Clinical trials: Genital Neoplasms, Male
Prostate Adenocarcinoma, PSA Failure
68Ga-PSMA PET/CT in Detecting Prostate Cancer Recurrence in Patients With Elevated PSA After Initial Treatment
The purpose of this research study is to see if recurrent prostate cancer can be identified using a special procedure called a positron emission tomography (PET) scan.
- Conditions
- Prostate Adenocarcinoma, PSA Failure, Recurrent Prostate Carcinoma
- Trial name
- NCT02673151
- Testing
- Computed Tomography (CT) scan, 68Ga-PSMA-11, Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Andrei Iagaru
Bladder (Urothelial, Transitional Cell) Cancer, Prostate Cancer
Selecting Hypoxic Tumours for Treatment Modification
Approximately 50% of cancer patients with solid tumours will be treated with radiotherapy. A significant proportion (>25%) of patients have hypoxic tumours which respond poorly to radiotherapy.
- Trial name
- SELECT (NCT06787053)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Manchester
Testicular Neoplasms
Risk of Venous Thromboembolism in Patients Receiving First-Line Chemotherapy for Disseminated Germ Cell Tumours
Recent data (Srikanthan and Tran et al. JCO 2014, in press) have demonstrated that the presence of large retroperitoneal lymph node metastases on baseline staging scans (measuring >5cm in axial dimension) are associated with…
- Trial name
- G3 RPLN PBC (NCT04122430)
- Testing
- Review of Health Information
- Where
- Australia
- Volunteers
- 1,135 people, healthy volunteers welcome
- Sponsor
- Walter and Eliza Hall Institute of Medical Research
Prostate Cancer
Pre-Prostatectomy Lovastatin on Prostate Cancer
To determine the dose of continuous daily oral lovastatin needed to achieve MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] down-regulation in prostatectomy specimens in intermediate-/high-risk localized prostate…
- Trial name
- NCT01478828
- Testing
- Lovastatin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Uterine Cancer, Rectal Cancer
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Female patients with early onset (<50 years old) pelvic malignancies such as uterine and rectal cancers are rising in incidence, which often requires pelvic radiation; many of these patients are premenopausal and at a high risk…
- Conditions
- Uterine Cancer, Rectal Cancer, Colon Cancer, Breast Cancer
- Trial name
- OvAR-Y (NCT06904365)
- Testing
- HyperSight cone beam computed tomography (CBCT) scan, ETHOS 2.0
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Washington University School of Medicine
Prostate Cancer
Danish Prostate Cancer Consortium Study-1
The purpose of the study is to investigate if a new promising microRNA-based urine biomarker test for prostate cancer, called uCaP, is better than the current standard test (PSA) to identify men who would benefit from an MRI scan…
- Trial name
- DPCC-1 (NCT05767307)
- Where
- 3 sites in Denmark
- Volunteers
- 2,500 people
- Sponsor
- Aarhus University Hospital
Prostate Cancer, Prostate Adenocarcinoma
A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer
Researchers conducting this study hope to learn about the safety and effectiveness of combining two study drugs, relacorilant and enzalutamide, plus androgen deprivation therapy (ADT), also known as hormone therapy.
- Trial name
- NCT05726292
- Testing
- Relacorilant, Enzalutamide, Androgen Deprivation Therapy
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Chicago
Prostate Cancer, Metastases
A Research Study for Patients With Prostate Cancer
The purpose of this study is to evaluate the activity of romidepsin (depsipeptide,FK228) in patients with metastatic prostate cancer who have developed a rising prostate specific antigen (PSA) while undergoing hormonal therapy.
- Trial name
- NCT00106418
- Testing
- Romidepsin
- Volunteers
- 35 people
- Sponsor
- Celgene
Bone Metastases, Breast Cancer
Safety and Efficacy Study of Concomitant Radiotherapy and Zoledronic Acid for Bone Metastases Palliation
Zoledronic acid (Zometa) belongs to a class of drugs called bisphosphonates. Bisphosphonates are used in bone metastases to keep the cancerous lesion under control in the bone and to help prevent calcium level elevations in the…
- Conditions
- Bone Metastases, Breast Cancer, Lung Cancer, Prostate Cancer
- Trial name
- NCT00264420
- Testing
- zoledronic acid
- Volunteers
- 4 people
- Sponsor
- The Cleveland Clinic
Prostate Cancer
MRI in Diagnosing Prostate Cancer
RATIONALE: Diagnostic procedures, such as magnetic resonance imaging (MRI), may help find prostate cancer and learn the extent of disease.
- Trial name
- NCT01292291
- Testing
- biologic sample preservation procedure, laboratory biomarker analysis, study of socioeconomic and demographic variables
- Volunteers
- 714 people
- Sponsor
- University College London Hospitals
Prostate Cancer
Choline PET/CT vs. Dual Time Point FDG PET/CT in Prostate Cancer
Prostate cancer is currently the leading newly diagnosed cancer in the industrialized world. Treatment of prostate cancer is highly dependent on the stage of the disease.
- Trial name
- NCT02232724
- Testing
- Choline PET/CT and Dual time point FDG PET/CT
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Squamous Cell Carcinoma of the Penis, Usual Type
International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)
This is an international phase III trial, with a Bayesian design, incorporating two sequential randomisations. It efficiently examines a series of questions that routinely arise in the sequencing of treatment.
- Trial name
- InPACT (NCT02305654)
- Testing
- ILND - Inguinal Lymph Node Dissection, Paclitaxel, Ifosfamide
- Where
- 17 sites in United States, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Cardiovascular Diseases, Breast Cancer
RCT of Strategies to Augment Physical Activity in Black and Hispanic Breast and Prostate Cancer Survivors (ALLSTAR)
This is a two-arm, randomized, controlled trial to evaluate the effectiveness of using a behaviorally designed gamification intervention with social support compared to an attention control group to increase physical activity…
- Conditions
- Cardiovascular Diseases, Breast Cancer, Prostate Cancer, Physical Inactivity
- Trial name
- ALLSTAR (NCT05176756)
- Testing
- Gamification and Social Support, Attention control
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Prostate Cancer
BIOPROP20: Biologically Optimised IMRT for Prostate Radiotherapy Hypofractionated Radiotherapy With Intra-prostatic Boosts to Tumour Nodules in Men With Intermediate and High Risk Prostate Cancer
High dose radiotherapy is a very effective treatment for prostate cancer. However, there is an increased risk of side effects compared to lower dose radiotherapy. This study will investigate the use of dose painting radiotherapy.
- Trial name
- BIOPROP20 (NCT02125175)
- Testing
- Hypofractionated IMRT boost Radiotherapy
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
Prostate Cancer
Assessing Quality of Life of Patients With Prostate Cancer
RATIONALE: Quality of life assessment in patients undergoing prostate cancer treatment may help determine the intermediate and long-term effects of the treatment on these patients.
- Trial name
- NCT00041301
- Testing
- QoL assessment
- Where
- 33 sites in Australia, Belgium and 9 more
- Volunteers
- 625 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Infectious Complications Following Prostate Biopsy, Prostate Cancer
A Study Comparing Infectious Complications After Transperineal Prostate Biopsy With or Without Antibiotic Prophylaxis
Prostate biopsy performed through the perineal skin (the area between the testicles and the anus), known as a transperineal biopsy, is currently considered the standard procedure for diagnosing prostate tumors, having replaced…
- Trial name
- NCT07557901
- Testing
- No antibiotic prophylaxis for prostate biopsy, Antibiotic prophylaxis (fosfomycin-trometamol) for prostate biopsy.
- Where
- Slovakia
- Volunteers
- 300 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Prostate Cancer
Retrospective Evaluation of a Commercially Available Hydrogel Spacer (BP-009)
Dosimetry efficacy of the hydrogel spacer.
- Trial name
- NCT05423431
- Testing
- Observation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- BioProtect
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer
This phase I trial is studying how well ipilimumab works after allogeneic stem cell transplant in treating patients with persistent or progressive cancer.
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Trial name
- NCT00060372
- Testing
- ipilimumab, therapeutic allogeneic lymphocytes
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
MR-guided Tumour Boost
This is a single-arm feasibility study that is recruiting 40 patients with histologically-proven localized prostate cancer and MRI-defined lesion(s).
- Trial name
- MRL-Boost PC (NCT05364229)
- Testing
- MR-guided Radiotherapy Boost
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
The purpose of this study is to characterize the safety and tolerability of KFA115 and KFA115 in combination with pembrolizumab in patients with select advanced cancers, and to identify the maximum tolerated dose and/or…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma, Carcinoma, Renal Cell, Carcinoma, Ovarian Epithelial
- Trial name
- NCT05544929
- Testing
- KFA115, pembrolizumab
- Where
- 18 sites in United States, Canada and 10 more
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
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