Clinical trials: Generalized Chronic Periodontitis
Generalized Chronic Periodontitis
Activated MMP-8 as Diagnostic Test for Periodontitis
Background: Untreated periodontal disease may influence general health. However, how may a physician who is not trained in periodontal probing detect untreated periodontitis? Activated matrix metalloproteinase-8 (aMMP-8) in…
- Trial name
- MMP-8 (NCT02280122)
- Testing
- no intervention provided
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Goethe University
Periodontitis, Periodontitis Chronic Generalized Severe
Effect of Non-surgical Treatment of Periodontitis Patients Focusing on Inflammatory Mediators in Gingival Crevicular Fluid
This study investigates inflammatory biomarkers in gingival crevicular fluid (GCF) from smokers and non-smokers with severe periodontitis, before and during non-surgical periodontal therapy (NSPT).
- Trial name
- NONSURG (NCT07503041)
- Testing
- Collecting fluid for biomarker analyses, Hygiene instruction, tooth cleaning, plaque removal
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Periodontitis Chronic Generalized Severe, Gingivitis
Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Periodontal disease is a chronic progressive state of inflammation pertaining to supporting tissues of the dentition that culminates in loss of the affected teeth.
- Conditions
- Periodontitis Chronic Generalized Severe, Gingivitis, Inflammatory Response
- Trial name
- NCT06016023
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis Chronic Generalized Moderate, Periodontitis
Effect of Periodontal Treatment on Metabolic Control in Patients with Type-2 Diabetes Mellitus Treated in the Cardiovascular Healt Program
The objective of this clinical trial is to evaluate the effect of periodontal treatment on the reduction of glycated hemoglobin levels in adult patients with concurrent type 2 diabetes mellitus and periodontitis.
- Conditions
- Periodontitis Chronic Generalized Moderate, Periodontitis, Periodontal Disease, Diabetes Mellitus Type 2
- Trial name
- T2D (NCT06895980)
- Testing
- Non-surgical periodontal treatment, glycated hemoglobin measurement and application of OHIP-14SP survey.
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- University of Chile
Periodontal Diseases, Coronary Artery Disease
Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects
Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease.
- Trial name
- NCT04127487
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Chronic Periodontitis, Smoking
MTZ Plus AMX in the Treatment of Smokers and Non-smokers
Randomized controlled clinical trials have demonstrated that the use of amoxicillin (AMX) and metronidazole (MTZ) as adjuncts to mechanical therapy improves the clinical and microbiological outcomes of scaling and root planing…
- Trial name
- NCT01837199
- Testing
- Metronidazole plus Amoxicillin
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Guarulhos
Periodontitis Chronic Generalized Severe
Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients.
This study aims to evaluate clinically the efficacy of flurbiprofen gel in comparison to Aloe Vera gel as adjunctive to SRP in the reduction of periodontal pockets in patients with chronic periodontitis in smoking patients.
- Trial name
- NCT06041178
- Testing
- 2.5% flurbiprofen, 98% aloe vera
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Beirut Arab University
Generalized Chronic Periodontitis, Vitamin D Deficiency
Effects of Vitamin D Supplementation During a Non-surgical Treatment of Generalized Chronic Periodontitis
The subjects participating in the trial will be randomly allocated to either the group receiving the treatment under investigation (scaling and root planning (SRP) accompanied by administration of vitamin D) or to a group…
- Trial name
- Protocol01 (NCT03162406)
- Testing
- Vitamin D3
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis
Treatment of Periodontitis With Er:YAG Laser
The purpose of this research project is to gain information on the best and most comfortable way to treat the periodontal disease.
- Conditions
- Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis, Periodontal Diseases
- Trial name
- NCT03628872
- Testing
- Scaling and root planing, Er:YAG Laser, Hand instruments
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Columbia University
Diabetes Mellitus, Type 2, Type 2 Diabetes Mellitus
Disruption of Immune Homeostasis in Type 2 Diabetics With Generalized Chronic Periodontitis
The primary objective of this study is to assess the short-term immune response of type-2 diabetics with generalized chronic periodontitis (GCP) to nonsurgical periodontal treatment.
- Conditions
- Diabetes Mellitus, Type 2, Type 2 Diabetes Mellitus, Periodontal Diseases, Periodontitis
- Trial name
- NCT02172716
- Testing
- Nonsurgical periodontal treatment
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis Stage II, Periodontitis Stage III
3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV
What is the purpose of this study? This study is to investigate the effect of a processed blood product in healing after treatment for gum disease.
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), Periodontitis
- Trial name
- NCT07293962
- Testing
- Normal saline irrigation, Platelet rich fibrin
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Periodontal Diseases, Chronic Periodontitis
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status…
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket, Tooth Mobility
- Trial name
- NCT03364751
- Testing
- IQOS, Cigarette
- Where
- 26 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Philip Morris Products S.A.
Periodontal Diseases
Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Chronic Periodontitis and Diabetic Subjects
The quantification of the proteomes : L-plastin, lipocalin and adiponectin was analysed in the subgingival tissue samples of generalized severe chronic periodontitis patients with and without diabetes mellitus.The demographic and…
- Trial name
- NCT03391349
- Volunteers
- 70 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Chronic Periodontitis, Generalized
Flapless Emdogain in the Treatment of Periodontal Residual Pockets
48 adult patients participated in a single-centre randomized clinical trial with split- mouth design. They had presented at re-evaluation after initial non-surgical periodontal therapy (steps 1 and 2 of periodontal therapy) for…
- Trial name
- NCT05823389
- Testing
- Re-instrumentation with flapless Emdogain application
- Where
- Palestinian Territories
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Arab American University (Palestine)
Periodontitis Chronic Generalized Severe, Intrabony Periodontal Defect
Clinical and Radiograhic Evaluation of NIPSA With and Without Allograft Plus Platelet Rich Fibrin in the Treatment of Intraosseous Defects in Stage III Periodontitis Patients
Several minimal invasive techniques have been proposed since the last decade aiming to enhance and provide adequate environment for periodontal regeneration.
- Trial name
- NCT04444063
- Testing
- Non-Incised Papilla Surgical Approach
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Generalized
The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients
Is the non-surgical periodontal therapy can improve glycemic control in type 2 diabetic patients with chronic periodontitis?
- Trial name
- NCT03783845
- Testing
- amoxicillin 500mg and metronidazole 400mg
- Volunteers
- 44 people
- Sponsor
- Taibah University
Chronic Periodontitis
Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis
Periodontal disease is an immune-inflammatory disease which consists of connective tissue breakdown, loss of attachment, and alveolar bone loss.In normal physiology, there is an equilibrium maintained between reactive oxygen…
- Trial name
- NCT03533972
- Testing
- Ashwagandha
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Chronic Periodontitis
Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis
The aim of this study was to compare the clinical and microbiological outcomes of different dosages of metronidazole (MTZ) and of the duration of the systemic administration of MTZ and amoxicillin as adjunct to scaling and root…
- Trial name
- NCT02735395
- Testing
- Scaling and root planing (SRP), Metronidazole 250 (7 days), Metronidazole 400 (7 days)
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- University of Guarulhos
Chronic Periodontitis, Generalized, Moderate
Er:YAG Laser Treatment of Moderate Chronic Periodontitis
The Er:YAG laser possesses specific characteristics allowing to be used in non-surgical periodontal treatment. The aim of the resent study was to evaluate the long-term clinical effectiveness of Er:YAG laser monotherapy in the…
- Trial name
- NCT05217823
- Testing
- Er:YAG laser, hand instruments
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Periodontitis Chronic Generalized Severe
Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis
the aim of this clinical trial is to compare the efficacy of hyaluronic acid (HA) used as an adjunctive to scaling and root planing (SRP) and red injectable platelet rich-fibrin (i-PRF) in the non-surgical treatment of stage III…
- Trial name
- NCT05768243
- Testing
- Hyaluronic acid, red injectable platelet rich fibrin (i-prf)
- Where
- Lebanon
- Volunteers
- 75 people
- Sponsor
- Beirut Arab University