Clinical trials: Generations
Hydrocephalus
Functional and Non-Functional CSF Shunt Flow Measured With a Second-Generation Wireless Thermal Device
This study compares the performance of two generations of non-invasive cerebrospinal fluid (CSF) shunt flow assessment devices. Measurements of known non-functional and functional implanted shunts will assess the diagnostic…
- Trial name
- NCT06506045
- Testing
- FlowSense
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Rhaeos, Inc.
Hemophilia A
Evaluation of a Standardized Protocol for Thrombin Generation Assay
This study is aims at determining the inter laboratory variation when using the thrombin generation assay calibrated automated thrombogram (TGA CAT). It is thus, not a clinical trial in its usual meaning.
- Trial name
- NCT03313531
- Testing
- Thrombin Generation Assay, Treatment with recombinant coagulation factor
- Where
- Sweden
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Lund University
Spinal Infection, Diagnositic Efficacy
Diagnostic Efficacy of Metagenomic Next-generation Sequencing in Patients With Spinal Infections: A Retrospective Study
Comparing the diagnostic efficacy between traditional laboratory methods and second-generation high-throughput sequencing in patients suspected of spinal infections.
- Trial name
- NCT06172153
- Testing
- No interventions
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Smoking Reduction
Switching to E-cigarettes in Smokers Not Interested in Quitting
The objectives of this application are to 1) compare short- and long-term harm reduction and abuse liability potential of a nicotine salt pod-based electronic cigarettes (EC) in adult (AA) exclusive EC, dual cig-EC, and exclusive…
- Trial name
- NCT05703672
- Testing
- Varenicline Tartrate, Electronic cigarette
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Hereditary Angioedema
Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks
The study objective was to evaluate the safety and efficacy of prophylactic use of C1INH-nf for the prevention of acute HAE attacks.
- Trial name
- CHANGE 3 (NCT00462709)
- Testing
- C1 esterase inhibitor [human] (C1INH-nf)
- Where
- 48 sites in United States
- Volunteers
- 146 people
- Sponsor
- Shire
Cryptogenic Organizing Pneumonia, Idiopathic Interstitial Pneumonias
Screening Microorganism of Cryptogenic Mechanical Pneumonia Through Next Generation Sequencing to Lung Tissue Fluid
The etiology of cryptogenic organizing pneumonia (COP)was not clear, but previous studies have shown that in some patients, some pathogen could be detected in bronchoalveolar lavage fluid (BALF), and may be one of the causes of…
- Trial name
- COPandNGS (NCT04511884)
- Testing
- Next-generation sequencing
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Community Acquired Pneumonia (CAP)
Effect of tNGS on CAP Patients With Initial Treatment Failure
This is a multicenter, randomized controlled trial designed to evaluate the impact of tNGS in patients with community-acquired pneumonia who experience initial treatment failure.
- Trial name
- NCT07472114
- Testing
- Targeted next-generation sequencing, Conventional microbiological testing, Follow-up at Day 30
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Capital Medical University
Hyperlipidemias
Elevated Serum HDL in Four Generations of a Nashville Family
The purpose of this study is to determine the genetic basis of one family's hereditary hyper-HDL-emia using multiple modalities such as linkage analysis and gene array.
- Trial name
- NCT00525109
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Primary Care
Relisten: Enhancing Care Quality and Saving Time With Automatic Clinical Note Generation in Primary Care
Background: Relisten is an artificial intelligence-based software developed by Recog Analytics that improves patient care by facilitating more natural interactions between healthcare professionals and patients.
- Trial name
- Relisten (NCT06618092)
- Testing
- Relisten
- Where
- 6 sites in Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Coronary Artery Disease
Intravascular ULTrasound Guided Versus Conventional Angiography Guided Strategy to Deploy Zotarolimus and Everolimus Eluting Third Generation Stents in the Long Coronary Artery Lesions: ULTRA-ZET Trial
Although first generation DES reduced instent restenosis, still remained the unsolved problems such as stent thrombosis and restenosis in the era of DES.
- Trial name
- NCT01979744
- Testing
- IVUS guided percutaneous coronary angioplasty with Resolute integrity stent insertion, Angiography guided percutaneous coronary angioplasty with Resolute integrity stent insertion, Angiography guided percutaneous coronary angioplasty with Promus element stent implantation
- Where
- South Korea
- Volunteers
- 568 people
- Sponsor
- Yonsei University
Myeloma Multiple
Study of Daratumumab in Multiple Myeloma (MM) Patients in >VGPR/MRD-positive
Aim of this study is to evaluate Daratumumab effect on MRD-positive patients with Multiple Myeloma (MM) who achieved >VGPR after any therapy (ASCT, VMP, Rev-Dex).
- Trial name
- DART4MM (NCT03992170)
- Testing
- Daratumumab
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Universitaria Senese
Sickle Cell Disease, Venous Thromboembolism
Comparison of Thrombin Generation, Platelet Activation and Aggregation Profiles in Patients With Sickle Cell Disease Depending on Their SS or SC Genotype (DrepAgreg)
Sickle cell disease (SCD) is characterized by chronic hemolytic anemia, painful crises called vaso-occlusive crises (VOC) and chronic inflammation.
- Trial name
- DrepAgreg (NCT07852442)
- Where
- 2 sites in France, Guadeloupe
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Stress Urinary Incontinence
Second-generation Radiofrequency Application and Therapeutic Exercise for Stress Urinary Incontinence
Stress urinary incontinence (SUI) is defined as the loss of the ability to hold urine after exertion, i.e., as a result of imbalances in intra-abdominal pressure, which directly affect the lower urinary tract.
- Trial name
- NCT07095283
- Testing
- Short International Consultation on Incontinence Questionnaire (ICIQ-SF), King's Health Questionnaire (KHQ), Ultrasound evaluation
- Where
- Spain
- Volunteers
- 239 people
- Sponsor
- Cardenal Herrera University
Depression Mild, Depression Moderate
iCBT for Seniors With Depression in Primary Care
This clinical trial aims to evaluate the potential benefits of internet cognitive behavioural therapy (iCBT) for elderly patients with mild/moderate depression and compare its effectiveness with the current treatment as usual…
- Trial name
- NCT06537869
- Testing
- iCBT for depression
- Where
- Sweden
- Volunteers
- 390 people
- Sponsor
- Göteborg University
Sleep Quality, Relaxation
The Usefulness of Automatic Massage Chairs Before Bedtime in Sleep Quality.
Modern technology is transforming the field of massage, enhancing relaxation and wellness through innovative devices. The automatic electric massage chair exemplifies this advancement, merging ergonomic design with advanced…
- Trial name
- RoboSleep (NCT06784700)
- Testing
- Massage, No intervention
- Where
- Greece
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Second Generation Antipsychotic Induced Metabolic Adverse Effects
Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics
Schizophrenia and bipolar disorder are frequently associated with an elevated risk for obesity, metabolic syndrome, diabetes mellitus, dyslipidemia and other metabolic disturbances.
- Trial name
- NCT01811160
- Testing
- Melatonin
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
HIV
Evaluating Demand Generation (Stylish Man , Stylish Living) for HIV Prevention/Family Planning Services, Rakai, Uganda
The study tests a novel demand generation strategy, "Stylish Man/Stylish Living", to increase uptake of Combined HIV Prevention (CHP) in Rakai, Uganda.
- Trial name
- NCT02448823
- Testing
- Mass media and Stylish Events, Mass Media
- Where
- Uganda
- Volunteers
- 17,386 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Neuroblastoma
3RD GENERATION GD2 SPECIFIC CHIMERIC ANTIGEN RECEPTOR TRANSDUCED AUTOLOGOUS NATURAL KILLER T-CELLS FOR NEUROBLASTOMA
This research study is for patients that have a cancer called Neuroblastoma that has either come back after treatment or did not respond to the standard medicines used to treat it.
- Trial name
- GINAKIT (NCT02439788)
- Testing
- cyclophosphamide, Fludarabine, GINAKIT Cells
- Where
- United States
- Sponsor
- Baylor College of Medicine
Crohns Disease
Impaired Insulin-like Growth Factor-1 (IGF-1) Generation Causes Protein Catabolism and Poor Growth in Children With Crohn Disease
The investigators will prospectively recruit 26 children with moderate - severe active Crohn disease (PCDAI >30). Results will be compared to 26 patients in sustained remission (PCDAI <10 and physician global assessment of…
- Trial name
- NCT00946361
- Testing
- Examinations
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Nationwide Children's Hospital
Lung Cancer
NGS Genome Analysis in Personalisation of Lung Cancer Treatment
The identification of driver mutations in the epidermal growth factor receptor (EGFR) as the primary oncogenic event in a subset of lung adenocarcinomas led to a model of targeted treatment and genetic profiling of the disease.
- Trial name
- ALCAPONE (NCT02281214)
- Testing
- blood sample, biopsy
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Centre Georges Francois Leclerc
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.