molecule that is important for vascular health. Because vascular factors such as hypertension and high cholesterol are risk factors for Alzheimer's disease and related dementias, we hypothesize…
- Trial name
- NCT05060848
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Gender Difference in V2 Receptor Function in Response to dDAVP Infusion, Nocturia
The Effect of Gender on Antidiuresis - Evaluated by Graded Low Dose Desmopressin Infusion
There is substantial evidence that women throughout life have significantly lower plasma levels of the antidiuretic hormone vasopressin (pAVP) compared to men.
- Conditions
- Gender Difference in V2 Receptor Function in Response to dDAVP Infusion, Nocturia, Nocturnal Enuresis
- Trial name
- NCT02068560
- Testing
- dDAVP infusion
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gender
[18F]MC225 PET to Evaluate Gender Differences in BBB P-gp Function
P-gp is one of the main efflux transporters at the blood-brain barrier and is responsible for the transport of a variety of neurotoxic substances, including pharmaceuticals.
- Trial name
- NCT05618119
- Testing
- [18F]MC225
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen