Clinical trials: Genital Infection Female
Genital Herpes
GUD Clinical and Virologic Response to Acyclovir in HIV Negative African Women
To examine the time to healing of genital lesion and duration of herpes simplex virus (HSV) shedding from genetic ulcer disease (GUD) among 90 HIV-negative African women who have a history of GUD and are HSV-2 seropositive and…
- Trial name
- PK/GUD (NCT00808405)
- Testing
- acyclovir
- Where
- 2 sites in South Africa, Zambia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cervical Cancer, Genital Warts
Study of an Investigational Vaccine in Pre-Adolescents and Adolescents (Gardasil)(V501-016)
The primary purpose of the study is to determine if an investigational vaccine Gardasil (V501) with 4 components will provide an immune response and will be well tolerated in pre-adolescents and adolescents.
- Trial name
- NCT00092495
- Testing
- V501, Gardasil, human papillomavirus (type 6, 11, 16, 18) recombinant vaccine
- Volunteers
- 3,055 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Solid Tumor, Adult, Advanced Solid Tumor
A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of SNS-101, a novel anti VISTA IgG1 monoclonal antibody as monotherapy or in combination with cemiplimab in patients with…
- Conditions
- Solid Tumor, Adult, Advanced Solid Tumor, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT05864144
- Testing
- SNS-101 (anti-VISTA), Cemiplimab
- Where
- 10 sites in United States
- Volunteers
- 98 people
- Sponsor
- Sensei Biotherapeutics, Inc.
HIV Infections, Transgender Women
Exploration of the Neo-Vagina Study
The current study will explore behavioral, surgical and biological neovaginal and rectal HIV transmission risks and feasibility of collection of blood and ano-genital samples (rectal, genital and neo-vaginal, including urine) for…
- Trial name
- NCT03049371
- Testing
- No Intervention for both groups
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
Bacterial Vaginosis
BASIC (Boric Acid, Alternate Solution for Intravaginal Colonization) Study
Bacterial vaginosis (BV), the world's most common vaginal infection, continues to cost patients time, energy, comfort and money.
- Trial name
- NCT00799214
- Testing
- Boric acid, Metronidazole
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Malaria, Falciparum, HIV Infections
Prevention of Malaria During Pregnancy Using Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine: Malawi
In Malawi, the standard of care to prevent malaria during pregnancy at the time of the study was a two dose sulfadoxine-pyrimethamine intermittent protective treatment (SP IPT) regimen administered in the second and third…
- Trial name
- NCT00126906
- Testing
- Monthly sulfadoxine/pyrimethamine, 2-dose sulfadoxine/pyrimethamine
- Where
- Malawi
- Volunteers
- 700 people
- Sponsor
- Centers for Disease Control and Prevention
Bacterial Vaginosis, Vulvovaginal Candidiases
Light Treatment of Vaginal Infections in Reproductive Age Women
Antimicrobials have helped in managing vaginal dysbiotic conditions such as bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC).
- Trial name
- NCT06985433
- Testing
- Vaginal light therapy - Once, Vaginal Light Therapy - Twice
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- UVISA Health ApS
Cervical Cancer, Human Papillomavirus Infection
Effect of Health Belief Model-Based Education on Cervical Cancer Knowledge and HPV Vaccine Attitudes in Women
This study evaluated the effect of a Health Belief Model-based educational intervention on women's knowledge of cervical cancer and their attitudes and beliefs toward HPV vaccination.
- Conditions
- Cervical Cancer, Human Papillomavirus Infection, Preventive Health Services
- Trial name
- HBM-HPV (NCT07521163)
- Testing
- Health Belief Model-Based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Muhammet Faruk Yigit
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Prostatic Hyperplasia, Urinary Retention
Comparing Clean Intermittent Self-catheterization and Indwelling Catheterization for the Management of Urinary Retention Before BPH Surgery.
The CATHETERS trial is a multicenter, randomized, open-label superiority study comparing two methods of managing urinary retention before surgery for benign prostatic hyperplasia (BPH): clean intermittent self-catheterization…
- Conditions
- Prostatic Hyperplasia, Urinary Retention, Urinary Catheterization, Intermittent Urethral Catheterization
- Trial name
- CATHETERS (NCT07555964)
- Testing
- ICSC, IDC
- Where
- 5 sites in France
- Volunteers
- 106 people
- Sponsor
- University Hospital, Bordeaux
Papillomavirus Infection
Acceptability of Human Papillomavirus Self-sampling in Women Living With HIV
Women living with HIV are unsufficiently screened for cervix cancer although they have a higher risk of developping it, resulting in many obstacles.
- Trial name
- AUTOCol (NCT05026047)
- Testing
- HPV self-sampling
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bacterial Vaginoses
Vaginal Microbiome Transplantation for Recurrent Bacterial Vaginosis
Vaginal Microbiome Transplantation (VMT) may be beneficial in treating the most severe cases of recurrent and antibiotics-nonresponsive cases of BV.
- Trial name
- NCT04517487
- Testing
- Vaginal Microbiome Transplantation (VMT)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
HIV Infections, Contraception
Evaluation of Pharmacokinetic Drug-drug Interactions Between Hormonal Contraceptives and Doravirine-containing ART Among Women Living With HIV in South Africa
The study investigators are conducting an observational, parallel group pharmacokinetic (PK) study among women living with HIV (WLHIV) already on 1st line antiretroviral therapy (ART) and virally suppressed, 18-45 years old…
- Conditions
- HIV Infections, Contraception, Drug-drug Interaction
- Trial name
- EPIC (NCT04669678)
- Testing
- Etonogestrel (ETG) implant, Intramuscular depo-medroxyprogesterone acetate (IM DMPA), Sub-cutaneous medroxyprogesterone acetate (SC MPA)
- Where
- South Africa
- Volunteers
- 110 people
- Sponsor
- University of Alabama at Birmingham
Candidiasis, Vulvovaginal, Recurrent Candidiasis of Vagina
Fluconazol Versus Medical Honey in the Treatment of Recurrent Vulvovaginal Candidiasis
The purpose of this study is to compare the efficacy of Flucanzol versus L-mesitran in the treatment of patients with recurrent vulvovaginal candidiasis. The investigator will look at vaginal swabs after 1, 6 and 12 months.
- Trial name
- NCT04626258
- Testing
- Fluconazole, L-Mesitran
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
HIV Infections
Multivitamin Dosage Regimens in the Prevention of Adverse Pregnancy Outcomes Among HIV-Positive Women
The purpose of this study is to examine effects of daily administration of multivitamin supplements at doses resembling the Recommended Dietary Allowance (RDA) during pregnancy to HIV positive women decreases the risks of low…
- Trial name
- NCT00197678
- Testing
- Multivitamins-Multiples of RDA, Multivitamins-Single RDA
- Where
- United States
- Volunteers
- 1,141 people
- Sponsor
- Harvard School of Public Health (HSPH)
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
HIV Infections, Sexually Transmitted Diseases
Safety, Tolerance and Acceptability Trial of the Invisible Condom® in Healthy Women
The objectives of this clinical study are to evaluate the extended safety, tolerance and acceptability of a vaginal gel formulation when applied in 452 healthy women volunteers.
- Trial name
- NCT00136643
- Testing
- Invisible Condom®
- Where
- Cameroon
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Laval University
Bacterial Vaginosis
Effect of Different Courses of Lactobacilli Treatment on Bacterial Vaginosis and Pregnancy Outcomes
The purpose of this study is to examine the effect of lactobacillus preparation on Bacterial vaginosis (BV) in low-risk pregnant women and to evaluate the value of double courses for the patients with durative positive result.
- Trial name
- BV (NCT01421615)
- Testing
- Vaginal capsules of lactobacilli
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Recurrent Vulvovaginal Candidiasis
Blue Light Emitting Diode Therapy on Vulvovaginal Candidiasis
With the knowledge that VVC is an infectious disease of the genitourinary tract that is common in women of reproductive age, and because of the shortage of non-drug therapies for this condition, this study will aim to evaluate…
- Trial name
- NCT05795491
- Testing
- Blue Light Emitting Diode Therapy, Azole Antifungal
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Bacterial Vaginoses
Multi-Gyn ActiGel Plus for Treatment of Bacterial Vaginosis
This is a randomized, double-blind, placebo-controlled clinical investigation. The objective of the study is to confirm the efficacy of Multi-Gyn ActiGel Plus to treat BV as compared to a placebo control.
- Trial name
- NCT04807842
- Testing
- vaginal gel
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- BioClin BV
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