Clinical trials: Genetic Polymorphism
Allergic Conjunctivitis
The Role of Vitamin D in Corneal Epithelial Barrier Function, Ocular Microbiome, Ocular Inflammation, and Visual Acuity of Children With Allergic Conjunctivitis
A double-blind study to evaluate the role of vitamin D in corneal epithelial barrier function, ocular microbiome, ocular inflammation, and visual acuity of children with allergic conjunctivitis.
- Trial name
- NCT05839938
- Testing
- Vitamin D
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Mammography
Single Nucleotide Polymorphism (SNP) Panels and Risk Assessment in Women Undergoing Mammography
The primary objective is to compare the predicted lifetime risk values produced by SNP panel assessment to the risk values produced by the prediction models that are most commonly used.
- Trial name
- NCT01124019
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Muscle Strength, Genetics
Effectiveness of Muscular Work and Genetic Variants in Strength Gain of Ischiofemoral and Quadriceps
In the field of sports training and recovery, the work of muscular strength has become the star theme in terms of its influence on the performance of athletes.
- Trial name
- NCT03973060
- Testing
- Concentric-eccentric muscular work, Genetic polymorphism
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Autism Spectrum Disorder
Study of the Genetic Factors Involved in Autism and Related Disorders
The main objective of the study is to define, for Autism Spectrum Disorder, the extent of genetic variation in synaptic pathways that may be targeted for therapeutic development.
- Trial name
- Gene&autism (NCT04727489)
- Testing
- DNA from subjects will be stored in the biobank of our study.
- Where
- 6 sites in France
- Volunteers
- 3,800 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pain, Genetic Change
COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children
The goal of this observational study is to investigate whether the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor1(OPRM1) and Catechol-O-methyltransferase (COMT) SNPs influence postoperative pain scores in…
- Conditions
- Pain, Genetic Change, Children, Only
- Trial name
- NCT06777875
- Where
- Lebanon
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Alzheimer's Disease
Effect of REST in the Alzheimer Disease Continuum
The investigators assume that REST gene polymorphism affects REST protein concentration, and REST protein concentration in peripheral blood is related to cognitive function and hippocampus.
- Trial name
- ERADC (NCT03884023)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Thrombocytopenia
Assessment of FOXP3 Gene Polymorphisms and Serum Interleukin 10 in Patients With ITP
Immune thrombocytopenia (ITP) is an autoimmune condition characterized by increased platelet destruction and suppression of production resulting in isolated thrombocytopenia.
- Trial name
- FoxP3ITP (NCT05410249)
- Testing
- Serum IL10 By ELISA, SNP -3279 A/C of FOXP3, SNP-924 A/G Of FOXP3
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sohag University
Crohn's Disease, Ustekinumab
A Study on the Associations of Toll-like Receptor 5 Gene Polymorphisms With Crohn's Disease in Chinese Patients
The exact etiology and pathogenesis of Crohn's disease (CD) have not been fully elucidated, and may be related to the combined effects of genetics, environment, immunity, gut microbiota, and many other factors.
- Conditions
- Crohn's Disease, Ustekinumab, Toll-like Receptor 5, Polymorphism, Single Nucleotide
- Trial name
- NCT07035678
- Where
- China
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Survival, Prosthesis
Osteopontin in Metastatic Breast Cancer Patients
OPN plays an important role in various aspects of malignancy, particularly those involved in tissue invasion and metastasis, and OPN levels have been associated with aggressive¬ness in several cancer types, including breast…
- Trial name
- NCT04274504
- Testing
- Osteopontin
- Where
- Egypt
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Lumbar Disc Degeneration, Low Back Pain
Interleukin-1β (rs 1143627 T/C) Gene Polymorphism May Increase the Risk of Developing LDD in Turkish Population
This study aims to show the association between the Interleukin-1β (rs 1143627 T/C) gene polymorphism and the patient's pain level, radiological features, functional disability, and spinal flexibility.
- Conditions
- Lumbar Disc Degeneration, Low Back Pain, Inflammation
- Trial name
- NCT05601739
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Healthy
Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects
Effects of clopidogrel and clarithromycin on the oral disposition of sibutramine in healthy subjects
- Trial name
- sibu (NCT01421706)
- Testing
- Sibutramine-clopidogrel, sibutramine-Clarithromycin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inje University
Rhabdomyolysis, Myopathy
The Association of Genetic Polymorphisms With Statin-Induced Myopathy.
To observe not only the distribution of single nucleotide polymorphism in genes related with pharmacodynamic and pharmacokinetics alteration of statins but also to analyze the correlation between these SNPs and the incidence of…
- Trial name
- NCT00549029
- Testing
- DNA
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Subjects, Heme Oxygenase
Effects of Heme Arginate in Healthy Male Subjects
Heme oxygenase 1 (HO-1) serves as a protective gene. It has been shown that one factor modulating HO-1 activity is a genetic variation in the HO-1 gene (functional GT length polymorphism in the promotor region).
- Conditions
- Healthy Subjects, Heme Oxygenase, Genetic Polymorphism
- Trial name
- HEMAHS (NCT00682370)
- Testing
- saline solution, heme arginate
- Where
- Austria
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Daniel Doberer
Healthy
Investigation Drug-drug Interaction Between Dabigatran and Clarithromycin
Dabigatran (Pradaxa ®) is a new oral anticoagulant. It is used to prevent venous thromboembolism in orthopedic surgery and has recently demonstrated efficacy and safety at least as good as anticoagulants in the prevention of…
- Trial name
- IMAGINE (NCT01385683)
- Testing
- Dabigatran then dabigatran and clarithromycin, Clarithromycin and dabigatran then dabigatran
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Adolescent Idiopathic Scoliosis, Single Nucleotide Polymorphisms
Investigation of LBX1, TIMP2, GPR126 and CHD7 Gene Polymorphisms in Adolescent Idiopathic Scoliosis Patients
Adolescent Idiopathic Scoliosis (AIS) is a common disease of the spine observed in individuals aged 10-18 who typically do not have any other health issues.
- Trial name
- NCT06540924
- Testing
- single nucleotide polymorphisms
- Where
- Turkey (Türkiye)
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Uludag University
Pharmacological Action
Pharmacogenomic in Colombian Patients With Rheumatoid Arthritis
The pharmacogenomics of the Colombian population with rheumatoid arthritis (RA), understood as the individual response to drugs depending on the genome of each patient, can be an explanation for the problems of effectiveness and…
- Trial name
- NCT03352622
- Testing
- CASES, CONTROLS
- Where
- Colombia
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Multiple Myeloma
BCMA Polymorphisms in Patients With Multiple Myeloma
The aim of this study is to investigate the effect of B cell maturation antigen (BCMA, TNFRSF17) gene polymorphisms on treatment response and survival in patients with multiple myeloma.
- Trial name
- BCMA in MM (NCT07906418)
- Testing
- BCMA polymorphism analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Healthy
A Clinical Study to Explore Biomarkers for Drug-induced Liver Injury (DILI)
This study has an open-label, one-sequence, multiple drug administration design. The purpose of this study is as follows; To evaluate the change of liver function according to glutathione s-transferase (GST) genotype after the…
- Trial name
- NCT02143323
- Testing
- Augmentin tablet
- Where
- 2 sites in South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy Lifestyle, Taste Disorders
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults
Personalized nutrition is one of the most up to date trends in human nutrition and gains much interest of general public and scientists as well.
- Conditions
- Healthy Lifestyle, Taste Disorders, Diet Habit
- Trial name
- NCT04145453
- Testing
- Intervention genotype personalized nutritional recommendations, Control Group 1 personalized nutritional recommendations, Control Group 2 general nutritional recommendations
- Where
- Poland
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Dementia, Movement Disorder
Genetic Characterization of Movement Disorders and Dementias
Background: There are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused by mutations in genes.
- Trial name
- NCT02014246
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)