Clinical trials: General Anesthetics
Hydrocephalus, Brain Damage
The Role of Neurofilament Light (NfL) in Patients With Hydrocephalus
Neurofilament Light Chain Protein (NfL) has been found by many studies as a sensitive biomarker of neuronal damage from several reasons, e.g.
- Conditions
- Hydrocephalus, Brain Damage, General Anesthetics Toxicity
- Trial name
- NCT05399602
- Testing
- Lumbar puncture, External lumbar drainage, Lumbar infusion test
- Where
- Czechia
- Volunteers
- 41 people
- Sponsor
- University Hospital Hradec Kralove
General Anesthetics
Effectiveness of Facial Mask NIV in Adults Under General Anesthesia: Two-Hand C-E vs V-E Techniques
This study aims to compare two different ways doctors hold a face mask to help the participant breathe during general anesthesia. The investigators are evaluating which method, the "C-E" or the "V-E" technique, works best.
- Trial name
- VENTMASK (NCT07179432)
- Testing
- V-E facial mask ventilation maneuver, C-E facial mask ventilation maneuver
- Where
- 2 sites in Colombia
- Volunteers
- 206 people
- Sponsor
- Universidad de Antioquia
General Anesthetic, Electroencephalogram
General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia
The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature.
- Trial name
- NCT05210764
- Testing
- propofol, sevoflurane, S-ketamine
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Peking University First Hospital
General Anesthesia, Spinal Anesthesia
General Anesthesia Versus Spinal Anesthesia With Local Anesthetic Infiltration for Buccal Mucosal Graft in Urethroplasty
This study aims to compare general anesthesia and spinal anesthesia with local anesthetic infiltration for buccal mucosal graft (BMG) in urethroplasty.
- Conditions
- General Anesthesia, Spinal Anesthesia, Local Anesthetic Infiltration, Buccal Mucosal Graft
- Trial name
- NCT07074730
- Testing
- Spinal anesthesia, General anesthesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Geriatrics, Hypotension on Induction
Carotid Artery Corrected Flow Time and Inferior Vena Cava Collapsibility Index for Prediction of Hypotension After Induction of General Anesthesia in Geriatric Patients Undergoing Elective Surgery
In this observational study, we will assess cFT by Carotid ultrasound and IVC collapsibility index for prediction of hypotension after induction of general anesthesia in geriatric patients undergoing elective surgery.
- Conditions
- Geriatrics, Hypotension on Induction, General Anesthetic Drug Adverse Reaction, Elective Surgery
- Trial name
- NCT06814054
- Testing
- Carotid Artery Corrected Flow Time measurement, Inferior vena cava collapsibility index
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Tanta University
Transurethral Resection of Prostate Syndrome, Elderly (People Aged 65 or More)
Hemoglobin-to-red Blood Cell Distribution Width Ratio and Hypothermia for Elderly Patient
As individuals age, they often enter a phase of increased "frailty." Elderly and frail patients represent a population that requires heightened sensitivity and close monitoring during surgical procedures.
- Conditions
- Transurethral Resection of Prostate Syndrome, Elderly (People Aged 65 or More), General Anesthetic
- Trial name
- NCT06790017
- Testing
- body temperature
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Spinal Aneshtesia, General Anesthetic
Effects of Anesthesia Type on Inflammatory Response
In total knee arthroplasty, surgical and anesthetic procedures can lead to a significant increase in systemic inflammation. This procedure is frequently performed under either general or spinal anesthesia.
- Conditions
- Spinal Aneshtesia, General Anesthetic, Inflammation, Neutrophils
- Trial name
- NCT06984315
- Testing
- The effects of the groups on perioperative inflammation changes were compared.
- Where
- Turkey (Türkiye)
- Volunteers
- 849 people
- Sponsor
- Tokat Gaziosmanpasa University
General Anesthesia, İnhalation Anesthetics
Effects of Anesthesia Type on QoR-40
To compare the effects of total intravenous anesthesia and inhalation anesthesia used for maintenance on postoperative recovery in patients undergoing septorhinoplasty surgery under general anesthesia, using the recovery quality…
- Conditions
- General Anesthesia, İnhalation Anesthetics, Quality of Recovery
- Trial name
- NCT06423313
- Testing
- maintenance of anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
General Anesthetic Drug Adverse Reaction
Predicting Outcomes Using Infra-red SEnsors, a Feasibility Study.
The aim of this study is to investigate if it is feasible to use a protocol in which avoiding oxygen desaturation in the brain during general anaesthesia can reduce the risk of negative postoperative behavior changes in children.
- Trial name
- PORPOISE-F (NCT06515080)
- Testing
- Near Red Infrascopy
- Where
- 5 sites in Australia, Belgium and 3 more
- Volunteers
- 500 people
- Sponsor
- Uppsala University
General Anesthetic Drug Adverse Reaction
Postoperative Effects of Propofol Versus Sevoflurane Anesthesia
Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life.
- Trial name
- NCT05935930
- Testing
- Propofol 10 MG/ML Injection, Sevoflurane Inhalation Liquid
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Damanhour Teaching Hospital
Kidney Failure, Acute, Myopathy; Drugs
The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)
The study aims to improve the safety of the electroporation ablation (PFA) procedure by using muscle relaxants to reduce skeletal muscle damage during the procedure.
- Conditions
- Kidney Failure, Acute, Myopathy; Drugs, Heart Arrhythmia, Succinylcholine Sensitivity
- Trial name
- NCT06707532
- Testing
- Propofol, Rocuronium
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Adverse Effect of Other General Anesthetics, Sequela
Automated Assessment of Difficult Airway With Facial Recognition Techniques
General anaesthesia mandates artificial ventilation and tracheal intubation in order to provide patients with artificial breathing.
- Trial name
- PeScho (NCT02022397)
- Where
- Switzerland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Used to Induce and Implement General Anesthesia in Combination With Sedative Anesthetics (Such as Propofol)
Pharmacokinetics, Safety and Efficacy of HR020602 Injection in Children Undergoing General Anesthesia
This study is divided into two stages: the first stage is a dose verification trial, with a multicenter, open, single arm trial design, which is planned to enroll 10 children with general anesthesia surgery (all using HR020602…
- Trial name
- NCT04867343
- Testing
- HR020602 injection, fentanyl injection ； remifentanil injection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
General Anesthetic Drug Adverse Reaction, Perioperative/Postoperative Complications
Observational of Emergence Time Between Patients Receive General Anesthesia With BIS or Spectrogram EEG Monitor
The bispectral index parameter is used to guide the titration of general anesthesia, however; conflicting results between different studies cannot prove the benefit of EEG monitor on improvement of OR efficiency.
- Trial name
- NCT05208502
- Testing
- DSA monitor
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- National Taiwan University Hospital
General Anesthetics
Changes in Autonomic Nervous Activity and Blood Pressure After Anesthesia Induction: Remimazolam Versus Propofol
The goal of this clinical trial is to compare the effects of changes in autonomic nervous activity on changes in blood pressure after anesthesia induction between propofol and remimazolam in patients undergoing low-risk surgery.
- Trial name
- NCT05635201
- Testing
- Anesthesia induction with propofol, Anesthesia induction with remimazolam
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Daegu Catholic University Medical Center
General Anesthetics Toxicity, Postoperative Cognitive Dysfunction
The Influence of Electroacupuncture on Postoperative Agitation of Pediatrics Undergoing Sevoflurane General Anesthesia
Postoperative agitation is a common complication in pediatric anesthesia, with an incidence ranging from 10% to 80%. Common surgical procedures in children include tonsillectomy, adenoidectomy, insidious penis prolongation and…
- Conditions
- General Anesthetics Toxicity, Postoperative Cognitive Dysfunction, Electroacupuncture
- Trial name
- DZDXEQFWQMSHZD (NCT05924854)
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Endobronchial Metastases, Bronchoesophageal Fistula
Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy
This study is a prospective, randomized, controlled trial. In this study, 30 patients who underwent endotracheal tumor resection under rigid bronchoscope or stent placement for acquired tracheoesophageal fistula were selected as…
- Conditions
- Endobronchial Metastases, Bronchoesophageal Fistula, General Anesthetic Drug Adverse Reaction
- Trial name
- NCT05468671
- Testing
- Remimazolam, Propofol, Rocuronium
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Zhejiang Cancer Hospital
General Anesthetics Toxicity, Postoperative Cognitive Dysfunction
Tau/P-Tau and Neurocognitive Outcomes in Children
The proposed studies are aimed to measure Tau and P-Tau levels in pre- and postoperative blood, urine, feces and saliva, as well as to assess pre- and postoperative neurocognitive function in children (3 to 5 years old) who will…
- Conditions
- General Anesthetics Toxicity, Postoperative Cognitive Dysfunction, Child Development
- Trial name
- NCT03511729
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
General Anesthetic
Comparison of the Effects of High, Low and Minimal Flow Anesthesia Managements on ORI and Partial Oxygen Pressure
The aim of our study is to show that continuous oxygen reserve index monitoring is a non-invasive monitoring method that can be used as a supporting parameter to PaO2 in blood gas in hypoxia and hyperoxia monitoring when…
- Trial name
- NCT05329233
- Testing
- Masimo Radical-7 Pulse CO-Oximeter
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Samsun Education and Research Hospital
Anesthesia, General, Anesthetics Adverse Reaction
Impact of Anesthetic Environment the Sex Ratio of the Children of Female Assistants
The aims of this multi center retrospective study was to determine: whether the sex ratio of the offspring of female assistants in anesthesia-resuscitation differs from that of the population at large whether the assistants' work…
- Trial name
- NCT04532502
- Testing
- Anesthetics, Inhalation
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- University of Liege