Clinical trials: Generations
Malignant Female Reproductive System Neoplasm, Metastatic Malignant Female Reproductive System Neoplasm
Influencing Next-Generation Oncologic Outcomes Through Rapid Integration of Functional Precision Medicine (NOORI): A Feasibility Study of SmartMatch in Rare Gynecologic Cancers
This study is being done to determine how easy it is to use standard of care (SOC) surgical resections or biopsy for SmartMatch analysis to determine treatment options in advanced gynecological malignancies.
- Conditions
- Malignant Female Reproductive System Neoplasm, Metastatic Malignant Female Reproductive System Neoplasm, Unresectable Malignant Female Reproductive System Neoplasm
- Trial name
- NCT07731880
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center
Breast Cancer, Lung Cancer
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation
Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma
- Trial name
- OCTANE (NCT02906943)
- Where
- 7 sites in Canada
- Volunteers
- 10,000 people
- Sponsor
- University Health Network, Toronto
Neurodevelopmental Disorder (Diagnosis)
Optical Genome Mapping for the Diagnosis of Neurodevelopmental Disorders
to evaluate the ability of the Optical genome Mapping (OGM) approach to detect simple and complex constitutional chromosomal aberrations of clinical relevance, which had previously been identified with standard diagnostic…
- Trial name
- NCT06347562
- Testing
- Optical Genome Mapping
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- IRCCS Eugenio Medea
Dry Eye
An Observational Study to Assess Next Generation Emulsion Preservative Free Eye Drops (NGE-UD) on Dry Eye Symptoms and Quality of Life of Adult Participants With Mild to Moderate Dry Eye Disease (DED)
Dry Eye Disease (DED) is a condition where the tear film of the eye becomes unstable and along with ocular surface inflammation and damage leads to inadequate tear production and eye lubrication.
- Trial name
- NCT06443775
- Testing
- Next Generation Emulsion Preservative Free Eye Drops (NGE-UD)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- AbbVie
ST Elevation Myocardial Infarction
3 Months Versus 12 Months Dual Antiplatelet Therapy After Drug-eluting Stent Implantation in STEMI
To compare the clinical outcomes of dual antiplatelet therapy with aspirin and P2Y12 receptor inhibitor vs. ticagrelor monotherapy at 3 months after PCI in patients with ST-elevation myocardial infarction.
- Trial name
- BULK-STEMI (NCT04570345)
- Testing
- ticagrelor monotherapy, Aspirin with P2Y12 receptor inhibitor
- Where
- South Korea
- Volunteers
- 1,002 people
- Sponsor
- Dong-A University
Adenocarcinoma of Lung Stage IIIB, Adenocarcinoma of Lung Stage IV
NOV120101 (Poziotinib) for 1st Line Monotherapy in Patients With Lung Adenocarcinoma
The purpose of this open-label, single-arm, multi-center phase II trial is to evaluate the efficacy and safety of novel pan-HER inhibitor, NOV120101 (Poziotinib), as a first-line monotherapeutic agent in patients with lung…
- Trial name
- NCT01819428
- Testing
- NOV120101 (Poziotinib)
- Where
- 6 sites in South Korea
- Volunteers
- 22 people
- Sponsor
- National OncoVenture
Refractory Solid Tumors, Next Generation Sequencing
MyCustom:Prospective Master Protocol Trial on Precision Medicine Treatment for Refractory Solid Tumors
The MyCustom study is a investigator initiated trial(IIT), prospective real-world clinical research project, a genetic biomarker-driven "basket" (tissue-type agonistic) study.
- Trial name
- NCT06030869
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tianjin Medical University Second Hospital
Pancreas Cancer, Pancreas Neoplasm
Patient-derived Organoids Drug Screen in Pancreatic Cancer
Few chemotherapeutic options exist for pancreatic cancer. Moreover, objective criteria are lacking for deciding which regimen is more beneficial for patient presenting with metastases at diagnosis.
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Adenocarcinoma, Pancreatic Cancer
- Trial name
- NCT05351983
- Testing
- Surgical biopsy of tumoral tissue for organoid generation
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. med. Dres. h.c. Jan Schmidt, MME
Loosening, Prosthesis
Identification of Infections in Hip Arthroplasty Loosening.
Recent data showed that the rate of periprosthetic infections in patients undergoing a hip arthroplasty revision for aseptic loosening is higher than what can be ascertained with conventional methods.
- Trial name
- NCT04773054
- Testing
- Microbiological analysis of periprosthetic tissue, Histological analysis of periprosthetic tissue, Characterization of tissue microbiota
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- Istituto Ortopedico Rizzoli
HIV Associated HCV
Analysis of the Impact of HCV Treatment by Last Generation Direct Antiviral Agents (DAA) on Antiviral Immunity and HIV DNA Reservoir in Coinfected HIV-HCV Patients
Spontaneous recovery of patients infected with HCV is related to the development of a cytotoxic immune response that is executed by specialized white blood cells, the CD8+ T cells, which develop a virus-specific response.
- Trial name
- HCURE (NCT03244371)
- Testing
- blood draw
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cataract
Next Generation Cataract Surgery Study
The purpose of this study is to obtain device-specific safety and performance clinical data to support marketability in Europe and to collect user preference data.
- Trial name
- NCT06071104
- Testing
- Anterior segment ophthalmic surgery, UNITY VCS
- Where
- 4 sites in United States
- Volunteers
- 121 people
- Sponsor
- Alcon Research
Metastatic Colorectal Cancer
Technical Optimization of Detection of KRAS, BRAF and NRAS Mutations on Tumor DNA Circulating in Metastatic Colorectal Cancer
The objective of this study is to optimize the search by next-generation sequencing (NGS) mutations in the KRAS, BRAF and NRAS on circulating tumor DNA and compare the genetic profiles obtained with those from tumors embedded in…
- Trial name
- CircuLOR-1 (NCT02827565)
- Testing
- KRAS, NRAS et BRAF mutation analysis from circulating plasma DNA
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut de Cancérologie de Lorraine
Carcinoma, Non-Small-Cell Lung
JIN-A02 Plus Amivantamab in EGFR-Mutant NSCLC After Third-Generation EGFR-TKI Failure
This Phase 1 study will evaluate the safety, maximum tolerated dose, recommended Phase 2 dose, and preliminary antitumor activity of JIN-A02 in combination with amivantamab in participants with advanced EGFR-mutant non-small cell…
- Trial name
- NCT07798921
- Testing
- JIN-A02 in Combination with Amivantamab
- Volunteers
- 36 people
- Sponsor
- Yonsei University
Non-small Cell Lung Cancer
Gumarontinib Combined With 3rd EGFR-TKI in Patients With Non-small Cell Lung Cancer.
This study evaluated the efficacy and safety of gumarontinib combined with third-generation EGFR-TKI in the treatment of locally advanced or metastatic NSCLC with MET amplification after first-line EGFR-TKI failure, without…
- Trial name
- NCT06452433
- Testing
- gumarontinib, third-generation EGFR-TKI (Osimertinib, Almonertinib or Furmonertinib)
- Volunteers
- 91 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Non-Small Cell Lung Carcinoma
Afatinib and Necitumumab in Patients With EGFR Mutation Positive Advanced or Metastatic Non-small Cell Lung Cancer
This phase I trial studies the side effects and best dose of afatinib and necitumumab and to see how well they work in treating patients with EGFR mutation positive non-small cell lung cancer that has spread to other places in…
- Trial name
- NCT03054038
- Testing
- Afatinib, Necitumumab, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Primary Open Angle Glaucoma (POAG)
iStent Inject in OAG Subjects on 2 Pre-op Topical Ocular Hypotensive Medications
The purpose of this study is to evaluate the intraocular pressure (IOP) lowering effect of iStent inject in eyes of subjects with primary open-angle glaucoma previously on two anti-glaucoma medications.
- Trial name
- NCT03478293
- Testing
- iStent inject surgery
- Where
- Brazil
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Primary Open Angle Glaucoma
Phase I Dose Escalation Study to Investigate the Safety of ISTH0036 in Subjects With Glaucoma Undergoing Trabeculectomy
This study evaluates the addition of ISTH0036, an antisense oligonucleotide against TGF-β2, to glaucoma filtration surgery (trabeculectomy).
- Trial name
- NCT02406833
- Testing
- TGF-β2 antisense oligonucleotide, Trabeculectomy
- Where
- 3 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Isarna Therapeutics GmbH
EGFR Positive Non-small Cell Lung Cancer
Retreatment With Epidermal Growth Factor Receptor(EGFR) Tyrosine Kinase Inhibitor in EGFR Mutation Positive Patients
In this trial, treatment efficacy and safety of retreatment with 1st generation epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI)s(Gefitinib/Erlotinib), will be assessed in patients with sensitizing EGFR…
- Trial name
- NCT03382795
- Testing
- EGFR
- Where
- 8 sites in South Korea
- Volunteers
- 63 people
- Sponsor
- Korea University Guro Hospital
Hypothyroidism
Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit
This is a Phase 4, single-center, open-label, interventional study, wherein all enrolled subjects will be tested for Thyroid Stimulating Hormone (TSH) by using the quantitative and the qualitative Point-of-Care (POC) TSH test…
- Trial name
- NCT01921452
- Testing
- Quantitative POC TSH Kit, Qualitative POC TSH Kit, Third generation TSH Kit
- Where
- China
- Volunteers
- 283 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Unipolar Major Depressive Episode
Strategic Use of New Generation Antidepressants for Depression
The purpose of the study is to establish the optimum treatment strategy for first-line and second-line antidepressants in the acute phase treatment of major depression.
- Trial name
- SUN(^_^)D (NCT01109693)
- Testing
- Sertraline, Mirtazapine
- Where
- 2 sites in Japan
- Volunteers
- 2,011 people
- Sponsor
- Kyoto University
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