Clinical trials: General Anesthesia
Metabolomics, Anesthesia, General
Metabolic and Physiological Changes During Minor Orthopaedic Surgery in Otherwise Healthy Patients
The air we breathe contains 21% of oxygen. Oxygen is vital for the cells ability to produce energy and without it we could not survive. Oxygen normally exists as a molecule consisting of two atoms, O2.
- Conditions
- Metabolomics, Anesthesia, General, Oxygen
- Trial name
- NCT03450746
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Postoperative Delirium, General Anesthesia
The Disorder of Circadian Clock Gene and Early Cognitive Dysfunction After General Anesthesia
Postoperative cognitive dysfunction (POCD) is a common postoperative complication in patients aged 65 and over, which refers to cognitive function changes such as memory decline and attention deficit after anesthesia and surgery.
- Conditions
- Postoperative Delirium, General Anesthesia, Exosomes, Clock Gene
- Trial name
- NCT04421872
- Testing
- receiving general anesthesia
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Anesthesia, General, Fluid Therapy
Management of Intraoperative Fluids in Ambulatory Surgery
This is a single-center prospective randomized control trial (RCT) to determine whether the continuous monitoring of the plethysmographic variability index (PVI) during low-risk surgeries, can be used to optimize the…
- Conditions
- Anesthesia, General, Fluid Therapy, Ambulatory Surgical Procedures
- Trial name
- MIFAS (NCT03193320)
- Testing
- Fluid therapy protocol
- Where
- Venezuela
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Policlinica Metropolitana
Electroencephalography, General Anesthesia
Multi-center Isoelectric EEG Study in Children Under General Anesthesia
Multi-center, prospective, observational study investigating the incidence of isoelectric electroencephalography (EEG) events and the associated peri-operative factors in infants 0-3yo undergoing general anesthesia.
- Conditions
- Electroencephalography, General Anesthesia, Pediatric Anesthesia
- Trial name
- NCT03432351
- Where
- 15 sites in United States, Australia and 3 more
- Volunteers
- 687 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Continuous Positive Airway Pressure, Hypoxia
Positive Pressure at Induction of Anesthesia in Children
SCENARIO: Hypoxemia is one of the most common adverse events during the induction of general anesthesia and may culminate with more serious complications such as cardiac arrest and death.
- Conditions
- Continuous Positive Airway Pressure, Hypoxia, General Anesthesia
- Trial name
- NCT03432390
- Testing
- Continuous Positive Airway Pressure, Open system ventilation
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Anesthesia, General, Infant
Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia
The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.
- Trial name
- NCT03567031
- Testing
- EtCO2 modification
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Endotracheal Intubation, General Anesthesia
Ultrasound-guided Identification of Cricoid Cartilage in Cricoid Pressure
This study is aimed to provide the evidence that ultrasound-guided identification of the cricoid cartilage can improve effectiveness of cricoid pressure.
- Trial name
- NCT03990337
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
General Anesthesia, Intravenous Anesthesia
Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol
Since the introduction of propofol into routine anesthesia practice, the phenomena of pain on injection has plagued anesthesia providers. Propofol, an unstable phenol, triggers the release of bradykinin on injection.
- Trial name
- NCT01342510
- Testing
- Magnesium Sulfate, Lidocaine, Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anesthesia, General, Hypotension
Can Continuous Cardiac Output Monitoring Before General Anesthesia Predict Hypotension After Induction?
Post-induction hypotension (PIH) is very common with high incidence about 9-60%. There are multiple factors that may cause PIH, like pre-operative fasting, bowel preparation, vasodilatation due to anesthetics, and reduced…
- Conditions
- Anesthesia, General, Hypotension, Cardiac Output
- Trial name
- NCT03718949
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
General Anesthesia
Ultrasound Guided Arterial Line Placement in Long Axis Versus Short Axis in Pediatric Patients
The use of ultrasound is becoming widespread to guide the placement of arterial lines for both vascular access and regional anesthesia in the field of anesthesia.
- Trial name
- NCT00859846
- Testing
- Arterial line placement
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
General Anesthesia
Ambu AuraGain Laryngeal Mask Airway and I-gel in Children
Children aged below 7 years are randomly assigned to AuraGain Group or I-gel group. After anesthetic induction, AuraGain or I-gel is inserted and mechanical ventilation is started.
- Trial name
- NCT03118245
- Testing
- AuraGain, I-gel
- Where
- South Korea
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
General Anesthesia
The Influence of Head and Neck Position on Performance of Ambu AuraGainTM in Children
The influence of different head and neck positions on the effectiveness of ventilation with the Ambu AuraGain airway remains unevaluated.
- Trial name
- NCT03127683
- Testing
- Neutral position, Extension, Flexion
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
General Anesthesia
Comparison of Conventional Lightwand Intubation Versus Video-laryngoscope Guided Lightwand Intubation in Simulated Cervical Spine-immobilized Patients
Among advanced intubation equipment for difficult intubation, a lighted stylet (lightwand) is a widely used equipment in cervical immobilized patients.
- Trial name
- NCT03169556
- Testing
- Video-laryngoscope guided lightwand, lightwand alone
- Where
- South Korea
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Muscle Relaxant, General Anesthesia
Effect of Neostigmine on the Recovery of Rocuronium: A Comparison Between Partial and TOF Ratio-Based Dose
This study aimed to evaluate the effect of Neostigmine partial dose towards neuromuscular blockade of rocuronium
- Trial name
- NCT03058263
- Testing
- Dose of Neostigmine
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Adult Patient Undergoing Elective Surgery With General Anesthesia and Needs Nasogastric Tube Placement
Nasogastric Tube Placement on Intubated Patient: Two-Finger Method vs Reverse Sellick's Maneuver
The study aimed to compare the efficacy between nasogastric tube placement using Two-Finger Method and Reverse Sellick's Maneuver
- Trial name
- NCT03134287
- Testing
- two-finger method, reverse sellick's method
- Where
- Indonesia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Adult Patients Undergoing Elective Surgery With General Anesthesia and LMA Insertion
Comparison Between Lidocaine Inhalation and Intravenous Dexamethasone in Reducing Pain After Laryngeal Mask Insertion
This study aimed to compare the efficacy between lidocaine inhalation vs intravenous dexamethasone to reduce pain after laryngeal mask insertion
- Trial name
- NCT03139591
- Testing
- lidocaine inhalation; intravenous dexamethasone
- Where
- Indonesia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Active Emergence From General Anesthesia
EEG Studies of IV Methylphenidate-Induced Emergence From Anesthesia
The aim of this study is to test the hypothesis that methylphenidate actively induces emergence from propofol and sevoflurane general anesthesia in healthy volunteers.
- Trial name
- NCT02429076
- Testing
- IV methylphenidate, Sevoflurane, Propofol
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Children Under General Anesthesia
Study on Changes of Pulse Oximeter Plethysmographic Amplitude Induced by Respiration in Pediatric Patients
The purpose of this study is to evaluate the variations of respiratory changes in pulse oximeter plethysmographic amplitude (delta POP) according to different contact forces between finger and sensor of pulse oximeter.
- Trial name
- NCT02940938
- Testing
- Applying pulse oximeter sensor
- Where
- South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pediatric General Anesthesia With Endotracheal Tube
Ultrasound Study of the Airway to Predict Endotracheal Tube Size in Anesthetized Pediatric Patients
The purpose of this study is to determine whether ultrasound study of the airway to predict endotracheal tube size in anesthetized pediatric patients better than the tube size formula
- Trial name
- NCT02321956
- Testing
- Ultrasound
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Intraoperative Complications, Postoperative Complications
Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade.
The goal of this study is to investigate the effect of depth of neuromuscular block (NMB) on global and regional (dependent versus nondependent) respiratory mechanics during laparoscopic surgery.
- Conditions
- Intraoperative Complications, Postoperative Complications, Laparoscopy, Surgical Complications From General Anesthesia
- Trial name
- NCT02025075
- Testing
- Rocuronium
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital