Clinical trials: Genetic Polymorphism
Chronic Low Back Pain
Genetic Predictors of Responsiveness to Radiofrequency Denervation in Chronic Low Back Pain
The Investigators have designed this exploratory study in patients suffering from zygapophysial joint mediated pain to investigate if a correlation exists between inter-individual genetic variability (genotype) with treatment…
- Trial name
- NCT02383524
- Testing
- Lumbar Radiofrequency Medial Branch Neurolysis
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Healthy
Investigation Drug-drug Interaction Between Dabigatran and Clarithromycin
Dabigatran (Pradaxa ®) is a new oral anticoagulant. It is used to prevent venous thromboembolism in orthopedic surgery and has recently demonstrated efficacy and safety at least as good as anticoagulants in the prevention of…
- Trial name
- IMAGINE (NCT01385683)
- Testing
- Dabigatran then dabigatran and clarithromycin, Clarithromycin and dabigatran then dabigatran
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Adolescent Idiopathic Scoliosis, Single Nucleotide Polymorphisms
Investigation of LBX1, TIMP2, GPR126 and CHD7 Gene Polymorphisms in Adolescent Idiopathic Scoliosis Patients
Adolescent Idiopathic Scoliosis (AIS) is a common disease of the spine observed in individuals aged 10-18 who typically do not have any other health issues.
- Trial name
- NCT06540924
- Testing
- single nucleotide polymorphisms
- Where
- Turkey (Türkiye)
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Uludag University
Angiotensin Converting Enzyme rs (1799752) Gene Polymorphism and Development of In-Stent Restenosis in Patients With Stable Coronary Artery Diseases
Angiotensin Converting Enzyme rs (1799752) Gene Polymorphism and Development of In-Stent Restenosis in Patients With Stable Coronary Artery Diseases in Sohag Hospital University.
One of the most common medical approaches to the treatment of coronary artery disease (CAD) is the percutaneous coronary intervention (PCI) which became frequent due to high efficiency and safety of this procedure.
- Trial name
- NCT06055673
- Testing
- DNA extraction AND Real- time polymerase chain reaction analysis to POLYMORPHISM OF in in-stent restenosis (ISR) in CAD
- Where
- Egypt
- Volunteers
- 182 people
- Sponsor
- Sohag University
Lymphoma, Follicular, Lymphoma, Non-Hodgkin
Study of Lymphoma in Asia
Background: Lymphoma rates in Asia have been lower than in the West, but rates have been rising in recent years. Most studies of lymphoma patients have been conducted in the West.
- Conditions
- Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Multiple Myleoma, Lympocytic, Follicular
- Trial name
- NCT01584141
- Where
- 4 sites in China, Hong Kong and 1 more
- Volunteers
- 13,433 people
- Sponsor
- National Cancer Institute (NCI)
Pharmacological Action
Pharmacogenomic in Colombian Patients With Rheumatoid Arthritis
The pharmacogenomics of the Colombian population with rheumatoid arthritis (RA), understood as the individual response to drugs depending on the genome of each patient, can be an explanation for the problems of effectiveness and…
- Trial name
- NCT03352622
- Testing
- CASES, CONTROLS
- Where
- Colombia
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Bipolar Disorder
Evaluation of the Genetics of Bipolar Disorder
This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.
- Trial name
- NCT00001174
- Where
- United States
- Volunteers
- 4,210 people
- Sponsor
- National Institute of Mental Health (NIMH)
Multiple Myeloma
BCMA Polymorphisms in Patients With Multiple Myeloma
The aim of this study is to investigate the effect of B cell maturation antigen (BCMA, TNFRSF17) gene polymorphisms on treatment response and survival in patients with multiple myeloma.
- Trial name
- BCMA in MM (NCT07906418)
- Testing
- BCMA polymorphism analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Cardiovascular Disease Risk Factors
Gene - Exercise Research Study
The investigators hypothesize that the degree to which older generally healthy but sedentary men and women improve a number of cardiovascular (CV) disease risk factors with 6 months of highly-standardized endurance exercise…
- Trial name
- GERS (NCT00976742)
- Testing
- Endurance exercise training
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- University of Maryland, College Park
Kidney Transplantation, Liver Transplantation
The Influence of ABCB1、CYP3A4、CYP3A5、POR Genetic Polymorphism and Other Factors on Tacrolimus Blood Concentration
The purpose of the study is to identify factors that may influence tacrolimus (TAC) pharmacokinetics, and the impact of gene polymorphism (ABCB1, CYP3A4, CYP3A5, POR) on pharmacokinetics of TAC in Taiwanese.
- Trial name
- NCT02707822
- Testing
- Clinical and genetic factors
- Where
- Taiwan
- Volunteers
- 440 people
- Sponsor
- National Taiwan University Hospital
Healthy
A Clinical Study to Explore Biomarkers for Drug-induced Liver Injury (DILI)
This study has an open-label, one-sequence, multiple drug administration design. The purpose of this study is as follows; To evaluate the change of liver function according to glutathione s-transferase (GST) genotype after the…
- Trial name
- NCT02143323
- Testing
- Augmentin tablet
- Where
- 2 sites in South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Gastroesophageal Reflux
Randomized Trial for Pharmacogenomics-based Proton Pump Inhibitor Therapy in Children
Proton pump inhibitors are administered to children as off-label use in Japan. The purpose of this study is to evaluate the effects of CYP2C19 genotypes on pharmacokinetic /pharmacodynamic profiles of PPI in children.
- Trial name
- NCT00299845
- Testing
- Lansoprazole
- Where
- Japan
- Sponsor
- Osaka University
Non-alcoholic Fatty Liver Disease, Obesity
The Influence of Autophagy on Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. It is not known why only some obese subjects develop NAFLD.
- Trial name
- NCT01988441
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- Far Eastern Memorial Hospital
Healthy Lifestyle, Taste Disorders
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults
Personalized nutrition is one of the most up to date trends in human nutrition and gains much interest of general public and scientists as well.
- Conditions
- Healthy Lifestyle, Taste Disorders, Diet Habit
- Trial name
- NCT04145453
- Testing
- Intervention genotype personalized nutritional recommendations, Control Group 1 personalized nutritional recommendations, Control Group 2 general nutritional recommendations
- Where
- Poland
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Dementia, Movement Disorder
Genetic Characterization of Movement Disorders and Dementias
Background: There are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused by mutations in genes.
- Trial name
- NCT02014246
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Estradiol Receptor Polymorphism, Progesterone Receptor Polymorphism
Gene-polymorphisms Relating to Human Subfertility
Estradiol is synthesized by granulosa cells of ovaries under control of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). It is known that Estradiol plays a crucial role in maturation and fertilization of oocytes.
- Conditions
- Estradiol Receptor Polymorphism, Progesterone Receptor Polymorphism, IVF, Subfertility
- Trial name
- NCT01385618
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Thyroid Cancer, Papillary, Hypothyroidism
Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused by Thyroidectomy in Thyroid Cancer Patients.
This project analyzes the relationship between type 2 deiodinase gene polymorphism and the TSH inhibitory treatment efficacy in thyroid cancer patients with thyroidectomy, and explored the factors influencing TSH inhibitory…
- Trial name
- NCT05247476
- Testing
- L-T4, L-T4+T3 (thyroid tablet)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Hospital Xiamen University
Primary Ovarian Insufficiency, Cardiovascular Diseases
Associations of Combinations of Single-nucleotide Polymorphisms in Women With Premature Ovarian Failure
Research objective. To study the associations between combinations of single nucleotide polymorphisms and behavioural risk factors with non-communicable diseases and adverse outcomes in women with premature ovarian failure.
- Conditions
- Primary Ovarian Insufficiency, Cardiovascular Diseases, Menopause, Premature, Coronary Disease
- Trial name
- NCT04943354
- Testing
- Taking a person's venous blood
- Where
- Russia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Puberty, Precocious, Adiposity
Long-term Outcome of GnRH Analogues Treatment of Children With Idiopathic Central Precocious Puberty
This study evaluates the influence of early adiposity rebound, genetic polymorphisms and GnRHa treatment on long-term outcome of girls with idiopathic central precocious puberty.
- Trial name
- NCT02790112
- Testing
- GnRHas
- Where
- Belgium
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Delayed Puberty
Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment
To evaluate the phenotype and biochemical characteristics of boys referred for delayed puberty, to describe the frequency of associated co-morbidities and diseases, to evaluate the diagnostic criteria and the effect of…
- Trial name
- NCT02034487
- Testing
- retrospective data collection
- Where
- Denmark
- Volunteers
- 451 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet