Clinical trials: Genetic Polymorphism
Drug Metabolism, Membrane Transport
Open Label Pharmacokinetic-Pharmacogenetic Study on Polymorphisms in the Organic Cation Transporter OCT1
The purpose of this study is to determine the effect of the organic cation transporter OCT1 polymorphisms on the pharmacokinetics of several drugs in order to explain efficacy and adverse effects.
- Trial name
- PG-OCT (NCT02054299)
- Testing
- Drug application Amitriptyline, Drug application Desvenlafaxine, Drug application Sumatriptan
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Breast Cancer
A Pilot Study of Varying Doses of Tamoxifen in the Setting of Genetic Polymorphisms of CYP2D6
The investigators plan to examine endoxifen and 4-OH-Tam as a function of the tamoxifen dose in patients with a genetic CYP2D6 polymorphism.
- Trial name
- NCT00900744
- Testing
- Tamoxifen
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Guillain-Barré Syndrome, Miller Fisher Syndrome
International Guillain-Barré Syndrome Outcome Study
International GBS Outcome Study (IGOS) is a study conducted by the members of the Inflammatory Neuropathy Consortium (INC) and Peripheral Nerve Society (PNS) on disease course and outcome in Guillain-Barré syndrome (GBS).
- Trial name
- IGOS (NCT01582763)
- Where
- 138 sites in United States, Argentina and 19 more
- Volunteers
- 2,000 people
- Sponsor
- Erasmus Medical Center
Sleep Apnea Syndrome, Oxidative Stress
NADPH Oxidase Polymorphisms in Obstructive Sleep Apnea Syndrome (OSAS)
Obstructive Sleep Apnea (OSA) is associated with increased oxidative stress. The major sources of Reactive Oxygen Species (ROS) in the vasculature are the NADPH oxidases.
- Conditions
- Sleep Apnea Syndrome, Oxidative Stress, Single Nucleotide Polymorphism
- Trial name
- NCT01141829
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Coronary Artery Stenosis, Maximal Platelet Aggregation
Comparison of Platelet Inhibition With Adjunctive Cilostazol Versus High Maintenance-Dose Clopidogrel According to Hepatic Cytochrome 2C19 Allele (CYP2C19) Polymorphism
The purpose of this study was to determine the impact of adjunctive cilostazol on platelet inhibition in carriers and non-carriers of the loss-of-function CYP2C19 allele.
- Conditions
- Coronary Artery Stenosis, Maximal Platelet Aggregation, Late Platelet Aggregation, High Post-Treatment Platelet Reactivity
- Trial name
- ACCEL2C19 (NCT00891670)
- Testing
- cilostazol, clopidogrel, aspirin
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Gyeongsang National University Hospital
ALL, Childhood, Pediatric Cancer
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia
A five-year prospective observational cohort study. The study is focused on observing the relation between static germline variants and therapeutic response in Indian children with acute lymphoblastic leukemia (ALL).
- Conditions
- ALL, Childhood, Pediatric Cancer, Toxicity, Drug, Adverse Drug Event
- Trial name
- MPGx-INDALL (NCT05512169)
- Where
- 2 sites in India
- Volunteers
- 556 people
- Sponsor
- University of Geneva, Switzerland
Postoperative Cognitive Dysfunction
Whole Genome Single Nucleotide Polymorphisms in Elderly Patients With Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) presents as a long-lasting decline in cognitive function following surgery. Recognized as an important neuropsychological complication of anesthesia and surgery, POCD occurs…
- Trial name
- GenPOCD (NCT02864173)
- Testing
- Whole genome small nucleotide polymorphism genotyping
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Myeloblastic Leukaemia
CML Treated With Bosutinib After Relapse
Prospective, open label, multicenter, phase II study evaluating correlation of SNPs with efficacy and toxicity in patients treated with Bosutinib.
- Trial name
- BOSTRO (NCT02445742)
- Testing
- Bosutinib
- Where
- 13 sites in Spain
- Volunteers
- 30 people
- Sponsor
- PETHEMA Foundation
Lymphoma, Diffuse Large Cell
Genetic Determinations for Side Effects and Response Rate for Patients Receiving Chemotherapy With Diffuse Large Cell Lymphoma
The purpose of this study is to determine whether people have genes that make them more likely to respond to chemotherapy and/or have side effects from chemotherapy for diffuse large cell lymphoma.
- Trial name
- NCT00590941
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Washington University School of Medicine
Asthma
A Cohort Study of Smoking Prevention and Health Promotion for Middle School Students in Wuhan, China
We propose to add a collection of buccal cells to a school-based cohort of 7th graders in Wuhan, a large industrial city in China.
- Trial name
- NCT00341653
- Where
- China
- Volunteers
- 5,051 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
CYP1A2 Polymorphism
Personalized Nutrition Caffeine Intake in Healthy Adults.
Personalized nutrition is one of the most up to date trends in human nutrition and gains much interest of general public and scientists as well.
- Trial name
- NCT04122053
- Testing
- Intervention group with genotype information, Control group without genotype information
- Where
- Poland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Diabetes, Heart Disease
Personalized Environment and Genes Study
Despite the overwhelming focus on genetic and genomic causes of human disease over the past two decades, it has been estimated that genetics is currently known to explain only 20% and 40% of the etiology of common disease.
- Conditions
- Diabetes, Heart Disease, Asthma
- Trial name
- NCT00341237
- Where
- 2 sites in United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
NAFLD
Genetic-specific Effects of Fructose on Liver Lipogenesis
The primary goal of this study is to identify a set of genotypes that increase the risk for nonalcoholic fatty liver disease (NAFLD) and predispose individuals to increased de novo lipogenesis (DNL) and liver fat accumulation…
- Trial name
- NCT03783195
- Testing
- Sugar drink
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Breast Cancer, Glioma
A Study of Gene Polymorphisms and Normal Tissue Radiation Injury in Patients Treated for Breast, Prostate, Brain, Lung, and Head and Neck Cancers
This study will examine, for the first time, the independent contribution of a patient's own genetic makeup to the development of post-radiation complications, permitting the future development of predictive tests to avoid…
- Conditions
- Breast Cancer, Glioma, Prostate Cancer, Carcinoma, Squamous Cell
- Trial name
- NCT00122239
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- AHS Cancer Control Alberta
Pain, Chronic Pain
Observational Study Linking Genetic Variants With Clinical Outcomes in Pain Management
The purpose of this study is to (a) evaluate the treatment approaches and changes in treatment regimens utilized by clinicians when genetic testing is performed in the clinic; and (b) create a patient data registry to identify…
- Trial name
- TROJAN (NCT02480075)
- Testing
- Observational
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Proove Bioscience, Inc.
Pediatric Liver Transplantation
Prospective Tacrolimus Pharmacokinetics Study in Pediatric Living Donor Liver Transplantation
Our first aim is thus to investigate, retrospectively first and then prospectively, in de novo pediatric (living donor) liver recipients, the tacrolimus in vivo and in vitro metabolism and its variability with focus on…
- Trial name
- NCT02064777
- Testing
- Tacrolimus
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Non-sarcopenic Subjects, Possible Sarcopenia
Research on the Possible Relationship Between Sarcopenia and Oral Muscle Function
This study will focus on community-dwelling elderly individuals and will follow the community screening process recommended by AWGS.
- Conditions
- Non-sarcopenic Subjects, Possible Sarcopenia, Sarcopenia (With Low ASM by BIM)
- Trial name
- GSOM (NCT07658612)
- Testing
- Non interventional study
- Where
- Taiwan
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Bipolar
Genetic Association Study Between Single Nucleotide Polymorphisms (SNPs) and Cognitive Performance in Young Bipolar Type I Patients: LICAVALGENE
This is a genetic association study of cognitive impairment in young bipolar disease type I patients without medications in mania, depression, hypomania or mixed states.
- Trial name
- Licavalgene (NCT00969930)
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Daily Step Count, MASLD
The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD.
The study conducted a health survey among Thai adults in 2022 and found a significant increase in obesity and nonalcoholic fatty liver disease (NAFLD), leading to metabolic-associated steatotic liver disease (MASLD).
- Conditions
- Daily Step Count, MASLD, BMI, Metabolic Syndrome
- Trial name
- NCT06334666
- Testing
- Encourage using pedometer
- Where
- Thailand
- Volunteers
- 86 people
- Sponsor
- Mahidol University
Breast Cancer
Aromatase Inhibitor Clinical Trial
You are invited to participate in a research study looking at metabolism (breakdown) and effects of aromatase inhibitors. The purpose of this research is to try to identify which women who take an aromatase inhibitor are more…
- Trial name
- NCT00228956
- Testing
- pharmacodynamic analysis
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)