Clinical trials: Gender Differences
Parkinson Disease
Effect of Biological Sex on Multimodal Biomarkers of Disease Progression in Patients with Parkinson's Disease
The GENDERIZE-PD study is a research project to understand how biological sex affects the progression of Parkinson's disease (PD). PD is a brain disorder that causes both movement and non-movement symptoms.
- Trial name
- GENDERIZE-PD (NCT06790381)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Ultra-marathon Runners
Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains
Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between…
- Trial name
- UTMB_2019 (NCT04025138)
- Testing
- Neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), Neuromuscular fatigue assessment test
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
CBD, Neural Responses
Sex Differences in Neural Response to Cannabidiol
This is a randomized, double-blind, within-subjects, cross-over design to assess neural changes following a single dose of cannabidiol (CBD) (600mg) versus placebo among healthy female volunteers.
- Trial name
- NCT04777643
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Yale University
Glycemic Control, Insulin Sensitivity
Comparing the Effects of Different Types of Exercise on Glucose Handling
The purpose of the proposed study is to compare the acute effects of different types of exercise modalities on glucose handling in young, healthy males and females.
- Conditions
- Glycemic Control, Insulin Sensitivity, Sex Differences
- Trial name
- NCT06217679
- Testing
- Control Oral Glucose Tolerance Test, Mixed Exercise
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
MACE, Atrial Fibrillation (AF)
throMboembolic Risk Associated To High atrIal Fibrillation riSk
Cardiovascular diseases are the leading cause of mortality from treatable conditions in the European Union and the second from preventable causes, with a standardized mortality rate of 257.8 deaths per 100,000 inhabitants.
- Conditions
- MACE, Atrial Fibrillation (AF), Quality-adjusted Life-years, Electronic Health Records
- Trial name
- MATHIAS (NCT07441759)
- Testing
- AI_MATHIAS
- Where
- Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Alcohol Use Disorder
Sex Differences in the Response to Abstinence From Alcohol.
In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that…
- Trial name
- SPAR (NCT03827460)
- Testing
- Abstinence from alcohol, Usual drinking, Intravenous Alcohol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obstructive Sleep Apnea
Obstructive Sleep Apnea Among Somali-Americans
The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences.
- Trial name
- Somali OSA (NCT04124848)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cannabis
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
- Trial name
- THC-Gender-II (NCT04704271)
- Testing
- Inhaled THC
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Harmonic Wave
Pulse Spectrum Analysis of Pregnant Women
ABSTRACT Background: Pulse diagnosis is a core clinical technique used in Chinese medicine to establish a patient's physiologic or pathologic status.
- Trial name
- NCT04845360
- Testing
- pressure transducer (PSL-200GL, Kyowa Electronic Instrument Co. Ltd., Japan)
- Where
- Taiwan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Healthy Adult Male, Healthy Adult Females
Investigating Sex Differences in Mitochondrial Function and Leg Blood Flow During Exercise
This study will compare mitochondrial function and leg blood flow during exercise in healthy endurance-trained females and males aged 19-35.
- Trial name
- MITOP (NCT07866651)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Aneurysm Dissecting
Gender-related Differences in Chinese Patients With AAD
Few data exist on gender-related differences in clinical features, management, and outcomes of acute aortic dissection (AAD) in China.
- Trial name
- NCT02200835
- Volunteers
- 2,015 people, healthy volunteers welcome
- Sponsor
- General Hospital of Beijing PLA Military Region
Sex Differences
Sex Differences in the Dilatory Response of Compound 21
When blood pressure changes, Angiotensin II is produced and released into the bloodstream. This substance can make blood vessels smaller (i.e., vasoconstriction) by acting through Angiotensin II type I receptors (AT1R) to…
- Trial name
- NCT05576155
- Testing
- Compound 21, Compound 21 + losartan
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Nicotine Dependence, E-cigarette Use
Sex Differences in E-Cigarette Perception
This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.
- Trial name
- NCT07398976
- Testing
- Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Elderly, Chronic Pain
Characterization of Chronic Pain in Elderly Population With Emphasis on Differences Between Gender
Introduction: It is estimated that by 2025 there will be approximately 1.2 billion people above 60 years old. Global projections indicate that by 2050 there will be about 2 billion elders, 80% of them living in developing…
- Conditions
- Elderly, Chronic Pain, Gender
- Trial name
- NCT06855797
- Testing
- Observation
- Where
- Brazil
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Healthy
Gender Difference in Response to Caffeine in Children and Adolescents
Caffeine use is on the rise in America, and one of the most popular sources is soda. Among youth ages 8-16, caffeine consumption has increased by over 70% in the past 30 years.
- Trial name
- NCT02119416
- Testing
- Low Caffeine Administration first (1mg/kg body weight), High Caffeine Administration first (2mg/kg body weight)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Dietary Habits, Nitrates
Effects of Beet Juice and Diet in Female Rowers
The purpose of this study is to determine the effects of nitrate-rich beetroot juice supplementation on exercise performance in female rowers when accounting for habitual vegetable nitrate consumption.
- Conditions
- Dietary Habits, Nitrates, Exercise
- Trial name
- NCT06045845
- Testing
- Beet Juice
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Sleep Deprivation, Sex Differences
Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep Curtailment
The goal of this study is to learn whether insufficient sleep affects glucose metabolism differently in healthy men and women.
- Conditions
- Sleep Deprivation, Sex Differences, Glucose Tolerance
- Trial name
- NCT06809023
- Testing
- Sleep restriction
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Athletic Performance, Sports Performance
Effects of Afternoon Napping, Caffeine, and Standardised Active Recovery on Evening Athletic Performance
This study evaluated whether afternoon napping, caffeine ingestion, and a standardised active recovery and nutritional protocol could influence evening physical and cognitive performance in healthy university athletes.
- Conditions
- Athletic Performance, Sports Performance, Exercise Performance, Circadian Rhythm
- Trial name
- NAP-CAF-REC (NCT07652424)
- Testing
- Afternoon Nap, Caffeine, Standardised Active Recovery and Nutritional Protocol
- Where
- Tunisia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Higher Institute of Sport and Physical Education of Sfax
Alcohol Use Disorder, Alcoholic Liver Disease
Alcoholic Liver Disease and the Gut Microbiome
Background: Significant sex differences exist in regard to alcohol use disorder (AUD) and alcoholic liver disease (ALD). To date, no studies have examined the brain-gut-microbiome (BGM) axis (which is the relationship between the…
- Conditions
- Alcohol Use Disorder, Alcoholic Liver Disease, Microbiome
- Trial name
- NCT05007470
- Testing
- VSL #3 112.5 Capsule
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Heat Acclimation and Thermotolerance, Heat Effect
Exercise in Extreme Hot Weather Conditions
Background: Core body temperature increases in hot climates due to exercise workload, disrupting heat gain and loss of balance. The human thermoregulatory system regulates core body temperature through factors such as metabolic…
- Trial name
- EXHOTCON (NCT07307391)
- Testing
- hot wet high (HWH), hot dry high (HDH), Experimental: hot dry low (HWL)
- Where
- Spain
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Valladolid