Clinical trials: Generations
Hepatic Fibrosis
Generation of Organotypic Liver Cultures for the Identification of Biomarkers for the Prevention and Treatment of Liver Fibrosis
Low-level, interventional, biological and non-pharmacological study prospective intervention for the preparation of organotypic human liver slice cultures Liver Slice Culture (hLSC) applying the protocol described by Jiang and…
- Trial name
- NCT06252272
- Testing
- Biopsy from patients undergoing surgery abdominal.
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Alzheimer Disease
Next-Generation alzheImer'S Therapeutics
Is this the right time to use next-generation approaches in Alzheimer's disease (AD)? In recent years, several large clinical trials testing treatments for AD have failed, putting the entire field on a reset.
- Trial name
- ENERGISE (NCT06372587)
- Testing
- genetically encoded engineered proteins
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Tourette Syndrome
Study of GABA-A Receptors in the Generation of Tics in Patients With Tourette's Syndrome
This study will investigate how the brain generates tics in patients with Tourette's syndrome and which areas of the brain are primarily affected.
- Trial name
- NCT00034398
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tuberculosis
Evaluation of the QuantiFERON-TB Test.
To compare the results of the investigational test to the currently approved QuantiFERON-TB Gold In-Tube test.
- Trial name
- NCT02256839
- Testing
- CST_001
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- QIAGEN Gaithersburg, Inc
Pregnancy Early, Outcome, Adverse Birth
Generation R Next - Optimaal Opgroeien
The aim of this randomized controlled trial is to improve birth outcomes and long-term outcomes in mother and child by optimizing lifestyle,nutrition and stress experience in the preconception period and early pregnancy in women…
- Conditions
- Pregnancy Early, Outcome, Adverse Birth, Lifestyle Factors, Preconception Care
- Trial name
- NCT05870878
- Testing
- Standard care, Lifestyle program
- Where
- Netherlands
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Mild Concussion, Healthy Volunteers
A New Generation of Magnetoencephalographs for High Speed Functional Brain Imaging
The goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography whole head device using optically pumped magnetometers using Helium 4 as the sensitive element (OPM He4) to…
- Trial name
- DEMAGUS (NCT06244472)
- Testing
- Experiment 1: visual and auditory attention task, Experiment 2: language production and rest tasks, Experiment 3: visuo-motor task
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Primary Care
Relisten: Enhancing Care Quality and Saving Time With Automatic Clinical Note Generation in Primary Care
Background: Relisten is an artificial intelligence-based software developed by Recog Analytics that improves patient care by facilitating more natural interactions between healthcare professionals and patients.
- Trial name
- Relisten (NCT06618092)
- Testing
- Relisten
- Where
- 6 sites in Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Pancreatic Cancer Stage I, Pancreatic Cancer Stage II
Clinical Validation of Immunovia Next-Generation Blood Biomarker Test to Detect Early-Stage Pancreatic Cancer
This is a case-control study to clinically validate the performance of a protein biomarker test to differentiate Stage I and Stage II pancreatic ductal adenocarcinoma (PDAC) patient samples from samples acquired from control…
- Conditions
- Pancreatic Cancer Stage I, Pancreatic Cancer Stage II, Cancer Diagnosis, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- CLARITI (NCT06947382)
- Where
- 15 sites in United States, Canada and 2 more
- Volunteers
- 1,066 people, healthy volunteers welcome
- Sponsor
- Immunovia, Inc.
Adolescence, Adolescent
Screen Culture's Impact on Generation Z Adolescents' Physical Activity, Posture and Well-being in Egypt
Ubiquitous adoption of screen-based technologies has transformed the behavioral and physiological environment of Generation Z youth.
- Conditions
- Adolescence, Adolescent, Well Being, Posture
- Trial name
- NCT07247305
- Testing
- BMI Measurement, Screen Time Questionnaire (QUEST), Insomnia Severity Index (ISI)
- Where
- Egypt
- Volunteers
- 532 people, healthy volunteers welcome
- Sponsor
- Sinai University
Epithelium, Corneal
Comparison of the Effect of 4th Generation Fluoroquinolones, Gatifloxacin and Moxifloxacin, on Epithelial Healing Following Photorefractive Keratectomy (PRK), A Substudy of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)
The purpose of this study is a prospective,double-blinded, randomized trial to compare the rate of healing following PRK after the use of two commercially available 4th generation fluoroquinolones, moxifloxacin and gatifloxacin.
- Trial name
- NCT00414011
- Testing
- Moxifloxacin, Gatifloxacin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
COVID-19
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
This phase 1 randomized, open-label, dose-escalation clinical trial evaluates the safety and immunogenicity of OCU500, a ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine, in healthy adults aged 18-64 who previously completed a…
- Trial name
- NCT07536308
- Testing
- OCU500
- Where
- 6 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bioelectrical Impedance Measurement of Healthy Adults
Generation of Prediction Equations to Analyze Body Composition of Adults Based on Bioelectrical Impedance Analysis (BIA)
Aim of the study is to develop prediction equations for calculating FFM, TBW, ECW and SMM based on the gold standard reference methods ADP, DXA, MRI, D2O and NaBr on the one hand and measurement data of the BIA devices on the…
- Trial name
- NCT01368640
- Where
- Germany
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Seca GmbH & Co. Kg.
Contraception
A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012)
The primary objective of this trial was to identify at least one next generation ring (NGR) that demonstrates inhibition of ovulation (which was considered confirmed if in the subset of participants ovulation was observed in less…
- Trial name
- NCT01709318
- Testing
- Nomegestrol acetate (NOMAC), Etonogestrel (ENG), Ethinyl estradiol (EE)
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Dentin Hypersensitivity
Efficacy of Seventh Generation Bonding Agents as Short-Term Desensitizers Among Patients With Hypersensitivity
The world lacks a gold standard treatment for treating dentin hypersensitivity. Fluoride varnish is most commonly used as a treatment but it causes temporary discoloration of tooth structure and may cause irritation or burning of…
- Trial name
- NCT04225247
- Testing
- Single Bond Universal, Bifluorid 12, Xeno V+
- Where
- Pakistan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Covid19
COVID-19 Oral and Subcutaneous Vaccination Using a 2nd Generation (E1/E2B/E3-Deleted) Adenovirus Platform in Healthy Volunteers in USA
This is a phase 1b, open-label study in adult healthy subjects. This clinical trial is designed to assess the safety, reactogenicity, and immunogenicity the combination of hAd5-S-Fusion+N-ETSD (Suspension for injection) and…
- Trial name
- NCT04732468
- Testing
- hAd5-S-Fusion+N-ETSD (Suspension for injection), hAd5-SFusion+ N-ETSD (Oral capsule)
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- ImmunityBio, Inc.
T2DM (Type 2 Diabetes Mellitus), Diet, Healthy
Substitution of Sulfonylureas With New Generation of Hypoglycemic Drugs for the Treatment of Type 2 Diabetes Mellitus
This is a multicentric, prospective, parallel groups study. Patient recruitment will be carried out at the U.O. Departmental Endocrinology and Diabetology ASST FBF Sacco, Fatebenefratelli and Ophthalmic Hospital, and at the SSD…
- Conditions
- T2DM (Type 2 Diabetes Mellitus), Diet, Healthy, Renal Function Disorder, Albuminuria
- Trial name
- Sulfa-Zero (NCT04272359)
- Testing
- Sulfa-zero: possible benefits of the treatment of new generation hypoglycaemic drugs compared to sulphonylureas
- Where
- Italy
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Milan
Child Maltreatment, Trauma
PRESERVE & CONNECT: Impact Study of the BPC
The PRESERVE \& CONNECT project is a multi-site randomized control trial of the Breakthrough Parenting Curriculum: Navigating Trauma Across Generations (BPC) in rural and racially and ethnically diverse communities in Vermont and…
- Trial name
- (BPC) (NCT06160050)
- Testing
- Breakthrough Parenting Curriculum: Transforming trauma across generations
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Vermont
COVID-19
COVID-19 Vaccination Using a 2nd Generation (E1/E2B/E3-Deleted) Adenoviral-COVID-19 in Normal Healthy Volunteers
This is a phase 1b, open-label study in adult healthy subjects. This clinical trial is designed to assess the safety, reactogenicity, and immunogenicity of the hAd5-S-Fusion+N-ETSD vaccine and select a dose for future studies.
- Trial name
- NCT04591717
- Testing
- hAd5-S-Fusion+N-ETSD vaccine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- ImmunityBio, Inc.
Eye Diseases
Pix2pix Networks for Scheimpflug Corneal Tomography Image Generation
Computer-aided medical image analysis has advantages, but requires large amounts of training data, which are scarce and costly to obtain, are subject to privacy concerns, and are often highly imbalanced, with over-representation…
- Trial name
- NCT04582253
- Testing
- Scheimpflug Camera Corneal Tomography
- Where
- Egypt
- Volunteers
- 923 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dental Implant Healing, Partial Edentulism Class 1
Internal Irrigation Surgery
Heat generated during osteotomy and implant placement may cause thermal injury to bone and adversely affect healing and osseointegration.
- Conditions
- Dental Implant Healing, Partial Edentulism Class 1, Partial Edentulism Class II, Partial Edentulism Class 3
- Trial name
- NCT07715825
- Testing
- Irrigation-Integrated Surgical Guide, Conventional Surgical Guide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore