Clinical trials: Genitourinary Disease
HIV Infections
BLQ Study: A Study of a Protease Inhibitor With Fuzeon (Enfuvirtide) in Treatment-Experienced Patients With HIV-1.
This single arm study will evaluate the efficacy, safety and tolerability of a new investigational protease inhibitor (PI) plus background antiretrovirals plus Fuzeon (90mg sc bid) in HIV-1 infected, triple-class…
- Trial name
- NCT00326963
- Testing
- Background ARVs, PI, enfuvirtide [Fuzeon]
- Where
- 38 sites in United States, Australia
- Volunteers
- 142 people
- Sponsor
- Hoffmann-La Roche
Vaginal Infection
Performance Proof of the New NORMA-SENSE
This study was designed to validate the color appearance on the newly developed panty liner (NORMA-SENSE). The NORMA-SENSE liner changes color when worn by the user and comes into contact with vaginal secretion with an elevated…
- Trial name
- NCT00802763
- Testing
- NORMA-SENSE
- Where
- Israel
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
HIV Infections
Endothelial Dysfunction as a Risk Factor in HIV Study
Highly active antiretroviral therapy (HAART) has proven effective in altering the natural history of HIV infection in many patients. However, this therapy may not be sustainable because of the toxicities of the medications.
- Trial name
- NCT00039663
- Testing
- Pravastatin, Gemfibrozil, Rosiglitazone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Kidney Transplant; Complications, Polycystic Kidney Diseases
Evaluation of Iliac and Renal Artery for Mechanism of Intracranial Aneurysm in ADPKD
ADPKD is the most common form of hereditary kidney disease and is known to occur in 1 of 400 to 1000 population in the U.S. ADPKD consists of 2.8% of patients receiving kidney transplantation in our center.
- Conditions
- Kidney Transplant; Complications, Polycystic Kidney Diseases, Aneurysm, Brain
- Trial name
- NCT03726463
- Testing
- Kidney transplantation
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Urinary Incontinence, Platelet Rich Plasma
Strategy for Managing Urinary Incontinence With PRP
Urinary incontinence is a public health issue; in France, approximately 3 million women are affected. Current treatment options-particularly surgical procedures involving the use of prosthetic materials-are being called into…
- Trial name
- PRPIU (NCT07832487)
- Testing
- Plasma rich platelet injection, Blood test, cytobacteriological examination of urine
- Where
- France
- Volunteers
- 41 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Prostate Cancer, Brachytherapy
PRO-BOOST-N: Prostate-First Versus Combined Prostate and Nodal Dose Escalation in PSMA PET-Staged Node-Positive Prostate Cancer
PRO-BOOST-N is a prospective, multicenter, randomized phase II/III clinical trial for patients with prostate cancer and pelvic lymph node involvement (cN1M0) confirmed by PSMA PET/CT, without distant metastatic disease.
- Conditions
- Prostate Cancer, Brachytherapy, Stereotactic Body Radiation Therapy (SBRT), Dose Escalation: Solid Tumors
- Trial name
- PRO-BOOST-N (NCT07426094)
- Testing
- Ultrahypofractionated Whole-Pelvis Radiotherapy, SBRT-Based Prostate Radiotherapy (No Boost), Ablative Prostate Boost
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Preventive Health Services, Health Communication
Patients Engaged in Prevention: Enhancing Outreach to Increase Patient Engagement in Diabetes Prevention
This study examines whether a health message that includes a self-affirmation intervention (where people reflect on values that are important to them) increases acceptance of the message and encourages people to take steps to…
- Trial name
- PEP (NCT03550066)
- Testing
- Values affirmation, No affirmation
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Urinary Tract Infections
General Practitioner Reassessment of Urinary Infection Antibiotherapy Prescribed by Emergency Departments
Urinary infections are at the origin of many emergency department consultations and antibiotic prescriptions. Increase of bacteria resistance to antibiotics is promoted by an inappropriate use of those antibiotics but initial…
- Trial name
- ATB-IU (NCT03928951)
- Testing
- General practitioner reassessment of urinary infection antibiotherapy prescribed by emergency departments
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Infection, Human Immunodeficiency Virus
A Study to Assess The Relative Bioavailability of New Tablet Formulations of GSK1265744 in Healthy Adult Subjects
This study will evaluate two new GSK1265744 sodium salt tablet formulations and provide data for selection of one of these tablet formulations for use in Phase 3.
- Trial name
- NCT02059031
- Testing
- GSK1265744 Reference formulation, GSK1265744 New formulation 1, GSK1265744 New formulation 2
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infections
Alternative Stress Management Approaches in HIV Disease
The overall purpose of the proposed study is to determine whether three short-term stress management interventions along with booster strategies will improve and sustain improvements in psychosocial functioning, quality of life…
- Trial name
- NCT00029237
- Testing
- Cognitive-behavioral relaxation (Positively Living), Spiritual growth group, Focused Tai Chi
- Where
- United States
- Volunteers
- 392 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Hyperandrogenism, Metabolic Cardiovascular Syndrome
Phlebotomy and Polycystic Ovary Syndrome
AIMS To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional…
- Trial name
- NCT02460445
- Testing
- Phlebotomy, ethinylestradiol, Cyproterone Acetate
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Manuel Luque Ramírez
Cervical Cancer, Endometrial Cancer
Epidural Analgesia or Patient-Controlled Analgesia in Treating Patients Who Have Undergone Surgery for Gynecologic Cancer
RATIONALE: Giving pain medication into the space between the wall of the spinal canal and the covering of the spinal cord or giving it into a vein may help lessen pain caused by cancer surgery.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00295945
- Testing
- fentanyl citrate, hydromorphone hydrochloride, ropivacaine hydrochloride
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Membranous Nephropathy
Role of Anti-mouse PLA2R1 ELISA in Membranous Nephropathy
Membranous Nephropathy (MN) is an auto-immune kidney disease and a common cause of nephrotic syndrome. About 30% of MN patients progress to end-stage kidney disease (ESKD) while 30% undergo spontaneous remission.
- Trial name
- SOURIS (NCT02199145)
- Testing
- Blood and urine analysis
- Where
- 3 sites in France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cervix; Intraepithelial Neoplasia
Depth of Necrosis in Normal Cervical Epithelium After 85% Trichloroacetic Acid (TCA) Application
Early detection and treatment of precancerous lesions are the pillars of cervical cancer prevention. Cervical Intraepithelial Neoplasia (CIN) is a precancerous lesion that histologically can be found in one of three stages of…
- Trial name
- NCT04911075
- Testing
- 85% TCA Solution
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Endometriosis
BGS649 Monotherapy in Moderate to Severe Endometriosis Patients
This study will assess the safety and tolerability of BGS649 in women with moderate to severe endometriosis.
- Trial name
- NCT01190475
- Testing
- Active treatment with a high dose of BGS649, Active treatment with a low dose of BGS649
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mereo BioPharma
Endometrial Cancer
MCC-24-GYN-11: Comparison of Nodal Sampling in Endometrial Cancer
This study aims to estimate the recurrence-free survival rates in women with endometrial cancer treated with selective versus sentinel node surgical staging.
- Trial name
- NCT06677112
- Testing
- Selective surgical staging, REFLEX
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- Rachel Miller
Cervical Cancer
Phase II Clinical Trial of Concurrent Chemoradiotherapy Combined Nimotuzumab for Stage IIB-IVA Cervical Cancer
The purpose of this phase II trial is to determine the feasibility and efficacy of nimotuzumab injection combined with concurrent chemoradiotherapy for initially inoperable locally advanced cervical cancer.
- Trial name
- NCT02705612
- Testing
- Cisplatin, External Beam Radiation Therapy, Internal Radiation Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Urinary Incontinence, Stress
Electrostimulation and PFMT for Stress Urinary Incontinence
The goal of this randomized controlled trial is to evaluate and compare the effects of electrostimulation in addition to pelvic floor muscle training and pelvic floor muscle training alone on pelvic floor muscle (PFM) function…
- Trial name
- NCT05871281
- Testing
- Pelvic floor muscle exercises
- Where
- Lithuania
- Volunteers
- 24 people
- Sponsor
- Lithuanian Sports University
Infertility
Comparing Two Different Embryo Transfer Catheters
Numerous published trials now document that the embryo transfer (ET) procedure has a huge impact on pregnancy and delivery rates after IVF (In Vitro Fertilization).
- Trial name
- CATH (NCT03161119)
- Testing
- Ultrasound guided embryotransfer with Cook K-Jets-551910-S, Ultrasound guided embryotransfer with Cook k-soft-5000 (or K-J-SP-681710 and K-J-SPPE-681710)
- Where
- Italy
- Volunteers
- 352 people
- Sponsor
- Istituto Clinico Humanitas
External Genital Warts
Efficacy and Tolerability of Topical LFX453 for External Genital Warts
The LFX453X2202 study tested the investigational drug LFX453 against placebo for safety, tolerability, and efficacy in treating genital warts in circumcised men, in parallel with an additional open label arm using imiquimod 5%.
- Trial name
- NCT02482428
- Testing
- Investigational Treatment, Aldara
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Novartis Pharmaceuticals
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.