Clinical trials: Generations
Supraglottic Airway Device
Optimizing Third-Generation Video Laryngeal Mask Position: SaCoVLM™ vs. Fiberoptic Bronchoscope
This study aims to compare the effectiveness of SaCoVLM™ in artificial airway ventilation during general anesthesia, focusing on the correlation between native video camera imaging and fiberoptic endoscopy.
- Trial name
- NCT06750926
- Testing
- video image through laryngeal mask specific channel
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Fall Prevention in Healthy Aging
Bridging Generations: Educating Children on Dementia and Fall Prevention Through Animation
A retrospective data review was conducted on a case-control trial involving 60 children (29 boys, 31 girls) as part of a public education initiative hosted on the web-based platform "Hand in Hand Across Barriers - Public…
- Trial name
- fall (NCT07000370)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Periodontitis, Peri-implant Mucositis
Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
This prospective parallel, double-blind, four-arm randomised controlled clinical study is planned to assess the difference in the level of the inflammatory biomarkers expressed following the placement of the first dental implant…
- Conditions
- Periodontitis, Peri-implant Mucositis, Peri-Implantitis
- Trial name
- NCT05834946
- Testing
- Megagen implant placement, Biomate-Swiss implant
- Where
- Malaysia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Malaya
T2DM (Type 2 Diabetes Mellitus), Diet, Healthy
Substitution of Sulfonylureas With New Generation of Hypoglycemic Drugs for the Treatment of Type 2 Diabetes Mellitus
This is a multicentric, prospective, parallel groups study. Patient recruitment will be carried out at the U.O. Departmental Endocrinology and Diabetology ASST FBF Sacco, Fatebenefratelli and Ophthalmic Hospital, and at the SSD…
- Conditions
- T2DM (Type 2 Diabetes Mellitus), Diet, Healthy, Renal Function Disorder, Albuminuria
- Trial name
- Sulfa-Zero (NCT04272359)
- Testing
- Sulfa-zero: possible benefits of the treatment of new generation hypoglycaemic drugs compared to sulphonylureas
- Where
- Italy
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Milan
Hepatic Fibrosis
Generation of Organotypic Liver Cultures for the Identification of Biomarkers for the Prevention and Treatment of Liver Fibrosis
Low-level, interventional, biological and non-pharmacological study prospective intervention for the preparation of organotypic human liver slice cultures Liver Slice Culture (hLSC) applying the protocol described by Jiang and…
- Trial name
- NCT06252272
- Testing
- Biopsy from patients undergoing surgery abdominal.
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Periodontal Diseases
Treatment of Periodontal Intrabony Defects With A-PRF or OFD
The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) toped flap debridement (OFD) in periodontitis patients.
- Trial name
- NCT04823572
- Testing
- A-PRF/OFD
- Where
- Hungary
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Unexplained Stillbirth
Low Molecular Weight Heparin in Pregnancies With Unexplained Stillbirths
Bemiparin for pregnant women with abnormal umbilical artery Doppler ultrasound
- Trial name
- NCT03601338
- Testing
- Bemiparin, multivitamins and routine antenatal follow up
- Where
- Iraq
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
COVID -19
A Safety, Reactogenicity and Immunogenicity Trial of RVX-sCPD9 Booster Intranasal COVID-19 Vaccine
This phase 1 clinical trial will evaluate the safety, reactogenicity, and immunogenicity of RVX-sCPD9, given Intranasally (IN), as a booster dose to previously vaccinated healthy adults.
- Trial name
- NCT07703475
- Testing
- RVX-sCPD9
- Where
- 4 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Whole Genome Sequencing
Ultra Rapid GEnome Sequencing
Next-generation sequencing (NGS) has revolutionized the field of genomics, allowing the detection of genetic abnormalities for diagnostic or therapeutic purposes.
- Trial name
- URGES (NCT06555731)
- Testing
- Ultra rapid genome sequencing
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- CMC Ambroise Paré
Lymphangioleiomyomatosis (LAM), Extracellular Vesicles; Generation and Function
Role of Extracellular Vesicles as Biomarkers of Pulmonary Involvement in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex
Lymphangioleiomyomatosis (LAM) is a rare lung disease, linked to Tuberous Sclerosis Complex (TSC) or occurring sporadically, and involves abnormal mTORC1 activation.
- Trial name
- NCT07304856
- Testing
- Pulmonary Function Test, Analysis of Extracellular Vesicles
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Milan
Heart Failure
Influence of Edoxaban on Coagulability and Thrombin Generation: An in Vitro Study Focusing on Thrombelastography
The influence of different doses of edoxaban on physical characteristics of the clot and thrombin generation kinetics in blood samples will be studied by in vitro spiking of blood samples collected from patients treated for heart…
- Trial name
- NCT02448901
- Testing
- Edoxaban
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Vancomycin-Resistant Enterococci, Probiotics
Investigation of the Optimal Cocktailed Probiotics for Decolonization of Vancomycin-resistant Enterococci in Human Gut
Vancomycin-resistant enterococci (VRE) has been a serious public health issue as an opportunistic pathogen and reservoir of antibiotic resistant genes.
- Trial name
- NCT03822819
- Testing
- probiotic cocktail capsules
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Child Maltreatment, Trauma
PRESERVE & CONNECT: Impact Study of the BPC
The PRESERVE \& CONNECT project is a multi-site randomized control trial of the Breakthrough Parenting Curriculum: Navigating Trauma Across Generations (BPC) in rural and racially and ethnically diverse communities in Vermont and…
- Trial name
- (BPC) (NCT06160050)
- Testing
- Breakthrough Parenting Curriculum: Transforming trauma across generations
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis
Glucagon Resistance in Patients With NAFLD
The investigators propose that the sensitivity to glucagon in hepatic lipid metabolism is impaired in subjects with non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH).
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis, Glucose Metabolism Disorders
- Trial name
- NCT04042142
- Testing
- glucagon
- Where
- Denmark
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
HIV/AIDS, Adherence
Monitoring Pre-exposure Prophylaxis for Young Adult Women
Next generation real-time monitoring for PrEP adherence in young Kenyan women
- Trial name
- MPYA (NCT02915367)
- Testing
- SMS Reminders
- Where
- 2 sites in Kenya
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Normal Subject, Patient With Pharmaco-resistant Epilepsy
Helium 4 Optically Pumped Magnetometers : a New Generation of Sensors for High Speed Functional Brain Imaging
Our goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography sensors (OPM He4) to record brain magnetic activities.
- Trial name
- NEW MEG (NCT04615637)
- Testing
- MEG recordings
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Sudden Infant Death
Generations in Families Talking Safe Sleep
Teen mothers present a unique set of challenges in reducing the risk for sleep-related infant mortality, in part because they may not be the sole decision-maker for an infant's sleep environment and position and they make seek…
- Trial name
- GIFTSS (NCT03186469)
- Testing
- Safety Baby shower, Standard of Care
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Cystic Fibrosis
Perceptions of the CF Screening Protocol Incorporating NGS
Newborn bloodspot screening (from now on referred to as screening) for cystic fibrosis (CF) became part of the national screening programme in 2007. Screening for CF is also well established internationally.
- Trial name
- NCT06299566
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- King's College London
Hypoxia, Oxygen Deficiency
Investigation of Hemoglobin Oxygenation With Third Harmonic Generation Microscopy
The specific aims of the project are performing a pre-clinical study on a human model and evaluating the oxygenation and other status of human erythrocytes by spectrally-resolved third harmonic generation (srTHG) microscopy .
- Conditions
- Hypoxia, Oxygen Deficiency, Tumor, Diabetes
- Trial name
- NCT03619356
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
COVID-19
Safety and Immunogenicity Trial of MPV/S-2P SARS-CoV-2 Vaccine in Adults
A clinical trial to evaluate the safety, reactogenicity, and immunogenicity of MPV/S-2P administered intranasally to adults who have previously received a primary series and at least one booster with an authorized or licensed…
- Trial name
- NCT06441968
- Testing
- MPV/S-2P
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)