Clinical trials: Genetics Predisposition
Prostate Cancer
An Exploration of Genetic Testing for Prostate Cancer Susceptibility
Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
- Trial name
- NCT00997464
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Malignant Neoplasm
Oncology Research Information Exchange Network in Improving Genetic Screening Rate in Patients With Cancer
This research trial studies how well Oncology Research Information Exchange Network (ORIEN) works in improving genetic screening rate in patients with cancer.
- Trial name
- NCT03348137
- Testing
- Questionnaire Administration
- Where
- United States
- Sponsor
- University of Southern California
Chronic Pain, Anaesthesia
Comprehensive Pain Programme to Determine Mechanism of Transition of Acute to Chronic Postsurgical Pain
To determine whether central sensitization is a mechanism of CPSP (chronic postsurgical pain) in women who will develop CPSP compared to women with no CPSP after hysterectomy.
- Conditions
- Chronic Pain, Anaesthesia, Genetics Predisposition
- Trial name
- TAHP (NCT02025153)
- Testing
- pain testing
- Where
- Singapore
- Volunteers
- 216 people
- Sponsor
- KK Women's and Children's Hospital
Optic Neuritis, Multiple Sclerosis
Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool
The goal of this observational study is to determine whether genetic information, together with clinical information, can be used to improve prediction of future multiple sclerosis (MS) diagnosis after a first-time episode of…
- Conditions
- Optic Neuritis, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders
- Trial name
- MS Predictor (NCT07704294)
- Testing
- No Intervention: Observational Cohort
- Where
- 3 sites in United Kingdom
- Volunteers
- 180 people
- Sponsor
- King's College London
Prostate Cancer, Familial Prostate Cancer
Prostate Cancer Prevention Clinic for Men With Risk of Familial Prostate Cancer
Secondary prevention of prostate cancer (PCa) is not standardized and high-risk groups at the time of diagnosis are not well defined.
- Trial name
- ProFam-Risk (NCT05681416)
- Testing
- Panel sequencing, whole exome sequencing, whole genome sequencing
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
ST Elevation (STEMI) Myocardial Infarction of Other Sites
PREdisposition Genetical in Cardiac Insufficiency = Genetic Predisposition to Heart Failure
Our main goal is to create a prospective cohort of 1500 patients with a first large myocardial infarction allowing us, in a second step, to identify susceptibility genes for the progression of patients towards chronic heart…
- Trial name
- PREGICA (NCT01113268)
- Testing
- Cohort
- Where
- France
- Volunteers
- 658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
MRI Scans
Quantitative Susceptibility Mapping (QSM) to Guide Iron Chelating Therapy
The overall goal of this research is to help develop a new magnetic resonance (MR) method, Quantitative Susceptibility Mapping (QSM), to improve the measurement of liver iron concentrations without the need for a liver biopsy.
- Trial name
- NCT04171635
- Testing
- Quantitative Susceptibility Mapping (QSM) Magnetic Resonance Imaging (MRI), R2* Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer Disease
REVEAL III: Risk Evaluation and Education for Alzheimer's Disease
The purpose of this study is to provide healthy adults with genetic testing and information about their chances of developing Alzheimer's disease.
- Trial name
- REVEAL (NCT00462917)
- Testing
- Pleiotropic info, in-person disclosure, AD-only info, in-person disclosure, Pleiotropic info, phone disclosure
- Where
- 4 sites in United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Recurrent Drug-induced Liver Injury
Clinicopathological Features and Genetic Susceptibility Screening of Recurrent Drug-induced Liver Injury
The goal of this observational study is to screening for clinical, pathological and HLA features in patients with recurrent drug-induced liver injury.
- Trial name
- RDILI-GS (NCT06547229)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Friendship Hospital
Pancreas Cancer, Pancreas Cyst
Pancreatic Cancer Early Detection Consortium
The purpose of the Pancreatic Cancer Early Detection (PRECEDE) Consortium is to conduct research on multiple aspects of early detection and prevention of pancreatic ductal adenocarcinoma (PDAC) by establishing a multisite cohort…
- Conditions
- Pancreas Cancer, Pancreas Cyst, Pancreatic Ductal Adenocarcinoma, Genetic Predisposition
- Trial name
- PRECEDE (NCT04970056)
- Where
- 62 sites in United States, Australia and 10 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Arbor Research Collaborative for Health
Miscarriage, Recurrent
Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score
Recurrent pregnancy loss (RPL) is a clinical problem affecting 1-5% of couples of reproductive age. The contribution of thrombophilia to RPL is disputed.
- Trial name
- TiC-RPL (NCT03336463)
- Where
- 8 sites in Spain, United Kingdom
- Volunteers
- 364 people
- Sponsor
- Ferrer inCode, S.L.
Genetic Predisposition, Genetic Hypertension
Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass
This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and…
- Trial name
- NCT05334355
- Testing
- Family history of hypertension
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Montclair State University
Breast Cancer, Genetic Predisposition
Oncotype DX in BRCA-mutated Breast Cancer Patients: Our Experience. A Retrospective Observational Monocentric Study
The study aims to evaluate the distribution of the Oncotype DX RS® genomic test in patients with ER-positive and HER2-negative breast cancer treated from January 2012 to December 2021, focusing on patients presenting germline…
- Trial name
- OnBRA (NCT06484725)
- Testing
- Oncotype DX assay
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Brain Tumors
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma
The study PNET 5 MB has been designed for children with medulloblastoma of standard risk (according to the risk-group definitions which have been used so far; e.g. in PNET 4).
- Trial name
- NCT02066220
- Testing
- Radiotherapy without Carboplatin, Reduced-intensity maintenance chemotherapy, Radiotherapy with Carboplatin
- Where
- 77 sites in Austria, Belgium and 14 more
- Volunteers
- 360 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ovarian Cancer
Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00757263
- Testing
- polymorphism analysis, laboratory biomarker analysis, questionnaire administration
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cancer Research UK
Listeriosis
Genetic Susceptibility to Listeriosis
Listeriosis is a rare, severe foodborne infection, responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and / or patients with comorbidities, with a deficit of innate or…
- Trial name
- Listeria-GEN (NCT03357536)
- Testing
- Human biological samples
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Breast Cancer, Ovarian Cancer
Genetic Counseling in African American Women
The objectives of this study are to develop a Culturally Tailored Genetic (CTGC) protocol for African American women and evaluate its impact on decision making and satisfaction about BRCA1/2 testing, quality of life, and cancer…
- Trial name
- NCT00419510
- Testing
- Culturally Tailored Genetic Counseling
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Participants With the MTHFR 677TT Genotype
RIBOGENE: Optimisation of Riboflavin Status in Hypertensive Adults With a Genetic Predisposition to Elevated Blood Pressure
Approximately 10% of the world's population have a particular genetic makeup (known as the TT genotype) that may increase their risk of having higher blood pressure.
- Trial name
- RIBOGENE (NCT02463513)
- Testing
- 1.6mg riboflavin (Vitamin B2), 10mg riboflavin (Vitamin B2)
- Where
- 3 sites in United Kingdom
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Bladder Cancer
Interdisciplinary Case-Control Study of Bladder Cancer in Spain
The incidence rate of bladder cancer in the Barcelona area of Spain is almost identical to that of the U.S. Cigarette smoking has been identified as the most significant risk factor for bladder cancer, followed by occupational…
- Trial name
- NCT00341861
- Where
- Spain
- Volunteers
- 2,925 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus
for Adipose Tissue DIabetes VAriants (fATDIVA)
The adipose (fat) cells under the skin are where individuals store excess fat. The more excess fat they have, the more "strain" they put on these cells which then get bigger and don't work as well as they should.
- Trial name
- fATDIVA (NCT02505321)
- Testing
- Oral Triglyceride Tolerance Test (OTTT), Abdominal fat biopsy (optional)
- Where
- United Kingdom
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust