Clinical trials: Genital Infection
Human Immunodeficiency Virus, Human Immunodeficiency Virus I Infection
HIV Therapeutic DNA Vaccine (ICVAX) Phase I Clinical Trial in Hong Kong
The goal of this randomized clinical trial is to evaluate the safety and immunogenicity of the HIV Therapeutic DNA Vaccine (ICVAX) in participants with HIV-1 infection under antiretroviral therapy (ART).
- Trial name
- NCT07530198
- Testing
- ICVAX (TERESA-EPT I device), ICVAX (PharmaJet Tropis device), ICVAX (TriGrid device)
- Where
- Hong Kong
- Volunteers
- 22 people
- Sponsor
- Immuno Cure Holding (HK) Limited
HIV Infection, Metabolic Syndrome
Safety, Tolerability and Effectiveness of DTG/3TC vs BIC/TAF/FTC in PWH Without Antiretroviral Experience
Background: The primary goal of antiretroviral therapy is to prevent HIV-associated morbidity and mortality. The effectiveness of first-line regimens is supported by a large number of clinical trials; current concerns focus on…
- Conditions
- HIV Infection, Metabolic Syndrome, Antiretroviral Treatment
- Trial name
- TEOTL (NCT07031063)
- Testing
- DTG/3TC, Bictegravir (BIC) plus Emtricitabine (FTC) plus Tenofovir Alafenamide (TAF)
- Where
- Mexico
- Volunteers
- 124 people
- Sponsor
- Instituto Mexicano del Seguro Social
HIV Infections
Evaluation of Simplified Antiretroviral Treatment Strategies in HIV Infected Children Treated by Antiretroviral (ARV) Before One Year of Age
The MONOD trial aim to evaluate the implementation of early antiretroviral treatment strategies in HIV-infected infants and assess the feasibility and efficacy of simplifying the initial proposed regimen after a successful one…
- Trial name
- NCT01127204
- Testing
- AZT-3TC-LPV/r twice a day, ABC-3TC-EFV once a day
- Where
- 4 sites in Burkina Faso, Côte d’Ivoire
- Volunteers
- 161 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections, HIV Wasting Syndrome
The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected Children
The purpose of this study is to see how beginning or changing anti-HIV medications affects the body composition (weight, height, growth, body fat, and muscle mass, or fat and muscle distribution) of HIV-infected children.
- Conditions
- HIV Infections, HIV Wasting Syndrome, Lipodystrophy
- Trial name
- NCT00006064
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Effects of Two Anti-HIV Drug Regimens on Quality of Life and Health Care Use Among SMART Study Participants
The purpose of this study is to compare the effects of two different anti-HIV drug regimens on quality of life and health care utilization among SMART study participants.
- Trial name
- NCT00385632
- Testing
- Antiretroviral Regimens
- Where
- 67 sites in United States
- Volunteers
- 1,224 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acquired Immunodeficiency Syndrome, Mycobacterium Avium-Intracellulare Infection
Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection
Disseminated infection with Mycobacteria avium complex (MAC) is one of the most common systemic bacterial infections in advanced stages of the acquired immunodeficiency syndrome (AIDS).
- Trial name
- NCT00001763
- Testing
- Interleukin-12
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Study of Abacavir Plus Indinavir Sulfate Plus Efavirenz in HIV-Infected Patients
To compare the virologic response between abacavir (ABC, 1592U89) regimens (drug vs. placebo) and between the 2 dosing regimens (BID vs.
- Trial name
- NCT00001086
- Testing
- Indinavir sulfate, Abacavir sulfate, Efavirenz
- Where
- 56 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection, Recurrent Non-Small Cell Lung Carcinoma
Erlotinib Hydrochloride in Treating Non-Small Cell Lung Cancer That is Metastatic or Cannot be Removed by Surgery in Patients With HIV Infection
This phase I trial studies the side effects and best dose of erlotinib hydrochloride in treating non-small cell lung cancer that has spread to other parts of the body or cannot be removed by surgery in patients with human…
- Conditions
- HIV Infection, Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer, Stage IIIB Non-Small Cell Lung Cancer
- Trial name
- NCT02134886
- Testing
- Erlotinib Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
Urinary Tract Infection
Role of Residual Urine and Asymptomatic Prostatitis in the Development of Urinary Tract Infections in Spinal Cord Injury
The purpose of this prospective study is to investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (>2 /year) symptomatic urinary tract…
- Trial name
- NCT01601041
- Testing
- sonographic assessment of residual urine, urine culture
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Osteopenia, Osteoporosis
Bone Mineral Density (BMD) in HIV Infection
Osteopenia and osteoporosis are increasingly reported in HIV-infected patients, and appear to be more frequent than in general population.
- Trial name
- NCT00146094
- Testing
- BMD Measurement, antiretrovirals
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Strasbourg, France
HIV Infections
Evaluating Once Daily Etravirine in Treatment-Naive Adults With HIV Infection
The main study is a single arm, open-label, prospective study to assess antiretroviral activity and tolerability of etravirine (TMC-125) 400 mg once daily, given with fixed-dose tenofovir/emtricitabine, in treatment-naïve…
- Trial name
- NCT00959894
- Testing
- Etravirine (Intelence), Truvada
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus, Hepatitis C
Pharmacokinetic Study of Raltegravir in Human Immunodeficiency Virus/Hepatitis C Virus (HIV/VHC) Coinfected Patients With Advanced (Child-Pugh C) Hepatic Cirrhosis
Raltegravir is the first integrase inhibitor used in humans. It has been shown to be highly efficacious and well tolerated in phase III clinical trials in multidrug experienced human immunodeficiency virus(HIV)-infected patients…
- Trial name
- LIVERAL (NCT01289951)
- Testing
- Raltegravir 400 mg/12hours
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Human Papillomavirus Infection
Communication Strategy to PROMOTE HPV Vaccination in Pharmacies: PROMOTE Study
This trial investigates how a communication strategy works in increasing human papillomavirus (HPV) vaccines in community pharmacies among adolescents.
- Trial name
- PROMOTE (NCT04660331)
- Testing
- Communication Intervention, Communication Skills Training, Healthcare Activity
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
HCV Infection, HIV Infections
Addressing the Cascade of Care in Vulnerable Populations With Poor Access to Healthcare in Madrid
Data on the prevalence of hepatitis C virus (HCV) for other vulnerable groups in Madrid, such as homeless persons and migrants, are scarce, and it is now necessary to implement intervention and elimination plans.
- Conditions
- HCV Infection, HIV Infections, Drug Use, HBV (Hepatitis B Virus)
- Trial name
- (UMC) (NCT04062253)
- Testing
- HCV rapid test
- Where
- Spain
- Volunteers
- 2,001 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Infanta Leonor
Breast Cancer, Chronic Myeloproliferative Disorders
Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer or Myelodysplastic Syndrome
RATIONALE: Probiotics, such as Lactobacillus, may be effective in preventing infections in patients with suppressed immune systems.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00946283
- Testing
- Lactobacillus rhamnosus GG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rutgers, The State University of New Jersey
Human Immunodeficiency Virus
A Single Dose of Pembrolizumab in HIV-Infected People
Background: Human immunodeficiency virus (HIV) attacks the immune system. Some people with HIV have a low CD4+ T-cell count despite taking antiviral medicines that control HIV replication.
- Trial name
- NCT03367754
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sexually Transmitted Infections, Pregnancy, Unplanned
Optimizing a Multi-Modal Intervention to Reduce Health-Risking Sexual Behaviors: Component Selection
The goal of this project is to evaluate the components of the app-based intervention Mission Wellness to reduce health-risking sexual behaviors (HRSBs; e.g., condom non-use, multiple sexual partners) in active-duty members of the…
- Conditions
- Sexually Transmitted Infections, Pregnancy, Unplanned, Military Personnel
- Trial name
- NCT04661566
- Testing
- Basic Education ("Education"), Narrative Videos ("Narratives"), Skills Building Videos ("Skills")
- Where
- United States
- Volunteers
- 549 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
HIV/AIDS
A Mobile Phone Game to Prevent HIV Among Young Africans
This project will test the feasibility of an electronic game to prevent HIV among African preadolescents, delivered via inexpensive Android smart phones.
- Trial name
- NCT03054051
- Testing
- Tumaini Mobile Phone Game
- Where
- Kenya
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emory University
Pneumocystis, HIV/AIDS
Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS
The treatment guidelines for Pneumocystis pneumonia (PCP) suggest adding 40mg of prednisone (or its equivalent in methylprednisolone) twice per day on days 1 through 5, 40 mg days 6 through 10, and 20 mg daily on days 11 through…
- Conditions
- Pneumocystis, HIV/AIDS, Steroid
- Trial name
- NCT03856229
- Testing
- Conventional steroid regimen, Shortened steroid regimen
- Where
- Mexico
- Volunteers
- 196 people
- Sponsor
- Centro de Investigación en. Enfermedades Infecciosas, Mexico
Acquired Immune Deficiency Syndrome
A Post Marketing Survey Study to Evaluate the Safety and Effectiveness of Prezista
The purpose of this study is to assess the safety data of darunavir in a natural clinical practice.
- Trial name
- NCT01741831
- Testing
- No intervention
- Where
- South Korea
- Volunteers
- 225 people
- Sponsor
- Janssen Korea, Ltd., Korea
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