Clinical trials: Generations
Pacing Leads Implantation
An Observational Study on the Sorin Group New Brady Leads XFine and Beflex
This observational study is a non-interventional multi-centre, prospective study. The aim of the study is to evaluate the Sorin Group new passive- and active- fixation pacing leads.
- Trial name
- XFine & Beflex (NCT01168518)
- Where
- France
- Volunteers
- 2,254 people
- Sponsor
- LivaNova
Cancer
EQUIP - Evaluation of Quality of Imaging on a Next-generation Total Body Pet Scan in Comparison to Conventional PET
The GE Healthcare Omni Total Body (TB) 128cms (Omni TB) is a long-axial field-of-view (LAFOV) PET/CT scanner and will be installed in a pre-market phase at the Peter MacCallum Cancer Centre.
- Trial name
- EQUIP (NCT07263815)
- Testing
- PET
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Metastatic Prostate Cancer
Study of 18F-DCFPyL, a Second Generation Low-molecular Weight PSMA-based PET Radiotracer, in Patients With Prostate Cancer
This study is being done to determine the safety, biodistribution, and radiation dosimetry of 18F-DCFPyL, and to detect prostate cancer by visual analysis.
- Trial name
- NCT02151760
- Testing
- 18F-DCFPyL
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Liver Cirrhosis
DOAC in Patients with Child a or B Liver Cirrhosis
The goal of this clinical trial is to investigate pharmacokinetics and pharmacodynamics of direct oral anticoagulant drugs (DOAC), specifically apixaban and edoxaban, in patients with Child A or B liver cirrhosis (LC).
- Trial name
- CIRROAC (NCT05869591)
- Testing
- Apixaban 5 MG [Eliquis], Edoxaban 60 MG [Lixiana]
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Lymphoma, Multiple Myeloma
Effects of Anticoagulant Preventive Injection in Patients With Blood Cancer
In cancer, the incidence of venous thromboembolism (VTE) is particularly high in patients with myeloma, especially when it is de novo and treated with thalidomide, lenalidomide or erythropoietin.
- Trial name
- METRO B (NCT02260414)
- Testing
- Tinzaparin, Blood sample
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Head Neck Cancer, Oral Cancer
Newer Therapeutic Targets in Head and Neck Cancers
Based on the recently identified mutations in HNSCCs, the major pathologic pathways implicated in the tumorigenesis of HNSCC include dysregulation of four processes: 1.
- Trial name
- NCT05382585
- Testing
- Next generation Sequencing
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Banaras Hindu University
Epidermolysis Bullosa Dystrophica
Proof of Concept Study for a Dressing Glove
Epidermolysis Bullosa (EB) is a group of genetic conditions causing extensive, painful skin blisters and wounds. Four main types of EB are recognised, which all affect the hands but those patients usually requiring hand therapy…
- Trial name
- NCT03241628
- Testing
- Dressing Glove
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Lymphoblastic Leukemia, Adult B-Cell, Chronic Lymphocytic Leukemia
The clonoSEQ® Watch Registry
This is a prospective, multicenter, observational study of adult patients with a diagnosis of acute lymphoblastic leukemia (ALL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), or non-Hodgkin lymphoma (NHL).
- Conditions
- Acute Lymphoblastic Leukemia, Adult B-Cell, Chronic Lymphocytic Leukemia, Multiple Myeloma, Non-hodgkin Lymphoma
- Trial name
- NCT04545333
- Testing
- clonoSEQ Assay
- Where
- 14 sites in United States
- Volunteers
- 465 people
- Sponsor
- Adaptive Biotechnologies
Aortic Stenosis
SecOnd-generation seLf-expandable Versus Balloon-expandable Valves and gEneral Versus Local Anesthesia in TAVI
Aim of the study is to demonstrate equivalence of second-generation self-expandable valves (CoreValve Evolut R) in comparison to second-generation balloon-expandable valves (Edwards Sapien 3) and of local anesthesia with…
- Trial name
- SOLVE-TAVI (NCT02737150)
- Testing
- CoreValve Evolut R, Edwards Sapien 3, Local anesthesia with conscious sedation
- Where
- Germany
- Volunteers
- 444 people
- Sponsor
- Helios Health Institute GmbH
Endometriosis, Adenomyosis
Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis
This study is a multicentric, observational, case-control, non-profit with additional procedures. It aims to deepen the understanding of the chronic gynecological conditions of endometriosis and adenomyosis, which significantly…
- Trial name
- AdEnd (NCT06572852)
- Testing
- No intervention
- Where
- 2 sites in Italy
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Breast Cancer, Ovarian Cancer
Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary Presentation
Despite relevant clinical and/or familial presentations suggesting a hereditary predisposition (early-onset, multiple primary tumors, familial aggregation), targeted genomic analysis based on the phenotype are often non…
- Conditions
- Breast Cancer, Ovarian Cancer, Colorectal Cancer, Pediatric Cancers
- Trial name
- PANEL (NCT02664389)
- Testing
- Genetic analysis
- Where
- France
- Volunteers
- 289 people
- Sponsor
- University Hospital, Rouen
NSCLC (Advanced Non-small Cell Lung Cancer), Brain Metastasases
AI-guided Prognostication and Cranial Radiotherapy Optimization in EGFR-TKI-treated Non-small Cell Lung Cancer Patients With Baseline Brain Metastases
The goal of this observational study is to extract the imaging features of brain lesions and primary lung lesions in NSCLC patients with brain metastases by deep learning, as well as common clinicopathological parameters, which…
- Trial name
- NCT06604689
- Testing
- third-generation EGFR TKIs (Almonertinib/Furmonertinib/Osimertinib)
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Fudan University
Cognition Disorders, Depression
Well-Being in Medical Residents in the HIBA
It is necessary and important to design tools to evaluate a central aspect of medical residents formation. The research group has been working with resident well-being since a few years in order to improve the global quality of…
- Conditions
- Cognition Disorders, Depression, Anxiety, Shift-Work Sleep Disorder
- Trial name
- NCT03087435
- Testing
- Well-Being questionnaire
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Depression, Child Development
Building Regulations in Dual Generations at KIDTHINK
Neurodevelopmental disorders (NDDs) such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID) are the most frequently diagnosed disability in children, accounting…
- Conditions
- Depression, Child Development, Self-regulation
- Trial name
- NCT04893850
- Testing
- BRIDGE Therapy Program, Community Services as Usual Clinical Referral list
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hypo or Hyperthyroidism
Thyroid Uptake Quantification Validation on a Three-dimensional (3D) Cadmium-Zinc-Telluride (CZT) New Generation Gamma Camera
Thyroid scintigraphy using technetium-99m (99mTc) pertechnetate is traditionally performed using planar imaging to estimate thyroid uptake.
- Trial name
- QThy2Dvc3D (NCT07610460)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Princesse Grace
Non Small Cell Lung Cancer
Liquid Biopsy as a Tool to Evaluate Resistance to First and Third (AZD9291) (EGFR) (TKIs) in (EGFR) Mutant NSCLC
Based on the possibilities that both plasma and circulating tumor cells (CTCs) (the "liquid biopsy") may offer, we consider that it could be feasible to longitudinally monitor the genetic evolution and the biologic…
- Trial name
- NCT02771314
- Testing
- AZD9291
- Where
- 13 sites in Greece
- Volunteers
- 48 people
- Sponsor
- Hellenic Oncology Research Group
Autoimmune Uveitis, Behçet Disease
Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease
This study aimed to discover the composition on the microbiome in several sites of the human body; and to find out the difference in microbiome composition on ocular fluid, blood, and feces before and after therapy in uveitis…
- Conditions
- Autoimmune Uveitis, Behçet Disease, Vogt-Koyanagi-Harada Disease, Idiopathic Uveitis
- Trial name
- NCT04126850
- Where
- Indonesia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Gastrointestinal Cancer
Next-generation Sequencing in Gastrointestinal Cancer
Liquid biopsy has been successfully applied to the treatment and diagnosis of cancer. cfDNA has been paid more and more attention in liquid biopsy.
- Trial name
- NCT03476057
- Testing
- Device： NGS sequencing cfDNA
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fujian Cancer Hospital
Obesity
Intestinal Microbiota in Patients Before and After Bariatric Surgery and Healthy Controls
Studying obesity and metabolic syndrome attention is focused more and more on gut microbiota. In humans and animals, bariatric surgery (mainly gastric bypass surgery) lead to alterations of gut microbiota, which seem to be…
- Trial name
- NCT02563119
- Testing
- Gastric Bypass or Sleeve gastrectomy
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Thrombocytopenia, Antibodies Drug Specific
Immunogenicity and Thrombotic Potential of Circulating Protamine-heparin Complexes in Cardiac Surgery Patients
The primary aim of this study was to describe the prevalence and time course of the occurrence of protamine/heparin antibodies in patients undergoing cardiac surgery on cardiopulmonary bypass.
- Trial name
- NCT06565364
- Testing
- "ZYMUTEST™ HIA" immunoglobulin g ELISA (enzyme-linked immunosorbent assay )
- Where
- Austria
- Volunteers
- 160 people
- Sponsor
- Medical University of Vienna
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