Clinical trials: Genital Endometriosis
Endometriosis
Visanne Study to Assess Safety in Adolescents
A clinical trial which was designed to demonstrate the safety and efficacy of Visanne (approved in endometriosis for adults) in the adolescent population.
- Trial name
- VISADO (NCT01283724)
- Testing
- Dienogest (Visanne, BAY86-5258)
- Where
- 36 sites in Austria, Czechia and 4 more
- Volunteers
- 111 people
- Sponsor
- Bayer
Endometriosis
RNA Assays for Endometriosis Detection and Diagnosis
Endometriosis is a common disease that affects up to 10% of women of reproductive age. Diagnosis, however, is typically delayed (up to 12 years) and is usually made after surgery.
- Trial name
- RNA-EndoDx (NCT06907303)
- Testing
- EndoDx
- Where
- 2 sites in United States, South Africa
- Volunteers
- 400 people
- Sponsor
- Wren Laboratories LLC
Endometriosis
BAY2328065 Single Dose Escalation, Safety and Tolerability, Pharmacokinetics, Relative Bioavailability, Food Effect
This single center, double-blind, randomized study with up to 11 treatment groups evaluates the safety and tolerability, pharmacokinetics, relative bioavailability and food effect of single ascending doses of BAY2328065
- Trial name
- NCT03427788
- Testing
- BAY2328065
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Bayer
Endometriosis
Open Label Immunotherapy of Endometriosis
Endometriosis is a chronic gynecological disease characterized by sustained painful symptoms that are responsible for a decline in the quality of life of sufferers.
- Trial name
- NCT03340324
- Testing
- V-Endo
- Where
- Mongolia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Immunitor LLC
Endometriosis, Uterine Fibroids
A Trial of SHR7280 in Healthy Subjects
The study is being conducted to evaluate the effect of high-fat meal on pharmacokinetics of SHR7280 after oral administration and the effect of SHR7280 on QT interval at low and high doses in healthy Chinese volunteers.
- Conditions
- Endometriosis, Uterine Fibroids, Assisted Reproduction
- Trial name
- NCT06969664
- Testing
- SHR7280 Tablet
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Endometriosis
A Trial to Learn What Happens to Different Medicinal Forms of BAY2328065 When They Enter the Body and How Safe They Are in Healthy Male and Female Participants
Researchers are looking for a different way to treat women with a condition in which tissue that normally lines the uterus grows outside the uterus. This condition is called endometriosis.
- Trial name
- NCT04851483
- Testing
- BAY2328065
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Bayer
Endometriosis (Diagnosis), Blood Biomarkers
EndoSearch : Endometriosis Biomarkers
EndoSearch aims to analytically validate a cluster of specific biomarkers for endometriosis diagnosis and disease recurrence. This signature will be tested on endometrium and blood from 975 patients, divided in two groups : 550…
- Conditions
- Endometriosis (Diagnosis), Blood Biomarkers, Endometrium Biomarkers
- Trial name
- NCT03376451
- Testing
- Assessment of endometrium and blood biomarkers for endometriosis diagnosis
- Where
- France
- Volunteers
- 975 people, healthy volunteers welcome
- Sponsor
- Dr Afchine Fazel
Endometriosis
A Randomized Open Label Study of KLH-2109 in Patients With Endometriosis(1)
The purpose of this study is to evaluate the efficacy and safety of KLH-2109 in patients with endometriosis.
- Trial name
- NCT01395940
- Testing
- KLH-2109
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Endometriosis
Study to Compare the Oestradiol Suppression, Clinical Efficacy and Safety of Two Formulations of Triptorelin (Triptorelin Pamoate PR 3-month and Triptorelin Acetate PR 1-month) in Chinese Subjects With Endometriosis
To assess the efficacy of triptorelin pamoate prolonged release (PR) 3-month formulation in Chinese female subjects with endometriosis by demonstrating the non-inferiority of triptorelin pamoate PR 3-month formulation injected…
- Trial name
- NCT03232281
- Testing
- Triptorelin Pamoate PR 3-month, Triptorelin Acetate PR 1-month
- Where
- 24 sites in China
- Volunteers
- 300 people
- Sponsor
- Ipsen
Endometriosis
Study to Evaluate the Pharmacodynamics and Efficacy of Leuprolide Tablets (Ovarest®) in Women With Endometriosis
The pharmacodynamic endpoint of percentage of subjects with suppressed estradiol level (less than 20 pg/mL) on cycle day 29 is the primary endpoint of the study.
- Trial name
- NCT05096065
- Testing
- Leuprolide Oral Tablet - 120 mg - QD- Treatment A, Leuprolide Oral Tablet - 80 mg - QD - Treatment B, Leuprolide Oral Tablet - 60 mg - QD - Treatment C
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Enteris BioPharma Inc.
Endometriosis
A Study to Assess the Efficacy and Safety of OBE2109 in Subjects With Endometriosis
The primary objective of this study is to assess the efficacy and safety of a range of oral doses of OBE2109 versus placebo, in reducing endometriosis associated pain.
- Trial name
- EDELWEISS (NCT02778399)
- Testing
- OBE2109
- Where
- 86 sites in United States, Poland and 2 more
- Volunteers
- 328 people
- Sponsor
- ObsEva SA
Endometriosis
A Study to Evaluate the Safety and Efficacy of BOL-DP-o-08 in Patients With Endometriosis Syndrome.
A Phase 2a, Single-center, randomized, double-blind, placebo-controlled study, in 80 subjects diagnosed with Endometriosis, stage 2-4
- Trial name
- NCT04174911
- Testing
- BOL-DP-o-08
- Sponsor
- Breath of Life International Pharma Ltd
Endometriosis
Evaluation of the Efficacy of an Innovative Digital Therapeutic Medical Device, Lyv Endo, for the Management of Patients With Endometriosis
The main objective of this clinical study is to evaluate the clinical impact of using an innovative digital therapeutic device on the quality of life of patients with endometriosis.
- Trial name
- LYVENDO (NCT07175857)
- Testing
- Lyv Endo app
- Where
- 8 sites in France
- Volunteers
- 400 people
- Sponsor
- Lyv Healthcare
Endometriosis
Clinical Study to Evaluate Efficacy and Safety of TAK-385 40 mg Compared With Leuprorelin in Patients With Endometriosis
The objective is to evaluate the efficacy and safety of TAK-385 40 mg orally administrated once daily for 24 weeks compared with Leuprorelin [once/4 weeks, 3.75 or 1.88 mg subcutaneously (SC)/time] in patients with endometriosis.
- Trial name
- NCT03931915
- Testing
- TAK-385, Leuprorelin acetate
- Where
- 41 sites in Japan
- Volunteers
- 335 people
- Sponsor
- ASKA Pharmaceutical Co., Ltd.
Endometriosis
A Study to Evaluate Safety and Efficacy of Elagolix in Patients With Moderate to Severe Endometriosis-Associated Pain
This is a Phase 3, multicenter, double-blind, placebo-controlled, randomized study to assess the safety and efficacy of elagolix versus placebo in premenopausal 18 to 49 year old women with moderate to severe…
- Trial name
- NCT05648669
- Testing
- Elagolix
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Endometriosis Related Pain
SPIRIT 1: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain
The purpose of this study is to determine the benefit and safety of relugolix 40 milligrams (mg) once daily, co-administered with low-dose estradiol (E2) and norethindrone acetate (NETA) compared with placebo for 24 weeks, on…
- Trial name
- NCT03204318
- Testing
- Relugolix, Estradiol/norethindrone acetate
- Where
- 123 sites in United States, Argentina and 11 more
- Volunteers
- 638 people
- Sponsor
- Myovant Sciences GmbH
External Genital Endometriosis
Study of the Efficacy and Safety of Longidaze® for the Treatment of Patients With External Genital Endometriosis
A study is being conducted to evaluate the efficacy and safety of Longidaze for the prevention and treatment of external genital endometriosis .
- Trial name
- NCT04962620
- Testing
- Bovhyaluronidase azoximer
- Where
- 6 sites in Russia
- Volunteers
- 149 people
- Sponsor
- NPO Petrovax
Genital Endometriosis
Observational Program to Assess Routine Use of Add-back Therapy in Patients With Endometriosis in Russian Federation, Planned for 6-month Course of Lucrin Depot® (Leuprorelin)
The purpose of this study is to assess rates of administration of add-back therapy in patients with endometriosis in the Russian Federation, during a 6-month course of gonadoliberin agonist leuprorelin 3.75 mg.
- Trial name
- NCT01294371
- Where
- 28 sites in Russia
- Volunteers
- 391 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Endometriosis
The EMPOWER Study: Endometriosis Diagnosis Using MicroRNA
Endometriosis is a complex, heterogeneous disease that may present inconsistently across women. Using disease-specific biomarkers and advanced biostatistics, DotLab is developing a biomarker test to confirm the presence of…
- Trial name
- EMPOWER (NCT04598698)
- Where
- 23 sites in United States
- Volunteers
- 750 people
- Sponsor
- Dot Laboratories, Inc.
Endometriosis
A Study to Evaluate the Safety and Effectiveness of Asoprisnil in the Treatment of Women With Endometriosis.
The objective of this study is to determine the safety and efficacy of 3 asoprisnil doses (0.5 mg, 1.5 mg, and 5.0 mg) for 12 weeks in women with endometriosis.
- Trial name
- NCT00160433
- Testing
- Asoprisnil
- Volunteers
- 131 people
- Sponsor
- Abbott