Clinical trials: Genome
Thyroid Cancer, Non-Cancer Thyroid Disease
Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Ukraine Following the Chernobyl Accident
The nuclear power plant accident at Chornobyl released large quantities of Iodine-131 and other radioisotopes of iodine in the atmosphere, contaminating thousands of square kilometers and exposing millions of people.
- Conditions
- Thyroid Cancer, Non-Cancer Thyroid Disease, Non Thyroid Cancer
- Trial name
- NCT00341094
- Where
- Ukraine
- Volunteers
- 23,143 people
- Sponsor
- National Cancer Institute (NCI)
Discordant Cancers
Genomic Analysis of Families With a History of Discordant Cancers
The purpose of this study is to identify novel gene mutations which have contributed to significant personal and family history of cancer. Adults with and without cancer will be accrued to the study.
- Trial name
- NCT04860453
- Testing
- WES via Illumina NextSeq 550 sequencing system, Blood Draw, Skin biopsy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Case Comprehensive Cancer Center
Leukemia, Acute Lymphoblastic
Acute Lymphoblastic Leukemia Therapies Informed by Genomic Analyses
Previous work performed by University of New Mexico Comprehensive Cancer Center (UNMCCC) investigators has revealed previously unknown genomic mutations in children, adolescents, and young adults with high-risk B and T cell…
- Trial name
- NCT02580981
- Testing
- Acute Lymphobastic Leukemia (ALL) Treatment Options
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- New Mexico Cancer Research Alliance
Acute Lymphoblastic Leukemia, Hodgkin Lymphoma
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors
This study examines the impact of social and genetic factors on outcomes in adolescent and young adult (AYA) cancer survivors of Hodgkin or non-Hodgkin lymphoma or leukemia.
- Conditions
- Acute Lymphoblastic Leukemia, Hodgkin Lymphoma, Non-Hodgkin Lymphoma
- Trial name
- NCT06002828
- Testing
- Non-Interventional Study
- Where
- 507 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Sickle Cell Disease
Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders
The primary objectives of this prospective mixed-method interview study are to use semi-structured interviews in parents of sickle cell disease (SCD) patients to describe parental attitudes of research involving genomic…
- Trial name
- NCT04416178
- Where
- United States
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Metastatic Biliary Tract Carcinoma, Metastatic Colorectal Carcinoma
Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer
This phase I/II trial studies the side effects and best dose of liposomal irinotecan and rucaparib when given together with fluorouracil and leucovorin calcium and to see how well they work in treating patients with pancreatic…
- Conditions
- Metastatic Biliary Tract Carcinoma, Metastatic Colorectal Carcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma, Metastatic Malignant Digestive System Neoplasm
- Trial name
- NCT03337087
- Testing
- Fluorouracil, Irinotecan Sucrosofate, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Academic and Community Cancer Research United
Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm
Does the Use of a Genomic Tumor Board Increase the Number of Patients Who Receive Genome-Informed Treatment
This clinical trial studies how well an educationally enhanced genomic tumor board (EGTB) intervention works to increase the number of patients with solid tumors that have come back (recurrent), do not respond to treatment…
- Conditions
- Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm
- Trial name
- NCT05455606
- Testing
- Best Practice, Chart Abstraction, Educational Intervention
- Where
- 72 sites in United States, Puerto Rico
- Volunteers
- 1,284 people
- Sponsor
- SWOG Cancer Research Network
Cardiac Transplant Rejection, Lung Transplant Rejection
Genome Transplant Dynamics: Non-invasive Sequencing-based Diagnosis of Rejection
The purpose of this study is to determine whether shotgun sequencing technology, which can be used to detect donor DNA in recipient plasma, can be used as a rapid, accurate, non-invasive method to detect Acute Cellular Rejection…
- Trial name
- GTD (NCT01985412)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Stanford University
Type2 Diabetes
Diabetes Research on Patient Stratification
The overarching goal of the IMI DIRECT (Innovative Medicines Initiative Diabetes Research on Patient Stratification) Consortium is the identification of biomarkers that aid therapeutic targeting in prediabetes (Study 1) or early…
- Trial name
- DIRECT (NCT03814915)
- Volunteers
- 3,049 people
- Sponsor
- Lund University
Breast Cancer Female
GENe EXpression After Regional or General ANesthesia in Patients Undergoing Breast Cancer Surgery
Breast cancer is the most commonly diagnosed cancer in females and the second leading cause of death from cancer in women. It was estimated that 2 million new cases have occurred in 2018 worldwide 1.
- Trial name
- GENEXAN (NCT03779685)
- Testing
- General anesthesia, Regional anesthesia
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Breast Cancer Female
MEND 2: Making Treatment Decisions Using Genomic Testing
Clinical guidelines for women with early stage breast cancer integrate genomic tumor profiling tests such as the Oncotype DX Recurrence Score to refine recurrence estimates and systemic therapy selection when combined with…
- Trial name
- MEND2 (NCT03183050)
- Testing
- Question Prompt List
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Georgetown University
Obesity and Overweight
The Effects of Environmental Factors on the Macro-genome and Metabolism of Obese Patients.
The present study was designed to include obese patients diagnosed with obesity in the First Affiliated Hospital of Chongqing Medical University and a healthy control population.
- Trial name
- NCT06673433
- Testing
- obesity, health
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dong Peng
Breast Cancer Invasive
Precision Regional Node Irradiation for Sentinel Node-positive Breast Cancer
Axillary lymph node dissection has long been regarded as standard if treatment of the axilla is indicated for patients with a positive sentinel node.
- Trial name
- NCT06583655
- Testing
- SLND(clinical low risk), SLND(clinical high risk, genomic low risk), SLND alone ,clinical high risk and genomic high risk group
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Ruijin Hospital
Prostate Cancer
Open Registry Measuring Impact of Genomic Testing on Treatment Decision After Biopsy in Newly Diagnosed Prostate Cancer Patients
This registry is intended to measure the impact of Prolaris® testing on therapeutic decisions when added to standard clinical-pathological parameters in men with newly diagnosed prostate cancer.
- Trial name
- PROCEDE-2000 (NCT02209584)
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Myriad Genetic Laboratories, Inc.
Hand Osteoarthritis
Genome-wide Study for Disease Susceptibility Gene(s) in Patients With Hand Osteoarthritis
This is a case-control study involving one medical center and one research institute to develop a data-set containing a minimum of 100 osteoarthritis cases, minimum of 100 independent controls of similar gender ratio and a…
- Trial name
- NCT01981265
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Non-Small Cell Lung Cancer
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
The purpose of this study is to evaluate efficacy and safety of Dato-DXd in combination with rilvegostomig or rilvegostomig monotherapy compared with pembrolizumab monotherapy as a first line therapy in participants with locally…
- Trial name
- TROPION-Lung10 (NCT06357533)
- Testing
- Datopotamab Deruxtecan, Rilvegostomig, Pembrolizumab
- Where
- 290 sites in United States, Australia and 19 more
- Volunteers
- 675 people
- Sponsor
- AstraZeneca
Cancer
Testing Gene PilotLX With Latinx Cancer Patients
This is a randomized controlled trial designed to evaluate the efficacy of an electronic health decision support tool called Gene PilotLX to increase informed decision making regarding hereditary risk information from tumor…
- Trial name
- NCT06476938
- Testing
- Gene PilotLX
- Where
- 4 sites in United States
- Volunteers
- 239 people
- Sponsor
- Fox Chase Cancer Center
Prostate Cancer, Adenocarcinoma of the Prostate
Neoadjuvant Docetaxel on Newly Diagnosed Intermediate and High Grade Cancer of the Prostate
This pilot phase II trial studies docetaxel and prednisone in treating patients with newly diagnosed stage I-II prostate cancer undergoing prostatectomy.
- Conditions
- Prostate Cancer, Adenocarcinoma of the Prostate, Stage I Prostate Cancer, Stage II Prostate Cancer
- Trial name
- 2007-5904 (NCT00598858)
- Testing
- Docetaxel, Prednisone
- Sponsor
- John P. Fruehauf
Undiagnosed Disease
Exome and Genome Analysis to Elucidate Genetic Etiologies and Population Characteristics in the Plain Community
This study is designed to utilize whole exome and whole genome sequencing techniques to identify underlying genetic causes for undiagnosed disorders in the Plain Communities, and to do population genetic studies looking at…
- Trial name
- NCT02927158
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8
Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial
This phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone therapy plus ribociclib for the treatment of patients with high anatomic stage breast cancer with low risk of the…
- Conditions
- Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, Estrogen Receptor-Positive Breast Carcinoma
- Trial name
- NCT07391774
- Testing
- Anastrozole, Biospecimen Collection, Bone Scan
- Where
- 248 sites in United States, Puerto Rico
- Volunteers
- 1,978 people
- Sponsor
- National Cancer Institute (NCI)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.