Clinical trials: Gene Polymorphism
Caffeine
Genetic Determinants of Cardiovascular Response to Coffee Drinking
Cardiovascular and neuropsychologic effects of coffee are still debated. The precise mechanism underlying the actions of caffeine on the cardiovascular and neuropsychologic systems is incompletely understood and a considerable…
- Trial name
- NCT01330680
- Testing
- Coffee, Decaffeinated coffee
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Urolithiasis
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study
Many things, like not drinking enough fluids, contribute to making kidney stones and there is also a genetic tendency. We looked into this in 1998-2000 in 14 families with several stone-formers.
- Trial name
- NCT06211842
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Body Weight Changes
Development of a Nutrigenetic Test for Personalized Prescription of Body Weight Loss Diets (Obekit)
This study evaluates the relationship between several genetic variants and the response to a hypocaloric diet, in order to design a genetic test which permits prescribe the more personalized diet for each individual according to…
- Trial name
- Obekit (NCT02737267)
- Testing
- Moderately high protein diet, Low fat diet
- Where
- Spain
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Parkinson's Disease
Genetic Polymorphism and Parkinson's Disease in Taiwanese
To observe and analyze the correlation between Single Nucleotide polymorphisms (SNPs) and the incidence of Parkinson's disease in Taiwanese.
- Trial name
- NCT01996878
- Where
- Taiwan
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Healthy
An Open-label, Single-dose, Two-treatment, Randomized, Cross-over Study to Investigate the Effects of the SLCO2B1 c.1457C>T Polymorphism and Apple Juice on the Pharmacokinetics and Pharmacodynamics of Acebutolol in Healthy Korean and Japanese Volunteers
An open-label, single-dose, two-treatment, randomized, cross-over study to investigate the effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics and pharmacodynamics of acebutolol in healthy Korean…
- Trial name
- NCT01514019
- Testing
- Acebutolol
- Where
- 2 sites in Japan, South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- In-Jin Jang, MD, PhD
Peri-Implantitis
Peri-implantitis and MMP-8
Peri-implantitis is defined as the pathological condition around dental implants characterized by inflammation in the peri-implant mucosa and progressive bone loss, eventually leading to implant loss.
- Trial name
- NCT05711407
- Testing
- Gene Polymorphisms of MMP-8
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Hypertension
Genetic Determinant of Blood Pressure Sensitivity to Salt Intake
Nedd4.2 is a regulator of ENac, a transporter of sodium involved in the regulation of salt retention by the kidney. The study address the consequence of a frequent genetic variation leading expected to impact the function of…
- Trial name
- JEU004 (NCT01706887)
- Testing
- Diet Amiloride
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Cell Studies of Parkinson's Disease
This study will examine and compare blood samples from healthy volunteers and patients with Parkinson's disease to identify abnormalities associated with Parkinson's disease.
- Trial name
- NCT00076505
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Crohn Disease
The Associations of Plasminogen Activator Inhibitor-1 Gene Polymorphisms With Crohn's Disease in Chinese Patients
From January 2020 to January 2025, Crohn's disease (CD) patients and gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT06935942
- Testing
- Ustekinumab - Standard Dosage
- Where
- China
- Volunteers
- 906 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
T2DM
The Imaging Genetic Study of Type 2 Diabetes and Depression
To investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.
- Trial name
- NCT03564431
- Testing
- Magnetic resonance
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kunming Medical University
Primary Prevention
Genetical, Anthropometrical and Biochemical Factors Influencing High Risk Subclinical Atherosclerosis
Subclinical atherosclerosis is the atherosclerotic process identified before clinical symptoms and thus it can be a useful marker of future cardiovascular events. It can be evaluated by many methods.
- Trial name
- NCT02487615
- Where
- 2 sites in Brazil
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Blood Flow in Healthy Volunteers
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral effects by stimulation of specific adenosine receptors.
- Trial name
- NCT00253929
- Testing
- Intra-arterial infusion of adenosine, intra-arterial infusion of caffeine, intra-arterial infusion of acetylcholine
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Wildtype, Polymorphism Liver FABP
Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance
The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin…
- Trial name
- NCT00277342
- Testing
- measurement of lipid-induced hepatic insulin resistance
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Skeletal Muscle Performance, Gene Polymorphisms
Assessment of the Impact of N-acetylcysteine Supplementation on Physical Performance
Study aims to verify the hypothesis: N-acetylcysteine (NAC) supplementation improves exercise capacity in people training endurance sports and the effectiveness of this supplementation depends on the polymorphism of genes related…
- Trial name
- NCT05604586
- Testing
- N-acetylcysteine
- Where
- Poland
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Hypertrophic Cardiomyopathy
Family Studies of Inherited Heart Disease
Hypertrophic cardiomyopathy (HCM) is a genetically inherited heart disease. It causes thickening of heart muscle, especially the chamber responsible for pumping blood out of the heart, the left ventricle.
- Trial name
- NCT00001225
- Where
- United States
- Volunteers
- 5,880 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Alcohol Intolerance, Alcohol Drinking in College
ALDH2 rs671, Alcohol Use, and Health Education in University Students
Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related…
- Conditions
- Alcohol Intolerance, Alcohol Drinking in College, Aldehyde Dehydrogenase-2 (ALDH2) Deficiency
- Trial name
- NCT07802613
- Testing
- Individual ALDH2 Genotype Feedback, Standardized Alcohol Health Education
- Where
- Taiwan
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Blood Pressure
Blood Pressure Lowering Effect of B-vitamins in Adults With a Genetic Pre-disposition to Elevated Blood Pressure.
Approximately 12% of the world's population have a have a common C677T polymorphism in the gene encoding the folate metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR).
- Trial name
- RAFA (NCT04278378)
- Testing
- Riboflavin, Folic acid
- Where
- United Kingdom
- Volunteers
- 2,564 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Cardiovascular Disease, Type 2 Diabetes
Moderate Alcohol Consumption, Risk of Cardiovascular Disease and Type 2 Diabetes: Influence of Alcohol Oxidation
Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease and type 2 diabetes. The association of alcohol consumption with cardiovascular disease is mediated by a functional polymorphism of…
- Trial name
- NCT00285909
- Testing
- Alcohol: 25 gday (white wine)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- TNO
Non-small Cell Lung Cancer, Primary Carcinoma
GWAS Research of Lung Cancer in Tianjin
To study the association of Genetic Polymorphisms with Lung Cancer Risk in Tianjin Population.
- Trial name
- NCT01255059
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li