Clinical trials: Genital Neoplasms, Male
Prostate Cancer
Prospective CiRculating prOstate Cancer Predictors in HighEr Risk mCRPC studY
This study will develop a first-in-man CTC-based molecular taxonomy of CRPC in the context of novel AR-directed therapies, categorize different patterns of resistance in this disease setting, and describe their evolution over…
- Trial name
- PROPHECY (NCT02269982)
- Testing
- AR-v7 assays
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- Duke University
Cancer of Prostate
Assessment of Supersonic Imagine Aixplorer for the Detection and Localisation of Prostate Cancer Foci
The primary aim of the study is to assess the elasticity (Young's modulus) of cancerous tumor foci, of normal peripheral zone, and of normal transition zone in the prostate.
- Trial name
- PROSTATE SSI (NCT01639859)
- Testing
- Elastography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer, Hyperplasia
Early Detection of Prostate Cancer by FACS
Early detection of prostrate cancer and development of metastases. The research will attempt to match the SCM test (structuredness of the cytoplasmic matrix) in lymphocytes as an early cancer detection test using Florescent…
- Trial name
- FACS (NCT00524823)
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Malignant Neoplasm of Prostate
Fluciclovine (Axumin) PET/CT vs. NaF PET/CT in Prostate Cancer Osseous Metastatic Disease
The purpose of this study is to look at whether F-18 Fluciclovine (i.e. Axumin) is better or as good as F-18 Sodium Fluoride (F-18 NaF) when looking at bone disease from prostate cancer.
- Trial name
- NCT04765423
- Testing
- [F-18] NaF PET/CT, [F-18] fluciclovine PET/CT
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Assessment of Prostate MRI Before Prostate Biopsies
Background: Prostate cancer is difficult to detect using ultrasound. As a result, in case of suspicion of prostate cancer based on digital rectal examination (DRE) or Prostate Specific Antigen (PSA) level, it is currently…
- Trial name
- MRI-FIRST01 (NCT02485379)
- Testing
- Prostate biopsy
- Where
- 20 sites in France
- Volunteers
- 275 people
- Sponsor
- Hospices Civils de Lyon
Hormone Sensitive Prostate Cancer, Prostate Cancer
Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
The purpose of this study is to assess enzalutamide plus leuprolide in patients with high-risk nonmetastatic prostate cancer progressing after radical prostatectomy or radiotherapy or both.
- Conditions
- Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate
- Trial name
- NCT02319837
- Testing
- Enzalutamide, Leuprolide Open Label
- Where
- 255 sites in United States, Australia and 15 more
- Volunteers
- 1,068 people
- Sponsor
- Pfizer
Prostate Cancer
Retrospective Analysis of 68Ga-PSMA-PET in Patients With Prostate Cancer: Experience From Brazil
Gallium-68-prostate-specific membrane antigen (68Ga-PSMA) positron emission tomography (PET) has been increasingly used in the management of PCa in Brazil.
- Trial name
- PET-PSMA (NCT05169372)
- Where
- 3 sites in Brazil
- Volunteers
- 12 people
- Sponsor
- Latin American Cooperative Oncology Group
Prostate Cancer
Hypo-fractionated Postoperative IMRT in Prostate Cancer
To report the outcome of hypo-fractionated radiotherapy after radical prostatectomy (RP) for prostate cancer (PCa) using IMRT-SIB.
- Trial name
- NCT03233672
- Testing
- Hypo-fractionated postoperative IMRT-SIB
- Volunteers
- 124 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Prostate Cancer
Randomized Trial of Prostate Only or Pelvic RT in High Risk Prostate Cancer
Evidence to justify the use of the pelvic field is lacking for men with high risk localized prostate cancer. An additional randomized study is needed in men with a potential risk of nodal involvement to test the hypothesis that…
- Trial name
- POP-RT (NCT02302105)
- Testing
- IGRT
- Where
- India
- Volunteers
- 224 people
- Sponsor
- Tata Memorial Centre
Prostate Cancer
A Real-world Study of Characteristics, Treatment Patterns, and Clinical Outcomes Among Lutetium-177 Vipivotide Tetraxetan Treated Patients
The aim of this study was to assess the characteristics, treatment patterns, and clinical outcomes among metastatic castration-resistant prostate cancer (mCRPC) patients in the United States (US) who were treated with…
- Trial name
- NCT07477756
- Where
- United States
- Volunteers
- 1,247 people
- Sponsor
- Novartis Pharmaceuticals
Testicular Cancer
Shared Care Follow-up After Chemotherapy for Testicular Cancer
The aim of this study is to develop and evaluate a shared care survivorship care plan (SCP) to follow-up patients with metastatic testicular cancer after completion of chemotherapy that resulted in complete remission.
- Trial name
- SCFU-TC (NCT01783145)
- Where
- Netherlands
- Volunteers
- 163 people
- Sponsor
- University Medical Center Groningen
Breast Cancer, Vaginal Dryness
Breast Cancer, Aromatase Inhibitor Therapy, and Sexual Functioning: The Effects of Vaginal Testosterone Therapy
It is well documented that women who have breast cancer may experience a decrease in quality of life and sexual functioning due to side effects from adjuvant endocrine therapy, typically aromatase inhibitors (AIs).
- Conditions
- Breast Cancer, Vaginal Dryness, Dyspareunia, Sexual Health Quality of Life
- Trial name
- NCT01697345
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Creighton University
Prostatic Neoplasms, Psychological Distress
ComCancer: Use of Let's Discuss Health Website by Patients With Prostate Cancer Undergoing Radiation Oncology Treatment
In Canada, the prevalence of cancer is growing and contributes significantly to health costs. The prevention and treatment of cancer is a major concern of our health system.
- Conditions
- Prostatic Neoplasms, Psychological Distress, Physician-Patient Relations, Communication
- Trial name
- NCT05787145
- Testing
- Let's Discuss Health Group
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Advanced Prostate Cancer, Lower Urinary Tract Symptoms
Lucrin® Depot Efficacy and Safety Monitoring Study in Patients With Advanced Prostate Cancer and Lower Urinary Tract Symptoms (LUTS)
The purpose of the study is to determine the influence of GnRH (gonadotropin releasing hormone) analogue - Lucrin Depot 11.25 mg (Lucrin Depot 3.75mg - in Ukraine) administration on intensity of lower urinary tract symptoms…
- Trial name
- LEMON (NCT01078545)
- Testing
- Leuprolide acetate Depot Susp. 11.25 mg (Poland), 3.75 mg (Ukraine)
- Where
- 143 sites in Poland, Ukraine
- Volunteers
- 729 people
- Sponsor
- Abbott
Prostate Cancer
PROState Cancer Patients Initiating Hormone Therapy: Effect of Exercise on CARDIOvascular Health (PROSCARDIO)
This study evaluates whether exercise can reduce treatment-related adverse effects in prostate cancer patients initiating androgen deprivation therapy.
- Trial name
- PROSCARDIO (NCT03776045)
- Testing
- Standard care plus exercise
- Volunteers
- 50 people
- Sponsor
- University of East Anglia
Cervical Cancer, Colorectal Cancer
89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
A prospective, open-label, phase 2 study to explore CAIX expression through 89Zirconium-labelled girentuximab deferoxamine (89Zr-girentuximab) PET/CT imaging in patients with solid tumors.
- Conditions
- Cervical Cancer, Colorectal Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- STARBURST (NCT05563272)
- Testing
- 89Zr-girentuximab for PET/CT imaging of CAIX positive tumors
- Where
- 10 sites in United States
- Volunteers
- 11 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Ltd
Prostate Cancer, Renal Cancer
Preliminary Evaluation of Uptake of [68Ga]P16-093 in Metastatic Prostate and Renal Cancer
An phase I study to evaluate the uptake of [68Ga]P16-093 in known or suspected metastatic prostate or renal cancer to establish the feasibility of using [68Ga]P16-093 to image PSMA expressing cancer.
- Trial name
- NCT03073395
- Testing
- [68Ga]P16-093
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Five Eleven Pharma, Inc.
Prostate Cancer
Randomized Controlled Trial of CAN-2409 Immunotherapy During Active Surveillance for Prostate Cancer (ULYSSES)
The purpose of this study is to evaluate the effectiveness of CAN-2409 immunotherapy in patients undergoing active surveillance for localized prostate cancer.
- Trial name
- NCT02768363
- Testing
- aglatimagene besadenovec, valacyclovir
- Where
- 23 sites in United States, Mexico
- Volunteers
- 187 people
- Sponsor
- Candel Therapeutics, Inc.
Prostate Cancer
Measurements Of Zinc Concentration On Specimens Taken During Trans-Perineal Prostate Biopsy
The purposes of this study are to: i) confirm and improve the accuracy of the correlation between levels of Zinc in prostate tissue and the grade of prostate cancer in that tissue as determined through pathology; and ii)…
- Trial name
- NCT01915316
- Testing
- prostate biopsy
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- ProSight
Prostate Cancer
FOcal Radiation for Oligometastatic Castration-rEsistant Prostate Cancer (FORCE)
This clinical trial will determine whether the addition of radiotherapy to standard of care systemic therapy improves objective progression-free survival compared to systemic therapy alone in patients with oligometastatic…
- Trial name
- NCT03556904
- Testing
- Ablative Radiation Therapy, Hormone therapy or chemotherapy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Michigan Rogel Cancer Center
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