Clinical trials: Genital Neoplasms, Male
Prostate Cancer, Chemotherapy Effect
Neoadjuvant Chemo-hormonal Therapy Combined With Radical Prostatectomy for Locally Advanced Prostate Cancer
To evaluate of the value of radical prostatectomy and extended pelvic lymph node dissection in locally advanced prostate cancer after neoadjuvant hormonal therapy with or without docetaxel chemotherapy.
- Conditions
- Prostate Cancer, Chemotherapy Effect, Hormone Sensitive Prostate Cancer, Locally Advanced Prostate Carcinoma
- Trial name
- NCT04220398
- Testing
- Neoadjuvant chemotherapy combined with hormone therapy, Neoadjuvant hormone therapy, Radical Prostatectomy (RP)+ extended lymph node dissection
- Volunteers
- 475 people
- Sponsor
- RenJi Hospital
Prostate Cancer
Safety and Efficacy of Firmagon® (Degarelix) for Injection
The purpose of this study is to assess the safety and efficacy of Firmagon® (degarelix) for injection under the conditions of general clinical practice in Korea.
- Trial name
- NCT02886598
- Testing
- degarelix
- Where
- South Korea
- Volunteers
- 368 people
- Sponsor
- Ferring Pharmaceuticals
Prostatic Neoplasms
Outpatient Radical Prostatectomy - Surgical and Anesthetic Considerations
Radical prostatectomy has become the gold standard treatment for prostate cancer. Regarding of morbidity of access on open retropubic radical prostatectomy a lot of centers around the world start to develop laparoscopic and…
- Trial name
- ORP-SAC (NCT01955863)
- Testing
- patient discharge on postoperative day 2, patient discharge on postoperative day 1, patient discharge in the day of surgery
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Wesley Justino Magnabosco
Breast Cancer, Cognitive/Functional Effects
Study of Symptoms Caused by Cancer and Cancer Therapy in Patients With Invasive Breast, Lung, Prostate, or Colorectal Cancer
RATIONALE: Questionnaires that assess symptoms caused by cancer and cancer therapy may help improve the ability to plan treatment for patients with invasive cancer to help them live longer and more comfortably.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Colorectal Cancer, Lung Cancer
- Trial name
- NCT00303914
- Testing
- assessment of therapy complications, cognitive assessment, psychosocial assessment and care
- Where
- 32 sites in United States
- Volunteers
- 2,310 people
- Sponsor
- Eastern Cooperative Oncology Group
Prostatic Neoplasms
Darolutamide in Addition to ADT Versus ADT in Metastatic Hormone-sensitive Prostate Cancer
The purpose of the study is to assess the efficacy and safety of darolutamide in combination with standard androgen deprivation therapy (ADT) in patients with metastatic hormone sensitive prostate cancer.
- Trial name
- ARANOTE (NCT04736199)
- Testing
- Darolutamide (Nubeqa, BAY1841788), Androgen deprivation therapy (ADT)
- Where
- 131 sites in Australia, Brazil and 13 more
- Volunteers
- 669 people
- Sponsor
- Bayer
Indirect Inguinal Hernia, Undescended Testis
INVESTIGATION OF THE GENETIC ETIOLOGY OF HERNIA SAC DEVELOPMENT IN MALE CHILDREN WITH UNDESCENDED TESTIS AND INGUINAL HERNIA
The aim of the project is to elucidate the genetic etiology underlying the development of the processus vaginalis (PV) in male children with indirect inguinal hernia (IIH) and undescended testis (UT), through the investigation of…
- Trial name
- NCT07586332
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Trakya University
Prostate Cancer (Post Prostatectomy)
Salvage Ultrahypofractionated Postoperative External Radiotherapy For Biochemical Recurrence
Recently, the Radiation Oncology Department at Fondazione IRCCS San Gerardo dei Tintori has been renovated and has been equipped with cutting edge technologies to treat prostate cancer.
- Trial name
- SUPERB (NCT06941363)
- Testing
- SDRT
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Milano Bicocca
Prostate Cancer
IONM During Radical Prostatectomy
At present, the preferred treatment for patients with prostate cancer is still radical prostatectomy. Postoperative patients often face some complications, the most common complications include urinary incontinence and erectile…
- Trial name
- NCT06950216
- Testing
- IONM
- Volunteers
- 40 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Prostate Cancer, Erectile Dysfunction
Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction
Erectile dysfunction is a frequent adverse event after radical prostatectomy for prostate cancer. It is the consequence of penile vascular damage, mainly arterial insufficiency and venous leakage associated with fibrosis of the…
- Trial name
- INSTIN (NCT01089387)
- Testing
- injection of bone marrow mononucleated cells
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Prostatic Neoplasms
A Phase I Study of Recombinant Vaccinia Virus That Expresses Prostate Specific Antigen in Adult Patients With Adenocarcinoma of the Prostate
This trial will evaluate, in patients with metastatic prostate cancer, the tolerability, toxicities, efficacy, and immunologic effects of repeated vaccinations with a recombinant vaccinia virus that contains the Prostate Specific…
- Trial name
- NCT00001382
- Testing
- PROSTVAC
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Prostate Cancer
Plasma Analysis for Response Assessment and to DIrect the manaGement of Metastatic Prostate Cancer
This research study is looking into plasma tumour deoxyribonucleic acid (ptDNA), a substance that is shed by cancer cells and can be detected in blood samples.
- Trial name
- PARADIGM (NCT04067713)
- Where
- 16 sites in United Kingdom
- Volunteers
- 192 people
- Sponsor
- University College, London
Relapsed Prostate Cancer
Prospective Evaluation of 68-Ga-prostate Specific Membrane Antigen (PSMA)-Positron Emission Tomograph (PET) and Early Prostatic Specific Antigen (PSA) Kinetics During Salvage Radiotherapy for Personalizing the Management of Men With Relapse of Prostate Cancer After Radical Prostatectomy
This is an open-label, phase II trial in patients with PSA recurrence after prostatectomy. Patients entering the study will all receive initial 50 Gray (Gy) radiotherapy (25 x 2Gy) to the prostate bed and thereafter be classified…
- Trial name
- PROPER (NCT02699424)
- Testing
- External radiation therapy
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University Hospital
Prostate Cancer
To Evaluate an MRI-based Optimized Prostate Cancer Diagnostic Pathway Powered by Artificial Intelligence
It is a prospective paired-cohort study for diagnostic test evaluation. The study aim to determine the accuracy of AI review and investigate whether AI review could detect MRI visible significant cancer as effective as…
- Trial name
- NCT06360523
- Testing
- AI modal, Standard review
- Where
- Hong Kong
- Volunteers
- 629 people
- Sponsor
- Chinese University of Hong Kong
Neoplasms, Prostatic Neoplasms
XRP6258 Plus Prednisone Compared to Mitoxantrone Plus Prednisone in Hormone Refractory Metastatic Prostate Cancer
This is a randomized, open-label, multi-center study comparing the safety and efficacy of XRP6258 plus prednisone to mitoxantrone plus prednisone in the treatment of hormone refractory metastatic prostate cancer previously…
- Trial name
- TROPIC (NCT00417079)
- Testing
- cabazitaxel (XRP6258) (RPR116258), mitoxantrone, prednisone
- Where
- 26 sites in United States, Argentina and 24 more
- Volunteers
- 755 people
- Sponsor
- Sanofi
Cancer of Prostate
De-implementation of Low Value Castration for Men With Prostate Cancer
This study will use a theory-based, mixed methods approach to identify, tailor and pilot two different de-implementation strategies that vary widely in delivery, impact, and expected results for reducing low value androgen…
- Trial name
- DeADT (NCT03579680)
- Testing
- ADT ORDER CHECK ATTESTATION (OR), PROVIDER SCRIPT (SC)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Prostate Cancer
Clinico-pathologic Correlative Study of 3T Magnetic Resonance Spectroscopy in the Localization of Prostate Cancer
We seek to develop an advanced imaging approach to identifying and localizing prostate cancer. We believe that high field MRI (magnetic resonance imaging) has the potential to do this and we will endeavor to prove this by having…
- Trial name
- NCT00310479
- Testing
- Magnetic Resonance Spectroscopy (3Tesla)
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- AHS Cancer Control Alberta
Prostate Cancer
Adjuvant Docetaxel and Estramustine Phosphate for High Risk Localized Prostate Cancer
This trial will evaluate the feasibility, toxicity, and efficacy of docetaxel/estramustine, as in the adjuvant therapy of patients with high-risk prostate cancer after definitive local therapy.
- Trial name
- NCT00193271
- Testing
- Docetaxel, Estramustine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- SCRI Development Innovations, LLC
Prostate Cancer, Surgery
The Effect of the Educatıon and Counselıng of Prostatectomy Patıents
The research was planned as a randomized controlled experimental study. This study is planned to be conducted in the Urology clinic of a university hospital located in the south of Turkey.
- Conditions
- Prostate Cancer, Surgery, Nursing Caries
- Trial name
- NCT05428098
- Testing
- education
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Prostate Cancer, Metastatic Prostate Cancer
Sipuleucel-T (Sip-T) in Combination With N-803 in Metastatic Androgen Pathway Modulation Resistant (mAPMR) Prostate Cancer
This phase Ib single-center open-label de-escalation study uses a modified 3+3 design to determine the safety, tolerability, and recommended phase II dose (RP2D) of the combination of standard of care Sip-T and N-803 in patients…
- Trial name
- NCT07756593
- Testing
- Sipuleucel-T, N803
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
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