Clinical trials: Gene Expression
Functional Dyspepsia, H. Pylori Infection
Gut Hormone, Nociceptors, Neurotrophic Factors Expression in Functional Dyspepsia
The pathophysiology of functional dyspepsia is still unclear but several peptides have been indicated in the etiological factors in FD.
- Trial name
- FD (NCT02173925)
- Where
- South Korea
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Congenital Cytomegalovirus, Cytomegalovirus Infections
Protein Biomarkers and Host RNA Expression Profiles in Congenital Cytomegalovirus Infection
This study seeks to identify and test host protein biomarkers and RNA expression profiles in dried blood spot samples as novel diagnostic markers of congenital cytomegalovirus sequelae and to improve the understanding of the…
- Conditions
- Congenital Cytomegalovirus, Cytomegalovirus Infections, Neonatal Infection, Sensorineural Hearing Loss
- Trial name
- NCT07635368
- Where
- 2 sites in Denmark
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy, Type 2 Diabetes
Study of Gene Activity in Fat and Muscle in Diabetics and Healthy Controls
The aim of the present protocol is to study gene activity in fat and muscle tissue in type 2 diabetics and healthy volunteers after injection of E.
- Conditions
- Healthy, Type 2 Diabetes, Endotoxemia
- Trial name
- NCT00412906
- Testing
- Escherichia Coli Endotoxin
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy
Effects of Fenofibrate on Gene Expression in Healthy Volunteers
The purpose of this study is to assess how fenofibrate modify gene expression in circulating monocytes of healthy volunteers after 6 weeks.
- Trial name
- NCT01109758
- Testing
- Fenofibrate
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Solvay Pharmaceuticals
Obesity, Lipid Metabolism
Metabolic Fate Modifications of Saturated Fats After an Overfeeding
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding.
- Conditions
- Obesity, Lipid Metabolism, Inflammation
- Trial name
- SURNUT (NCT00905892)
- Testing
- Hyperlipidic overfeeding
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Non-Small Cell Lung Cancer
Evaluation of PD1 / PDL1 Expression on Blood Cells & Tumor Tissue, Their Role as a Prognostic Target in NSCLC Patients
Several reports have examined Programmed Death 1 (PD-1) expression on tumor-infiltrating T-cells, and its correlation with prognosis has been discussed.
- Trial name
- NCT02758314
- Testing
- Evaluation of PD-1/PDL-1 expression.
- Where
- Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Metabolic Syndrome, Impaired Glucose Tolerance
The Health Effect of Diet Rich in Nordic Berries
Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures.
- Conditions
- Metabolic Syndrome, Impaired Glucose Tolerance, Low-grade Inflammation, Dyslipidemia
- Trial name
- Berry (NCT01414647)
- Testing
- 300 g of strawberry, raspberry and cloudberry, 400 g of bilberry, Control diet
- Where
- Finland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Study During Pregnancy of Expression of miRNAs in RA or SLE
Rheumatoid arthritis (RA) is a systemic disease, which mainly targets joints and results in osteoarticular destruction and serious disability.
- Trial name
- SPIRALE (NCT02350491)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Infertility
Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women
The aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using Next Generation Sequencing of total RNA.
- Trial name
- NCT02219425
- Testing
- endometrial biopsy
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Breast Milk Expression
Effect of Consuming a Combination of Probiotic Strains and a Combination of Plant Extracts and a Probiotic Strain on the Production and Nutritional Composition of Breast Milk
The objective of this trial is to evaluate the effect of the consumption of a combination of probiotic strains (Prob-milk) and of a combination of plant extracts plus an inactivated probiotic strain (VoluntasProb) on the…
- Trial name
- NCT04639232
- Testing
- Prob-milk, Voluntas-Prob
- Where
- Spain
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Diabetes Mellitus, Obesity
Gymnema Sylvestre vs Berberine in Obesity Gene Expression of Adipokines
Obesity is a disease that affects a large part of the world's population and is a risk factor for the development of metabolic, cardiovascular, oncological, and neurodegenerative diseases.
- Trial name
- GS VS BBR A (NCT06426966)
- Testing
- Berberine, Gymnema sylvestre
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Polytechnic Institute, Mexico
Esophageal Neoplasm, Head and Neck Neoplasm
The Effects of Upper Airway and Digestive Tract Tumors on the Immune System
The goal of this study is to learn how tumors of the upper airway and digestive passages (tongue, throat, mouth, and voicebox) affect the body's immune defenses and energy storage.
- Conditions
- Esophageal Neoplasm, Head and Neck Neoplasm, Laryngeal Neoplasm, Papilloma
- Trial name
- NCT00001603
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Insulin Sensitivity, Aging
Implication of Metabolic and Genomic Modifications in Elderly Subjects
An increase of longevity and of the number of men and women older than 60 years old is observed in most industrialized countries.
- Trial name
- COMPALICLAMP (NCT00951392)
- Testing
- euglycemic hyperinsulinemic clamp, muscle biopsy, indirect calorimetry
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Healthy
Exercise-induced Changes in DNA-methylation
The purpose of the study was to investigate whether regular moderate- or high-intensity interval training can change the DNA methylation in a long-lasting state, and whether these changes affect the gene expression.
- Trial name
- NCT01931072
- Testing
- High-intensity interval training, Moderate training
- Where
- Norway
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Energy, Cardiovascular Disease
Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action
The objective of this study is to measure the energy value of pistachios in the human diet and study molecular mechanisms that may help explain the beneficial health effects of pistachios.
- Conditions
- Energy, Cardiovascular Disease, Cancer
- Trial name
- NCT00942695
- Testing
- 1.5PD, 3.0PD, control
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Prostatic Neoplasms
The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females
Background: Insomnia is associated with difficulty sleeping. The drug zolpidem is widely prescribed for insomnia. Women have reported worse effects from the drug than men.
- Trial name
- NCT03436745
- Testing
- Zolpidem, ECG
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Obesity
Effect of an Antiinflammatory Diet on Postprandial Gene Expression of Mononuclear Cells of Adult Obese Women
Obesity is one of the major health problems worldwide. The consumption of healthy-dietary patterns can be difficult in some countries due to the availability of certain foods. Suggestion of alternative foods could be a necessity.
- Trial name
- NCT04920409
- Testing
- FAWGT diet, Usual diet (UD)
- Where
- Colombia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad de Caldas
Erythroid Differentiation Regulator 1 (Erdr1) Cytokine
Expression of Erythroid Differentiation Regulator 1 (Erdr1) in Vitiligo
Expression of Erythroid differentiation regulator 1 (Erdr1) cytokine in vitiligo
- Trial name
- NCT03377998
- Testing
- skin biopsy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Milk Collection
Analysis of Lipids in Human Milk At Different Gestational Ages
Various studies have shown that the milk of a preterm infant differs from that of a term infant in the composition of micronutrients, vitamins, macronutrients, carbohydrates and proteins.
- Trial name
- NCT05989009
- Testing
- Breastfeeding
- Where
- 2 sites in Italy
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ospedale Buon Consiglio Fatebenefratelli
MCI, Subjective Cognitive Decline (SCD)
FACE Phase II (a Stage II Trial)
How to ensure adherence to computerized cognitive training in unsupervised circumstances (e.g., at-home, self-administered) in older adults at risk for Alzheimer's disease (AD) or AD related dementia (AD/ADRD) is understudied.
- Conditions
- MCI, Subjective Cognitive Decline (SCD), Mild Behavioral Impairment
- Trial name
- NCT07130669
- Testing
- Cognitive Remediation, Cognitive Remediation II
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University