Clinical trials: Gene Polymorphism
Healthy
Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)
The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points.
- Trial name
- POLYGENDOMUS (NCT06740136)
- Testing
- Exercise
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Lille University
Ligament; Laxity, Recurrent Patellar Dislocation
Clinical Significance and Coexistence of Polymorphisms of Individual Collagen-coding Genes
The purpose of this study is to assess correlation between recurrent patella dislocation and genetic polymorphism rs1800012 of the COL1A1 Gene and rs12722 of the COL5A1 Gene.
- Trial name
- NCT05763108
- Testing
- genetic test, Beighton joint laxity test
- Where
- 2 sites in Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Cancer Cachexia
Effect of Gene Polymorphisms on the Pathogenesis of Cancer Cachexia
Cachexia not only directly increases the morbidity and mortality, it also aggravates the side effects of chemotherapy and reduces the overall quality of life that is often considered the major and direct cause of morbidity of a…
- Trial name
- NCT04131478
- Testing
- Pharmacogenetic testing
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Disease
C-Reactive Protein (CRP) Gene Variants and Coronary Artery Disease in a Chinese Han Population
The recognition of the association between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD) has led to an increased emphasis on CRP genetic effects on CRP level and CHD.
- Trial name
- CRP-Han (NCT00780221)
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Pharmacogenetic and Duration of Labor Fentanyl Analgesia
μ-opioid Receptor Polymorphism and Opioid Analgesia
In this prospective observational double-blind study, the investigators aim to assess the effect of the single nucleotide polymorphism of the μ-opioid receptor gene (OPRM1, p.118A/G) on the duration of epidural fentanyl labor…
- Trial name
- NCT02099877
- Testing
- Fentanyl
- Where
- Lebanon
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Asthma in Children, Wheezing
Secondhand Smoking in Asthmatic Children
This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.
- Trial name
- NCT03099902
- Testing
- Lung function, White blood cell DNA extraction, Urinary testing
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- AHEPA University Hospital
Pharmacological Action
Pharmacogenomic in Colombian Patients With Rheumatoid Arthritis
The pharmacogenomics of the Colombian population with rheumatoid arthritis (RA), understood as the individual response to drugs depending on the genome of each patient, can be an explanation for the problems of effectiveness and…
- Trial name
- NCT03352622
- Testing
- CASES, CONTROLS
- Where
- Colombia
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Psoriasis Vulgaris
Correlation Between Vaspin Gene Polymorphism and Serum Vaspin Levels in Psoriasis Vulgaris
Psoriasis is a common immune-mediated inflammatory skin disease affecting at least 100 million individuals worldwide. In Egypt, the prevalence of psoriasis ranges between 0.19% and 3% of the Egyptian people.
- Trial name
- NCT07320872
- Testing
- vaspin gene polymorphism
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Polymorphism (Genetics), Endometriosis
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population
Endometriosis, defined as the presence of endometrial tissue outside the uterine cavity, affects 6-10% of the general population of women in childbearing age. The pathogenesis of the disease is unknown.
- Trial name
- NCT02388854
- Testing
- SNPs analysis with Sanger sequencing
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Hypovitaminosis D, Insulin Resistance
Hypovitaminosis D : A Link Between Bone/Mineral and Fat/Fuel Metabolism
The optimal dose of vitamin D needed to optimize beneficial effects on musculoskeletal outcomes remains to be defined. Equally unclear is the impact of vitamin D on fuel metabolism and insulin sensitivity in human subjects.
- Conditions
- Hypovitaminosis D, Insulin Resistance, Obesity, Osteoporosis
- Trial name
- GEHF-VitD (NCT01315366)
- Testing
- Euro D and Ci-CalD, Euro D, Ci-CalD
- Where
- Lebanon
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Appetitive Behavior
Effect of Exercise on Appetite, Gut Peptides and Butyrylcholinesterase Activity in Variants of the FTO Gene
Using a database of individuals with FTO genetic data, the study aims to assess the appetite, energy intake, butyrylcholinesterase, gut hormone responses to a bout of moderate- to high intensity exercise in individuals with…
- Trial name
- NCT03025347
- Testing
- Control, Exercise
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Hypertension
Genetic Determinant of Blood Pressure Sensitivity to Salt Intake
Nedd4.2 is a regulator of ENac, a transporter of sodium involved in the regulation of salt retention by the kidney. The study address the consequence of a frequent genetic variation leading expected to impact the function of…
- Trial name
- JEU004 (NCT01706887)
- Testing
- Diet Amiloride
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Healthy
Genetic Influence on Susceptibility to Type 1 Diabetes Mellitus
Type 1 diabetes mellitus is an autoimmune disease in which the body's immune cells attack the insulin-producing cells of the pancreas.
- Trial name
- NCT00001985
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phantom Limb
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group.
- Trial name
- NCT01462448
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Primary Ovarian Insufficiency, Cardiovascular Diseases
Associations of Combinations of Single-nucleotide Polymorphisms in Women With Premature Ovarian Failure
Research objective. To study the associations between combinations of single nucleotide polymorphisms and behavioural risk factors with non-communicable diseases and adverse outcomes in women with premature ovarian failure.
- Conditions
- Primary Ovarian Insufficiency, Cardiovascular Diseases, Menopause, Premature, Coronary Disease
- Trial name
- NCT04943354
- Testing
- Taking a person's venous blood
- Where
- Russia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
BDNF, Polymorphism, Genetic
BDNF and Motor Learning
The purpose of the study is to assess the status of brain-derived neurotrophic factor brain (BDNF) and how the brain behaves in response to skill acquisition.
- Trial name
- BDNF (NCT02074696)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Ulcerative Colitis (UC)
The Association Between Interleukin-7 Receptor Gene Polymorphism and the Risk of Ulcerative Colitis
From January 2020 to December 2024, diagnosed ulcerative colitis(UC) patients and gender- and age-matched normal controls were enrolled from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical…
- Trial name
- NCT07398586
- Testing
- Vedolizumab
- Where
- China
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
COMT Gene Polymorphism
Pharmacogenetics of Cannabinoid Response
This study attempts to examine genetic influences on the effects of tetrahydrocannabinol (Δ9-THC), the active ingredient of marijuana, cannabis, "ganja", or "pot".
- Trial name
- NCT00678730
- Testing
- delta 9 tetrahydrocannabinol
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy Volunteers
Pharmacogenomic Study on PKD/PKC of Dabigatran Etexilate and Rivaroxaban
The study will address the impact of genetical variation of a protein involved in the intestinal absorption of two new anticoagulants : Dabigatran etexilate and Rivaroxaban.
- Trial name
- DRIVING (NCT01627665)
- Testing
- D->R->C+R, D->R->C+D, R->D->C+D
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Generalized Aggressive Periodontitis, Chronic Periodontitis
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Generalized aggressive Periodontitis (GAgP) and chronic periodontitis (CP) are inflammatory diseases. Little is known about molecular changes and signaling cascade of host response.
- Trial name
- NCT04026828
- Testing
- Periodontitis Group
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kocaeli University