Clinical trials: Generations
Death
Multicenter Study of Generation Comorbidity Score
The purpose of the study is to generate and valid a co-morbidity score with updated definitions and suitable for use in Argentina in both public and private settings.
- Trial name
- NCT01346111
- Where
- 5 sites in Argentina
- Volunteers
- 2,640 people
- Sponsor
- Hospital Italiano de Buenos Aires
Glaucoma, Open-Angle
A Prospective Evaluation of Glaucoma Subjects Treated With Two Second Generation iStents and One iStent Supra
Prospective Evaluation of Open-Angle Glaucoma Subjects treated with two second generation iStents and one iStent Supra
- Trial name
- GCF-041 (NCT03255798)
- Testing
- G2 and G3
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Glaukos Corporation
NSCLC, Adjuvant Drug Therapy
Sequential Chemotherapy With Befotertinib in Non-Small Cell Lung Cancer (NSCLC) Patients With Resistance to Third-Generation EGFR-TKI
Non-small cell lung cancer (NSCLC) accounts for over 85% of lung cancers. Approximately 30-40% of East Asian adenocarcinoma patients harbor EGFR mutations.
- Conditions
- NSCLC, Adjuvant Drug Therapy, EGFR
- Trial name
- NCT07181499
- Testing
- Befotertinib, Pemetrexed + Carboplatin
- Where
- 2 sites in China
- Volunteers
- 28 people
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
Parenting, Early Child Development
Family and Childhood Development: The Next Generation ('Kizazi Kijacho')
Digital solutions can significantly improve the delivery of Early Childhood Development (ECD) services in Low- and Middle-Income Countries (LMICs).
- Trial name
- NCT05598970
- Testing
- Digital application supported CHW Parenting Intervention, Unconditional Cash Transfer only Intervention fixed amount, Unconditional Cash Transfer Intervention
- Where
- Tanzania
- Volunteers
- 3,585 people, healthy volunteers welcome
- Sponsor
- Stockholm University
Heavy, Bad Odour From Armpit
Microbial Community Transplantation on the Armpit.
The malodour generation of a person's armpit is caused by the bacteria thriving on that armpit. In order to alter or reduce once bad body odour, the living microbial community on the armpit of a non-malodorous person will be…
- Trial name
- NCT01944566
- Testing
- Microbial transplant
- Where
- 2 sites in Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Ghent
Peripheral T Cell Lymphoma
Circulating Tumor DNA Sequencing in Patients With Peripheral T-cell Lymphomas
The purpose of this study is to assess the feasibility of analyzing circulating tumor DNA (ctDNA) as a biomarker using the shallow whole genome sequencing (lpWGS) technique coupled with deep sequencing of a targeted panel of…
- Trial name
- PTCL-SEQ (NCT06089941)
- Testing
- circulating tumoral DNA detection
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Henri Becquerel
Asthma
Characterization of Aerosol Generation and Transport in the Human Lung
This study is aiming at evaluating whether the number and size of exhaled particles changes during the increase and decrease of bronchial constriction in subjects with mild intermittent asthma.
- Trial name
- NCT01095627
- Testing
- Metacholine challenge
- Volunteers
- 10 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Environmental Awareness, Ecological Footprint
Effect of AI-Based Image Generation on Children's Ecological Footprint Awareness
The aim of this study is to examine the effect of artificial intelligence-based image generation on children's ecological footprint awareness.
- Conditions
- Environmental Awareness, Ecological Footprint, Healthy Children
- Trial name
- NCT07898527
- Testing
- AI-Based Image Generation Activity
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Hereditary Colorectal Cancer
Next-generation Sequencing of Colorectal Cancer Somatic Cells to Guide Genetic Susceptibility Gene Mutations Screening.
This is a prospective, single-center, clinical study.This study is to evaluate the feasibility of genetic susceptibility screening based on the detection of tumor tissue mutations by a NGS panel.
- Trial name
- NCT04280666
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Epithelial Ovarian Cancer, Gastro-esophageal Junction Cancer
EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial Sarcoma
MDG1015 is a third generation TCR-T therapy product targeting NY-ESO-1/LAGE-1a armored and enhanced by the PD1-41BB costimulatory switch protein (CSP).
- Conditions
- Epithelial Ovarian Cancer, Gastro-esophageal Junction Cancer, Soft Tissue Sarcoma (STS), Myxoid Liposarcoma
- Trial name
- EPITOME-1015-I (NCT06748872)
- Testing
- Lymphodepletion, TCR-T cells (MDG1015)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Medigene AG
Workflow, Nursing
RTLS for Healthcare Process Validation
The purpose of the project is to develop a new way to understand patient care data analytics by using a real-time location system (RTLS).
- Trial name
- NCT04116957
- Testing
- RTLS current tag, RTLS tag revised
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Cancer
ORganoid GeneratioN Study for Cancer
ORIGINS - a multi-site sample collection study to establish patient-derived pre-clinical models for cancers
- Trial name
- ORIGINS (NCT05734963)
- Testing
- DNA sequencing, RNA gene expression analysis, molecular profiling
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
The Diagnosis Was ALK Positive NSCLC, Second Generation ALK-TKI is Resistant
Ensatinib Treat Second-generation ALK-TKI Resistance After Second-generation ALK-TKI Resistance
After the use of second-generation ALK-TKI drug resistance, about 50% of tissue biopsies showed mutations in the ALK kinase domain, and appropriate ALK-TKI could be selected according to different mutation sites .Phase I/II…
- Conditions
- The Diagnosis Was ALK Positive NSCLC, Second Generation ALK-TKI is Resistant, Efficacy of Ensatinib in This Subset of Patients
- Trial name
- ERSGATR (NCT05178511)
- Testing
- Ensartinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Li Zhang, MD
Vector-Borne Diseases, Emerging Pathogens
Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing
Background: Vector-borne diseases are caused by the bite of an infected mosquito, fly, flea, tick, or other blood-feeder. These diseases cause almost 1 million deaths per year.
- Trial name
- NCT04034264
- Where
- 6 sites in Cambodia
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Clinical Presentation, Natural History
Epithelioid Haemangioendothelioma Observational Study
The EHE observational study was developed to obtain a high number of datas such as clinical presentation, natural history, and treatment outcomes, cto identificate cytokines and hormones as biomarkers and generate patient-derived…
- Conditions
- Clinical Presentation, Natural History, Treatment Outcomes
- Trial name
- NCT06680401
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
COPD
Clinical Efficacy and Cost Effectiveness of MYCOPD in Patients With Mild and Moderate Newly Diagnosed COPD
Millions of patients in the UK live with long term medical conditions such as diabetes, heart disease and lung diseases. These conditions are the major cause of ill health in the UK and cost the NHS billions of pounds each year.
- Trial name
- EARLY (NCT03620630)
- Testing
- myCOPD
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- my mhealth Ltd
Normal Full-Term Deliveries
Generation of Dendritic Cell Precursors From Cord Blood Stem Cells
There is a growing interest in generating dendritic cells (DCs) for using as vaccines. Several cytokines, especially stem cell factor (SCF) and FLT3-ligand (FL), have been identified as essential to produce large numbers of…
- Trial name
- NCT00731744
- Testing
- Normal full-term deliveries
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Type 1 Diabetes
Accuracy, Reliability and Safety of GlucoMen®Day, a New Generation Microdialysis Continuous Glucose Monitor
Monocenter single-arm, prospective clinical study in 20 type 1 diabetic subjects, equipped with the GlucoMen®Day system, over up to 100 hours observation after implantation of the microdialysis probe.
- Trial name
- NCT01407315
- Testing
- GlucoMenDay
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Thrombin, Hemostatic Disorder
Thrombin in Cardiac Surgery
Coagulopathy, bleeding, and transfusion are common in cardiac surgical patients. Our collaborator has developed a novel point of care device that can be used to assess thrombin generation in real-time in cardiac surgical…
- Conditions
- Thrombin, Hemostatic Disorder, Surgical Blood Loss, Coagulation Disorder
- Trial name
- NCT04762576
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Rehabilitation, Pain, Shoulder
Precision Medicine for Nociception, Sngception and Proprioception.
Precision medicine is defined as "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person" by the Precision Medicine…
- Conditions
- Rehabilitation, Pain, Shoulder, Pain, Chronic, Idiopathic Scoliosis
- Trial name
- NCT06161038
- Testing
- LASER, Ultrasound, Prolotherapy
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
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