Clinical trials: Genetic Risk Factors
Cardiovascular Diseases
Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
The risk of cardiovascular disease is determined by the complex interplay between an individual's genetic make-up, lifestyle, and the environment.
- Trial name
- GENBIO (NCT04931498)
- Testing
- Questionnaire, Anthropometric measurements: height, weight, and body fat, Blood pressure and heart rate
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Multiple Myeloma, Amyloidosis Cardiac
The Diagnostic Pattern and Prognosis of Multiple Myeloma Patients With Myocardial Amyloidosis Were Evaluated by NMR Based Metabolomics
In this clinical study, a single-center retrospective cohort study was used to explore the clinical characteristics and risk factors of patients with multiple myeloma myocardial amyloidosis.
- Trial name
- NCT05718401
- Testing
- NMR
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Binge Drinking
Risk Factors Associated With Binge Drinking Behaviors Among College Students
The purpose of this study is to specify the psychological, cognitive, neuro-functional and genetic profile associated with binge drinker behaviors among young adults.
- Trial name
- AlcoolPredict (NCT02794311)
- Testing
- Alcoolpredict
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alzheimer Disease, Late Onset Alzheimer Disease
Alzheimer's Disease Genetics Study
The purpose of the Alzheimer's Disease Genetics Study is to identify the genes that are responsible for causing Alzheimer's Disease (AD).
- Conditions
- Alzheimer Disease, Late Onset Alzheimer Disease, Dementia
- Trial name
- NCRAD (NCT00064870)
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Benign Breast Disease
Risk Factors for Benign Breast Disease
Benign diseases of the breast are common clinical conditions that affect young women. Complaints related to the breast often cause significant discomfort and mental stress.
- Trial name
- NCT04127422
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Overweight and Obesity, Type IIb Hyperlipidaemia
Low Carbohydrate Diet - Effect on Plasma Lipids and Metabolic Markers
Low carbohydrate diet may influence the plasma lipid levels.
- Conditions
- Overweight and Obesity, Type IIb Hyperlipidaemia, Hypercholesterolemia Aggravated
- Trial name
- NCT01476436
- Testing
- Low carbohydrate dietary advice, Continue usual diet
- Where
- 2 sites in Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Age-related Macular Degeneration, Age-related Maculopathy
GARM II: A Study on the Genetics of Age-related Maculopathy
The original study (GARM I) has been conducted for more than 18 years at the University of Pittsburgh Medical Center (UPMC). GARM II is a nationwide research study about age-related macular degeneration in the next generation of…
- Trial name
- NCT01115387
- Testing
- Observational-1, Observational-2
- Where
- 2 sites in United States
- Volunteers
- 603 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pediatric Multiple Sclerosis
Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis
The purpose of this study is to better understand multiple sclerosis (MS) in children and adolescents, to learn if it differs from adult MS and to investigate if genes or environmental exposures or a combination of both put…
- Trial name
- NCT01396343
- Where
- 17 sites in United States
- Volunteers
- 1,276 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Congenital Heart Disease
Study on Clinical Prognosis, Risk Factors and Genetic Basis of Congenital Heart Disease
The objective of this study is to investigate the effect of parental peri-natal environmental risk factors and genetic factors on the development of Congenital Heart Disease (CHD).
- Trial name
- SCPRFGBCHD (NCT01669057)
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Cholesterol, LDL
Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both
The purpose of this study is to compare the percent change in LDL cholesterol induced by ezetimibe or simvastatin monotherapy and by co-administration of both agents in Black, White and Hispanic men.
- Trial name
- NCT00461968
- Testing
- Ezetimibe and Simvastatin
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Glaucoma
Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma?
Matrix metalloproteinases (MMPs) fulfill diverse important molecular functions and play pivotal roles in development, tissue morphogenesis, repair, aging, and inflammatory processes.
- Trial name
- NCT00312403
- Testing
- Blood Sample
- Where
- Austria
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Allergic Diseases, Food Allergy
Systems Biology of Early Atopy
The goal of this study is to establish a birth cohort that collects prenatal and early life biosamples and environmental samples and rigorously phenotypes young children for food allergy and Atopic Dermatitis (AD) to identify…
- Conditions
- Allergic Diseases, Food Allergy, Atopic Dermatitis
- Trial name
- SUNBEAM (NCT04798079)
- Where
- 13 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Prostate Cancer
An Exploration of Genetic Testing for Prostate Cancer Susceptibility
Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
- Trial name
- NCT00997464
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Men, Age Problem
Register of Therapeutical Patients Over 60 Years
Register for the study of the prevalence and burden of diseases, risk factors and outcomes of hospitalizations in older age groups in the countries of Eurasia.
- Conditions
- Men, Age Problem, Therapeutic Alliance
- Trial name
- ASCLEPIUS (NCT04295057)
- Testing
- Non-intervention
- Where
- Russia
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Eurasian Association of Therapists
Atopic Dermatitis
Comprehending Atopic Risk Elements
Skin barrier impairment and familial atopy have been implicated as crucial risk factors for the development of atopic dermatitis (AD).
- Trial name
- CARE (NCT04325451)
- Where
- 2 sites in Israel
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- MYOR Ltd.
Porphyrias, Hepatic
Acute Intermittent Porphyria Related Abnormalities in Cardiovascular System
This study aims to assess the changes in the cardiovascular system in patients with acute intermittent porphyria (AIP).
- Trial name
- AIPRACUS (NCT05882136)
- Where
- 2 sites in Poland
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Body Mass Index Quantitative Trait Locus 8 Disorder, Tangier Disease
High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese Women
The investigators aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women.
- Trial name
- NCT01763528
- Testing
- nutrition intervention
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Obesity, Dyslipidemia
Meta-analyses of the Effect of Sucrose Versus High Fructose Corn Syrup on Cardiometabolic Risk
The rise in high fructose corn syrup (HFCS) consumption over the past 40 years since its introduction as a popular sweetener in the United States has led to much concern regarding its contribution to the rise in obesity (1)…
- Conditions
- Obesity, Dyslipidemia, Prediabetes, Dysglycemia
- Trial name
- NCT02702479
- Testing
- High Fructose Corn Syrup, Sucrose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Influenza
Influenza Vaccine With Topical Imiquimod in Influenza Vaccine Non-responsive Children
Aims and hypotheses to be tested: Primary objective To compare the IIV responses, in terms of seroconversion rates, using ID IIV with topical 5% imiquimod (IIV-Q-ID), ID influenza vaccine alone (IIV-ID), and the second dose of IM…
- Trial name
- NCT05315024
- Testing
- Fluarix Tetra, Imiquimod cream
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cardiovascular Diseases
HOPE-CVD-Virtual: A Virtual Trial to Evaluate the Primary Prevention of CVD
This 4-arm (1:1:1:1) single-blind randomized controlled trial. Arm 1 will communicate risk and encourage behavioral change that mirrors the standard pathway for health screening in Singapore.
- Trial name
- NCT05827861
- Testing
- HeartAge, HOPE-CVD Mobile App, Genetic Risk Score
- Where
- Singapore
- Volunteers
- 1,121 people, healthy volunteers welcome
- Sponsor
- National University of Singapore