Clinical trials: Geriatric Cancer Patients
Undernutrition, Cancer
Management of Malnutrition in Oncogeriatrics
In France, undernutrition affects almost three million people, a third of whom are over 70 (Diagnosing undernutrition earlier in the elderly aged 70 and over, n.d.).
- Trial name
- NCT06425315
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer
Immediate Curative vs Conservative Treatment in Older Men With M0, High-risk Prostate Cancer
It is currently unclear if immediate curative treatment (radiotherapy or surgery) of high-risk prostate cancer without metastasis in older men (>=75 years) generates the same survival benefits as in younger patients or if the…
- Trial name
- GrandP/SPCG19 (NCT05448547)
- Testing
- Radiotherapy or surgery, initial observation, Hormone therapy
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 980 people, healthy volunteers welcome
- Sponsor
- Sven Löffeler
Glioblastoma
Avastin Plus Radiotherapy in Elderly Patients With Glioblastoma
The purpose of this study is to explore the efficacy of bevacizumab combined with radiotherapy compared with radiotherapy alone in the treatment of newly diagnosed glioblastoma in the elderly. Trial with medicinal product
- Trial name
- ARTE (NCT01443676)
- Testing
- Bevacizumab, Radiation therapy
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Gynecologic Cancer, Frailty
Cognitive and Physical Frailty as Predictors of Decision Satisfaction in Geriatric Gynecologic Oncology
This prospective observational study aims to evaluate the association between preoperative cognitive function, measured by the Montreal Cognitive Assessment (MoCA), and physical frailty, assessed using the Clinical Frailty Scale…
- Conditions
- Gynecologic Cancer, Frailty, Cognitive Impairment, Geriatric Oncology
- Trial name
- GYNCOGFRAIL (NCT07085000)
- Testing
- No Intervention - Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir City Hospital
Esophageal Squamous Cell Carcinoma (ESCC)
An Observational Study on the Safety and Efficacy of Immunotherapy Combined With Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma
Title: Observational Study on the Safety and Efficacy of Immunotherapy Combined with Concurrent Chemoradiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma Study Purpose: This single-center, open-label…
- Trial name
- NCT07080437
- Testing
- Immunotherapy Therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Three Gorges Hospital of Chongqing University
Carcinoma, Non-Small-Cell Lung
Comprehensive Geriatric Assessment and Complications Following Lung Resection for Lung Cancer
schema : Prospective prognostic study The main objective is to study the value of the Comprehensive Geriatric Assessment in predicting the risk of post operative complications after lung resection for cancer.
- Trial name
- OPERAGE (NCT01956331)
- Where
- 25 sites in France
- Volunteers
- 302 people
- Sponsor
- Groupe Francais De Pneumo-Cancerologie
Colon Cancer Patients Receiving Chemotherapy in the Adjuvant or Metastatic Setting, Aged 70 or Older
MOST: Mediterranean Oncology Senior Tests
MOST is a longitudinal study whose aim is to test the hypothesis that frailty markers are better at detecting vulnerable patients and that they are a better "Adverse Events" predictive tool than the CGA (Comprehensive Geriatric…
- Trial name
- MOST (NCT02148731)
- Testing
- Frailty markers
- Where
- 8 sites in France
- Volunteers
- 180 people
- Sponsor
- Association Sud pour la Recherche en Oncogériatrie
Colorectal Neoplasms, Frailty
Effect of CGA for Frail Elderly Patients Operated for Colorectal Cancer - The CRC Frailty-study
This multicentre randomized controlled trial aims to investigate whether an individualized comprehensive geriatric assessment (CGA) and care will improve postoperative results in frail elderly patients undergoing surgery for…
- Conditions
- Colorectal Neoplasms, Frailty, CGA
- Trial name
- NCT04358328
- Testing
- Comprehensive geriatric assessment (CGA) and care, Standard care
- Where
- 2 sites in Sweden
- Volunteers
- 340 people
- Sponsor
- Sahlgrenska University Hospital
Osteosarcoma, Neoplasms, Connective Tissue
Neoadjuvant Combination of Doxorubicin, Cisplatin and Methotrexate in Patients Aged 24-40 Years With Primary Bone Tumors
Two cycles of neoadjuvant three-component chemotherapy according to the MAP prototoc: Doxorubicin 25 mg / m2 IV on days 1-3, Cisplatin 120 mg / m2 IV on day 1 against the background of hyperhydration.
- Conditions
- Osteosarcoma, Neoplasms, Connective Tissue, Neoplasms, Connective and Soft Tissue, Sarcoma
- Trial name
- NCT05057130
- Testing
- Doxorubicin, Cisplatin, Methotrexate, Doxorubicin, Cisplatin
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Leukemia
Paclitaxel in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I/II trial to study the effectiveness of paclitaxel in treating patients with refractory or…
- Trial name
- NCT00003230
- Testing
- paclitaxel
- Where
- 9 sites in Switzerland
- Volunteers
- 33 people
- Sponsor
- Swiss Cancer Institute
Cancer (Solid Tumors), Geriatric Oncology
TRTRM (ACTTOP) -Guided Dosing Strategy in Older Patients With Cancer
Older adults receiving systemic cancer treatments are at increased risk of developing severe treatment-related toxicities (TRT).
- Trial name
- NCT07484932
- Testing
- TRTRM-guided risk-stratified treatment strategy
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The University of Hong Kong
Leukemia
Gemtuzumab Ozogamicin With or Without Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Trial name
- NCT00006122
- Testing
- cytarabine, etoposide, gemtuzumab ozogamicin
- Where
- 18 sites in Austria, Belgium and 5 more
- Volunteers
- 106 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer, Fatigue
Physical Activity Intervention for Older Patients During Chemotherapy for Colorectal Cancer
This study will see if patient who undergo a physical activity intervention called Walk With Ease report experiencing less fatigue and a higher quality of life during chemotherapy for colorectal cancer than those who do not…
- Trial name
- NCT02191969
- Testing
- Walk With Ease
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Quality of Life, Primary Patient Caregiver
Perceived Burden and Quality of Life of Primary Caregivers of Cancer Patients Aged 70 and Older After 5 Years of Management
Cancer is a disease that requires long-term management, especially now that medical advances have transformed most cancers from an acute to a chronic condition.
- Conditions
- Quality of Life, Primary Patient Caregiver, Cancer
- Trial name
- FARAPPAC (NCT04478903)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Non Small Cell Lung Cancer
Elderly Dependent Patients With Non Small Cell Lung Cancer (NSCLC)
The purpose of this study is in non small-cell lung cancer stage IV et IIIB (T4 with pleural effusion) in elderly dependent patients with evaluation of the sequence Gemcitabine first line followed by Erlotinib when progression…
- Trial name
- NCT00419042
- Testing
- TARCEVA, Gemzar
- Where
- 23 sites in France
- Volunteers
- 100 people
- Sponsor
- Groupe Francais De Pneumo-Cancerologie
Non-small Cell Lung Cancer, Stereotactic Body Radiotherapy
LIVELUNG - Impact of CGA in Patients Diagnosed With Localized NSCLC Treated With SBRT
Older patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT) often die from other causes than lung cancer due to age-related comorbidities.
- Conditions
- Non-small Cell Lung Cancer, Stereotactic Body Radiotherapy, Comprehensive Geriatric Assessment
- Trial name
- LIVELUNG (NCT05919641)
- Testing
- Comprehensive Geriatric Assessment
- Where
- 4 sites in Denmark
- Volunteers
- 130 people
- Sponsor
- Odense University Hospital
Non Small Cell Lung Cancer
Trial of Docetaxel Versus Vinorelbine as 1st Line Treatment in Elderly Patients With Non-Small-Cell Lung Cancer (NSCLC)
This trial will compare the efficacy of docetaxel versus vinorelbine as first-line treatment in elderly patients with advanced NSCLC.
- Trial name
- NCT00441922
- Testing
- Docetaxel, Vinorelbine
- Where
- 10 sites in Greece
- Volunteers
- 166 people
- Sponsor
- Hellenic Oncology Research Group
Geriatric Assessment, Geriatric Patients
Development and Verification of a Screening Tool for Comprehensive Geriatric Assessment of Elderly Tumor Patients
This study is an observational research. 1. The study first conducted an electronic questionnaire survey among clinicians working in general and specialized hospitals at various levels nationwide to understand the implementation…
- Conditions
- Geriatric Assessment, Geriatric Patients, Patients With Cancer, Assessment Tool
- Trial name
- NCT06761534
- Testing
- Screening of comprehensive geriatic assessment., the G8 assessment, Comprehensive Geriatric Assessment (CGA)
- Where
- China
- Volunteers
- 678 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Cancer, Elderly
COVID-19-Study of Immune Responses Following Vaccination Against SARS-CoV-2
T-cell adaptive immunity is known to be required to sustain a long term immunoglobulin production and a long term memory against several infections.
- Conditions
- Cancer, Elderly, Healthy Aging
- Trial name
- CACOV-VAC (NCT04836793)
- Testing
- Additional biological samples
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Glioblastoma (GBM)
Hypofractionated Radiotherapy Plus Temozolamide in Patients Younger Than 70 Years With Glioblastoma
The goal of this clinical trial is to evaluate the feasibility, safety and effectiveness of radiotherapy with fewer days of treatment and a higher dose of radiation each day in patients under 70 years of age diagnosed with a…
- Trial name
- HipoGBM (NCT07492836)
- Testing
- Hypofractionated Radiation Therapy
- Volunteers
- 10 people
- Sponsor
- Hospital do Coracao
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