Clinical trials: Generations
In Need of a Total Hip Arthroplasty
E-MAX 2nd Gen Vit E Poly On BIOLOX Delta Ceramic Heads
The purpose of this study is to monitor outcomes of total hip arthroplasties performed with E-MAX polyethylene and BIOLOX Delta Ceramic head.
- Trial name
- NCT01943149
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Renovis Surgical Technologies, Inc.
Sepsis, Severe
The Value of Full-targeted Pathogen Capture Metagenomics Next Generation Sequencing in Etiological Diagnosis of Sepsis
The etiological diagnosis of sepsis is the key to guide clinical treatment. Metagenomic sequencing (mNGS) is very suitable for the diagnosis of sepsis due to its rapid, accurate and not easy to be disturbed by the environment.
- Trial name
- NCT05540808
- Volunteers
- 86 people
- Sponsor
- Shenzhen Second People's Hospital
Hematological Malignancies
Molecular Disease Profile of Hematological Malignancies
In this prospective multicentric study, the University of Pavia together with the Fondazione IRCCS Policlinico San Matteo, Pavia and the IRCCS Fondazione Maugeri, Pavia, Italy will provide a systematic analysis of gene mutations…
- Trial name
- RELab1 (NCT02459743)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Pavia
Colorectal Cancer, Colon Cancer
Molecular Profiling of Colorectal Cancer
In this translational research study, Formalin-Fixed-Paraffin-Embedded (FFPE) tumor tissue blocks from patients with early-stage (II-III) colorectal cancer will be assessed for a comprehensive cancer gene panel from NIPD Genetics…
- Conditions
- Colorectal Cancer, Colon Cancer, Colon Adenocarcinoma
- Trial name
- NCT04863768
- Testing
- Gene panel
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- Hellenic Cooperative Oncology Group
Chronic Obstructive Pulmonary Disease, Physical Activity
Promoting Physical Activity in Chronic Obstructive Pulmonary Disease (COPD) Through New Technology and Health Coaching
The objective of this project is to validate the proposed smartphone-based activity monitor and to test its use for Motivational Interviewing based counseling for physical activity in Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT01217710
- Testing
- Activity monitor/smartphone health coaching
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Treatment With Second-generation Bruton's Tyrosine Kinase Inhibitors (Acalabrutinib, Zanubrutinib)
Innovative Biomarkers of Cardiovascular Complications Associated With Second-generation Bruton Tyrosine Kinase Inhibitor Treatments: a Single-center Cohort Study
Second-generation Bruton's tyrosine kinase inhibitors (BTKIs) (zanubrutinib, acalabrutinib) are recently discovered oral targeted therapies used to treat hematological disorders such as chronic lymphocytic leukemia, mantle cell…
- Trial name
- CACIS II (NCT07174141)
- Testing
- Ophthalmological examination, Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Stroke, Vascular Dementia
Aricept to Improve Functional Tasks in Vascular Dementia
Medications for memory improvement are available but they may not actually improve the ability to do real world tasks. The purpose of this research study is to determine if a medicine used to treat memory problems…
- Conditions
- Stroke, Vascular Dementia, Memory Deficits
- Trial name
- NCT00457769
- Testing
- Donepezil and self-generated memory training, Donepezil and experimenter-administered memory training
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Kessler Foundation
Endometrial Cancer
Generation of Endometrial Carcinoma Organoids
A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice.
- Trial name
- organoids endo (NCT07258186)
- Testing
- Generation of organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Regina Elena Cancer Institute
Infectious Keratitis
Investigation of the Microbiome of the Cornea in Microbial Keratitis
Design: Prospective observational diagnostic study and methods-comparison. Aims: The overall aim of the project is to better define the pathogenic microorganisms in patients with microbial keratitis (MK) through a better…
- Trial name
- STOICA (NCT04030403)
- Where
- United Kingdom
- Volunteers
- 219 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Shigellosis
Study to Expand Safety and Immunogenicity Data With Shigella Bioconjugate Vaccine (Shigella4V2) in 9-month-old Infants.
In this study, the second-generation tetravalent bioconjugate candidate vaccine Shigella4V2 will be tested to confirm data on its safety and immunogenicity in infants and to identify the best dose of Shigella4V2 in 9-month-old…
- Trial name
- S4V02 (NCT06523231)
- Testing
- Shigella4V2, MenACWY
- Where
- Kenya
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
COVID-19 Pneumonia
Efficacy and Safety of Oral Immunotherapy With GcMAF in Hospitalized Patients With COVID-19 Pneumonia
As of August 16, 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for more than 21 294 000 infections and about 760 000 deaths worldwide.
- Trial name
- COral-MAF1 (NCT04845971)
- Testing
- Saisei Maf capsules
- Where
- Italy
- Volunteers
- 97 people
- Sponsor
- Dr. Spadera Lucrezia
Metastatic Gastrointestinal Cancer, Genitourinary Cancer
Next Generation pErsonalized tX(Therapy) With Plasma DNA Trial-2 in Refractory Solid Tumors (The NEXT-2 Trial)
Analysis of cell free DNA(cfDNA), unlike tissue biopsy, presents a new tool for the monitoring and treatment of cancer. The investigators have developed a differentiated sequencing assay, Digital Sequencing Technology (DST) that…
- Trial name
- NCT02140463
- Where
- South Korea
- Volunteers
- 229 people
- Sponsor
- Samsung Medical Center
Breast Cancer, Metastatic Breast Cancer
Prospective Study to Evaluate the Clinical Utility of ctDNA Tumor Fraction (TF) for Detection of ESR1 Mutations in HR+/HER2- Metastatic Breast Cancer (MBC)
This is a prospective, single center, single-arm interventional study to evaluate the clinical utility of protocol-mandated diagnostic testing algorithm incorporating liquid biopsy and reflex tissue biopsy NGS for detection of…
- Conditions
- Breast Cancer, Metastatic Breast Cancer, HR+/HER- Metastatic Breast Cancer
- Trial name
- NCT07910565
- Testing
- FoundationOne® Liquid CDx (F1LCDx), Reflex tissue biopsy
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Yale University
Cancer, Mindfulness-based Intervention
Effects of a Second-generation Mindfulness-based Intervention on Quality of Life, Pain Management, and Psycho-spiritual Wellbeing in Cancer Patients: A Randomised Controlled Trial
Background This study explores the effectiveness of Meditation Awareness Training (MAT), a second-generation mindfulness-based intervention, in enhancing quality of life, pain management, and psycho-spiritual wellbeing among…
- Conditions
- Cancer, Mindfulness-based Intervention, Meditation, Psychological Well-Being
- Trial name
- NCT06695234
- Testing
- Meditation Awareness Training
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Derby
Dissection Carotid Artery, Dissection Arterial
Next Generation Sequencing Analysis of Patients with Spontaneous Dissection of Cervical Arteries
The goal of this observational study is to analyze the existence of a genetic predisposition in patients with spontaneous dissections of the cervical arteries (SCeAD). The main questions it aims to answer are: 1.
- Conditions
- Dissection Carotid Artery, Dissection Arterial, Dissecting Aneurysm
- Trial name
- NASCeAD (NCT06862063)
- Testing
- Genetic testing
- Where
- Italy
- Volunteers
- 145 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Non-Small Cell Lung Cancer, c-MET
A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) is a common type of lung cancer where abnormal cells in the lungs grow out of control. The purpose of this study is to assess adverse events and change in disease activity of telisotuzumab…
- Trial name
- NCT07155187
- Testing
- Telisotuzumab Adizutecan, Standard of Care, Osimertinib
- Where
- 117 sites in United States, Australia and 18 more
- Volunteers
- 490 people
- Sponsor
- AbbVie
Deep Venous Thrombosis
Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies
The goal of the CRETE Studies is to investigate the newly identified age-dependent heterogeneity in the efficacy of enoxaparin in reducing the risk of central venous catheter-associated deep venous thrombosis in critically ill…
- Trial name
- CRETE (NCT04924322)
- Testing
- Enoxaparin
- Where
- 22 sites in United States
- Volunteers
- 258 people
- Sponsor
- Yale University
Covid19, Interstitial Pneumonia
Identification of Predictors for the Evolution of COVID-19 Related Pneumonia by Transcriptomic and Seroproteomic
The investigating group aims at performing an observational, prospective study that involves the evaluation of circulating biomarkers predictive of clinical evolution in patients suffering from COVID-19 disease.
- Trial name
- COVID_OMICS (NCT04441502)
- Where
- Italy
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
PreDiabetes, Obesity
Telehealth Diabetes Prevention Intervention for African American Youth
The Telehealth Diabetes Prevention Intervention for the Next Generation of African American Youth (TELE-GEN) pilot study will evaluate the implementation and early efficacy of a telehealth diabetes prevention intervention for…
- Conditions
- PreDiabetes, Obesity, Obesity, Childhood
- Trial name
- TELE-GEN (NCT04618458)
- Testing
- Power to Prevent
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Mississippi Medical Center
Leiomyoma, Uterine, Leiomyosarcoma Uterus
Accuracy of the Preoperative Molecular Diagnosis of Uterine Tumors by Liquid Biopsy
The development of precise and non-invasive diagnostic methods is a priority in areas such as gynaecology and oncology, and above all in improving the health of those patients with a surgical indication for hysterectomy…
- Trial name
- MYOSARCII (NCT04935333)
- Testing
- Collection of Leiomyoma samples, Collection of Leiomyosarcoma samples, Collection of control samples
- Where
- 21 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Igenomix
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