Clinical trials: Generations
Antidepressive Agents, Second-Generation
Antidepressants, Emotions and Personality
Neuroticism is a personality trait described as an enduring tendency to experience negative emotional states and to respond poorly to environmental stress.
- Trial name
- NCT01946607
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Measuring Red Blood Cell Survival After Transfusion
Optimization of Biotinylation Protocol for Studies of Red Blood Cell Survival and Function After Transfusion
The goal of this clinical trial is to compare two methods of labeling red blood cells with biotin. The main question to answer is whether red blood cells labeled 48 hours before transfusion survive as long as red blood cells…
- Trial name
- NCT06788080
- Testing
- BioRBC
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vitalant Research Institute
Coronavirus, SARS-CoV-2 Infection
Next Generation T-cell Vaccine Against Coronavirus Disease (COVID-19)
The study aims to investigate the safety and immunogenicity of one dose vs two doses of a T-cell priming next-generation vaccine against Coronavirus disease.
- Conditions
- Coronavirus, SARS-CoV-2 Infection, COVID-19
- Trial name
- NCT05633446
- Testing
- PepGNP-COVID19 (One vaccination), Water for injection (One vaccination), PepGNP-COVID19 (Two vaccinations)
- Where
- 2 sites in Philippines
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gylden Pharma Ltd
Healthy
A Study to Evaluate the Reactogenicity, Safety, and Immunogenicity of the Third Generation Hepatitis B Vaccine
A single center, randomized, double blinded phase I/IIa exploratory study to evaluate reactogenicity, safety, immunogenicity and dose-response of a new hepatitis B vaccine in human adult
- Trial name
- NCT02692170
- Testing
- CVI-HBV-001, Conventional Hepatitis B vaccine (20 μg)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aribio Lab Co., Ltd.
Chronic Liver Disease (CLD), Healthy Volunteers
Equivalence of New Breath AnalyzerCompared to Currently BreathID System in Assessment of Liver Function
The aim of the study is to confirm that the new generation state of the art breath analyzer gives equivalent results to the previous model of the Exalenz breath analyzer.
- Trial name
- NCT02187601
- Testing
- MPBA System, BreathID
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Meridian Bioscience, Inc.
Hyperlipidemias
Elevated Serum HDL in Four Generations of a Nashville Family
The purpose of this study is to determine the genetic basis of one family's hereditary hyper-HDL-emia using multiple modalities such as linkage analysis and gene array.
- Trial name
- NCT00525109
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Short Stature
The Role of Igf-1 Generation Test in Diagnosis and Treatment of Short Stature
The purpose of the study is to evaluate the predictive value of IGF-1 generation test for growth velocity during GH treatment for 12 months.
- Trial name
- NCT01970800
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Maimonides Medical Center
Aging, Influenza Vaccine
A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults
This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults.
- Conditions
- Aging, Influenza Vaccine, Dendritic Cell, Vaccine Response
- Trial name
- FluVax3 (NCT05518500)
- Testing
- Flu Vaccine (Year 1), Flu Vaccine (Year 2), Flu Vaccine (Year 3)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The Jackson Laboratory
Anterior Mandibular Fracture
Comparing Bone Healing in Jaw Fractures Fixed With Herbert Screws Versus 3D Miniplates
the goal of this clinical trial is to compare two methods of fixing fractures in the front part of the jaw (mandible): second-generation Herbert screws and 3-dimensional miniplates.
- Trial name
- herbert screw (NCT07826416)
- Testing
- headless compression screw, 3D mini plates
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cardiovascular Prevention, Healthy
Connect2Move: Valorization of Natural Cardio Trekking Hiking Trails
Regular exercise improves performance and reduces the risk of cardiovascular disease. Endurance and strength training are therefore forms of therapy with a high level of evidence in the prevention and rehabilitation of…
- Conditions
- Cardiovascular Prevention, Healthy, Healthy Lifestyle
- Trial name
- Connect2Move (NCT05226806)
- Testing
- Measurement of cardiorespiratory performance in 3 different settings, GENERAL CARDIO HIKES AS PART OF GENERAL TOURIST OFFER OF MUNICIPALITIES
- Where
- Germany
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Spinal Infection, Diagnositic Efficacy
Diagnostic Efficacy of Metagenomic Next-generation Sequencing in Patients With Spinal Infections: A Retrospective Study
Comparing the diagnostic efficacy between traditional laboratory methods and second-generation high-throughput sequencing in patients suspected of spinal infections.
- Trial name
- NCT06172153
- Testing
- No interventions
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Healthy
A Study of LY3848575 in Healthy Participants
The main purpose of this study is to evaluate the safety and tolerability of LY3848575 when administered either intravenously or subcutaneously in single ascending or multiple doses in healthy non-Japanese and first generation…
- Trial name
- NCT05727072
- Testing
- LY3848575
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hypoxia, Oxygen Deficiency
Investigation of Hemoglobin Oxygenation With Third Harmonic Generation Microscopy
The specific aims of the project are performing a pre-clinical study on a human model and evaluating the oxygenation and other status of human erythrocytes by spectrally-resolved third harmonic generation (srTHG) microscopy .
- Conditions
- Hypoxia, Oxygen Deficiency, Tumor, Diabetes
- Trial name
- NCT03619356
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Posture Disorders in Children
Posture and Body Composition in Gen Z Adolescent
This study aims to explore the relationship between posture and body composition in adolescents from Generation Z (born between 2002 and 2005). It was conducted as a cross-sectional study at a high school in Ankara, Turkey.
- Trial name
- NCT07124026
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- Ordu University
Healthy
Bioequivalence of Two Different Generations of Drug Product of Dabigatran Etexilate Following Oral Administration in Healthy Male and Female Volunteers
The objective was to demonstrate the bioequivalence of capsules made from 2 different drug product batches. The reference batch was representative of the current commercial drug product and of the pivotal Phase III batches.
- Trial name
- NCT02171520
- Testing
- Dabigatran etexilate generation I, Dabigatran etexilate generation II
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Radiology, Artificial Intellegence
Chest X-Ray Image Diagnosis and Report Generation Dedicated Model Based on Deepseek
The global shortage of radiologists is a pressing issue, particularly in regions with limited medical resources. Against this backdrop, making report generation the core objective of radiology AI systems not only aligns with the…
- Conditions
- Radiology, Artificial Intellegence, Large Language Model, Chest X-ray for Clinical Evaluation
- Trial name
- NCT06874647
- Testing
- AI-generated report for reference
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Retinal Disease, AMD
Cell Collection to Study Eye Diseases
Background: Best Vitelliform Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the retina, the light sensing area at the back of the eye.
- Conditions
- Retinal Disease, AMD, Retinal Degeneration, Retinitis Pigmentosa
- Trial name
- NCT01432847
- Where
- United States
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Chronic Obstructive Pulmonary Disease
A Study to Assess the Total Systemic Exposure Bioequivalence of of Budesonide, Glycopyrronium, and Formoterol Delivered by BGF MDI With Next-Generation Propellant Compared With BGF MDI With HFA Propellant
The study will evaluate bioequivalence, pharmacokinetics, safety, and tolerability of Budesonide, Glycopyrronium and Formoterol (BGF) metered dose inhaler (MDI) formulated with hydrofluoroolefin (HFO) [Test] and hydrofluoroalkane…
- Trial name
- NCT05569421
- Testing
- Treatment A: BGF MDI HFO, Treatment B: BGF MDI HFA
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity
"Generation Fit and Exerlearning With In the Groove"
In middle schools participating in a statewide program called "Take Time", we are randomizing youth to a 10-12 week intervention using the dance mat games on the Playstation2 (like Dance Dance Revolution).
- Trial name
- NCT00424918
- Testing
- Physical Activity, reduced sedentary behavior
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Maternal Depression, Child Development
Building Regulation in Dual Generations - Telehealth Model
Families who experience maternal mental illness and a variety of chronic stressors are currently underserved by the parenting programs.
- Conditions
- Maternal Depression, Child Development, Child Mental Health
- Trial name
- BRIDGE (NCT04639557)
- Testing
- BRIDGE Therapy Program
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba