Clinical trials: Genital Endometriosis
Endometriosis
Open-Label Extension Study to ZPE-202
This study is a phase 2, open-label extension study of 12 mg Proellex for 2 treatment cycles, each with a 16 week active dosing period.
- Trial name
- NCT01961908
- Testing
- Proellex
- Where
- 7 sites in United States
- Sponsor
- Repros Therapeutics Inc.
Endometriosis, Diagnosis
Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers
This study is testing a way to diagnose endometriosis using a uterine tissue biopsy (similar to a pap smear) as opposed to undergoing laparoscopy surgery.
- Trial name
- NCT05698212
- Testing
- MetriDx
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hera Biotech, Inc.
Endometriosis
Pain Associated With Endometriosis
This study will evaluate the efficacy and safety of an investigational medication compared with placebo in the treatment of pain associated with endometriosis.
- Trial name
- NCT00758953
- Testing
- Danazol Once Weekly, Danazol Twice Weekly
- Where
- 49 sites in United States, Canada and 1 more
- Volunteers
- 66 people
- Sponsor
- Lumara Health, Inc.
Endometriosis
Study to Determine Intraperitoneal,Tissue, Serum Concentrations of VML-0501 Following Five Days of Daily Vaginal Single Dose of VML-0501 (100 mg Danazol), in Comparison to Oral Danazol Capsules Daily 600 mg), in Women With Signs and Symptoms of Endometriosis Undergoing Laparoscopy
A Comparative, Open-Label, Randomized, Parallel Group Study to determine Intraperitoneal fluids, tissue, and serum concentrations of VML-0501 following five days of daily vaginal applications of single dose of VML-0501 (100 mg…
- Trial name
- NCT03352076
- Testing
- Vaginal Danazol, Oral Danatrol
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Viramal Limited
Endometriosis
To Evaluate Effectiveness of Visanne in Improving Quality of Life in Asian Women With Endometriosis
This study is a prospective observational cohort study. The study will be conducted in routine clinical practice settings. It is planned to enroll 870 patients with endometriosis for whom a decision has been made by the physician…
- Trial name
- ENVISIOeN (NCT02425462)
- Testing
- Dienogest (Visanne, BAY86-5258)
- Where
- 6 sites in Indonesia, Malaysia and 4 more
- Volunteers
- 895 people
- Sponsor
- Bayer
Endometriosis
Safety and Efficacy of Telapristone Acetate (Proellex®) in the Treatment of Pre-Menopausal Women With Confirmed, Symptomatic Endometriosis
The primary purpose of this study is to determine the safety and efficacy of two oral doses of telapristone acetate administered to premenopausal women with pelvic pain associated with endometriosis confirmed within the last…
- Trial name
- NCT01728454
- Testing
- Telapristone acetate
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Repros Therapeutics Inc.
Endometriosis
Efficacy and Safety Study of Elagolix Versus Placebo or Leuprorelin Acetate in Endometriosis
This study is designed to evaluate the safety and beneficial effects of elagolix (NBI-56418) compared to placebo and leuprorelin (an approved endometriosis therapy) over a three month period followed by an additional three months…
- Trial name
- NCT00797225
- Testing
- Leuprorelin Acetate Depot, Elagolix
- Volunteers
- 174 people
- Sponsor
- AbbVie
Endometriosis
Safety and Efficacy Study to Evaluate Proellex in the Treatment of Premenopausal Women With Symptomatic Endometriosis
The purpose of this study is to determine whether Proellex is safe and effective for the treatment of symptomatic endometriosis.
- Trial name
- NCT00556075
- Testing
- Proellex 25 mg, Proellex 50 mg
- Where
- 17 sites in United States
- Volunteers
- 67 people
- Sponsor
- Repros Therapeutics Inc.
Endometriosis, Rectum
Evaluation of High Intensity Focused Ultrasound (HIFU) in the Treatment of Rectal Endometriosis
Rectal endometriosis (RE) induces lesions associated with painful symptoms that can alter quality of life. High Intensity Focused Ultrasound (HIFU) is a non-invasive ablative procedure using a high-intensity ultrasound probe to…
- Trial name
- ENDO-HIFU-R1 (NCT04494568)
- Testing
- HIFU treatment
- Where
- 5 sites in France
- Volunteers
- 60 people
- Sponsor
- EDAP TMS S.A.
Endometriosis
Comparison Between the Effects of Implantable Gestrinone and Oral Dienogest in the Treatment of Endometriosis
This study aims to evaluate the effects of therapy with implantable Gestrinone compared to oral Dienogest in relieving complaints related to endometriosis.
- Trial name
- NCT06543550
- Testing
- Implantable gestrinone, Oral Dienogest
- Where
- 4 sites in Brazil
- Volunteers
- 70 people
- Sponsor
- Bio Meds Pharmaceutica Ltda
Severe and Recurrent Endometriosis
Letrozole in the Treatment of Severe and Recurrent Endometriosis
Endometriosis is a condition in which abnormal growth of tissue histologically resembling the lining of the uterus (endometrium) is present outside of the uterus.
- Trial name
- NCT00240942
- Testing
- Letrozole
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Endometriosis
A Study to Assess the Efficacy and Safety of HMI-115 in Subjects With Endometriosis-Associated Pain
This study is designed to evaluate the safety and efficacy of HMI-115 compared to placebo over a 12 weeks period on subjects with moderate to severe endometriosis-associated pain.
- Trial name
- NCT05101317
- Testing
- HMI-115
- Where
- 5 sites in United States, China and 1 more
- Volunteers
- 142 people
- Sponsor
- Hope Medicine (Nanjing) Co., Ltd
Endometriosis
A Multinational, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Investigate the Efficacy, Safety and Duration of Effect of a Single Administration of Various Doses of Cetrorelix SR in Subjects With Histologically Confirmed Endometriosis
Identify effective doses of cetrorelix SR in the treatment of symptoms of endometriosis, describe dose effect relationship and duration of symptom relief
- Trial name
- NCT00244452
- Testing
- Cetrorelix
- Where
- 57 sites in Australia, Belgium and 6 more
- Sponsor
- Solvay Pharmaceuticals
Endometriosis Pelvic, Endometriosis Ovaries
PRECISION-E2: Teverelix in Women With Endometriosis - Pharmacodynamics, Safety and Precision Medicine Correlates
PRECISION-E2 is a Phase IIa randomized, placebo-controlled study evaluating the pharmacodynamic profile, safety and tolerability of teverelix in premenopausal women with moderate-to-severe pain associated with endometriosis in…
- Conditions
- Endometriosis Pelvic, Endometriosis Ovaries, Premenopausal, Endometriosis (Diagnosis)
- Trial name
- NCT07914062
- Testing
- Teverelix DP
- Volunteers
- 84 people
- Sponsor
- Antev Ltd.
Endometriosis
Argon Plasma Treatment for Ovarian Endometrioma Compared to Standard Cystectomy
The study is a prospective, monocentric, randomized controlled, two-armed, pilot-study conducted at Department for Women's Health, Tuebingen, Germany.
- Trial name
- OVAPLAS (NCT07065214)
- Testing
- APC, Lap bipolar forceps
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Erbe Elektromedizin GmbH
Endometriosis
Treatment by HIFU With Focal One® of Posterior Deep Infiltrating Endometriosis Lesions With Intestinal Involvement.
Deep invasive endometriosis (DIE) includes lesions of the rectosigmoid. Theses lesions are associated with painful symptoms that can alter quality of life.
- Trial name
- NCT03613298
- Testing
- HIFU (Focal One®)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- EDAP TMS S.A.
Endometriosis, Reproductive System Disorder
Developing an US-MRI Biomarker Fusion Model for Endometriosis
Single centre, prospective, observational, cohort study looking to develop a database representing the variability of disease and imaging seen in women with clinically diagnosed endometriosis, awaiting laparoscopic surgery.
- Trial name
- DEFEND (NCT04974710)
- Testing
- Outpatient MRI
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Perspectum
Endometriosis, Endometriosis Ovary
Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis
Background: Endometriosis is a chronic gynecological disease with the growth of endometrial tissue outside the endometrium. In all its properties, this tissue is similar to the mucous membrane of the uterus.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis Externa, Endometriosis, Rectum
- Trial name
- ELTA (NCT03481842)
- Testing
- Linifanib, BIBW2992, Axitinib
- Where
- Switzerland
- Sponsor
- BioGene Pharmaceutical Ltd.
Endometriosis
A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain
A randomized study evaluating the safety and efficacy of elagolix in the management of moderate to severe endometriosis-associated pain in adult premenopausal female subjects.
- Trial name
- ELARIS EM-II (NCT01931670)
- Testing
- Elagolix
- Volunteers
- 815 people
- Sponsor
- AbbVie
Endometriosis
Non-Interventional Study to Evaluate Effect of Zoladex In EndometrioSIS
To observe the effect of goserelin 3,6mg sc depot injection by assessment of the mean percent reduction scores for symptoms: dysmenorrhoea, dyspareunia and pelvic pain; to observe the effect of goserelin 3,6mg sc depot injection…
- Trial name
- ESIS (NCT00761683)
- Where
- 3 sites in Romania
- Volunteers
- 105 people
- Sponsor
- AstraZeneca